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公开(公告)号：US10533175B2
公开(公告)日：2020-01-14
申请号：US15761964
申请日：2016-09-23
发明人： Frank Rigo , Thazha P. Prakash , Wilhelmina Maria Clasina Van Roon-Mom , Lodewijk Julius Anton Toonen
IPC分类号： C12N15/113 , A61K31/712 , C12N9/48
摘要： Disclosed are methods for modulating splicing of Ataxin 3 mRNA in an animal with modified oligonucleotides. Such compounds and methods are useful to treat, prevent, or ameliorate spinocerebellar ataxia type 3 (SCA3) in an individual in need thereof.
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公开(公告)号：US20190004044A1
公开(公告)日：2019-01-03
申请号：US16120946
申请日：2018-09-04
发明人： Leendert Adrianus Trouw , Reinaldus Everardus Maria Toes , Thomas Willem Johannes Huizinga , Petrus Antonius van Veelen , Anthony Cerami , Jing Shi
IPC分类号： G01N33/564 , G01N33/68
CPC分类号： G01N33/564 , G01N33/6854 , G01N2333/75 , G01N2440/00 , G01N2800/101 , G01N2800/102 , G01N2800/104 , G01N2800/105 , G01N2800/107 , G01N2800/50 , Y02A50/57
摘要： Antibodies against citrullinated protein antigens (ACPA) have shown their relevance for the diagnosis and possibly pathogenesis in arthritis. Described are means and methods for determining antibodies against homocitrulline-containing proteins or carbamylated proteins/peptides (anti-CarP) for the classification of individuals suffering from, or at risk of suffering from, arthritis.
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公开(公告)号：US20180258425A1
公开(公告)日：2018-09-13
申请号：US15761964
申请日：2016-09-23
发明人： Frank RIGO , Thazha P. PRAKASH , Wilhelmina Maria Clasina VAN ROON-MOM , Lodewijk Julius Anton TOONEN
IPC分类号： C12N15/113 , A61K31/712
CPC分类号： C12N15/113 , A61K31/712 , C12N9/485 , C12N2310/11 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/3525 , C12Y304/19012
摘要： Disclosed are methods for modulating splicing of Ataxin 3 mRNA in an animal with modified oligonucleotides. Such compounds and methods are useful to treat, prevent, or ameliorate spinocerebellar ataxia type 3 (SCA3) in an individual in need thereof.
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公开(公告)号：US09764023B2
公开(公告)日：2017-09-19
申请号：US14453286
申请日：2014-08-06
IPC分类号： A61K39/12 , C07K14/005 , C12N7/00 , A61K39/00 , A61K38/00
CPC分类号： A61K39/12 , A61K38/00 , A61K2039/585 , C07K14/005 , C12N7/00 , C12N2710/20022 , C12N2710/20034 , C12N2740/16043
摘要： The present invention relates to novel CD4+ and CD8+ T cell epitopes that are specific for HPV-specific E6 and E7 oncoproteins, to peptides comprising these novel T cell epitopes, and to (vaccine) compositions comprising these peptides for use in methods for the prevention and/or treatment of HPV related diseases. Preferred epitopes are recognized by a T cell that infiltrates a cervical neoplastic lesion or by a T cell from a draining lymph node, and are presented by an HLA-DQ or HLA-DP molecule, or an HLA-B.
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25.发明申请公开(公告)号：US20170175117A1
公开(公告)日：2017-06-22
申请号：US15439776
申请日：2017-02-22
发明人： Wilhelmina M.C. van Roon-Mom , Melvin Maurice Evers , Barry Antonius Pepers , Annemieke Aartsma-Rus , Garrit-Jan Boudewijn Van Ommen
IPC分类号： C12N15/113
CPC分类号： C12N15/1137 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/346 , C12N2320/33 , C12Y304/19012 , C12N2310/3521
摘要： The invention relates to means and methods for removing a proteolytic cleavage site from a protein comprising providing a cell that expresses pre-mRNA encoding the protein with an anti-sense oligonucleotide that induces skipping of the exonic sequence that encodes the proteolytic cleavage site, the method further comprising allowing translation of mRNA produced from the pre-mRNA.
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26.发明申请公开(公告)号：US20160333065A1
公开(公告)日：2016-11-17
申请号：US15228234
申请日：2016-08-04
CPC分类号： C07K14/4748 , A61K39/00 , A61K39/0011 , A61K2039/57 , A61K2039/572
摘要： The invention relates to a peptide having a length of no more than 100 amino acids and comprising at least 19 contiguous amino acids from the amino acid sequence of the human PRAME protein, wherein the peptide comprises at least one HLA class II epitope and at least one HLA class I epitope from the amino acid sequence of the human PRAME protein and to its use as such or in a composition as a medicament for the treatment and/or prevention of cancer.
摘要翻译： 本发明涉及长度不超过100个氨基酸并且包含来自人PRAME蛋白质的氨基酸序列的至少19个连续氨基酸的肽，其中所述肽包含至少一个HLA II类表位和至少一个 来自人PRAME蛋白质的氨基酸序列的HLA I类表位，以及其本身的用途或组合物中用作治疗和/或预防癌症的药物。
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27.发明申请MEANS AND METHODS FOR MODULATING NOTCH3 PROTEIN EXPRESSION AND/OR THE CODING REGION OF NOTCH3; COMPOSITIONS AND USE THEREOF IN THE TREATMENT OF CADASIL 有权用于调节NOTCH3蛋白表达和/或NOTCH3编码区的方法和方法; 组合物及其在治疗CADASIL中的应用公开(公告)号：US20150274796A1
公开(公告)日：2015-10-01
申请号：US14738593
申请日：2015-06-12
发明人： Saskia Anne-Marie Jenny Lesnik Oberstein , Garrit-Jan Boudewijn van Ommen , Adriana Marie Rus , Johannes Gregorius Dauwerse
IPC分类号： C07K14/485
CPC分类号： C07K14/485 , C07K14/70567 , C12N15/1138 , C12N2310/11 , C12N2320/33
摘要： The invention among other provides means and methods for modulating NOTCH3 expression and/or protein coding domain. In one aspect the invention provides a method for at least reducing an elevated level of NOTCH3 protein in a NOTCH3 expressing cell or the immediate vicinity thereof said method comprising providing said cell with an anti-sense oligonucleotide specific for NOTCH3 mRNA or pre-mRNA thereby decreasing production of said NOTCH3 protein or thereby altering the protein coding region in said NOTCH3 mRNA or pre-mRNA
摘要翻译： 本发明还提供了用于调节NOTCH3表达和/或蛋白质编码结构域的方法和方法。 一方面，本发明提供了一种用于至少降低NOTCH3表达细胞或其紧邻附近的Notch3蛋白水平升高的方法，所述方法包括向所述细胞提供对NOTCH3 mRNA或前mRNA特异性的反义寡核苷酸，从而减少 所述NOTCH3蛋白的产生或由此改变所述NOTCH3 mRNA或前mRNA中的蛋白质编码区
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28.发明申请COMPOUNDS AND METHODS FOR ALTERING ACTIVIN RECEPTOR-LIKE KINASE SIGNALING 审中-公开用于改变激活受体激动激酶信号的化合物和方法公开(公告)号：US20140088174A1
公开(公告)日：2014-03-27
申请号：US14110036
申请日：2012-04-05
发明人： Peter Abraham Christiaan "T Hoen , Wilhelmus Martinus Hendrikus Hoogaars , Dwi Utami Kemaladewi , Adriana Marie Rus , Peter Ten Duke
IPC分类号： C12N15/113
CPC分类号： C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3233 , C12N2310/346 , C12N2320/33 , C12N2310/3521
摘要： Described are compounds and methods useful in the promotion of muscle growth, the treatment of muscle loss or insufficient muscle growth, and the treatment of fibrotic conditions.
摘要翻译： 描述了可用于促进肌肉生长，治疗肌肉损失或肌肉生长不足以及治疗纤维化病症的化合物和方法。
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29.发明申请ANTISENSE OLIGONUCLEOTIDE DIRECTED REMOVAL OF PROTEOLYTIC CLEAVAGE SITES, THE HCHWA-D MUTATION, AND TRINUCLEOTIDE REPEAT EXPANSIONS 审中-公开抗原寡核苷酸方向去除蛋白酶切位点，HCHWA-D突变体和TRINUCLEOTIDE REPEAT扩增公开(公告)号：US20140039037A1
公开(公告)日：2014-02-06
申请号：US14047876
申请日：2013-10-07
发明人： WIHELMINA M. C. VAN ROON-MOM , MELVIN MAURICE EVERS , BARRY ANTONIUS PEPERS , ANNEMIEKE AARTSMA-RUS , GARRIT-JAN BOUDEWIJN VAN OMMEN
IPC分类号： C12N15/113
CPC分类号： C12N15/1137 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/346 , C12N2320/33 , C12Y304/19012 , C12N2310/3521
摘要： Described are methods for removing a proteolytic cleavage site, the HCHWA-D mutation or the amino acids encoded by a trinucleotide repeat expansion from a protein comprising providing a cell that expresses pre-mRNA encoding the protein with an anti-sense oligonucleotide that induces skipping of the exonic sequence that comprises the proteolytic cleavage site, HCHWA-D mutation or trinucleotide repeat expansion, respectively, the method further comprising allowing translation of mRNA produced from the pre-mRNA.
摘要翻译： 描述了去除蛋白水解切割位点，HCHWA-D突变或由来自蛋白质的三核苷酸重复扩增编码的氨基酸的方法，包括使用诱导跳跃的反义寡核苷酸提供表达编码蛋白质的mRNA前体的细胞 分别包含蛋白水解切割位点，HCHWA-D突变或三核苷酸重复扩增的外显子序列，所述方法还包括允许由mRNA产生的mRNA的翻译。
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公开(公告)号：US20240182974A1
公开(公告)日：2024-06-06
申请号：US17767788
申请日：2020-10-08
IPC分类号： C12Q1/6886 , C12Q1/686 , C12Q1/6881
CPC分类号： C12Q1/6886 , C12Q1/686 , C12Q1/6881 , C12Q2600/118
摘要： The present invention provides novel methods and kits for quantifying immune cells, specifically B-cells and T-cells, in a sample. The methods and kits may be used to monitor disease progression. They may also be used to determine the effect of a medicament used in the treatment of a disease. They may also be used to determine disease prognosis. They may also be used to diagnose disease.
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