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    MARKER FOR EARLY DIAGNOSIS OF KIDNEY FAILURE
    204.
    发明申请
    MARKER FOR EARLY DIAGNOSIS OF KIDNEY FAILURE 审中-公开
    早期诊断KIDNEY失败的标记

    公开(公告)号：US20160313342A1

    公开(公告)日：2016-10-27

    申请号：US15103539

    申请日：2014-12-11

    Applicant: SHISEIDO COMPANY, LTD. ,  KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION

    Inventor： Kenji Hamase ,  Yurika MIYOSHI ,  Masashi MITA

    IPC: G01N33/68

    CPC classification number: G01N33/6812 ,  G01N2800/347

    Abstract: The present invention addresses the problem of identifying a biomarker of renal failure, said biomarker being available from urine or blood, and fluctuating from an early stage than glomerular filtration rate and serum creatinine level, and thus developing a technique for diagnosing early stage kidney failure. A method for analyzing the blood, plasma, serum or urine of a renal failure suspected subject comprises a step of measuring the concentration of a pair of D-form and L-form of at least one amino acid selected from the amino acid group consisting of [D-serine] and [L-serine], etc., contained in the blood, plasma, serum or urine of the subject, and calculating, as an pathological index of the subject, the ratio of the D-form concentration to the L-form concentration or the percentage of the D-form concentration relative to the total concentration of the D-form and L-form.

    Abstract translation: 本发明解决了鉴定肾衰竭的生物标志物的问题，所述生物标志物可从尿液或血液中获得，并且从早期阶段比肾小球滤过率和血清肌酐水平波动，从而开发用于诊断早期肾衰竭的技术。 用于分析肾衰竭疑似受试者的血液，血浆，血清或尿液的方法包括测量一对D型和L型的至少一种氨基酸的浓度的步骤，所述氨基酸选自由以下组成的氨基酸组： [D-丝氨酸]和[L-丝氨酸]等，包含在受试者的血液，血浆，血清或尿液中，并计算作为受试者的病理学指标，D型浓度与 L型浓度或D-型浓度相对于D-型和L-型总浓度的百分比。

    SKIN COSMETIC PRODUCT
    205.
    发明申请
    SKIN COSMETIC PRODUCT 审中-公开
    皮肤化妆品

    公开(公告)号：US20160310403A1

    公开(公告)日：2016-10-27

    申请号：US15099737

    申请日：2016-04-15

    Applicant: SHISEIDO COMPANY, LTD.

    Inventor： KAZUTAKA SASAKI

    IPC: A61K8/87 ,  A61K8/02 ,  A61Q19/00 ,  A61K8/85

    CPC classification number: A61K8/87 ,  A61K8/0216 ,  A61K8/022 ,  A61K8/85 ,  A61K2800/26 ,  A61Q19/00 ,  A61Q19/008

    Abstract: An aqueous skin cosmetic product exerting a high irregularity correction effect, providing a non-greasy and light feeling when applied and having an excellent sebum suppressing effect is provided. The skin cosmetic product of the present invention is characterized by comprising (A) 15 to 50% by mass of a powder formed of an (adipic acid/neopentyl glycol) crosspolymer and (B) 0.5 to 3% by mass of a hydrophobically modified polyurethane. (PEG-240/Decyltetradeceth-20/HDI) copolymer is preferable as the hydrophobically modified polyurethane, It is preferable that the skin cosmetic product is a gel having a viscosity of 15,000 mPa·s or more and 200,000 mPa·s or less.

    Abstract translation: 提供具有高不规则矫正效果的水性皮肤化妆品，在使用时提供非油腻感和具有优异的皮脂抑制作用。 本发明的皮肤化妆品的特征在于，包含（A）15质量％〜50质量％的由（己二酸/新戊二醇）交联聚合物形成的粉末，（B）0.5〜3质量％的疏水改性聚氨酯 。 （PEG-240 /癸基十四碳烯-20 / HDI）共聚物优选作为疏水改性聚氨酯。优选皮肤化妆品为粘度为15000mPa·s以上且200,000mPa·s以下的凝胶。

    Whitening agent, anti-aging agent, and antioxidant agent
    206.
    发明授权
    Whitening agent, anti-aging agent, and antioxidant agent 有权
    美白剂，抗衰老剂和抗氧化剂

    公开(公告)号：US09364423B2

    公开(公告)日：2016-06-14

    申请号：US13954176

    申请日：2013-07-30

    Applicant: Shiseido Company, Ltd.

    Inventor： Rikako Suzuki ,  Kiyotaka Hasegawa ,  Kiyoshi Sato ,  Tokiya Yokoi ,  Ken Kusakari

    IPC: A61K36/00 ,  A61K8/97 ,  A61K36/11 ,  A61Q19/02 ,  A61Q19/08

    CPC classification number: A61K8/97 ,  A61K36/11 ,  A61Q19/02 ,  A61Q19/08

    Abstract: The present invention is directed to an extrace of Psilotum spp., as a skin whitening agent. Whitening agents according to the invention exhibit superior effects, for example, by lightening and whitening skin pigmentation, lightening and whitening aging spots, freckles, chloasma, or the like after sunburn. The Psilotum spp. extract of the invention has a superior free radical scavenging ability permitting the extract to control skin aging and skin diseases caused by active oxygen (free radicals), while having a high level of safety.

    Abstract translation: 本发明涉及Psilotum spp。作为皮肤增白剂。 根据本发明的美白剂显示出优异的效果，例如通过在晒伤后减轻和增白皮肤色素沉着，减轻和增白老化点，雀斑，黄褐斑等。 Psilotum属 本发明的提取物具有优异的自由基清除能力，其允许提取物控制皮肤老化和由活性氧（自由基）引起的皮肤疾病，同时具有高水平的安全性。

    SKIN DULLNESS EVALUATION APPARATUS AND SKIN DULLNESS EVALUATION METHOD
    210.
    发明申请
    SKIN DULLNESS EVALUATION APPARATUS AND SKIN DULLNESS EVALUATION METHOD 有权
    皮肤深度评估装置和皮肤瑕疵评估方法

    公开(公告)号：US20160035109A1

    公开(公告)日：2016-02-04

    申请号：US14783159

    申请日：2014-03-24

    Applicant: SHISEIDO COMPANY, LTD.

    Inventor： Kumiko KIKUCHI ,  Yuji MASUDA

    IPC: G06T7/40 ,  G06K9/46 ,  G06T7/00 ,  A61B5/103 ,  A61B5/00

    CPC classification number: G06T7/90 ,  A61B5/1032 ,  A61B5/107 ,  A61B5/441 ,  G06K9/4652 ,  G06K2009/4666 ,  G06T7/0012 ,  G06T2207/30088

    Abstract: A skin dullness evaluation apparatus includes a frequency analyzing unit that decomposes a skin image into color heterogeneity of a predetermined size; a color heterogeneity index obtaining unit that obtains color data of skin from each of the color heterogeneity decomposed by the frequency analyzing unit, and obtains a color heterogeneity index of the color heterogeneity from the obtained color data of skin; and a dullness evaluation unit that evaluates skin dullness corresponding to the skin image based on the color heterogeneity index obtained by the color heterogeneity index obtaining unit.

    Abstract translation: 皮肤暗淡评估装置包括频率分析单元，其将皮肤图像分解成具有预定尺寸的颜色异质性; 从所述频率分析单元分解的每个颜色异质性中获得皮肤的颜色数据的颜色异质性指标获取单元，并从所获得的皮肤颜色数据中获得颜色异质性的颜色异质性指数; 以及基于由所述颜色异质性指标获取单元获得的颜色异质性指数来评估与所述皮肤图像相对应的皮肤暗淡的浊度评估单元。

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