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公开(公告)号：US20230042253A1
公开(公告)日：2023-02-09
申请号：US17934747
申请日：2022-09-23
发明人： Colette SONG , Oliver SCHOOR , Jens FRITSCHE , Toni WEINSCHENK , Harpreet SINGH
IPC分类号： C07K14/47 , C07K7/06 , C07K14/725 , A61K35/17 , C07K14/74 , C07K16/30 , C07K16/28 , C12N15/10 , A61K39/00 , C07K14/54 , G01N33/574 , C12N5/0783 , C12N15/115 , A61P35/00
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US20230040789A1
公开(公告)日：2023-02-09
申请号：US17843733
申请日：2022-06-17
发明人： Colette SONG , Oliver SCHOOR , Jens FRITSCHE , Toni WEINSCHENK , Harpreet SINGH
IPC分类号： C07K14/47 , A61K35/17 , C07K14/725 , C12N15/115 , G01N33/574 , C12N15/10 , C07K16/28 , C07K14/74 , C07K16/30 , C12N5/0783 , A61K39/00 , C07K7/06 , A61P35/00 , C07K14/54 , A61K38/00
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US11564944B2
公开(公告)日：2023-01-31
申请号：US16462733
申请日：2017-11-20
发明人： Patrick Soon-Shiong
IPC分类号： A61K35/17 , A61K47/64 , A61K35/761 , A61K39/00 , C07K14/52 , C07K14/74 , C12N5/0783
摘要： Contemplated compositions and methods generate a durable immune synapse and so lead to activated T-cells and memory T-cell formation by use of selected co-stimulatory receptors and their ligands in conjunction with selected neoepitopes. Moreover, immune competent cells are attracted into a tumor microenvironment after activation of the T-cells using hybrid or chimeric binding proteins that comprise a chemokine portion and that target components of necrotic cells.
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公开(公告)号：US20230023408A1
公开(公告)日：2023-01-26
申请号：US17930969
申请日：2022-09-09
发明人： Colette SONG , Heiko SCHUSTER , Daniel Johannes KOWALEWSKI , Oliver SCHOOR , Jens FRITSCHE , Toni WEINSCHENK , Harpreet SINGH
IPC分类号： C07K14/47 , A61K35/17 , A61K39/00 , C07K14/725 , C07K14/74 , C07K16/18 , C12N5/0783 , C12Q1/6886
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US20230021673A1
公开(公告)日：2023-01-26
申请号：US17822657
申请日：2022-08-26
发明人： Colette SONG , Oliver SCHOOR , Jens FRITSCHE , Toni WEINSCHENK , Harpreet SINGH
IPC分类号： C07K14/47 , C07K7/06 , C07K14/725 , A61K35/17 , C07K14/74 , C07K16/30 , C07K16/28 , C12N15/10 , A61K39/00 , C07K14/54 , G01N33/574 , C12N5/0783 , C12N15/115 , A61P35/00
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US11559573B2
公开(公告)日：2023-01-24
申请号：US17728756
申请日：2022-04-25
发明人： Toni Weinschenk , Andrea Mahr , Jens Fritsche , Phillip Mueller , Anita Wiebe , Sarah Kutscher
IPC分类号： A61K35/17 , A61K39/00 , A61K38/04 , C07K7/00 , C07K7/06 , C07K7/08 , C07K14/435 , C07K14/725 , C07K14/74 , C07K16/18 , C12N5/0783 , C12N15/115 , G01N33/68 , A61K51/10 , A61K35/12
摘要： A method of eliciting an immune response in a patient who has a cancer includes administering to said patient a composition containing a population of activated T cells that selectively recognize the cancer cells in the patient that aberrantly express a peptide consisting of the amino acid sequence of GVYDGEEHSV (SEQ ID NO: 303), in which the peptide is in a complex with an MHC molecule.
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公开(公告)号：US20230000965A1
公开(公告)日：2023-01-05
申请号：US17781616
申请日：2020-12-01
申请人： ASTELLAS PHARMA INC. , RIKEN
摘要： An object of the present invention is to provide clinically applicable aAVC-NY-ESO-1 cells stably expressing NY-ESO-1 in order to use aAVC-NY-ESO-1 cells in treating patients having a NY-ESO-1-expressing cancer. The present invention provides, for example, a human-derived cell comprising a polynucleotide encoding CD1d and a polynucleotide encoding NY-ESO-1 or a fragment thereof, wherein the polynucleotide encoding NY-ESO-1 or a fragment thereof is operably linked to an inducible promoter.
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公开(公告)号：US11541107B2
公开(公告)日：2023-01-03
申请号：US17717850
申请日：2022-04-11
发明人： Andrea Mahr , Toni Weinschenk , Oliver Schoor , Jens Fritsche , Harpreet Singh
IPC分类号： A61K39/00 , A61P35/00 , C12Q1/6886 , C12N15/115 , C07K16/28 , C07K14/74 , C07K16/30 , G01N33/574 , C07K7/08 , C07K14/725 , C12N5/0783 , C07K7/06 , C07K14/47
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：US20220403003A1
公开(公告)日：2022-12-22
申请号：US17764013
申请日：2020-09-25
IPC分类号： C07K14/74 , A61K9/127 , C07K14/47 , A61K47/69 , A61K47/64 , A61K47/55 , A61K38/46 , A61K31/7088 , C12N5/00 , C12N15/62 , C12N9/22
摘要： Disclosed herein are minimal arrestin domain containing protein 1 (ARRDC1) constructs, which drive the formation of ARRDC1-mediated microvesicles (ARMMs). These vesicles can be harnessed to package and deliver a variety of molecular cargos such as small molecules, nucleic acids, and proteins. An example of such cargo is the genome editor Cas9.
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公开(公告)号：US20220389079A1
公开(公告)日：2022-12-08
申请号：US17327171
申请日：2021-05-21
申请人： Cue Biopharma, Inc.
IPC分类号： C07K14/74 , C07K14/55 , A61K45/06 , A61K38/17 , A61K38/20 , G01N33/50 , C07K14/005 , A61K39/12 , C12N7/00 , C07K14/47 , A61K39/00
摘要： The present disclosure provides T-cell modulatory multimeric polypeptides that comprise an immunomodulatory polypeptide, an epitope-presenting peptide, and class I MHC polypeptides. A T-cell modulatory multimeric polypeptide is useful for modulating the activity of a T cell, and for modulating an immune response in an individual.
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