公开(公告)号：US20130253313A1

公开(公告)日：2013-09-26

申请号：US13813896

申请日：2011-08-02

Applicant: Jin Kang ,  Marcin Arkadiusz Balicki ,  Rajesh Kumar ,  Russell H. Taylor

Inventor： Jin Kang ,  Marcin Arkadiusz Balicki ,  Rajesh Kumar ,  Russell H. Taylor

IPC: A61B1/00 ,  A61B3/10 ,  A61B1/07

CPC classification number: A61B1/00188 ,  A61B1/00004 ,  A61B1/00165 ,  A61B1/00172 ,  A61B1/0669 ,  A61B1/07 ,  A61B1/313 ,  A61B3/102 ,  A61B3/1225 ,  A61F9/007

Abstract: An autofocusing endoscope includes an objective lens, a relay optical system arranged to relay an image between the objective lens and a proximal end of the autofocusing endoscope, an optical fiber arranged with a distal end proximate the objective lens, a light source arranged to couple light into the optical fiber, an optical detection system arranged to receive and detect light from the optical fiber, and a data processor constructed to communicate with the optical detection system while in operation. The data processor is configured to determine a distance of a surface to be imaged through the objective lens and provide instructions for adjusting a focus of the autofocusing endoscope of the surface.

Abstract translation: 一种自动对焦内窥镜，包括：物镜;中继光学系统，被配置为中继所述物镜与所述自聚焦内窥镜的近端之间的图像，配置有靠近所述物镜的远端的光纤;光源， 光纤检测系统被布置成接收和检测来自光纤的光;以及数据处理器，被构造成在操作中与光学检测系统进行通信。 数据处理器被配置为确定要通过物镜成像的表面的距离，并提供用于调整表面的自动聚焦内窥镜的焦点的指令。

公开(公告)号：US20130216480A1

公开(公告)日：2013-08-22

申请号：US13610150

申请日：2012-09-11

Applicant: Clark K. Colton ,  Arthur Watterson ,  Rajesh Kumar ,  Virinder S. Parmar ,  Robert Fisher ,  Jayant Kumar

Inventor： Clark K. Colton ,  Arthur Watterson ,  Rajesh Kumar ,  Virinder S. Parmar ,  Robert Fisher ,  Jayant Kumar

IPC: A61K49/12 ,  G01N33/574 ,  G01N33/50 ,  A61K51/06

CPC classification number: A61K49/126 ,  A61K9/51 ,  A61K31/785 ,  A61K38/10 ,  A61K47/593 ,  A61K47/60 ,  A61K47/6907 ,  A61K49/0002 ,  A61K49/0032 ,  A61K49/0041 ,  A61K49/0043 ,  A61K49/0054 ,  A61K49/0056 ,  A61K49/0082 ,  A61K49/14 ,  A61K49/1809 ,  A61K49/1818 ,  A61K51/06 ,  A61K51/1237 ,  B82Y5/00 ,  C08G63/668 ,  C08G63/672 ,  C08G63/6826 ,  C08G63/6854 ,  C08G63/914 ,  C08G69/40 ,  C08G73/028 ,  C08G2261/126 ,  C08L77/00 ,  C08L79/02 ,  G01N33/5091 ,  G01N33/57492

Abstract: The present invention relates to amphiphilic polymers, and micelles and compositions comprising the same, and their use in a variety of biological settings, including imaging, targeting drugs, or a combination thereof for diagnostic and therapeutic purposes.

Abstract translation: 本发明涉及两亲性聚合物，以及包含该两性聚合物的胶束和组合物，以及它们在各种生物学设置中的用途，包括成像，靶向药物或其组合用于诊断和治疗目的。

公开(公告)号：US08461105B2

公开(公告)日：2013-06-11

申请号：US12585574

申请日：2009-09-17

Applicant: Steven G. Wright ,  Troy Christensen ,  Thean Yeoh ,  Michael E. Rickey ,  Joyce M. Hotz ,  Rajesh Kumar ,  Henry R. Costantino

Inventor： Steven G. Wright ,  Troy Christensen ,  Thean Yeoh ,  Michael E. Rickey ,  Joyce M. Hotz ,  Rajesh Kumar ,  Henry R. Costantino

IPC: A61K38/00 ,  C07K14/00

CPC classification number: A61K47/34 ,  A61K9/0024 ,  A61K9/1623 ,  A61K9/1647 ,  A61K9/1694 ,  A61K38/2278 ,  A61K38/26 ,  A61K47/26 ,  A61K47/38

Abstract: This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.

公开(公告)号：US08431685B2

公开(公告)日：2013-04-30

申请号：US12713036

申请日：2010-02-25

Applicant: Steven G. Wright ,  Troy Christensen ,  Thean Yeoh ,  Michael E. Rickey ,  Joyce M. Hotz ,  Rajesh Kumar ,  Henry R. Costantino

Inventor： Steven G. Wright ,  Troy Christensen ,  Thean Yeoh ,  Michael E. Rickey ,  Joyce M. Hotz ,  Rajesh Kumar ,  Henry R. Costantino

IPC: C07K14/00 ,  A61K38/00 ,  A61K9/14

CPC classification number: A61K47/34 ,  A61K9/0024 ,  A61K9/1623 ,  A61K9/1647 ,  A61K9/1694 ,  A61K38/2278 ,  A61K38/26 ,  A61K47/26 ,  A61K47/38

Abstract: This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.

公开(公告)号：US08349991B2

公开(公告)日：2013-01-08

申请号：US11405012

申请日：2006-04-17

Applicant: Clark K. Colton ,  Arthur Watterson ,  Rajesh Kumar ,  Virinder S. Parmar ,  Robert Fisher ,  Jayant Kumar

Inventor： Clark K. Colton ,  Arthur Watterson ,  Rajesh Kumar ,  Virinder S. Parmar ,  Robert Fisher ,  Jayant Kumar

IPC: C08G63/06 ,  C08G63/12 ,  C08G69/08 ,  C08G75/00 ,  C08G63/00 ,  C08G67/00 ,  C08G69/00 ,  A61K47/30

CPC classification number: A61K49/126 ,  A61K9/51 ,  A61K31/785 ,  A61K38/10 ,  A61K47/593 ,  A61K47/60 ,  A61K47/6907 ,  A61K49/0002 ,  A61K49/0032 ,  A61K49/0041 ,  A61K49/0043 ,  A61K49/0054 ,  A61K49/0056 ,  A61K49/0082 ,  A61K49/14 ,  A61K49/1809 ,  A61K49/1818 ,  A61K51/06 ,  A61K51/1237 ,  B82Y5/00 ,  C08G63/668 ,  C08G63/672 ,  C08G63/6826 ,  C08G63/6854 ,  C08G63/914 ,  C08G69/40 ,  C08G73/028 ,  C08G2261/126 ,  C08L77/00 ,  C08L79/02 ,  G01N33/5091 ,  G01N33/57492

Abstract: The present invention relates to amphiphilic polymers, and micelles and compositions comprising the same, and their use in a variety of biological settings, including imaging, targeting drugs, or a combination thereof for diagnostic and therapeutic purposes.

Abstract translation: 本发明涉及两亲性聚合物，以及包含该两性聚合物的胶束和组合物，以及它们在各种生物学设置中的用途，包括成像，靶向药物或其组合用于诊断和治疗目的。

公开(公告)号：US20120316421A1

公开(公告)日：2012-12-13

申请号：US13382855

申请日：2010-07-07

Applicant: Rajesh Kumar ,  Themistocles Dassopoulos ,  Hani Girgis ,  Gregory Hager

Inventor： Rajesh Kumar ,  Themistocles Dassopoulos ,  Hani Girgis ,  Gregory Hager

IPC: A61B6/00 ,  H04N7/18

CPC classification number: A61B1/041 ,  A61B1/00009 ,  G06T7/0012 ,  G06T2207/10016 ,  G06T2207/10068 ,  G06T2207/30032

Abstract: A system and method for automated image analysis which may enhance, for example, capsule endoscopy diagnosis. The system and methods may reduce the time required for diagnosis, and also help improve diagnostic consistency using an interactive feedback tool. Furthermore, the system and methods may be applicable to any procedure where efficient and accurate visual assessment of a large set of images is required.

Abstract translation: 用于自动图像分析的系统和方法，其可以增强例如胶囊内窥镜诊断。 系统和方法可以减少诊断所需的时间，并且还可以使用交互式反馈工具来帮助提高诊断一致性。 此外，该系统和方法可以适用于需要对大量图像进行高效和准确的视觉评估的任何程序。

公开(公告)号：US08308975B2

公开(公告)日：2012-11-13

申请号：US13280645

申请日：2011-10-25

Applicant: Yeonsuk Roh ,  Rajesh Kumar ,  Cheng-Le Zhao ,  David Kaczan ,  Theodore Michael Smiecinski

Inventor： Yeonsuk Roh ,  Rajesh Kumar ,  Cheng-Le Zhao ,  David Kaczan ,  Theodore Michael Smiecinski

IPC: C07D303/02

CPC classification number: C08G18/7621 ,  C08G18/36 ,  C08G18/4081 ,  C08G18/4829 ,  C08G18/64 ,  C08G2101/0008 ,  C08G2101/0083 ,  C08L83/00 ,  C11C3/006

Abstract: A polyol includes the reaction product of an epoxidized oil and an organic acid. The epoxidized oil and the organic acid are reacted in the presence of a Lewis base catalyst including at least one of a phosphorous atom or a nitrogen atom. The polyol is formed by a method that includes the step of reacting the epoxidized oil with the organic acid in the presence of the Lewis base catalyst.

Abstract translation: 多元醇包括环氧化油和有机酸的反应产物。 在包含磷原子或氮原子中的至少一种的路易斯碱催化剂的存在下使环氧化油和有机酸反应。 通过包含在路易斯碱催化剂存在下使环氧化油与有机酸反应的步骤的方法形成多元醇。

公开(公告)号：US08293871B2

公开(公告)日：2012-10-23

申请号：US11578712

申请日：2005-04-15

Applicant: Steven G. Wright ,  Troy Christensen ,  Thean Yeoh ,  Michael E. Rickey ,  Joyce M. Hotz ,  Rajesh Kumar ,  Henry R. Costantino ,  Christine Smith ,  David M. Lokensgard ,  Mark Fineman ,  John Ong

Inventor： Steven G. Wright ,  Troy Christensen ,  Thean Yeoh ,  Michael E. Rickey ,  Joyce M. Hotz ,  Rajesh Kumar ,  Henry R. Costantino ,  Christine Smith ,  David M. Lokensgard ,  Mark Fineman ,  John Ong

IPC: A61K38/00

CPC classification number: A61K47/34 ,  A61K9/0024 ,  A61K9/1623 ,  A61K9/1647 ,  A61K9/1694 ,  A61K38/2278 ,  A61K38/26 ,  A61K47/26 ,  A61K47/38

Abstract: This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.

Abstract translation: 本发明涉及用于持续释放生物活性多肽的组合物，以及形成和使用所述组合物用于持续释放生物活性多肽的方法。 本发明的缓释组合物包含分散在其中的生物相容性聚合物，生物活性多肽和糖。

公开(公告)号：US20120123145A1

公开(公告)日：2012-05-17

申请号：US13252576

申请日：2011-10-04

Applicant: Ashok L. Cholli ,  Rajesh Kumar

Inventor： Ashok L. Cholli ,  Rajesh Kumar

IPC: C07C229/42 ,  C07C215/80 ,  C07C233/29 ,  C07C237/20

CPC classification number: C07C231/12 ,  C07C235/34 ,  C07C235/38 ,  C08K5/005 ,  C08K5/13 ,  C08K5/132 ,  C08L21/00 ,  C09K15/00 ,  C09K15/08 ,  C09K15/22 ,  C09K15/24

Abstract: Described are antioxidant macromolecules and methods of making and using same.

Abstract translation: 描述了抗氧化剂大分子及其制备和使用方法。

公开(公告)号：US20110297383A1

公开(公告)日：2011-12-08

申请号：US13126905

申请日：2009-10-29

Applicant: Christopher M. Tanguay ,  John Erickson ,  Victoria Manea ,  Jyh-Chiarng Huarng ,  Rajesh Kumar ,  Fikri Emrah Alemdaroglu

Inventor： Christopher M. Tanguay ,  John Erickson ,  Victoria Manea ,  Jyh-Chiarng Huarng ,  Rajesh Kumar ,  Fikri Emrah Alemdaroglu

IPC: E21B43/26 ,  B05D7/00 ,  C09K8/92

CPC classification number: C09K8/805 ,  C09K8/62

Abstract: A proppant comprises a particle and a polycarbodiimide coating disposed on the particle. The polycarbodiimide coating comprises the reaction product of a polymeric isocyanate and a monomeric isocyanate, in the presence of a catalyst. A method of forming the proppant comprises the steps of providing the particle, providing the polymeric isocyanate, providing the monomeric isocyanate, providing the catalyst, reacting the polymeric isocyanate and the monomeric isocyanate in the presence of the catalyst to form the polycarbodiimide coating, and coating the particle with the polycarbodiimide coating.

Abstract translation: 支撑剂包括颗粒和设置在颗粒上的聚碳二亚胺涂层。 聚碳化二亚胺涂层包括聚合异氰酸酯和单体异氰酸酯在催化剂存在下的反应产物。 形成支撑剂的方法包括提供颗粒，提供聚合异氰酸酯，提供单体异氰酸酯，提供催化剂，在催化剂存在下使聚合异氰酸酯和单体异氰酸酯反应形成聚碳二亚胺涂层和涂层 具有聚碳化二亚胺涂层的颗粒。