公开(公告)号：US10288638B2

公开(公告)日：2019-05-14

申请号：US15356057

申请日：2016-11-18

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  Aric Sanders

Inventor： Owen Hildreth ,  Aric Sanders ,  Galen Arnold

IPC: G01B11/00 ,  G01N35/10

Abstract: Systems and methods are described for a non-contact method for positioning a tip of an object. A light beam of known dimensions is projected and a position of the tip of the object relative to the light beam is adjusted. Light scatter indicative of the tip of the object being positioned within the dimensions of the light beam is detected and a position of the tip of the object is determined based at least in part on the known dimensions of the light beam and the detected light scatter.

公开(公告)号：US20190134111A1

公开(公告)日：2019-05-09

申请号：US16306240

申请日：2017-06-14

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： James ADAMS ,  Dae-Wook KANG ,  Rosa KRAJMALNIK-BROWN

IPC: A61K35/741 ,  A61K35/74 ,  A61K35/745

Abstract: The present disclosure relates to compositions and methods for treating autism spectrum disorder (ASD) by restoring an ASD patient's gut microbiota. These methods can be used with ASD patient with or without ongoing gastrointestinal symptoms. Provided here is a method for modulating the abundance of one or more gut microorganisms in a subject in need thereof, said method comprising administering to said subject a therapeutically effective amount of a pharmaceutical composition comprising a fecal microbe preparation to achieve at least a 2-fold change of the abundance of said one or more fecal microorganisms, wherein said one or more gut microorganisms are selected from the group consisting of Bifidobacterium, Prevotella, Desulfovibrio, Copprococcus, Clostridium, and Bacteroides.

公开(公告)号：US10265439B2

公开(公告)日：2019-04-23

申请号：US15242039

申请日：2016-08-19

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Mehdi Nikkhah ,  Brent Vernon

IPC: A61L27/52 ,  A61K38/18 ,  A61L27/54 ,  A61L27/38 ,  A61L27/26 ,  A61K9/00 ,  C12N5/077 ,  C12N5/00

Abstract: The present invention provides a temperature-responsive dual-gelling hydrogel comprising a plurality of hydrogel polymers and a polymer cross-linking moiety, wherein the LCST of the hydrogel polymers is less than 37° C., and the polymer cross-linking moiety is capable of chemically cross linking to the hydrogel polymers to form a polymer matrix.

公开(公告)号：US10238655B2

公开(公告)日：2019-03-26

申请号：US15878297

申请日：2018-01-23

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Carl E. Wagner ,  Pamela A. Marshall ,  Peter W. Jurutka

IPC: A61K31/10 ,  A61P25/28 ,  A61P35/00 ,  A61K31/136 ,  A61K31/192 ,  A61K31/196 ,  A61K31/505

Abstract: The invention provides compounds of formula I: and salts thereof, as well as pharmaceutical compositions comprising such compounds. The compounds are useful for treating cancers, Alzheimer's disease, and conditions associated with demyelination.

公开(公告)号：US20190078052A1

公开(公告)日：2019-03-14

申请号：US16084415

申请日：2017-03-16

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Kaushal Rege ,  Taraka Sai Pavan Grandhi

IPC: C12N5/00 ,  C12N5/09

Abstract: Methods and compositions involving hydrogel compositions utilized for growing, separating, isolating, and/or screening cancer cells for resistance to one or more anti-cancer cell agents, such as a drug or biologic. Some hydrogel compositions utilize the monomer aminoglycoside amikacin AM1 or aminoglycoside amikacin AM3 in combination with a variety of crosslinkers.

公开(公告)号：US20190074548A1

公开(公告)日：2019-03-07

申请号：US16181937

申请日：2018-11-06

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Daniel A. Buttry ,  Tylan S. Watkins ,  Joseph Rheinhardt

IPC: H01M10/0569 ,  H01M10/0567 ,  H01M10/0568 ,  H01M10/054

CPC classification number: H01M10/0569 ,  H01M10/054 ,  H01M10/0567 ,  H01M10/0568 ,  H01M2300/0022 ,  H01M2300/0045

Abstract: Ionic liquids suitable for use in magnesium batteries are disclosed. In an exemplary embodiment, a rechargeable magnesium battery comprises an anode electrode, a cathode electrode, and a chelating ionic liquid solution in contact therewith. The chelating ionic liquid may comprise at least one cation, at least one anion, and at least one soluble, magnesium salt. The magnesium salt may comprise MgX2, wherein X comprises at least one of Cl—, Br—, I—, TFSI—, FSI—, ClO4—, BF4—, PF6—, RSO3— (wherein R consists of at least one of an alkyl or aryl group), RCO2— (wherein R consists of at least one of an alkyl or aryl group), alkyl borides, alkyl borates, AlCl4—, AlXaRb— (wherein the sum of subscripts a and b is 4, X consists of a halide, and R consists of at least one of an alkyl or aryl group), carboranes, or hexamethyldisilazide.

公开(公告)号：US10221143B2

公开(公告)日：2019-03-05

申请号：US15550259

申请日：2016-03-01

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Carl Wagner ,  Peter Jurutka ,  Pamela Marshall

IPC: A61K31/136 ,  C07C211/48 ,  C07D239/42 ,  C07D213/79 ,  C07D237/24 ,  C07D241/28 ,  C07C229/60 ,  C07D213/80

Abstract: The invention provides alkyl benzene compounds. The compounds are useful for treating conditions including Alzheimer's disease, Parkinson's disease, diabetes, cancer, inflammation, hyperresponsiveness, allergic conditions, asthma, and psychotic disorders such as schizophrenia. The compounds are also useful to lower IL-4, IL-5, or IL-15 levels in an animal.

公开(公告)号：US20190062728A1

公开(公告)日：2019-02-28

申请号：US15748946

申请日：2016-09-13

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

Inventor： Joshua Labaer ,  Kevin Gorman ,  Brian Kay ,  Jie Wang ,  Ji Qiu

IPC: C12N15/10

Abstract: Methods for screening of affinity reagents for many target proteins of interest simultaneously. Arrayed targets (e.g., peptide, protein, RNA, cell, etc.) are used in affinity selection experiments to reduce the amount of target needed and to improve the throughput of discovering recombinant affinity reagents to a large collection of targets.

公开(公告)号：US20190054277A1

公开(公告)日：2019-02-21

申请号：US16078388

申请日：2017-02-21

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Jeffrey LaBelle ,  Julio Morera ,  Marco Santello

IPC: A61M25/09

Abstract: Guidewires useful for cooperating with catheters may be actively steered and/or provide adjustable stiffness. Angle or curvature of a guidewire, and/or flexural modulus of a guidewire, may be adjusted at one or more locations between ends thereof. Variable stiffness segments may include electrically operated compressible and/or extensible materials. Multiple tensile elements may terminate at different body elements to adjust angle or curvature at multiple locations. Multiple circumferentially and/or radially contractible fiber regions may be provided and distributed over a length of a guidewire. Adjustable flexure elements arranged in or along a guidewire may be electrically operated. A flexible core member may be centrally arranged in a tubular body. A flexible guide wire or track may cooperate with electrically operable motor units.

公开(公告)号：US10211411B2

公开(公告)日：2019-02-19

申请号：US15246754

申请日：2016-08-25

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Jian Li ,  Daijun Feng

IPC: H01L51/00 ,  C07D471/22 ,  C07D471/06 ,  C09K11/06 ,  C07D519/00 ,  C07F9/6561 ,  C07F9/572 ,  H01L51/50

Abstract: Thermally activated delayed fluorescent compounds and uses thereof are described. The thermally activated delayed fluorescent compounds are an analogs of 9,10-dihydro-9,9-dimethylacridine compounds.