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公开(公告)号：US20210277116A1
公开(公告)日：2021-09-09
申请号：US17328239
申请日：2021-05-24
摘要： Novel monoclonal antibodies directed against immune checkpoint modulator (ICM) proteins TIM-3 and B7-H3 are useful in treating cancer and immune system disorders.
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公开(公告)号：US11046764B2
公开(公告)日：2021-06-29
申请号：US15861410
申请日：2018-01-03
摘要： Novel monoclonal antibodies directed against immune checkpoint modulator (ICM) proteins TIM-3 and B7-H3 are useful in treating cancer and immune system disorders.
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23.发明申请公开(公告)号：US20210054075A1
公开(公告)日：2021-02-25
申请号：US17091526
申请日：2020-11-06
IPC分类号： C07K16/28 , A61K39/395 , A61K45/06
摘要： Monoclonal antibodies derived from the native human repertoire that bind the extracellular portion of Killer IgG Receptor (KIR) and pharmaceutical and veterinary compositions thereof are useful in treating cancer in human and other subjects.
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公开(公告)号：US10654915B2
公开(公告)日：2020-05-19
申请号：US14363297
申请日：2012-12-05
发明人： Lawrence M. Kauvar , Stote Ellsworth , William Usinger , Krista Maureen McCutcheon , Minha Park
摘要： Specific monoclonal antibodies and fragments including bispecific antibodies thereof that are crossreactive with multiple clades of influenza virus including both Group 1 and Group 2 representatives are disclosed. These antibodies are useful in controlling influenza epidemics and pandemics as well as in providing prophylactic or therapeutic protection against seasonal influenza.
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公开(公告)号：US10570193B2
公开(公告)日：2020-02-25
申请号：US16181260
申请日：2018-11-05
发明人： Lawrence M. Kauvar , Stefan Ryser , Angeles Estelles , Reyna J. Simon , Lauren Opremcak Bakaletz , Steven David Goodman
IPC分类号： A01N63/00 , A61K48/00 , A61K39/395 , C07K16/12 , A61K39/40 , A01N63/02 , A61K45/06 , A61K49/00 , C07K14/31 , G01N33/569 , C12Q1/18 , G01N33/566 , A61K39/00 , C12N15/86 , A61K35/12
摘要： Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies suitable for administration to a selected species, and antibody mimics including aptamer nucleic acids. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
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26.发明申请公开(公告)号：US20180002420A1
公开(公告)日：2018-01-04
申请号：US15619327
申请日：2017-06-09
IPC分类号： C07K16/28 , A61K39/395 , A61K45/06
摘要： Monoclonal antibodies derived from the native human repertoire that bind the extracellular portion of Killer IgG Receptor (KIR) and pharmaceutical and veterinary compositions thereof are useful in treating cancer in human and other subjects.
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27.发明授权High affinity human antibodies to human cytomegalovirus (CMV) gB protein 有权人类巨细胞病毒（CMV）gB蛋白的高亲和力人抗体公开(公告)号：US09017668B2
公开(公告)日：2015-04-28
申请号：US13162497
申请日：2011-06-16
申请人： Lawrence M. Kauvar , Stote Ellsworth , William Usinger , Krista Maureen McCutcheon , Ying-Ping Jiang , Fen Zhang , Bo Chen , Gizette Sperinde , Minha Park , Orit Foord
发明人： Lawrence M. Kauvar , Stote Ellsworth , William Usinger , Krista Maureen McCutcheon , Ying-Ping Jiang , Fen Zhang , Bo Chen , Gizette Sperinde , Minha Park , Orit Foord
IPC分类号： A61K39/12 , A61K39/215 , C07K16/08 , C07K16/46
CPC分类号： C07K16/088 , A61K39/245 , A61K2039/505 , C07K16/08 , C07K16/468 , C07K2317/14 , C07K2317/21 , C07K2317/30 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Antibodies to human Cytomegalovirus (CMV) gB protein have been isolated from human B cells. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.
摘要翻译： 已从人B细胞中分离出人巨细胞病毒（CMV）gB蛋白的抗体。 这些抗体的亲和力高于先前报道的最佳抗体。 由于高亲和力对于预防跨越胎盘的病毒转移至关重要，本发明的抗体可用作预防或改善对怀孕期间CMV感染胎儿的影响的治疗和预防剂。
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公开(公告)号：US08362215B2
公开(公告)日：2013-01-29
申请号：US12770674
申请日：2010-04-29
申请人： Bruce Keyt , Lawrence M. Kauvar , Ellen J. Collarini , Orit Foord , Gizette Sperinde , Marjan Fatholahi , Hung Nguyen
发明人： Bruce Keyt , Lawrence M. Kauvar , Ellen J. Collarini , Orit Foord , Gizette Sperinde , Marjan Fatholahi , Hung Nguyen
IPC分类号： C07K16/00 , A61K39/395
CPC分类号： C07K16/2863 , C07K16/22 , C07K16/30 , C07K16/32 , C07K16/40 , C07K2317/32 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： Antibodies which specifically bind heregulin-coupled HER3, at a site distinct from the heregulin binding site, are described. These antibodies are particularly useful in treating cancer.
摘要翻译： 描述了在不同于调节蛋白结合位点的位点上特异性结合随机结合的HER3的抗体。 这些抗体特别可用于治疗癌症。
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