公开(公告)号：US20100016443A1

公开(公告)日：2010-01-21

申请号：US12525331

申请日：2008-02-03

Applicant: Ofer Toledano ,  Haim Bar-Simantov ,  Nissim Bilman ,  Leora Shapiro ,  Raed Abu-Reziq ,  Srikanth Sriadibhatla ,  William T. Sommer

Inventor： Ofer Toledano ,  Haim Bar-Simantov ,  Nissim Bilman ,  Leora Shapiro ,  Raed Abu-Reziq ,  Srikanth Sriadibhatla ,  William T. Sommer

IPC: A61K31/327 ,  B05D7/00 ,  B32B5/16 ,  A61K47/02 ,  A01N25/26 ,  A61K31/11 ,  A01N31/04 ,  A01N35/02 ,  A61K31/07 ,  A01P7/04 ,  A61P17/00 ,  A61P17/10 ,  A61P17/04 ,  A61P17/06

CPC classification number: A61K9/5073 ,  A01N25/26 ,  A01N53/00 ,  A61K8/11 ,  A61K8/25 ,  A61K8/38 ,  A61K8/671 ,  A61K9/501 ,  A61K9/5021 ,  A61K9/5026 ,  A61K2800/412 ,  A61Q19/00 ,  B01J13/02 ,  B01J13/22 ,  C09C3/063 ,  Y10T428/2991 ,  A01N2300/00

Abstract: The invention relates to a process for coating a solid, water-insoluble particulate matter, with a metal oxide comprising: (a) contacting the solid, water-insoluble particulate matter with an ionic additive and an aqueous medium to obtain a dispersion of said particulate matter having positive charges on its surface; (b) subjecting the particulate matter to a coating procedure comprising precipitating a metal oxide salt onto the surface of the particulate matter to form a metal oxide layer thereon to thereby obtain particulate matter coated by a metal oxide coating layer; (c) repeating step (b) at least 4 more times; and (d) aging said coating layer. The invention further relates to particles comprising a particulate matter coated by a metal oxide layer, to a use of the particles for topical administration, and to a method for preventing, reducing, or eliminating pests at a locus, using the particles.

Abstract translation: 本发明涉及一种用金属氧化物涂覆固体，不溶于水的颗粒物质的方法，包括：（a）使固体，水不溶性颗粒物质与离子添加剂和水性介质接触，以获得所述颗粒的分散体 表面上有正面指控的事情; （b）对颗粒状物质进行包括在金属氧化物表面上析出金属氧化物盐以形成金属氧化物层的涂覆方法，从而获得由金属氧化物涂层涂覆的颗粒状物质; （c）重复步骤（b）至少4次以上; 和（d）老化所述涂层。 本发明还涉及包含由金属氧化物层涂覆的颗粒物质，使用该颗粒用于局部给药的颗粒，以及使用该颗粒来防止，减少或消除某些场所的害虫的方法。

公开(公告)号：US20090081262A1

公开(公告)日：2009-03-26

申请号：US11997823

申请日：2006-08-02

Applicant: Ofer Toledano ,  Hanan Sertchook ,  Natalia Loboda ,  Hiam Bar-Simantov

Inventor： Ofer Toledano ,  Hanan Sertchook ,  Natalia Loboda ,  Hiam Bar-Simantov

IPC: A01N25/28 ,  A61K8/02 ,  A01N31/00 ,  A01N53/02 ,  A01N47/10 ,  A01N57/00 ,  A01P3/00 ,  A01P7/00 ,  A01P13/00 ,  A61K31/66 ,  A61K31/203 ,  A61K31/12 ,  A61K9/50

CPC classification number: B01J13/22 ,  A01N25/26 ,  A61K8/11 ,  A61K9/1676 ,  A61K9/5078 ,  A61K2800/412 ,  A61K2800/434 ,  A61K2800/57 ,  A61Q19/00 ,  B01J13/02 ,  A01N51/00 ,  A01N53/00

Abstract: The invention relates to process for coating a solid, water-insoluble particulate matter, with a metal oxide comprising: (a) contacting the solid water-insoluble particulate matter with a cationic additive in an aqueous medium to obtain a dispersion of said particulate matter having a positive zeta potential; (b) coating the solid water-insoluble particulate matter by precipitation of a metal oxide salt onto the surface of the particulate matter, forming a metal oxide layer thereon; and (c) aging said coating layer The invention further relates to coated particulate matter obtained by the process and to compositions comprising solid, water-insoluble particulate matter, coated by a metal oxide layer, the particulate matter being a dermatological active agent or a pesticide. The invention additionally relates to methods of treating a surface condition in a subject using compositions comprising solid, water insoluble dermatologically active agent, coated by a metal oxide layer.

Abstract translation: 本发明涉及一种用金属氧化物涂覆固体，不溶于水的颗粒物质的方法，包括：（a）将固体不溶于水的颗粒物质与阳离子添加剂接触在水性介质中，以获得具有 正ζ电位; （b）通过将金属氧化物盐沉淀到颗粒物质的表面上来涂覆固体不溶于水的颗粒物质，在其上形成金属氧化物层; 和（c）老化所述涂层本发明还涉及通过该方法获得的包覆颗粒物质和包含由金属氧化物层涂覆的固体，水不溶性颗粒物质的组合物，所述颗粒物质是皮肤病学活性剂或农药 。 本发明还涉及使用包含由金属氧化物层涂覆的固体，水不溶性皮肤病学活性剂的组合物来治疗受试者的表面状况的方法。

公开(公告)号：US12133919B2

公开(公告)日：2024-11-05

申请号：US17327729

申请日：2021-05-23

Applicant: Sol-Gel Technologies Ltd.

Inventor： Ofer Toledano ,  Karine Neimann ,  Danil Finkel-Moiseev ,  Maya Erlich ,  Dorit Marco

IPC: A61K9/48 ,  A61K9/00 ,  A61K9/50 ,  A61K31/202 ,  A61K31/203 ,  A61K31/235 ,  A61K31/327 ,  A61K31/336

Abstract: The present application is directed to stabilized core-shell microcapsules comprising a core of benzoyl peroxide (BPO) or all trans retinoic acid (ATRA) and a metal-oxide shell; and to pharmaceutical compositions and methods of use thereof.

公开(公告)号：US11865100B2

公开(公告)日：2024-01-09

申请号：US17154689

申请日：2021-01-21

Applicant: Sol-Gel Technologies Ltd.

Inventor： Ofer Toledano ,  Ofra Levy-Hacham ,  Ori Nov ,  Vered Ram

IPC: A61K31/327 ,  A61P17/10 ,  A61K9/00 ,  A61K9/06 ,  A61K9/107 ,  A61P17/00 ,  A61K9/50 ,  A61K9/10

CPC classification number: A61K31/327 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/10 ,  A61K9/107 ,  A61K9/50 ,  A61P17/00 ,  A61P17/10

Abstract: A regimen for the therapeutic treatment of rosacea in subjects aged 65 years and older, the regimen comprising topically applying to the skin of a subject aged 65 years and older in need of said treatment a pharmaceutical composition, the pharmaceutical composition comprising about 1% w/w to about 10% w/w benzoyl peroxide as an active ingredient, and a pharmaceutically acceptable carrier or excipient, wherein the benzoyl peroxide is the only active ingredient in said pharmaceutical composition, wherein said pharmaceutical composition is applied once daily for a period of at least about 2 weeks, to achieve, in a group of such subjects, a success rate of at least about 15%, wherein the success rate is defined as the number of subjects achieving clear or almost clear skin on the investor global assessment (IGA) scale after treatment with the pharmaceutical composition.

公开(公告)号：US20230364050A1

公开(公告)日：2023-11-16

申请号：US18225397

申请日：2023-07-24

Applicant: Sol-Gel Technologies Ltd.

Inventor： Ofer TOLEDANO ,  Ofra LEVY-HACHAM ,  Ori NOV ,  Vered RAM

IPC: A61K31/327 ,  A61K9/50 ,  A61K9/06 ,  A61K9/00 ,  A61P17/10 ,  A61K9/107 ,  A61P17/00 ,  A61K9/10

CPC classification number: A61K31/327 ,  A61K9/50 ,  A61K9/06 ,  A61K9/0014 ,  A61P17/10 ,  A61K9/107 ,  A61P17/00 ,  A61K9/10

Abstract: A regimen is described for the therapeutic treatment of rosacea including topically applying to the skin of a subject in need of the treatment a pharmaceutical composition. The pharmaceutical composition includes about 1% w/w to about 10% w/w benzoyl peroxide as an active ingredient, and a pharmaceutically acceptable carrier or excipient. The benzoyl peroxide is the only active ingredient in said pharmaceutical composition, and the pharmaceutical composition is applied once daily for a period of at least about 2 weeks, about 4 weeks, about 8 weeks or about 12 weeks. A decrease in Patient Assessment of Papulopustular Rosacea Signs and Symptoms (PAPSS) is at least about 40% after treatment with the pharmaceutical composition for about 4 weeks, and a decrease in Patient Assessment of Papulopustular Rosacea Impacts (PAPI) is from about 60% to about 70% after treatment with the pharmaceutical composition for at least about 8 weeks.

公开(公告)号：US20220142944A1

公开(公告)日：2022-05-12

申请号：US17582273

申请日：2022-01-24

Applicant: Sol-Gel Technologies Ltd.

Inventor： Moshe ARKIN ,  Marcel ZIGHELBOIM ,  Ori NOV ,  Ofer TOLEDANO ,  Karine NEIMANN ,  Hila HAKAK DJERBI

IPC: A61K31/05 ,  A61K47/18

Abstract: Disclosed are topical compositions and methods of treatment of a skin or mucosal disorder selected from palmoplantar psoriasis, hereditary palmoplantar keratoderma, acquired palmoplantar keratoderma, hydradenitis suppurativa, dermatitis, ichthyosis vulgaris, hereditary ichthyosis, acquired ichthyosis, actinic keratosis, a keratinization skin disorder, a keratinization mucosal disorder, Gorlin syndrome, nail psoriasis, flexural/inverse psoriasis, non-melanoma skin cancer, Cutaneous T-cell lymphoma and precancerous skin, mucosal and nail lesions, by once or twice daily topical administration to a subject of a composition comprising therapeutically effective amount of tapinarof.

公开(公告)号：US20210361608A1

公开(公告)日：2021-11-25

申请号：US17327729

申请日：2021-05-23

Applicant: Sol-Gel Technologies Ltd.

Inventor： Ofer TOLEDANO ,  Karine NEIMANN ,  Danil FINKEL-MOISEEV ,  Maya ERLICH ,  Dorit MARCO

IPC: A61K31/202 ,  A61K9/50 ,  A61K9/00 ,  A61K31/327

Abstract: The present application is directed to stabilized core-shell microcapsules comprising a core of benzoyl peroxide (BPO) or all trans retinoic acid (ATRA) and a metal-oxide shell; and to pharmaceutical compositions and methods of use thereof.

公开(公告)号：US20210361586A1

公开(公告)日：2021-11-25

申请号：US17327724

申请日：2021-05-23

Applicant: Sol-Gel Technologies Ltd.

Inventor： Ofer Toledano ,  Karine Neimann ,  Danil Finkel-Moiseev ,  Maya Erlich ,  Dorit MARCO

IPC: A61K9/50 ,  A61K31/327 ,  A61K31/203 ,  A61K9/00

Abstract: The present application is directed to stabilized core-shell microcapsules comprising a core of benzoyl peroxide (BPO) or all trans retinoic acid (ATRA) and a metal-oxide shell; and to pharmaceutical compositions and methods of use thereof.

公开(公告)号：US20210212962A1

公开(公告)日：2021-07-15

申请号：US17147602

申请日：2021-01-13

Applicant: Sol-Gel Technologies Ltd.

Inventor： Marcel Zighelboim ,  Hila Hakak Djerbi ,  Karine Neimann

IPC: A61K31/05 ,  A61K31/44 ,  A61K9/00 ,  A61K9/06 ,  A61P17/00

Abstract: The present invention, in some embodiments thereof, relates to topical compositions and methods of treatment, prevention and/or amelioration of granuloma annulare, a non-infection granulomatous disease, or a subcutaneous inflammation by topical or intralesional administration of compositions comprising tapinarof.

公开(公告)号：US10653899B2

公开(公告)日：2020-05-19

申请号：US16052635

申请日：2018-08-02

Applicant: SOL-GEL TECHNOLOGIES LTD.

Inventor： Ofer Toledano ,  Haim Bar-Simantov ,  Hanan Sertchook ,  Sharon Fireman-Shoresh ,  Dorit Marco

IPC: A01N25/28 ,  A61Q19/00 ,  B01J13/14 ,  A61K9/51 ,  A61K9/00 ,  A61K8/67 ,  A61K8/38 ,  A61K8/26 ,  A61K8/25 ,  A61K8/11 ,  A61K9/50 ,  A61K9/06 ,  A61K8/28 ,  A61K8/29 ,  A61K8/27 ,  A61K8/73 ,  A61K47/02 ,  A61K8/06 ,  F28D20/02

Abstract: The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within an inorganic oxide shell, processes for their preparations, comparisons comprising them and uses thereof.