公开(公告)号：US11651954B2

公开(公告)日：2023-05-16

申请号：US16651055

申请日：2017-09-27

Applicant: CAMBRIDGE ENTERPRISE LTD

Inventor： Tongtong Zhu ,  Rachel A. Oliver ,  Yingjun Liu

IPC: H01L21/3205 ,  H01L33/00 ,  H01L21/02 ,  C25F3/12

CPC classification number: H01L21/02203 ,  C25F3/12 ,  H01L33/007

Abstract: A method for porosifying a Ill-nitride material in a semiconductor structure is provided, the semiconductor structure comprising a sub-surface structure of a first Ill-nitride material, having a charge carrier density greater than 5×1017 cm−3, beneath a surface layer of a second Ill-nitride material, having a charge carrier density of between 1×1014 cm−3 and 1×1017 cm−3. The method comprises the steps of exposing the surface layer to an electrolyte, and applying a potential difference between the first Ill-nitride material and the electrolyte, so that the sub-surface structure is porosified by electrochemical etching, while the surface layer is not porosified. A semiconductor structure and uses thereof are further provided.

公开(公告)号：US11630037B2

公开(公告)日：2023-04-18

申请号：US16644846

申请日：2018-09-18

Applicant: Cambridge Enterprise Limited

Inventor： Luigi Occhipinti ,  Pelumi Oluwasanya

IPC: G01N1/22 ,  B01D49/02 ,  G01N15/02 ,  G01N15/06 ,  G01N15/00

Abstract: A particle sensing device is disclosed for sensing particles entrained in a gas, distribution of particle sizes including a first size range (e.g. PM2.5) and a second size range (e.g. PM10), larger than the first size range. A thermophoretic impulse is applied to the entrained particles. The device has a a first sensor, downstream of the thermophoretic impulse region. The thermophoretic impulse, the flow of gas and gravity combine to cause at least some of the particles to follow respective trajectories within the sampling volume. An interception unit is interposed between the thermophoretic impulse region and the first sensor, to intercept the respective trajectories of particles of the second size range but not respective trajectories of particles of the first size range. The first sensor is located to intercept and detect the respective trajectories of particles of the first size range.

公开(公告)号：US20230096352A1

公开(公告)日：2023-03-30

申请号：US18060317

申请日：2022-11-30

Applicant: CAMBRIDGE ENTERPRISE LTD

Inventor： Tongtong ZHU ,  Rachel A. OLIVER ,  Yingjun LIU

IPC: H01L21/02 ,  C25F3/12 ,  H01L33/00

Abstract: A method for porosifying a III-nitride material in a semiconductor structure is provided, the semiconductor structure comprising a sub-surface structure of a first III-nitride material, having a charge carrier density greater than 5×1017 cm−3, beneath a surface layer of a second III-nitride material, having a charge carrier density of between 1×1014 cm−3 and 1×1017 cm−3. The method comprises the steps of exposing the surface layer to an electrolyte, and applying a potential difference between the first III-nitride material and the electrolyte, so that the sub-surface structure is porosified by electrochemical etching, while the surface layer is not porosified. A semiconductor structure and uses thereof are further provided.

公开(公告)号：US20230053938A1

公开(公告)日：2023-02-23

申请号：US17792017

申请日：2021-01-13

Applicant: Cambridge Enterprise Limited

Inventor： Gita Khalili Moghaddam ,  Christopher Robin Lowe ,  Jeffrey Blyth

IPC: G01N21/45 ,  G01N21/77

Abstract: The present invention relates to sensors for detecting the presence or measuring the concentration of a target analyte, the sensor comprising: (i) a first phase comprising a first crosslinked polymer; (ii) a second phase comprising a second crosslinked polymer; and (ill) a target analyte recognition agent; the first phase and second phase arranged to form an optical grating. The first crosslinked polymer comprises low amounts of a crosslinking agent. The present invention also relates to methods of making a sensor for detecting the presence or measuring the concentration of a target analyte.

公开(公告)号：US20230027723A1

公开(公告)日：2023-01-26

申请号：US17859500

申请日：2022-07-07

Applicant: California Institute of Technology ,  Cambridge Enterprise Limited

Inventor： Cheng Shen ,  Changhuei Yang ,  Adiyant Lamba ,  Magdalena D. Zernicka-Goetz

IPC: G06N3/08 ,  G06N3/04 ,  G06V10/82 ,  G06T7/00

Abstract: Disclosed herein include systems, devices, and methods for detecting embryo polarization from a 2D image generated from a 3D image of an embryo that is not fluorescently labeled using a convolutional neural network (CNN), e.g., deep CNN.

公开(公告)号：US11525133B2

公开(公告)日：2022-12-13

申请号：US16428451

申请日：2019-05-31

Applicant: Cambridge Enterprise Limited

Inventor： Laura Itzhaki ,  Alberto Perez Riba ,  Pamela Rowling ,  Grasilda Zenkevi{hacek over (c)}iüte

IPC: C40B30/04 ,  C12N15/10 ,  C12N15/62 ,  C40B40/10 ,  C40B50/06

Abstract: This invention relates to modular proteins that interact with one or more target molecules. The chimeric proteins comprise two or more repeat domains, such as tetratricopeptide repeat domains; inter-repeat loops linking the repeat domains; and one or more peptide ligands. Each peptide ligand is located in an inter-repeat loop or at the N or C terminus of the chimeric protein. The peptide ligands may include heterologous peptidyl binding motifs, such as short linear motifs (SLiMs). Chimeric proteins with various configurations and methods for their production and use are provided.

公开(公告)号：US20220365075A1

公开(公告)日：2022-11-17

申请号：US17764145

申请日：2020-09-25

Applicant: Cambridge Enterprise Limited

Inventor： Tuomas Pertti Jonathan Knowles ,  Kadi Liis Saar ,  Alekszej Morgunov

IPC: G01N33/52 ,  G01N33/68 ,  B01L3/00 ,  G01N21/64

Abstract: The present invention relates to the identification of proteins involving measurement and characterisation of multidimensional aspects of said proteins.

公开(公告)号：US20220324947A1

公开(公告)日：2022-10-13

申请号：US17632023

申请日：2020-08-05

Applicant: Stichting VU ,  Cambridge Enterprise Limited

Inventor： Martine Joyce Smit ,  Timo Werner Marcella De Groof ,  Raimond Heukers ,  John Sinclair ,  Elizabeth Elder

IPC: C07K16/08 ,  C12N7/00 ,  G01N33/50

Abstract: The invention relates to the use of a single heavy chain variable domain antibody against human cytomegalovirus protein US28, which antibody binds to the extracellular region including, for example, the N-terminal extracellular region and/or the extracellular loops of US28, for isolation of cells that are infected with cytomegalovirus and/or for ex vivo reactivation of cytomegalovirus in latently infected cells. The invention further relates to the anti-US28 antibody for use in a method of reactivating cytomegalovirus in infected cells, or in a method of eliminating infected cells. The invention further relates to a tissue, organ, or cells such as bone marrow stem cells, from which cells that were infected with CMV have been removed with the use of the anti-US28 antibody.

公开(公告)号：US20220323935A1

公开(公告)日：2022-10-13

申请号：US17641055

申请日：2020-09-15

Applicant: Cambridge Enterprise Limited

Inventor： David Fairen-Jimenez ,  Mark Egdell Carrington

IPC: B01J20/28 ,  B01J20/30 ,  B01J20/22 ,  B01D53/04

Abstract: The present invention provides a covalent-organic framework (COF) body, populations of such bodies, a method for manufacturing a covalent-organic framework (COF) body, and (a) a gas storage system or a gas separation system comprising a gas storage vessel and a population of such COF bodies. The COF body comprises a plurality of primary COF particles, some or all of the primary COF particles being agglomerated as COF agglomerates. The average diameter of the primary COF particles is between nm and 120 nm, and the average diameter of the agglomerates is larger than the average diameter of the primary COF particles and between 15 nm and 250 nm. By careful control over particle size distribution during the formation of the COF material, it is possible (b) to form COF materials into high bulk density shapes and forms which are industrially useful and practical without losing sorbent performance.

公开(公告)号：US20220277456A1

公开(公告)日：2022-09-01

申请号：US17606996

申请日：2020-04-30

Applicant: CAMBRIDGE ENTERPRISE LIMITED

Inventor： Adam WOOLF ,  Martin BENNETT

IPC: G06T7/00 ,  G06V10/764 ,  G06V10/82 ,  G06V10/40 ,  G06V10/774 ,  G06V10/766 ,  A61B5/00 ,  G16H30/20

Abstract: Embodiments of the present techniques provide apparatus and methods for analysing intracoronary images, for example to predict the likelihood of a disease, disease presentation or event, and/or to track performance of a drug or other treatment. The method may comprise: for each image in the set of images of a coronary artery: classifying the image, using a first neural network, for the presence or absence of diseased tissue; when the image is classified as having diseased tissue present, classifying the image, using a second neural network, for the presence or absence of an artefact; determining whether to analyse the image based on the classifying steps; when the image is to be analysed, analysing the image by identifying, using a third neural network, one or more features of interest in a coronary artery tissue; and measuring each identified feature of interest.