Pharmaceutical elastomeric articles
    12.
    发明授权
    Pharmaceutical elastomeric articles 有权
    医药弹性制品

    公开(公告)号:US09580523B2

    公开(公告)日:2017-02-28

    申请号:US13570920

    申请日:2012-08-09

    Abstract: Elastomeric polymers and compounded elastomers having reduced amounts of leachables and improved resistance to γ-irradiation sterilization suitable for pharmaceutical stopper and seal applications. These polymers and compounded elastomers maintain their physical performances upon being exposed to γ-irradiation over time and typical use conditions. The polymer is prepared by reacting a mixture of i) a C4 to C7 isoolefin monomer, ii) a styrene based monomer, and optionally iii) a C4 to C14 multiolefin monomer wherein the polymer contains 5 to 15 wt % of styrene derived units.

    Abstract translation: 弹性体聚合物和复合弹性体具有减少量的可浸出物和改善的抗γ射线灭菌的适用于药物塞和密封应用的耐受性。 这些聚合物和复合弹性体随着时间和典型的使用条件暴露于γ照射时保持其物理性能。 聚合物通过使i)C 4 -C 7异烯烃单体,ii)苯乙烯基单体和任选地iii)C 4至C 14多烯烃单体的混合物反应制备,其中聚合物含有5至15重量%的苯乙烯衍生单元。

    PREPARATION OF ISOBUTENE HOMO- OR COPOLYMER DERIVATIVES
    14.
    发明申请
    PREPARATION OF ISOBUTENE HOMO- OR COPOLYMER DERIVATIVES 审中-公开
    ISOBUTENE共聚物衍生物的制备

    公开(公告)号:US20160168282A1

    公开(公告)日:2016-06-16

    申请号:US15046987

    申请日:2016-02-18

    Applicant: BASF SE

    Abstract: A process for preparing isobutene homo- or copolymer derivatives by (i) polymerizing isobutene or an isobutene-comprising monomer mixture in the presence of an iron halide-donor complex, an aluminum trihalide-donor complex, or an alkylaluminum halide-donor complex, (ii) reacting a resulting high-reactivity isobutene polymer with a compound which introduces a low molecular weight polar group or a substructure thereof, and (iii) in the case of reaction with a substructure, further reacting to complete the formation of the low molecular weight polar group. The homo- or copolymer derivatives include a radical of a hydrophobic polyisobutene polymer having a number-average molecular weight of 110 to 250 000 and low molecular weight polar groups including amino functions, nitro groups, hydroxyl groups, mercaptan groups, carboxylic acid or carboxylic acid derivative functions, sulfonic acid or sulfonic acid derivative functions, aldehyde functions and/or silyl groups.

    Abstract translation: (i)在卤化铁 - 给体络合物,三卤化铝 - 供体络合物或烷基铝卤化物 - 供体络合物存在下聚合异丁烯或含异丁烯的单体混合物来制备异丁烯均聚物或共聚物衍生物的方法( ii)使所得高反应性异丁烯聚合物与引入低分子量极性基团或其下结构的化合物反应,和(iii)在与亚结构反应的情况下,进一步反应以完成低分子量的形成 极地组。 均聚物或共聚物衍生物包括数均分子量为110至250,000的疏水聚异丁烯聚合物基团和包括氨基官能团的低分子量极性基团,硝基,羟基,硫醇基,羧酸或羧酸 衍生功能,磺酸或磺酸衍生物功能,醛官能团和/或甲硅烷基。

    Preparation of isobutene homo- or copolymer derivatives
    16.
    发明授权
    Preparation of isobutene homo- or copolymer derivatives 有权
    异丁烯均聚物或共聚物衍生物的制备

    公开(公告)号:US09296841B2

    公开(公告)日:2016-03-29

    申请号:US13305283

    申请日:2011-11-28

    Abstract: A process for preparing isobutene homo- or copolymer derivatives by (i) polymerizing isobutene or an isobutene-comprising monomer mixture in the presence of an iron halide-donor complex, an aluminum trihalide-donor complex, or an alkylaluminum halide-donor complex, (ii) reacting a resulting high-reactivity isobutene polymer with a compound which introduces a low molecular weight polar group or a substructure thereof, and (iii) in the case of reaction with a substructure, further reacting to complete the formation of the low molecular weight polar group. The homo- or copolymer derivatives include a radical of a hydrophobic polyisobutene polymer having a number-average molecular weight of 110 to 250,000 and low molecular weight polar groups including amino functions, nitro groups, hydroxyl groups, mercaptan groups, carboxylic acid or carboxylic acid derivative functions, sulfonic acid or sulfonic acid derivative functions, aldehyde functions and/or silyl groups.

    Abstract translation: (i)在卤化铁 - 给体络合物,三卤化铝 - 供体络合物或烷基铝卤化物 - 供体络合物存在下聚合异丁烯或含异丁烯的单体混合物来制备异丁烯均聚物或共聚物衍生物的方法( ii)使所得高反应性异丁烯聚合物与引入低分子量极性基团或其下结构的化合物反应,和(iii)在与亚结构反应的情况下,进一步反应以完成低分子量的形成 极地组。 均聚物或共聚物衍生物包括数均分子量为110至250,000的疏水聚异丁烯聚合物基团和包括氨基官能团的低分子量极性基团,硝基,羟基,硫醇基,羧酸或羧酸衍生物 功能,磺酸或磺酸衍生物功能,醛官能团和/或甲硅烷基。

    METHOD FOR THE PRODUCTION OF HOMO- OR COPOLYMERS
    20.
    发明申请
    METHOD FOR THE PRODUCTION OF HOMO- OR COPOLYMERS 审中-公开
    共聚物生产方法

    公开(公告)号:US20120208971A1

    公开(公告)日:2012-08-16

    申请号:US13503710

    申请日:2010-11-02

    CPC classification number: C08F10/10 C08F4/00

    Abstract: Preparation of homo- or copolymers, especially of high-reactivity isobutene homo- or copolymers with a number-average molecular weight Mn of 400 to 1 000 000, by polymerizing one or more ethylenically unsaturated monomers in the liquid phase in the presence of a dissolved, dispersed or supported catalyst complex based on a protic acid compound obtainable by reacting a reactive inorganic or organic pentavalent phosphorus compound with three equivalents of an organic alpha,beta-dihydroxy compound, for example a tris(oxalato)- or tris(ortho-phenylenedioxy)phosphoric acid stabilized by a dialkyl ether.

    Abstract translation: 通过在溶解的条件下使液相中的一种或多种烯键式不饱和单体聚合,制备数均分子量为400至1 000 000的高反应异丁烯均聚物或共聚物的均聚物或共聚物 ,基于可通过使反应性无机或有机五价磷化合物与三当量的有机α,β-二羟基化合物反应获得的质子酸化合物的分散或负载的催化剂络合物,例如三(草酸) - 或三(邻 - 亚苯二氧基 )由二烷基醚稳定的磷酸。

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