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    CLOSED LOOP OPTIMIZATION OF CONTROL PARAMETERS DURING CARDIAC PACING
    241.
    发明申请
    CLOSED LOOP OPTIMIZATION OF CONTROL PARAMETERS DURING CARDIAC PACING 有权
    闭环控制参数的闭环优化

    公开(公告)号：US20160184590A1

    公开(公告)日：2016-06-30

    申请号：US15062945

    申请日：2016-03-07

    Applicant: Medtronic, Inc.

    Inventor： Subham Ghosh

    IPC: A61N1/368

    CPC classification number: A61N1/3682 ,  A61N1/3627 ,  A61N1/3684

    Abstract: A system and method control a pacing parameter in a closed-loop manner by determining a value of an EGM-based index corresponding an optimal electrical activation condition of a patient's heart and adjusting a pacing therapy to maintain the EGM-based index value. The closed loop control method performed by the system may establish a relationship between an EGM-based index and multiple settings of a pacing control parameter. Values of the EGM-based index are stored with corresponding setting shifts relative to a previously established optimal setting. A processor of an implantable medical device monitors the EGM-based index during cardiac pacing. Responsive to detecting an EGM-based index value corresponding to a non-optimal setting of the control parameter, the processor determines an adjustment of the control parameter from the stored index values and corresponding setting shifts.

    Abstract translation: 系统和方法以闭环方式控制起搏参数，通过确定对应于患者心脏的最佳电活化状态的EGM指数的值并调整起搏治疗以维持基于EGM的指数值。 由系统执行的闭环控制方法可以建立基于EGM的索引与起搏控制参数的多个设置之间的关系。 基于EGM的索引的值相对于先前确定的最佳设置存储相应的设置位移。 可植入医疗装置的处理器在心脏起搏期间监测基于EGM的指数。 响应于检测对应于控制参数的非最优设置的基于EGM的索引值，处理器根据存储的索引值和相应的设置偏移来确定控制参数的调整。

    Bioelectric sensor device and methods
    242.
    发明授权
    Bioelectric sensor device and methods 有权
    生物传感器装置及方法

    公开(公告)号：US09320446B2

    公开(公告)日：2016-04-26

    申请号：US14227719

    申请日：2014-03-27

    Applicant: Medtronic, Inc.

    Inventor： Jeffrey Gillberg ,  Subham Ghosh

    IPC: A61B5/0408 ,  A61B5/04 ,  A61B5/00

    CPC classification number: A61B5/04085 ,  A61B5/04 ,  A61B5/04087 ,  A61B5/6805 ,  A61B5/6823 ,  A61B5/683 ,  A61B5/6832 ,  A61B2562/046 ,  A61B2562/164

    Abstract: Various embodiments of a bioelectric sensor device for sensing bioelectric data from a human body are disclosed. The device can include a flexible substrate, a plurality of sensors arranged in a sensor array on a sensor array portion of the substrate, an electrically conductive network located on the substrate, and a plurality of lines of weakness formed in the sensor array portion of the substrate. In one or more embodiments, each line of weakness is configured to enhance separation of the sensor array portion of the substrate along a separation line that extends between at least two sensors of the plurality of sensors. The device can also include a left reference electrode proximate a distal end of a left reference electrode arm of the substrate and a right reference electrode proximate a distal end of a right reference electrode arm of the substrate.

    Abstract translation: 公开了用于感测人体生物电数据的生物电传感器装置的各种实施例。 该装置可以包括柔性基板，布置在基板的传感器阵列部分上的传感器阵列中的多个传感器，位于基板上的导电网络，以及形成在传感器阵列部分中的多个弱线 基质。 在一个或多个实施例中，每条弱线被配置为增强沿着在多个传感器的至少两个传感器之间延伸的分隔线的衬底的传感器阵列部分的分离。 该装置还可以包括靠近基板的左参考电极臂的远端的左参考电极和靠近基板的右参考电极臂的远端的右参考电极。

    Identification of healthy versus unhealthy substrate for pacing from a multipolar lead
    243.
    发明授权
    Identification of healthy versus unhealthy substrate for pacing from a multipolar lead 有权
    从多极引线鉴定健康对不健康的基质起搏

    公开(公告)号：US09278220B2

    公开(公告)日：2016-03-08

    申请号：US13948503

    申请日：2013-07-23

    Applicant: Medtronic, Inc.

    Inventor： Subham Ghosh

    IPC: A61N1/18 ,  A61N1/368 ,  A61N1/37 ,  A61B5/04 ,  A61B5/0408 ,  A61B5/042 ,  A61N1/362

    CPC classification number: A61N1/3686 ,  A61B5/04012 ,  A61B5/04085 ,  A61B5/0422 ,  A61B2562/046 ,  A61N1/3627 ,  A61N1/3702 ,  A61N1/3704

    Abstract: A medical device system performs a method for determining presence of scar tissue through an implanted lead having an electrode for cardiac pacing and sensing. A sensing module senses heart activity with the electrode to produce a unipolar electrogram (EGM) waveform. A processor receives the unipolar EGM waveform and extracts two or more features representative of heart activity at the electrode. Scar tissue is identified at the site of the first electrode based upon at least two of the extracted features indicating scar tissue.

    Abstract translation: 医疗装置系统执行用于通过具有用于心脏起搏和感测的电极的植入导线来确定瘢痕组织的存在的方法。 感测模块​​用电极感测心脏活动以产生单极电描记图（EGM）波形。 处理器接收单极EGM波形，并提取代表电极心脏活动的两个或多个特征。 基于指示瘢痕组织的提取特征中的至少两个，在第一电极的位置处鉴定瘢痕组织。

    Closed loop optimization of control parameters during cardiac pacing
    244.
    发明授权
    Closed loop optimization of control parameters during cardiac pacing 有权
    心脏起搏期间控制参数的闭环优化

    公开(公告)号：US09278219B2

    公开(公告)日：2016-03-08

    申请号：US13833882

    申请日：2013-03-15

    Applicant: MEDTRONIC, INC.

    Inventor： Subham Ghosh

    IPC: A61N1/36 ,  A61N1/368 ,  A61N1/362

    CPC classification number: A61N1/3682 ,  A61N1/3627 ,  A61N1/3684

    Abstract: A system and method control a pacing parameter in a closed-loop manner by determining a value of an EGM-based index corresponding an optimal electrical activation condition of a patient's heart and adjusting a pacing therapy to maintain the EGM-based index value. The closed loop control method performed by the system may establish a relationship between an EGM-based index and multiple settings of a pacing control parameter. Values of the EGM-based index are stored with corresponding setting shifts relative to a previously established optimal setting. A processor of an implantable medical device monitors the EGM-based index during cardiac pacing. Responsive to detecting an EGM-based index value corresponding to a non-optimal setting of the control parameter, the processor determines an adjustment of the control parameter from the stored index values and corresponding setting shifts.

    Abstract translation: 系统和方法以闭环方式控制起搏参数，通过确定对应于患者心脏的最佳电活化状态的EGM指数的值并调整起搏治疗以维持基于EGM的指数值。 由系统执行的闭环控制方法可以建立基于EGM的索引与起搏控制参数的多个设置之间的关系。 基于EGM的索引的值相对于先前确定的最佳设置存储相应的设置位移。 可植入医疗装置的处理器在心脏起搏期间监测基于EGM的指数。 响应于检测对应于控制参数的非最优设置的基于EGM的索引值，处理器根据存储的索引值和相应的设置偏移来确定控制参数的调整。

    SYSTEMS AND METHODS FOR CONFIGURATION OF INTERVENTRICULAR INTERVAL
    246.
    发明申请
    SYSTEMS AND METHODS FOR CONFIGURATION OF INTERVENTRICULAR INTERVAL 有权
    用于配置间隔间隔的系统和方法

    公开(公告)号：US20160045737A1

    公开(公告)日：2016-02-18

    申请号：US14703348

    申请日：2015-05-04

    Applicant: Medtronic, Inc.

    Inventor： Subham Ghosh ,  Jeffrey Gillberg

    IPC: A61N1/368 ,  A61N1/372 ,  A61N1/365

    CPC classification number: A61N1/3684 ,  A61B5/04085 ,  A61B5/0452 ,  A61B5/6805 ,  A61B5/7282 ,  A61N1/36514 ,  A61N1/3682 ,  A61N1/37247

    Abstract: Systems and methods are described herein for assisting a user in identification of interventricular (V-V) delay for cardiac therapy. The systems and methods may monitor electrical activity of a patient using external electrode apparatus to provide electrical heterogeneity information for a plurality of different V-V intervals and may identify a V-V interval based on the electrical heterogeneity information.

    Abstract translation: 本文描述了用于帮助用户识别用于心脏治疗的室间（V-V）延迟的系统和方法。 系统和方法可以使用外部电极装置监测患者的电活动，以提供用于多个不同V-V间隔的电异质性信息，并且可以基于电异质性信息识别V-V间隔。

    NON-INVASIVE DETECTION OF PHRENIC NERVE STIMULATION
    247.
    发明申请
    NON-INVASIVE DETECTION OF PHRENIC NERVE STIMULATION 有权
    非侵入性检测微波神经刺激

    公开(公告)号：US20150265840A1

    公开(公告)日：2015-09-24

    申请号：US14220733

    申请日：2014-03-20

    Applicant: Medtronic, Inc.

    Inventor： Subham Ghosh ,  Vincent Splett

    IPC: A61N1/37

    CPC classification number: A61N1/3702 ,  A61B5/04001 ,  A61B5/04012 ,  A61B5/04085 ,  A61B5/1107 ,  A61B5/6823 ,  A61B5/7235 ,  A61B5/7267 ,  A61B5/743 ,  A61N1/37247

    Abstract: Systems, methods, and graphical user interfaces are described herein for non-invasively detecting phrenic nerve stimulation during cardiac pacing therapy. Phrenic nerve stimulation information may be generated for one or more electrical pacing vectors at one or more power configurations. The phrenic nerve stimulation information may be displayed to a user for use in configuring and/or evaluating cardiac pacing therapy.

    Abstract translation: 本文描述了系统，方法和图形用户界面，用于在心脏起搏治疗期间非侵入性地检测膈神经刺激。 可以以一个或多个功率配置为一个或多个电起搏向量产生膈神经刺激信息。 膈神经刺激信息可以显示给用户以用于配置和/或评价心脏起搏治疗。

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