公开(公告)号：US1936607A

公开(公告)日：1933-11-28

申请号：US58697332

申请日：1932-01-15

Applicant: RINKENBACH WILLIAM H

Inventor： RINKENBACH WILLIAM H

IPC: C07C201/16

CPC classification number: C07C201/16 ,  C06B21/0091 ,  C07C205/06

公开(公告)号：US1450675A

公开(公告)日：1923-04-03

申请号：US20036917

申请日：1917-11-05

Applicant: DU PONT

Inventor： STINE CHARLES M

IPC: C07C201/16

CPC classification number: C07C201/16 ,  C06B21/0091 ,  C07C205/06

公开(公告)号：US20250074912A1

公开(公告)日：2025-03-06

申请号：US18727092

申请日：2023-01-06

Applicant: MSN LABORATORIES PRIVATE LIMITED, R&D CENTER

Inventor： Thirumalai Rajan SRINIVASAN ,  Eswaraiah SAJJA ,  Vijayavitthal T. MATHAD ,  Rajeshwar Reddy SAGYAM ,  Venkata Narasayya SALADI ,  Navin Kumar Reddy KESHAVAREDDY ,  Balraju KAMMARI ,  Raghavendar Reddy PARIGI ,  Venkata Chary UTNOORI ,  Murali YATA

IPC: C07D471/14 ,  A61K31/437 ,  C07C67/52 ,  C07C69/78 ,  C07C201/16 ,  C07C205/57

Abstract: The present invention relates to an improved process for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide formula-1. The present invention relates to crystalline form of 8-((3R,4S)-4-ethylpyrrolidin-3-yl)-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine compound of formula-2.
The present invention also relates dibenzoyl-L-tartaric acid salt and 4-nitrobenzoic acid salt of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoro ethyl)pyrrolidine-1-carboxamide and its polymorph forms which are useful in the preparation of pure Upadacitinib. The present invention also relates to a crystalline form of Upadacitinib tartrate and its process thereof.

公开(公告)号：US12162815B2

公开(公告)日：2024-12-10

申请号：US17258385

申请日：2019-07-03

Applicant: F.I.S.—Fabbrica Italiana Sintetici S.P.A. ,  AMGEN INC.

Inventor： Elena Brasola ,  Marco Di Silvestro

IPC: C07C205/12 ,  C07C201/16

Abstract: The present invention refers to a crystalline 2-fluoro-3-nitrotoluene compound of formula (I), and a process for the preparation thereof. Furthermore, the present invention relates to a process for the synthesis of a compound of formula (II) or salts thereof by means of the crystalline 2-fluoro-3-nitrotoluene.

公开(公告)号：US11970436B2

公开(公告)日：2024-04-30

申请号：US17749293

申请日：2022-05-20

Applicant: NEONC Technologies, Inc.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Puppali

IPC: C07C29/92 ,  A61K31/045 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07C29/78 ,  C07C29/86 ,  C07C29/88 ,  C07C67/14 ,  C07C201/12 ,  C07C201/16

CPC classification number: C07C29/92 ,  A61K31/045 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07C29/78 ,  C07C29/86 ,  C07C29/88 ,  C07C67/14 ,  C07C201/12 ,  C07C201/16 ,  C07B2200/07 ,  C07C2601/16 ,  C07C29/92 ,  C07C33/14 ,  C07C201/12 ,  C07C205/57 ,  C07C67/14 ,  C07C69/76 ,  C07C67/14 ,  C07C69/92

Abstract: The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

公开(公告)号：US20220324790A1

公开(公告)日：2022-10-13

申请号：US17634276

申请日：2020-09-02

Applicant: BASF AGRO B.V.

Inventor： Timo Frassetto ,  Florian Vogt ,  Swapnil Yerande ,  Christiane Alznauer ,  Sebastian Illies ,  Philip Muelheims ,  Daniel Saelinger ,  Robin Thiele ,  Heinz Friedrich Sutoris

IPC: C07C201/02 ,  C07C201/08 ,  C07C205/11 ,  C07C203/02 ,  C07C201/16

Abstract: The present invention relates to a process for the preparation of α-methyl-[4-(nitro)-2-(trifluoromethyl)]-benzyl nitrate and to the α-methyl-[4-(nitro)-2-(trifluoromethyl)]-benzyl nitrate.

公开(公告)号：US20220169592A1

公开(公告)日：2022-06-02

申请号：US17602366

申请日：2020-04-14

Applicant: Covestro Deutschland AG ,  Covestro Intellectual Property GmbH & Co. KG

Inventor： Thomas Knauf ,  Murat Kalem ,  Christian Drumm ,  Alexandre Racoes

IPC: C07C201/08 ,  C07C201/16 ,  B01J19/24 ,  B01D19/00 ,  B01D17/02

Abstract: The invention relates to a continuously operating process for producing nitrobenzene, comprising the following steps: a) nitriding benzene in adiabatic conditions with sulfuric acid and nitric acid, using a stoichiometric excess of benzene in relation to the nitric acid; b) first separating a gaseous phase containing benzene and gaseous secondary components from the raw process product of the nitridation in a gas separator provided specifically for this purpose, then separating, in a downstream phase-separating apparatus, the resulting liquid phase, which is depleted in gaseous components and contains nitrobenzene and sulfuric acid, into a sulfuric acid phase and a nitrobenzene phase; and c) processing the nitrobenzene phase, obtaining nitrobenzene. The invention also relates to a production plant suitable for carrying out the claimed process.

公开(公告)号：US20220162151A1

公开(公告)日：2022-05-26

申请号：US17602333

申请日：2020-04-14

Applicant: Covestro Deutschland AG ,  Covestro Intellectual Property GmbH & Co. KG

Inventor： Thomas Knauf ,  Murat Kalem ,  Christian Drumm ,  Alexandre Racoes

IPC: C07C201/08 ,  C07C201/16

Abstract: The invention relates to a continuously operating process for producing nitrobenzene, comprising the following steps: a) nitriding benzene in adiabatic conditions with sulfuric acid and nitric acid, using a stoichiometric excess of benzene in relation to the nitric acid, in multiple parallel reactors; b) first combining the raw process products of the nitridation from the parallel reactors to form a mixed flow in a device provided specifically for this purpose, then separating the mixed flow into a sulfuric acid phase and a nitrobenzene phase in a downstream phase separation apparatus; and c) processing the nitrobenzene phase, obtaining nitrobenzene. The invention also relates to a production plant suitable for carrying out the claimed process.

公开(公告)号：US10913695B2

公开(公告)日：2021-02-09

申请号：US15742614

申请日：2016-07-08

Applicant: IFP ENERGIES NOUVELLES ,  ARKEMA FRANCE

Inventor： Catherine Laroche ,  Ludivine Bouvier ,  Javier Perez-Pellitero

IPC: B01J20/18 ,  C07C7/13 ,  C07C29/76 ,  C07C37/82 ,  B01J20/30 ,  B01J20/16 ,  B01J29/08 ,  B01J37/02 ,  B01J37/30 ,  C07C39/07 ,  C07C15/02 ,  B01D15/08 ,  B01J20/04 ,  C07C15/08 ,  C07C209/86 ,  C07C201/16 ,  C07C211/50 ,  C07C205/06

Abstract: The present invention relates to zeolite adsorbents based on agglomerated zeolite X crystals comprising barium, potassium and sodium. These adsorbents find applications in the separation of aromatic C8 isomer fractions and especially xylene.

公开(公告)号：US10815189B2

公开(公告)日：2020-10-27

申请号：US16491287

申请日：2018-03-05

Applicant: Covestro Deutschland AG

Inventor： Denise Chan ,  Thomas Knauf ,  Juergen Muennig

IPC: C07C201/08 ,  C07C201/16

Abstract: The invention relates to a method for continuous production of nitrobenzene by means of nitration of benzene with nitric acid and sulfuric acid, in which load change (i.e. a reduction or increase in the quantity of nitric acid supplied to the process per time interval) is particularly advantageously developed. The invention particularly relates to a method in which, in the case of a load reduction, the ratio of the masses of benzene and nitric acid supplied per time interval is significantly increased compared to said ratio before the load change and/or the ratio of the masses of nitric acid and sulfuric acid supplied per time interval is significantly reduced compared to said ratio before the load change. In the event of a load increase, the reverse is carried out.