公开(公告)号：US20190143002A1

公开(公告)日：2019-05-16

申请号：US16098994

申请日：2017-06-23

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Mitsuhiro DENDA ,  Sumiko DENDA ,  Junichi KUMAMOTO ,  Yasuaki KOBAYASHI ,  Masaharu NAGAYAMA

IPC: A61L27/60 ,  C12N5/071 ,  B01L1/02 ,  C12N5/00

Abstract: A thick three-dimensional culture skin sheet is provided. The invention provides a three-dimensional culture skin sheet comprising at least epidermal cells and having concavoconvexities in at least one portion of the base section. The invention further provides a cell culturing vessel to be used for production of the three-dimensional culture skin sheet, having on at least one portion of the culture surface a porous film comprising convex sections for formation of concavoconvexities in the base section of the three-dimensional culture skin sheet. The invention still further provides a method for preparing a three-dimensional culture skin sheet using the cell culturing vessel.

公开(公告)号：US20190076342A1

公开(公告)日：2019-03-14

申请号：US16080693

申请日：2017-02-28

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Ayumi ASAI ,  Akinori ONO

IPC: A61K8/34 ,  A61K8/02 ,  A61K8/06 ,  A61K8/891 ,  A61K8/86 ,  A61Q19/00 ,  A61Q1/02

Abstract: An aqueous cosmetic composition provides a proper amount of a hydrophobic spherical powder blended in an aqueous phase stably even though an aqueous base material having a fresh sensation upon use is used, and which corrects the appearance of skin. The present invention provides a cosmetic composition characterized by comprising (A) at least one higher alcohol having a saturated straight alkyl chain, (B) hydrophilic surfactants including a nonionic surfactant, (C) a powder having an average particle diameter of 1 to 30 μm in an amount of 4 to 30% by mass and (D) water, wherein the ratio of the number of moles of a hydrophilic nonionic surfactant to the total number of moles of the hydrophilic surfactants (B) is 0.5 or more, the percentage of the amount of a hydrophobic spherical powder in the total amount of the powder having an average particle diameter of 1 to 30 μm (C) is 50% by mass or more, and the hydrophobic spherical powder is added to an aqueous phase.

公开(公告)号：US20190000727A1

公开(公告)日：2019-01-03

申请号：US16021439

申请日：2018-06-28

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Malyn CONCINA ,  Akane YANAGIHARA

IPC: A61K8/06 ,  A61Q1/02

Abstract: The present invention provides a makeup cosmetic and method of manufacturing the same attained by a water-in-oil emulsion cosmetic supplemented with an oil-in-water emulsion as a water phase in which fine (nano-sized) oil droplets containing a solid oil and having a specified predetermined particle size are dispersed. Specifically, the present invention provides a makeup cosmetic comprising an oil-in-water-in-oil (O/W/O) composite emulsion in which an oil-in-water (O/W) emulsion is dispersed in an external oil phase, wherein the oil-in-water (O/W) emulsion comprises oil droplets having a number-average particle size of 200 nm or smaller and containing a solidified oil.

公开(公告)号：US20180344791A1

公开(公告)日：2018-12-06

申请号：US16054001

申请日：2018-08-03

Applicant: Shiseido Company, Ltd.

Inventor： Kaedeko Fukada ,  Tatsuya Hasegawa ,  Hiroshi Mori ,  Yoshiharu Suzuki

IPC: A61K36/23

CPC classification number: A61K36/23 ,  A61K2236/15 ,  A61K2236/17 ,  A61K2236/333 ,  A61K2236/53

Abstract: The present invention provides a novel sirtuin-1 activating agent, and a formulation for suppressing cell senescence caused by oxidative stress, comprising the agent.In particular, the invention provides a sirtuin-1 activating agent consisting of a plant body or solvent extract of Peucedanum japonicum Thunb., and a formulation for suppressing cell senescence due to oxidative stress, comprising the agent.

公开(公告)号：US20180325783A1

公开(公告)日：2018-11-15

申请号：US15755849

申请日：2016-10-04

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Toru KINA

IPC: A61K8/02 ,  A61K8/58 ,  A61K8/25 ,  A61K8/26 ,  A61K8/27 ,  A61K8/29 ,  A61Q1/12

CPC classification number: A61K8/022 ,  A61K8/19 ,  A61K8/25 ,  A61K8/26 ,  A61K8/27 ,  A61K8/29 ,  A61K8/58 ,  A61K8/585 ,  A61K2800/436 ,  A61K2800/612 ,  A61K2800/805 ,  A61Q1/00 ,  A61Q1/12

Abstract: [Problem] To provide a decorating powder composition for decorating the surface of a solid cosmetic material, in particular, for obtaining a solid cosmetic material having a beautiful appearance which is decorated with a glossy powder, and a decorating method using the decorating powder composition.[Solution] Provided are a decorating powder composition including a glossy powder which has been surface-treated with a silane compound or a silazane compound, and a method for decorating a solid cosmetic material, the method including causing the decorating powder composition to adhere to a printing plate and then bringing the printing plate into contact with a surface of the solid cosmetic material to transfer the decorating powder composition to the surface of the solid cosmetic material and decorate the solid cosmetic material.

公开(公告)号：US20180200179A1

公开(公告)日：2018-07-19

申请号：US15749949

申请日：2015-08-04

Applicant: Shiseido Company, Ltd.

Inventor： Tomonobu EZURE ,  Takahiro OCHIYA

IPC: A61K8/96 ,  A61Q19/08

Abstract: The purpose of the present invention is to provide an agent for improving skin looseness or aging caused by dermal cavitation. By attracting fat stem cells into cavities in the dermis, dermal fibroblasts around the cavities can be activated and thus dermal cavitation can be ameliorated. As the results of a screening for fat stem cell attractants, it was found that rosemary extract and licorice extract are capable of attracting fat stem cells and, therefore, can improve skin looseness or aging caused by dermal cavitation.

公开(公告)号：US10017817B2

公开(公告)日：2018-07-10

申请号：US14857014

申请日：2015-09-17

Applicant: Shiseido Company, Ltd.

Inventor： Tsutomu Soma ,  Haruyo Yamanishi ,  Yumiko Ishimatsu

IPC: C12Q1/68 ,  C12Q1/6876 ,  G01N33/50 ,  A61K8/67 ,  A61Q19/08 ,  C12Q1/686

CPC classification number: C12Q1/6876 ,  A61K8/671 ,  A61Q19/08 ,  C12Q1/686 ,  C12Q2600/148 ,  C12Q2600/158 ,  G01N33/5064

Abstract: This method, which screens drugs that activate the skin, is characterized by causing candidate drugs to act on vascular endothelial cells, and selecting drugs that enhance the expression of PDGF-BB by the cells as a skin activation agent.

公开(公告)号：US20180036221A1

公开(公告)日：2018-02-08

申请号：US15784337

申请日：2017-10-16

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Atsushi Sogabe ,  Ayano Matsuo ,  Shin-Ichi Yusa

IPC: A61K8/81 ,  A61Q19/00 ,  C08F8/44 ,  C08F120/58 ,  C08F120/06

CPC classification number: A61K8/8147 ,  A61K8/8152 ,  A61K8/8158 ,  A61K2800/10 ,  A61K2800/48 ,  A61Q19/00 ,  C08F8/44 ,  C08F120/06 ,  C08F120/58

Abstract: The invention provides methods of thickening aqueous compositions without increasing stringiness. The method involves using, as thickeners, polymers of polyacrylic acid, poly(2-acryamide-2-methylpropanesulfonate), or salts thereof, having a weight average molecular weight of 500,000-8,000,000. The polymers contain no more than 10 mass % of polymers having a molecular weight of 10,000,00 or more, and/or contain no more than 10 mass % of polymers having more than three times the weight average molecular weight. Aqueous solutions of these polymers have a low degree of stringiness, and are particularly useful as thickeners for cosmetics.

公开(公告)号：US20170368374A1

公开(公告)日：2017-12-28

申请号：US15533569

申请日：2015-12-08

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Takashi MATSUDA

IPC: A61Q5/06 ,  A61K8/04 ,  A61K8/34 ,  A61K8/41

CPC classification number: A61Q5/06 ,  A61K8/02 ,  A61K8/046 ,  A61K8/34 ,  A61K8/41 ,  A61K8/44 ,  A61K8/49

Abstract: An aerosol cosmetic exhibits an improved feeling of use while having high UV blocking properties. An aerosol cosmetic is filled up as a bulk solution together with a propellant in a pressure-resistant container and includes ethyl alcohol that is a main dispersion medium, an organic ultraviolet absorber, and an ester oil. The organic ultraviolet absorber includes an organic ultraviolet absorber that is solid at room temperature. The solid organic ultraviolet absorber is dissolved in the ester oil.

公开(公告)号：US20170313982A1

公开(公告)日：2017-11-02

申请号：US15643869

申请日：2017-07-07

Applicant: Shiseido Company, Ltd.

Inventor： Haruyo Yamanishi ,  Tsutomu Soma ,  Yuzo Yoshida

IPC: C12N5/071

CPC classification number: C12N5/0625 ,  C12N5/0628 ,  C12N2500/90 ,  C12N2501/135

Abstract: The problem to be solved by the present invention is to provide a serum-free medium suitable for culturing of DS cells. The present invention relates to a serum-free medium for culturing of DS cells containing platelet-derived growth factor (PDGF), or to a method for culturing of dermal sheath (DS) cells, using serum-free medium comprising PDGF.