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公开(公告)号：US20220390628A1
公开(公告)日：2022-12-08
申请号：US17805869
申请日：2022-06-08
Applicant: Academia Sinica , National Central University
Inventor： Mythra Varun Nemallapudi , Chih-Hsun Lin , Shih-Chang Lee , Augustine Ei-fong Chen
IPC: G01T1/20
Abstract: The invention is related to particle induced radiography system, comprising a particle radiation source device, implant module, external detector device, central module and other controls, in which the implant module comprises active and/or passive components in tandem with the readout electronics and communication chosen to measure the beam properties and to generate and detect secondary gamma photons from the nuclear interactions, the external detector device provides a position sensitive gamma detector with a high detection efficiency, good spatial resolution and a relatively large field of view necessary for particle treatments useful in monitoring both the implanted device and the patient anatomical areas under treatment, and the external detector device can also be used to perform 3D spectral imaging on any material samples using proton beam as a probe.
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公开(公告)号：US11500265B2
公开(公告)日：2022-11-15
申请号：US17281814
申请日：2019-10-01
Applicant: William Marsh Rice University , Academia Sinica
Inventor： Michael Semmlinger , Ming-Lun Tseng , Jian Yang , Ming Zhang , Din Ping Tsai , Liangliang Dong , Arash Ahmadivand , Peter Nordlander , Naomi Jean Halas
Abstract: A harmonic light-generating metasurface includes a base substrate and a plurality of structures, that include nonlinear material, that are disposed in a pattern on a surface of the base substrate. Each structure of the plurality of structures individually supports a magnetic dipole mode. An electromagnetic field enhancement of the magnetic dipole mode induces generation of a harmonic signal by the plurality of structures. Alternatively, a harmonic light-generating metasurface, includes a base substrate, a supporting substrate that includes a nonlinear material, and a plurality of paired structures disposed in a pattern on a surface of the supporting substrate. Each paired structure, of the plurality of paired structures, collectively supports a toroidal dipole mode. An electromagnetic field enhancement of the toroidal dipole mode penetrates the supporting substrate to induce generation of a harmonic signal by the supporting substrate.
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公开(公告)号：US11480391B2
公开(公告)日：2022-10-25
申请号：US16348421
申请日：2017-11-08
Applicant: Academia Sinica
Inventor： Chi-Huey Wong , Chung-Yi Wu
Abstract: Immunogenic compositions comprising hemagglutinin (HA) variants and/or neuraminidase (NA) variants, which may be contained in an influenza A virus, and uses thereof for eliciting immune responses against influenza A virus.
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公开(公告)号：US20220267478A1
公开(公告)日：2022-08-25
申请号：US17631698
申请日：2020-07-29
Applicant: Academia Sinica
Inventor： Che-ming Jack Hu , Chien-wei Lin , Jung-chen Lin , Chen-hsueh Pai
Abstract: A carrier system that includes a nanocarrier and a peptide non-covalently associated with the nanocarrier. The peptide contains an adaptor peptide sequence fused to the N-terminus of a target peptide, the adaptor peptide sequence being designed to facilitate the association to the nanocarrier. Also disclosed is a method for improving the immunogenicity of a peptide antigen by fusing it to an adaptor peptide sequence to form an immunizing peptide and contacting the immunizing peptide with a compatible nanocarrier. Further, a method is provided for treating a condition by immunization with a target peptide that has been fused to an adaptor peptide sequence and thereby associated with a nanocarrier. The method induces an immune response against the target peptide for treating cancer, viral infection, bacterial infection, parasitic infection, autoimmunity, or undesired immune responses to a biologies treatment.
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公开(公告)号：US20220267382A1
公开(公告)日：2022-08-25
申请号：US17627212
申请日：2020-09-18
Applicant: ACADEMIA SINICA
Inventor： Yu-Chan CHAO , Chih-Hsuan TSAI , Chia-Jung CHANG , Sung-Chan WEI , Lin-Li LIAO , Huei-Ru LO
IPC: C07K14/005 , A61P31/16
Abstract: Provided is a chimeric hemagglutinin (HA) protein including an HA1 subunit and an HA2 subunit, in which the HA1 subunit is composed of a first domain derived from a parental HA1 subunit of a first subtype influenza virus and a second domain derived from a parental HA1 subunit of a second subtype influenza virus. The chimeric HA protein has improved thermal stability and can be used in a vaccine composition for preventing influenza virus infection. Also provided is a method of inducing an immune response against an influenza virus in a subject in need thereof that includes administering the chimeric HA protein to the subject, thereby conferring protection against the influenza virus infection on the subject.
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Patent Agency Ranking
公开(公告)号：US20220267363A1
公开(公告)日：2022-08-25
申请号：US17598064
申请日：2020-03-10
Applicant: Academia Sinica
Inventor： Chi-Huey Wong , Hong-Jay Lo
Abstract: Disclosed are a method of preparing a saccharide that contains a 3-fluoro-sialic acid and a method of bonding it to a homogeneous antibody. Also within the scope of this invention are compounds each containing a 3-fluoro-sialic acid, monoclonal antibodies bonded to α2,6-linked 3-fluoro-sialo-side terminated N-glycans, and treatment of cancer with such monoclonal antibodies.
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公开(公告)号：US20220257684A1
公开(公告)日：2022-08-18
申请号：US17628191
申请日：2020-07-18
Applicant: Academia Sinica
Inventor： Wen-Chin YANG
IPC: A61K36/282 , A61K36/28 , A61K31/216 , A61P33/02 , A61K9/00 , A23K10/30 , A23K50/75
Abstract: The present invention relates to anti-coccidial phytogenic formulations. Specifically, anti-coccidial compositions and use thereof are disclosed. An anti-coccidial composition comprises (a) an effective amount of Artemisia indica extract; and (b) an effective amount of Bidens pilosa extract. The composition may further comprise a pharmaceutically acceptable vehicle, excipient, or carrier, and/or an animal feed. The anti-coccidial compositions may be used in the manufacture of a medicament for killing coccidian oocysts, inhibiting oocyst sporulation, reducing sporozoite invasion, and lessening bloody stools, or for alleviating or treating coccidiosis, in a subject in need thereof. In another aspect, the invention relates to use of an anti-coccidial formulation comprising an effective amount of Artemisia indica extract, and a pharmaceutical acceptable vehicle in the manufacture of a medicament for killing coccidian oocysts and inhibiting coccidian oocyst sporulation, and sporozoite invasion.
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公开(公告)号：US20220249648A1
公开(公告)日：2022-08-11
申请号：US17611925
申请日：2020-07-31
Applicant: Ming-Che Shih , Academia Sinica
Inventor： Yu-Chan Chao , Wei-Ting Hsu
IPC: A61K39/12 , A61P31/12 , A61P37/04 , A61K47/69 , G01N33/569
Abstract: Provided are a vector, a recombinant virus, and a method of using and making thereof. Also provided are immunological compositions containing the recombinant African swine fever virus (ASFV) for inducing an immunological response in a host animal to which the immunological composition is administered. Further provided is a kit and a method of detecting the presence of ASFV immunogens in a sample from an animal.
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公开(公告)号：US20220204944A1
公开(公告)日：2022-06-30
申请号：US17566179
申请日：2021-12-30
Applicant: Academia Sinica
Inventor： Ying-Chih CHANG
Abstract: The present disclosure provides a substrate for cell culture. Systems comprising the substrate, and methods for using and manufacturing the substrate are also disclosed herein.
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公开(公告)号：US20220204943A1
公开(公告)日：2022-06-30
申请号：US17566166
申请日：2021-12-30
Applicant: Academia Sinica
Inventor： Ying-Chih CHANG
Abstract: The present disclosure provides a surface coating comprising a hydrophilic polymer and polyelectrolyte multilayers. Also provided is a cell culture system comprising a cell culture article having a surface coated with the surface coating. Uses and methods of preparing the surface coatings and systems are provided as well.
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