公开(公告)号：US20040109874A1

公开(公告)日：2004-06-10

申请号：US10724727

申请日：2003-12-02

Applicant: PowderJect Vaccines, Inc.

Inventor： Dexiang Chen ,  Sangeeta Bhargava ,  Deborah Fuller

IPC: A61K039/12 ,  A61K039/02

CPC classification number: A61K39/05 ,  A61K39/12 ,  A61K39/145 ,  A61K39/39 ,  A61K2039/5252 ,  A61K2039/541 ,  A61K2039/543 ,  A61K2039/55544 ,  A61K2039/55561 ,  A61K2039/57 ,  A61K2039/70 ,  C12N2760/16134

Abstract: Methods for generating an immune response at a mucosal surface are described. Compositions suitable for use in the methods for generating an immune response at a mucosal surface are also described. In addition, methods for treating or preventing a disease caused by the entry of a pathogen into the body of a subject via a mucosal surface are provided.

Abstract translation: 描述了在粘膜表面产生免疫应答的方法。 还描述了适用于在粘膜表面产生免疫应答的方法中的组合物。 此外，提供了用于治疗或预防由病原体经由粘膜表面进入受试者体内引起的疾病的方法。

公开(公告)号：US5733600A

公开(公告)日：1998-03-31

申请号：US747870

申请日：1996-11-13

Applicant: Dennis E. McCabe

Inventor： Dennis E. McCabe

IPC: C12M1/00 ,  A61K39/00 ,  A61K48/00 ,  B05D1/00 ,  B05D7/22 ,  C12N15/89 ,  C12Q1/68

CPC classification number: B05D1/002 ,  B05D7/222 ,  C12N15/895

Abstract: Particles coated with biological substances are deposited onto the concave inner surface of a length of tubing by a process which includes preparing a uniform suspension of coated particles and introducing the particles into the tubing while rotating horizontally. Then the speed of rotation is increased to drive the particles out of suspension and against the inner surface. After particle separation, the rotational speed is decreased and a gas is passed through the tubing to blow out the separated liquid. Next both the speed of rotation and the gas flow rate are increased to dry the particles that have been deposited against the inner surface of the tubing. An apparatus for performing the method also is disclosed.

Abstract translation: 用生物物质涂覆的颗粒通过包括制备涂覆颗粒的均匀悬浮液并在水平旋转的同时将颗粒引入管中的方法沉积在一段管道的凹内表面上。 然后提高旋转速度以驱动颗粒脱离悬浮液并抵靠内表面。 颗粒分离后，旋转速度降低，气体通过管道吹出分离液体。 接下来，提高旋转速度和气体流速以干燥已经沉积在管的内表面上的颗粒。 公开了一种用于执行该方法的装置。