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公开(公告)号：US20240285693A1
公开(公告)日：2024-08-29
申请号：US18424000
申请日：2024-01-26
Applicant: Cell Cure Neurosciences Ltd.
Inventor： Dana Hayoun Neeman , Ofer Wiser , Ravid Tikotzki , Lilach Alon
CPC classification number: A61K35/30 , C12N5/0621 , C12N2501/15 , C12N2506/02 , C12N2531/00
Abstract: Presented herein are methods and compositions for expanding RPE cells with the use of a suspendable cell support matrix. Also provided are pharmaceutical compositions containing RPE cells, and methods of treating an eye disorder or disease using RPE cells.
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公开(公告)号：US11987810B2
公开(公告)日：2024-05-21
申请号：US17546013
申请日：2021-12-08
Applicant: Cell Cure Neurosciences Ltd.
Inventor： Osnat Bohana-Kashtan , Lior Ann Rosenberg Belmaker , Ofer Wiser
CPC classification number: C12N5/0621 , A61K35/30 , C12N2500/02 , C12N2500/38 , C12N2501/115 , C12N2501/15 , C12N2501/16 , C12N2506/02 , C12N2533/52
Abstract: A population of human polygonal RPE cells is disclosed. At least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms. Methods of generating same are also disclosed.
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公开(公告)号：US20230028133A1
公开(公告)日：2023-01-26
申请号：US17943462
申请日：2022-09-13
Applicant: CELL CURE NEUROSCIENCES LTD.
Inventor： Eyal Banin , Benjamin Eithan Reubinoff , Osnat Bohana-Kashtan , Nir Netzer , Charles Sherard Irving
Abstract: A method of treating a subject with dry-form age-related macular degeneration (AMD) is disclosed. The method comprises administering into the subretina of the subject a therapeutically effective amount of a pharmaceutical composition comprising human RPE cells, wherein at least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), and wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms to the subject, thereby treating the subject.
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公开(公告)号：US20220408719A1
公开(公告)日：2022-12-29
申请号：US17893977
申请日：2022-08-23
Applicant: CELL CURE NEUROSCIENCES LTD.
Inventor： Nir Netzer , Ofer Wiser , Bat Shahaf , Orit Gamburg , Lior Rosenberg Belmaker , Dana Hayoun Neeman , Osnat Bohana Kashtan
Abstract: Presented herein are ready to administer (RTA) retinal pigment epithelium (RPE) cell therapy compositions for the treatment of retinal degenerative diseases and injuries. A method of formulating human RPE cells for administration to a subject directly after thawing and of formulating RPE cell therapy compositions for cryopreservation and administration of the cryopreserved composition to a subject subsequent to thawing are also presented. In another aspect, the RTA composition may be formulated as a thaw and inject (TAI) composition, whereby the composition is administered by injection subsequent to thawing.
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公开(公告)号：US20190137482A1
公开(公告)日：2019-05-09
申请号：US16242023
申请日：2019-01-08
Inventor： Talya MORDECHAI DANIEL , Ofer WISER , Benjamin Eithan REUBINOFF
IPC: G01N33/50
Abstract: A method of determining whether an agent is a neuroeffector is disclosed. The method comprises: (a) labeling dopaminergic neurons which are comprised in a mixed population of cells with a fluorescent dopamine analog; (b) measuring a level of fluorescence in the mixed population of cells; (c) exposing the mixed population of cells to the agent; (d) remeasuring a level of fluorescence in the mixed population of cells, wherein a change in the level of fluorescence is indicative of the substance being a neuroeffector.
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Patent Agency Ranking
公开(公告)号：US20180312805A1
公开(公告)日：2018-11-01
申请号：US15771046
申请日：2016-10-26
Inventor： Benjamin Eithan REUBINOFF , Orna SINGER , Osnat BOHANA-KASHTAN , Ofer WISER
IPC: C12N5/079 , C12N5/0735 , C12N5/00
CPC classification number: C12N5/0621 , C12N2501/15 , C12N2501/16 , C12N2506/02 , C12N2533/52
Abstract: A method of generating retinal pigment epithelium cells is disclosed. Cell populations comprising same and uses thereof are also disclosed.
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公开(公告)号：US20150377864A1
公开(公告)日：2015-12-31
申请号：US14766784
申请日：2014-02-12
Inventor： Talya MORDECHAI DANIEL , Ofer WISER , Benjamin Eithan REUBINOFF
IPC: G01N33/50
CPC classification number: G01N33/5058 , G01N33/502 , G01N2333/70571
Abstract: A method of determining whether an agent is a neuroeffector is disclosed. The method comprises: (a) labeling dopaminergic neurons which are comprised in a mixed population of cells with a fluorescent dopamine analog; (b) measuring a level of fluorescence in the mixed population of cells; (c) exposing the mixed population of cells to the agent; (d) remeasuring a level of fluorescence in the mixed population of cells, wherein a change in the level of fluorescence is indicative of the substance being a neuroeffector.
Abstract translation: 公开了一种确定药剂是否是神经递质的方法。 该方法包括：（a）将含有荧光多巴胺类似物的混合细胞群中的多巴胺能神经元标记; （b）测量混合细胞群体中的荧光水平; （c）将混合的细胞群暴露于所述试剂; （d）重新测量混合细胞群体中的荧光水平，其中荧光水平的变化指示物质是神经递质。
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公开(公告)号：US12188047B2
公开(公告)日：2025-01-07
申请号：US15771046
申请日：2016-10-26
Inventor： Benjamin Eithan Reubinoff , Orna Singer , Osnat Bohana-Kashtan , Ofer Wiser
IPC: C12N5/079 , C12N5/00 , C12N5/0735 , G01N33/53
Abstract: A method of generating retinal pigment epithelium cells is disclosed. Cell populations comprising same and uses thereof are also disclosed.
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公开(公告)号：US20210388316A1
公开(公告)日：2021-12-16
申请号：US17355093
申请日：2021-06-22
Applicant: Cell Cure Neurosciences LTD
Inventor： Osnat Bohana-Kashtan , Ofer Wiser
IPC: C12N5/079
Abstract: A method of generating retinal pigment epithelium cells is disclosed. Cell populations comprising same and uses thereof are also disclosed.
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公开(公告)号：US11090337B2
公开(公告)日：2021-08-17
申请号：US15750049
申请日：2016-08-04
Applicant: CELL CURE NEUROSCIENCES LTD
Inventor： Osnat Bohana-Kashtan
IPC: A61K35/30 , C12N5/07 , C12N5/079 , C12N5/0793 , A01N1/02
Abstract: A method of generating photoreceptors is disclosed. Cell populations comprising photoreceptors and uses thereof are also disclosed.
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