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77 条记录 (耗时 0.038 秒)

    Process for biologically combating pseudomonas
    21.
    发明授权
    Process for biologically combating pseudomonas 有权
    生物防治假单胞菌的方法

    公开(公告)号：US09288994B2

    公开(公告)日：2016-03-22

    申请号：US14365237

    申请日：2012-12-20

    申请人： AMOEBA

    发明人： Fabrice Plasson ,  Séléna Bodennec

    IPC分类号： A01N63/00 ,  C12R1/90

    CPC分类号： A01N63/00 ,  C12R1/90

    摘要： The invention relates to a method for controlling the proliferation of Pseudomonas, with the exception of the treatment methods applied to the human or animal body, characterized in that it uses protozoa of the Willaertia magna species, and also to a disinfecting agent containing such protozoa.

    摘要翻译： 本发明涉及一种控制假单胞菌增殖的方法，除了应用于人体或动物体的治疗方法之外，其特征在于它使用Willaertia magna物种的原生动物，以及含有这种原生动物的消毒剂。

    Effective treatment of esophogeal adenocarcinoma using triciribine and related compounds
    24.
    发明授权
    Effective treatment of esophogeal adenocarcinoma using triciribine and related compounds 有权
    使用triciribine及相关化合物有效治疗非典型腺癌

    公开(公告)号：US09150604B2

    公开(公告)日：2015-10-06

    申请号：US13908821

    申请日：2013-06-03

    申请人： University of South Florida

    发明人： Jin Q. Cheng

    IPC分类号： A01N43/04 ,  A61K31/70 ,  C07H19/23 ,  A61K31/7042 ,  A61K31/7052

    CPC分类号： A61K31/7064 ,  A61K9/0019 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  C07H19/23 ,  G01N33/57407 ,  G01N2333/912

    摘要： The inventors have determined, contrary to the prior art and experience, how to successfully use triciribine to treat esophogeal adenocarcinoma by one or a combination of (i) administering triciribine only to patients which according to a diagnostic test described below, exhibit enhanced sensitivity to the drug; (ii) use of a described dosage level that minimizes the toxicity of the drug but yet still exhibits efficacy; or (iii) use of a described dosage regimen that minimizes the toxicity of the drug.

    摘要翻译： 发明人已经确定，与现有技术和经验相反，如何成功地使用三苯呋嗪来治疗卵巢癌，其中一种或其组合（i）仅对根据下述诊断试验的患者给予三苯呋嗪，表现出对 药物; （ii）使用使药物的毒性最小化但仍显示功效的所述剂量水平; 或（iii）使用最小化药物的毒性的所述剂量方案。

    Tidal current power generator
    25.
    发明授权
    Tidal current power generator 有权
    潮流发电机

    公开(公告)号：US09103316B2

    公开(公告)日：2015-08-11

    申请号：US13981827

    申请日：2011-02-25

    申请人： Jong-Seon Park

    发明人： Jong-Seon Park

    IPC分类号： F03B13/10 ,  F03B13/12 ,  H02P9/04 ,  F03B13/00 ,  F03B13/26

    CPC分类号： F03B13/264 ,  F05B2240/40 ,  F05B2240/90 ,  F05B2240/95 ,  F05B2240/97 ,  Y02E10/28 ,  Y02E10/38

    摘要： The present invention relates to a tidal current power generator. In the tidal current power generator, tidal current flows in a concentrated manner into a power generation module for generating electrical energy using the flow of tidal current, in order to increase the speed of the tidal current. Thus, the amount of electrical energy generated by the power generation module may be improved to achieve highly efficient performance. Also, the range of locations in which the power generation module may be installed is significantly expanded in order to increase the electrical generation using tidal current. Since the power generation module is integrally assembled and then refloated in order to install same on the bottom of the sea, the power generation module may be easily installed as well as easily repaired and maintained.

    摘要翻译： 潮汐发电机技术领域本发明涉及一种潮汐发电机。 在潮汐发电机中，潮汐流集中地流入发电模块，用于利用潮汐流的流动产生电能，以增加潮汐流的速度。 因此，可以提高发电模块产生的电能量，以实现高效率的性能。 此外，为了增加使用潮汐流的发电量，能够大幅度地扩大发电模块的安装位置的范围。 由于发电模块被整体组装并且然后被补充以便将其安装在海底，所以发电模块可以容易地安装并且容易地修理和维护。

    Compositions and methods for treating and preventing dermatoses
    26.
    发明授权
    Compositions and methods for treating and preventing dermatoses 有权
    用于治疗和预防皮肤病的组合物和方法

    公开(公告)号：US09084788B2

    公开(公告)日：2015-07-21

    申请号：US13566632

    申请日：2012-08-03

    申请人： John P. Ford

    发明人： John P. Ford

    IPC分类号： A01N43/54 ,  A61K31/505 ,  A61K31/513 ,  A61K31/00 ,  A61K31/337 ,  A61K31/555 ,  A61K31/704 ,  A61K31/7072

    CPC分类号： A61K31/513 ,  A61K9/006 ,  A61K9/06 ,  A61K31/00 ,  A61K31/337 ,  A61K31/505 ,  A61K31/555 ,  A61K31/704 ,  A61K31/7072 ,  A61K2300/00

    摘要： The invention encompasses protectant agents including uracil or a metabolite thereof that effectively treat the cutaneous toxicities and dermatological side-effects associated with chemotherapeutic agents. Specifically, and surprisingly, the compositions of the invention including uracil or a metabolite thereof are effective for treating various dermatoses including atopic dermatitis, irritant contact dermatitis, radiation-induced dermatitis, dry skin dermatitis, papulopustular rashes, xerosis, pruitus, actinic keratosis, and genital warts.

    摘要翻译： 本发明包括有效治疗与化学治疗剂相关的皮肤毒性和皮肤病学副作用的包括尿嘧啶或其代谢物的保护剂。 具体而且令人惊奇的是，包括尿嘧啶或其代谢物的本发明组合物可有效治疗各种皮肤病，包括特应性皮炎，刺激性接触性皮炎，辐射诱发的皮炎，干性皮肤皮炎，丘疹性腮腺炎，干燥症，瘙痒症，光化性角化病和 生殖器疣。

    Antibiotic peptides
    28.
    发明授权
    Antibiotic peptides 有权
    抗生素肽

    公开(公告)号：US09060513B2

    公开(公告)日：2015-06-23

    申请号：US12670118

    申请日：2008-07-21

    申请人： Ralf Hoffmann ,  Patricia Czihal

    发明人： Ralf Hoffmann ,  Patricia Czihal

    IPC分类号： C07K7/08 ,  A61K38/00 ,  A01N37/46 ,  A01N63/02

    CPC分类号： A01N37/46 ,  A01N63/02 ,  A61K38/00 ,  C07K7/08 ,  C07K14/43572 ,  C12Q1/18 ,  G01N2500/02 ,  G01N2500/10 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/481 ,  Y02A50/483

    摘要： This invention concerns novel antibiotic peptide and peptide derivates, especially for use in medicine. Further, the invention relates to compositions and methods for killing microbes, like bacteria or fungus, and methods to treat microbial infections. The invention further relates to a method for drug screening analysis. The peptides and peptide derivates have the general formula Sub1-X1 N X2 X3 P V Y I P X4 X5 R P P H P-Sub2 (SEQ ID NO:169) wherein X1 is a neutral or positively charged moiety, X2 is a polar or positively charged moiety, X3 is a positively charged moiety, X4 is a polar or positively charged moiety, X5 is a proline or a proline derivate, Sub1 being the free or modified N-terminus, and Sub2 being the free or modified C-terminus. The peptides or peptide derivates according to the invention possess at least one of the following advantages compared to the natural occurring apidaecin peptides: (i) an increased half-live in mammalian serum due to a higher protease resistance and (ii) an increased antimicrobial activity against one or several bacterial strains, especially human pathogens, or fungus or other microbial infections (iii) show an enlarged spectrum of antimicrobial activity, (iv) do induce less resistance in microbes and (v) are not toxic to human cells including erythrocytes.

    摘要翻译： 本发明涉及新型抗生素肽和肽衍生物，特别是用于医学中。 此外，本发明涉及杀死微生物（如细菌或真菌）的组合物和方法以及治疗微生物感染的方法。 本发明还涉及药物筛选分析方法。 肽和肽衍生物具有通式Sub1-X1 N X2 X3 PVYIP X4 X5 RPPH P-Sub2（SEQ ID NO：169），其中X1是中性或带正电荷的部分，X2是极性或带正电荷的部分，X3是 带正电荷的部分，X 4是极性或带正电荷的部分，X5是脯氨酸或脯氨酸衍生物，Sub1是游离或修饰的N末端，Sub2是游离或修饰的C-末端。 根据本发明的肽或肽衍生物与天然存在的apidaecin肽相比具有以下优点中的至少一个：（i）由于较高的蛋白酶抗性，哺乳动物血清中的半活性增加，和（ii）增加的抗微生物活性 针对一种或几种细菌菌株，特别是人类病原体，或真菌或其他微生物感染（iii）显示出增加的抗微生物活性谱，（iv）确实在微生物中诱导较少的抗性，（v）对包括红细胞在内的人类细胞无毒性。

    Methods of ganglioside production
    29.
    发明授权
    Methods of ganglioside production 有权
    神经节苷脂生产方法

    公开(公告)号：US09051592B2

    公开(公告)日：2015-06-09

    申请号：US13796213

    申请日：2013-03-12

    申请人： Garnet BioTherapeutics, Inc.

    发明人： Vanessa Ragaglia ,  Vandana Madanlal Sharma

    IPC分类号： C12P1/00 ,  C12N5/00 ,  C12P19/44 ,  A61K31/7032 ,  G01N33/92 ,  A61K31/4706

    CPC分类号： C12P19/44 ,  A61K31/4706 ,  A61K31/7032 ,  C12N5/0663 ,  C12N5/0693 ,  C12N2500/30 ,  G01N33/92 ,  Y02A50/471

    摘要： The invention provides methods for production of gangliosides, e.g., GM1, from cells in culture using, for example, bone marrow cells and neuroblastoma cells. Methods include the treatment of cells with neural induction media and chloroquine, or chloroquine alone in the case of, e.g., human bone marrow cells, neuraminidase or glucosamine, to induce the production of gangliosides, e.g., GM1, in the cells. Also provided are methods of long-term, high density culturing of cells without passaging to produce gangliosides, e.g., GM1. Methods of quantifying gangliosides, e.g., GM1 in cell culture are also provided.

    摘要翻译： 本发明提供了使用例如骨髓细胞和神经母细胞瘤细胞从培养物中的细胞生产神经节苷脂，例如GM1的方法。 方法包括在例如人骨髓细胞，神经氨酸酶或葡糖胺的情况下用神经诱导培养基和氯喹或单独的氯喹处理细胞，以在细胞中诱导神经节苷脂（例如GM1）的产生。 还提供了长期，高密度培养细胞而不传播以产生神经节苷脂（例如GM1）的方法。 还提供了定量细胞培养中神经节苷脂（例如GM1）的方法。

    Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
    30.
    发明授权
    Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof 有权
    制备抗体或抗体片段靶向免疫脂质体用于全身给药治疗剂或诊断剂及其用途

    公开(公告)号：US09034329B2

    公开(公告)日：2015-05-19

    申请号：US11520796

    申请日：2006-09-14

    申请人： Esther H. Chang ,  Kathleen F. Pirollo

    发明人： Esther H. Chang ,  Kathleen F. Pirollo

    IPC分类号： A61K39/395 ,  A61K9/127 ,  C12P21/08 ,  C12N15/11 ,  C07K16/28 ,  G01N33/53

    CPC分类号： C12N15/1138 ,  A61K9/1271 ,  A61K9/1272 ,  C07K16/2881 ,  C07K2317/622 ,  C12N2310/14

    摘要： The present invention provides methods of preparing an antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex comprising (a) preparing an antibody or antibody fragment; (b) mixing said antibody or antibody fragment with a cationic liposome to form a cationic immunoliposome or with a cationic polymer to form a polyplex; and (c) mixing said cationic immunoliposome or said polyplex with a therapeutic or diagnostic agent to form said antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex. The present invention also provides cationic immunoliposome or polymer complexes produced by such methods and compositions comprising such complexes. The present invention also provides methods for treating various diseases and disorders, including cancers, by administering the complexes and compositions of the invention to a patient.

    摘要翻译： 本发明提供制备抗体或抗体片段靶向阳离子免疫脂质体或聚合物复合物的方法，其包括（a）制备抗体或抗体片段; （b）将所述抗体或抗体片段与阳离子脂质体混合以形成阳离子免疫脂质体或用阳离子聚合物形成聚合物; 和（c）将所述阳离子免疫脂质体或所述多聚体与治疗剂或诊断剂混合以形成所述抗体或抗体片段靶向阳离子免疫脂质体或聚合物复合物。 本发明还提供了由包含这种复合物的方法和组合物制备的阳离子免疫脂质体或聚合物复合物。 本发明还提供了通过将本发明的复合物和组合物给予患者来治疗各种疾病和病症（包括癌症）的方法。