公开(公告)号：US11447446B2

公开(公告)日：2022-09-20

申请号：US16907188

申请日：2020-06-20

Applicant: Fujian Yongjing Technology Co., Ltd

Inventor： Changyue Zhou ,  Hongjun Du ,  Wenting Wu

IPC: C07C253/30 ,  C01B21/083 ,  C07C67/307 ,  C07C201/12 ,  C07C303/22 ,  C07D317/42 ,  C07B39/00

Abstract: The invention relates to a use of a fluorination gas, and the elemental fluorine (F2) is present in a high concentration, for example, in a concentration of elemental fluorine (F2), especially of equal to much higher than 15 or even 20% by volume, and to a process for the manufacture of a fluorinated compound by direct fluorination employing a fluorination gas, wherein the elemental fluorine (F2) is present in a high concentration. The process of the invention is directed to the manufacture of a fluorinated compound, for the exception of fluorinated benzene, by direct fluorination. Especially the invention is of interest in the preparation of fluorinated organic compounds, final products and as well intermediates, for usage in agro-, pharma-, electronics-, catalyst, solvent and other functional chemical applications. The fluorination process of the invention may be performed batch-wise or in a continuous manner.

公开(公告)号：US20220168720A1

公开(公告)日：2022-06-02

申请号：US17673220

申请日：2022-02-16

Applicant: UNIVERSITA DEGLI STUDI DI UDINE ,  INNOVATION FACTORY S.R.L.

Inventor： Walter BARATTA ,  Salvatore BALDINO ,  Steven GIBOULOT

IPC: B01J31/24 ,  C07B41/02 ,  C07F15/00 ,  C07C29/143 ,  C07C29/145 ,  C07C41/26 ,  C07C201/12 ,  C07C29/14 ,  B01J31/18

Abstract: The invention relates to monocarbonyl complexes of ruthenium and osmium with bi- and tridentate nitrogen and phosphine ligands. The invention relates to methods for preparing these complexes and the use of these complexes, isolated or prepared in situ, as catalysts for reduction reactions of ketones and aldehydes both via transfer hydrogenation or hydrogenation with hydrogen.

公开(公告)号：US20220135516A1

公开(公告)日：2022-05-05

申请号：US17572688

申请日：2022-01-11

Applicant: Fujian Yongjing Technology Co.,Ltd

Inventor： Changyue Zhou ,  Hongjun DU ,  Wenting WU

IPC: C07C253/30 ,  C01B21/083 ,  C07C67/307 ,  C07C201/12 ,  C07C303/22 ,  C07D317/42 ,  C07B39/00

Abstract: The invention relates to a use of a fluorination gas, and the elemental fluorine (F2) is present in a high concentration, for example, in a concentration of elemental fluorine (F2), especially of equal to much higher than 15 or even 20% by volume, and to a process for the manufacture of a fluorinated compound by direct fluorination employing a fluorination gas, wherein the elemental fluorine (F2) is present in a high concentration. The process of the invention is directed to the manufacture of a fluorinated compound, for the exception of fluorinated benzene, by direct fluorination. Especially the invention is of interest in the preparation of fluorinated organic compounds, final products and as well intermediates, for usage in agro-, pharma-, electronics-, catalyst, solvent and other functional chemical applications. The fluorination process of the invention may be performed batch-wise or in a continuous manner.

公开(公告)号：US20220127228A1

公开(公告)日：2022-04-28

申请号：US17296542

申请日：2020-07-21

Applicant: SOOCHOW UNIVERSITY

Inventor： Xiaobing WAN ,  Pengcheng LIAN ,  Wenhao LONG ,  Jingjing LI ,  Yonggao ZHENG

IPC: C07D209/48 ,  C07C303/40 ,  C07C67/287 ,  C07C201/12 ,  C07C253/30 ,  C07C315/04 ,  C07B39/00

Abstract: The invention provides a method for producing a dichloro addition product of an aliphatic olefin by photocatalysis under visible light. The method includes reacting an aliphatic olefin as a substrate with hydrochloric acid as a chlorine source in an organic solvent under visible light irradiation in the presence of copper chloride with visible light absorption ability as a catalyst, to obtain the dichloro addition product of the aliphatic olefin, wherein the reaction is carried out under an oxygen-containing atmosphere, the aliphatic olefin comprises a carbon-carbon double bond and a C9-C15 aliphatic chain connected to the carbon-carbon double bond by a covalent bond. In the invention, visible light is used to provide the energy and a transition metal chloride with visible light absorption ability is used to undergo light-induced electron transfer from chloride with a reaction substrate, thereby initiating an addition reaction to obtain a dichloro addition product.

公开(公告)号：US11278876B2

公开(公告)日：2022-03-22

申请号：US16075315

申请日：2017-02-03

Applicant: UNIVERSITA DEGLI STUDI DI UDINE ,  INNOVATION FACTORY S.R.L.

Inventor： Walter Baratta ,  Salvatore Baldino ,  Steven Giboulot

IPC: B01J31/24 ,  C07B41/02 ,  C07F15/00 ,  C07C29/143 ,  C07C29/145 ,  C07C41/26 ,  C07C201/12 ,  C07C29/14 ,  B01J31/18

Abstract: The invention relates to monocarbonyl complexes of ruthenium and osmium with bi- and tridentate nitrogen and phosphine ligands. The invention relates to methods for preparing these complexes and the use of these complexes, isolated or prepared in situ, as catalysts for reduction reactions of ketones and aldehydes both via transfer hydrogenation or hydrogenation with hydrogen.

公开(公告)号：US20210380513A1

公开(公告)日：2021-12-09

申请号：US17303462

申请日：2021-05-28

Applicant: McMaster University

Inventor： Jake Magolan ,  Nick Jentsch ,  Xiong Zhang ,  Mathew Piotrowski ,  Partick Darveau ,  Meghan Fragis ,  Jarrod Johnson ,  Nikki Ritchie ,  Arnav Kaul

IPC: C07C37/14 ,  C07J7/00 ,  B01J21/04 ,  C07D209/08 ,  C07C41/26 ,  C07C253/30 ,  C07C201/12 ,  C07J1/00 ,  C07D311/30 ,  C07D311/32 ,  C07D307/80

Abstract: The present application describes process for preparing an ortho-allylated hydroxy aryl compounds such as compounds of Formula (I) by reacting an allylic alcohol with a hydroxy aryl compound in the presence of aluminum compound selected from alumina and aluminum alkoxides and in a non-protic solvent wherein at least one carbon atom ortho to the hydroxy group in the hydroxy aryl compound is unsubstituted. The present application also includes compounds of Formula (I).

公开(公告)号：US10988446B2

公开(公告)日：2021-04-27

申请号：US16321137

申请日：2016-09-28

Applicant: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION

Inventor： Fujie Tanaka ,  Feng Yin

IPC: C07D209/54 ,  C07D207/16 ,  C07C201/12 ,  C07C205/51

Abstract: The present invention relates to a process for preparing 3-pyrrolidine carboxylic acid derivatives, and particularly a simple process for preparing 5-substituted 3-pyrrolidine carboxylic acid derivatives. In addition, the present invention relates to a novel pyrrolidine carboxylic acid derivative, its manufacture, pharmaceutical compositions containing it and its use as a catalyst.

公开(公告)号：US20210107859A1

公开(公告)日：2021-04-15

申请号：US17044774

申请日：2019-04-03

Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

Inventor： Davide Audisio ,  Thibault Cantat ,  Gianluca Destro

IPC: C07C201/12 ,  C07B59/00 ,  C07D307/85 ,  C07D333/40 ,  C07C253/30 ,  C07C51/347 ,  C07D311/12 ,  C07D207/34 ,  C07D471/06 ,  C07D277/56 ,  C07D209/42 ,  C07D311/92 ,  C07C303/40

Abstract: A process for the synthesis of a carbon labeled organic compound containing a carbon labeled carboxyl group is described. A method of using carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; a process for manufacturing labeled pharmaceuticals and agrochemicals comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; and a process for producing tracers comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure are also described.

公开(公告)号：US20210101872A1

公开(公告)日：2021-04-08

申请号：US16976012

申请日：2019-03-08

Applicant: The USA, as represented by the Secretary, Dept. of Health and Human Services ,  Pontificia Universidad Católica de Chile

Inventor： Juan J. Marugan ,  Marc Ferrer ,  Noel T. Southall ,  Andres E. Dulcey ,  Xin Hu ,  Christopher R. Dextras ,  Daniel C. Talley ,  Alejandra Alvarez ,  Silvana Zanlungo ,  Rommy M. Von Bernhardi

IPC: C07D243/38 ,  C07D267/20 ,  C07F7/08 ,  C07D281/16 ,  C07D267/18 ,  C07C227/22 ,  C07C201/12 ,  C07C319/14 ,  C07D401/04 ,  C07D403/04 ,  C07D413/10 ,  C07F5/02 ,  C07D413/04 ,  C07D471/04 ,  C07D487/04 ,  C07D413/14 ,  C07D417/04 ,  A61P33/06 ,  A61P25/28 ,  A61P25/08 ,  A61P35/02 ,  A61K31/554 ,  A61K31/5513 ,  A61K31/553

Abstract: Disclosed herein are embodiments of a compound that inhibits c-Abl tyrosine kinase (also referred to herein as “c-Abl”). The compound embodiments described herein are novel c-Abl inhibitors that can bind to c-Abl at an allosteric site and inhibit its activity in various pathways. The compound embodiments also are capable of crossing the blood brain barrier and therefore are useful in inhibiting c-Abl activity as it affects pathways and/or proteins in the brain. The compound embodiments described herein are effective therapeutic agents for treating diseases involving c-Abl, such as cancers, motor neuron diseases, and neurodegenerative diseases. Also disclosed herein are embodiments of methods for making and using the c-Abl inhibitory compound embodiments.

公开(公告)号：US10913696B2

公开(公告)日：2021-02-09

申请号：US16847193

申请日：2020-04-13

Applicant: DOW GLOBAL TECHNOLOGIES LLC ,  The REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Melanie S. Sanford ,  Douglas Bland ,  Patrick S. Hanley ,  Megan A. Cismesia ,  Sydonie D. Schimler

IPC: C07C17/02 ,  C07D453/02 ,  C07D311/16 ,  C07C17/093 ,  C07D209/08 ,  C07D213/79 ,  C07D213/61 ,  C07C231/12 ,  C07C41/22 ,  C07C45/63 ,  C07D213/57 ,  C07C201/12 ,  C07C67/307 ,  C07D213/75 ,  C07J21/00 ,  C07D279/16 ,  C07C253/30 ,  C07D209/88 ,  C07D215/18 ,  C07C25/13 ,  C07C317/14

Abstract: Disclosed is a fluorination method comprising providing an aryl fluorosulfonate and a fluorinating reagent to a reaction mixture; and reacting the aryl fluorosulfonate and the fluorinating reagent to provide a fluorinated aryl species.
Also disclosed is a fluorination method comprising providing, a salt comprising a cation and an aryloxylate, and SO2F2 to a reaction mixture; reacting the SO2F2 and the ammonium salt to provide a fluorinated aryl species.
Further disclosed a fluorination method comprising providing a compound having the structure Ar—OH to a reaction mixture; where Ar is an aryl or heteroaryl; providing SO2F2 to the reaction mixture; providing a fluorinating reagent to the reaction mixture; reacting the SO2F2, the fluorinating reagent and the compound having the structure Ar—OH to provide a fluorinated aryl species having the structure Ar—F.