NANOSTRUCTURE, A BIOSENSOR INCLUDING THE NANOSTRUCTURE, AND A SCREENING METHOD

    公开(公告)号:US20210262014A1

    公开(公告)日:2021-08-26

    申请号:US16803731

    申请日:2020-02-27

    Abstract: Disclosed are a nanostructure including a nanoparticle, and a first compound including a probe and bound to the surface of the nanoparticle, a second compound including a DNA sequence encoding the probe and bound to the surface of the nanoparticle, and optionally substituted or unsubstituted polyalkylene glycol bound to the surface of the nanoparticle, wherein when the nanostructure does not include substituted or unsubstituted polyalkylene glycol bound to the surface of the nanoparticle, a ratio ((n1+n2)/w) of the sum of the number of moles (n1) of the first compound and the number of moles (n2) of the second compound relative to the weight (w) of the nanostructure is about 1.2 nmol/g to about 85 μmol/g on average, a biosensor including the nanostructure, and a method of screening a biological material using the nanostructure or the biosensor.

    Genetic biocontainment system to prevent theft and misuse of biological resources and uses thereof

    公开(公告)号:US20250163408A1

    公开(公告)日:2025-05-22

    申请号:US18743720

    申请日:2024-06-14

    Abstract: The present invention relates to a genetic biocontainment technology to prevent theft or misuse of biological resources (e.g., nucleic acid molecule, plasmid or microbial strain containing the nucleic acid molecule, or sequence information associated with the nucleic acid molecule) using a quadruplet codon and decoding system thereof. In particular, the present invention relates to a system or a microbial strain comprising a nucleic acid molecule in which a triplet codon encoding a specific amino acid in a nucleic acid sequence has been replaced with a quadruplet codon, wherein genetic biocontainment occurs in an environment where tRNA for the quadruplet codon does not exist, and a method using the same. The present invention also relates to a biocontainment method to protect sequence information using a quadruplet codon.

    System and method for estimating E2E delay among blockchain nodes over P2P networks

    公开(公告)号:US12278750B1

    公开(公告)日:2025-04-15

    申请号:US18511886

    申请日:2023-11-16

    Abstract: Provided is a system and method for estimating an end-to-end delay between blockchain nodes in peer-to-peer (P2P) networks. The system includes a coordinate system construction unit configured to designate an origin node and anchor nodes among participating nodes having a distributed ledger of P2P networks, construct a first coordinate system of a predetermined dimension by exchanging control messages between the origin node and the anchor nodes and the participating nodes, and construct a second coordinate system of another predetermined dimension and a dimension determination unit configured to determine a dimension to be applied to the current P2P networks by comparing dimension-specific delays or control message overheads of the first coordinate system and the second coordinate system.

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