公开(公告)号：US06280413B1

公开(公告)日：2001-08-28

申请号：US08889432

申请日：1997-07-08

申请人： David W. Clark ,  Souise S. Clark ,  Victor I. Chornenky ,  Michael R. Forman ,  Jeffrey A. Lee

发明人： David W. Clark ,  Souise S. Clark ,  Victor I. Chornenky ,  Michael R. Forman ,  Jeffrey A. Lee

IPC分类号： A61M2900

CPC分类号： A61M25/0082 ,  A61F2/013 ,  A61F2230/0006 ,  A61F2230/005 ,  A61M25/0071 ,  A61M25/0074 ,  A61M2025/0057

摘要： A thrombolytic filtration and drug delivery catheter is disclosed comprising a shaft which longitudinal ribs. The ribs are compressed while being advanced to the site of interest and are released at the site, flaring to a diameter greater than the diameter of the shaft. The ribs can be compressed by a sleeve or thread, for example. Drugs or other agents can be delivered through lumens in the shaft and ribs, out through ports in the ribs. Preferably, the ports are positioned to deliver the drugs or other agents between the ribs and within the region defined by the ribs.

摘要翻译： 公开了溶栓过滤和药物递送导管，其包括纵轴的轴。 肋骨被压缩，同时前进到感兴趣的部位，并在现场释放，扩张到比轴的直径大。 例如，可以通过套筒或螺纹将肋压缩。 药物或其他药剂可以通过轴和肋中的腔进出，通过肋中的端口排出。 优选地，端口被定位成在肋之间并且在由肋限定的区域内递送药物或其它药剂。

公开(公告)号：US5713853A

公开(公告)日：1998-02-03

申请号：US488216

申请日：1995-06-07

申请人： David W. Clark ,  Souise S. Clark ,  Michael R. Forman

发明人： David W. Clark ,  Souise S. Clark ,  Michael R. Forman

IPC分类号： A61B17/22 ,  A61F2/958 ,  A61M25/00 ,  A61M29/02 ,  A61M31/00

CPC分类号： A61M25/007 ,  A61M29/02 ,  A61B2017/22082 ,  A61M2025/105 ,  A61M25/10

摘要： A catheter for delivering drugs or other agents is disclosed particularly suited for delivering drugs proximate the walls of a vessel or lumen, such as an artery or vein. The catheter comprises a shaft with a distal portion comprising at least one and preferably a plurality of delivery members. When deployed, the delivery members flare from the catheter shaft at an acute or obtuse angle. At least a portion of the delivery members are within a restraining member such as a sleeve or thread, for example, to maintain the delivery member within the diameter of the shaft prior to deployment. Delivery lumens provide drugs to ports in the delivery members for delivery out of the catheter. The delivery members preferably bear against the wall of the vessel when deployed, to deliver the drug or other agent proximate the walls of the blood vessel, where blood flow is slow. In another embodiment the delivery members comprise a first tapered portion, a second longitudinal portion and a plurality of drug delivery ports.

摘要翻译： 公开了用于递送药物或其它药剂的导管，其特别适合于在血管或内腔（例如动脉或静脉）的壁附近输送药物。 导管包括具有远端部分的轴，该远侧部分包括至少一个且优选地多个递送构件。 当展开时，输送构件以尖锐或钝角从导管轴上扩张。 输送构件的至少一部分在诸如套筒或螺纹的限制构件内，例如在展开之前将输送构件保持在轴的直径内。 输送流体向输送部件中的端口提供药物以从导管输送。 递送构件优选在展开时抵靠血管的壁，以在血液流动缓慢的血管壁附近递送药物或其它药剂。 在另一个实施例中，递送构件包括第一锥形部分，第二纵向部分和多个药物输送端口。

公开(公告)号：US4708429A

公开(公告)日：1987-11-24

申请号：US780311

申请日：1985-09-26

申请人： David W. Clark ,  Morton Freedman

发明人： David W. Clark ,  Morton Freedman

IPC分类号： G02B6/42 ,  G02B6/44 ,  G02B7/26

CPC分类号： G02B6/4202 ,  G02B6/4248 ,  G02B6/4428

摘要： An optically-coupled device package including a housing containing an optical device further includes an optical fiber assembly which comprises an optical cable with a support sleeve on its end. The support sleeve comprises a body with an axial opening therethrough and has a plurality of holes near a first end. The optical cable includes a first portion comprising a protective coating overlying an optical fiber, and a second portion comprising an optical fiber extending from said coating. The cable enters the first end of the sleeve and nodules integral with the protective coating extend into the plurality of holes. In one embodiment, the optical fiber is sealed to the inside of the sleeve through a solder window provided through the side of the sleeve. The second end of the sleeve extends through an aperture in said housing and is aligned to the device therein. The invention also includes a method for making such a fiber assembly which comprises inserting the optical cable into a first end of the sleeve, forming nodules integral with the protective coating which extend into the plurality of holes. The method may comprise sealing the optical fiber to the inside of the sleeve through a solder window in said sleeve. Fabrication of an optically-coupled device package further comprises inserting the fiber assembly through an aperture in said housing and aligning said fiber with the optical device therein.

摘要翻译： 包括包含光学装置的外壳的光耦合器件封装还包括光纤组件，其包括在其端部具有支撑套筒的光缆。 支撑套筒包括具有穿过其中的轴向开口的主体，并且在第一端附近具有多个孔。 光缆包括第一部分，其包括覆盖在光纤上的保护涂层，第二部分包括从所述涂层延伸的光纤。 电缆进入套筒的第一端，与保护涂层成一体的结节延伸到多个孔中。 在一个实施例中，光纤通过穿过套筒一侧提供的焊接窗口密封到套筒的内部。 套筒的第二端延伸穿过所述壳体中的孔并且与其中的装置对准。 本发明还包括制造这种纤维组件的方法，该方法包括将光缆插入到套筒的第一端中，形成与延伸到多个孔中的保护涂层一体的结节。 该方法可以包括通过所述套筒中的焊接窗将光纤密封到套筒的内部。 光学耦合器件封装的制造还包括将光纤组件穿过所述壳体中的孔并将所述光纤与其中的光学器件对准。

公开(公告)号：US20100036249A1

公开(公告)日：2010-02-11

申请号：US12516957

申请日：2007-12-03

申请人： David W. Clark

发明人： David W. Clark

IPC分类号： A61B8/14

CPC分类号： A61B8/06 ,  A61B8/0883 ,  A61B8/0891 ,  G01S7/52023 ,  G01S7/52077 ,  G01S7/52085 ,  G01S7/52095 ,  G01S15/8909 ,  G01S15/8979 ,  G10K11/346

摘要： A method for multiline ultrasound imaging comprises implementing multiline beamforming with a number of ensembles (52,54,56,58). Each ensemble includes a sequence (64,66,68,70,72,74) of transmit beams (T) of a given transmit direction and a first multiple of receive beams (R) per transmit beam. The method further includes constructing an overlap multiline image (50) at a frame rate equivalent to a second multiple non-overlapping multiline. The second multiple is a multiple different from the first multiple.

摘要翻译： 一种用于多行超声成像的方法包括实现具有多个集合的多行波束形成（52,54,56,58）。 每个集合包括给定发射方向的发射波束（T）的序列（64,66,68,70,72,74）和每个发射波束的接收波束（R）的第一倍数。 该方法还包括以等于第二多个不重叠多行的帧速率来构建重叠多行图像（50）。 第二个倍数是与第一个倍数不同的倍数。

公开(公告)号：US06193661B1

公开(公告)日：2001-02-27

申请号：US09287982

申请日：1999-04-07

申请人： David W Clark ,  Richard A Hager

发明人： David W Clark ,  Richard A Hager

IPC分类号： A61B800

CPC分类号： G01S7/52068 ,  A61B8/0858 ,  A61B8/14 ,  G01S7/52034 ,  G01S7/52044

摘要： Disclosed is a system and method for generating two dimensional renderings on a display device of acoustic volumetric data that provides depth perception to the user. The system includes an acoustic data acquisition circuit, which includes a sonic transducer and other components, that generates and stores an acoustic data set from medium such as a human body, etc. A scan converter generates a perspective volumetric data set of the medium based upon the acoustic data set, and a single dimensional interpolator that generates at least one interpolated data set from the perspective volumetric data set. The perspective volumetric and interpolated data sets are processed by a compositor that generates two dimensional renderings of the perspective volumetric data set and the interpolated data sets. The system includes a display device which displays the two dimensional renderings in a predetermined fashion to provide depth perception to the viewer.

摘要翻译： 公开了一种用于在声学体积数据的显示装置上产生二维效果的系统和方法，其向用户提供深度感知。 该系统包括一个声学数据采集电路，它包括声音传感器和其他组件，其产生和存储来自诸如人体等介质的声学数据集。扫描转换器基于以下方式产生介质的透视体积数据集 声学数据集，以及从透视体积数据集生成至少一个内插数据集的单维插值器。 透视体积和插值数据集由合成器处理，该合成器生成透视体积数据集和内插数据集的二维渲染。 该系统包括以预定方式显示二维渲染以向观看者提供深度感知的显示装置。

公开(公告)号：US07350538B2

公开(公告)日：2008-04-01

申请号：US11186224

申请日：2005-07-21

申请人： Charles C. Kuyava ,  John W. Westrum, Jr. ,  David W. Clark

发明人： Charles C. Kuyava ,  John W. Westrum, Jr. ,  David W. Clark

IPC分类号： F16K15/00 ,  A61F2/26

CPC分类号： A61F2/26 ,  Y10T137/1842 ,  Y10T137/7777 ,  Y10T137/7838 ,  Y10T137/7842 ,  Y10T137/785

摘要： A pump assembly for a penile implant is provided having a mechanism which prevents spontaneous inflation of the cylinders implanted within the user. The preventative mechanism uses overpressure generated by the reservoir during unintentional compression to effectively seal the pump assembly from unintended fluid flow. The prevention mechanism itself creates all necessary forces to prevent the undesired fluid flow to the cylinders. This is accomplished by incorporating appropriate mechanisms within the pump itself.

摘要翻译： 提供了一种用于阴茎植入物的泵组件，其具有防止植入在使用者内的气缸的自发膨胀的机构。 预防机构在非故意压缩期间使用由储存器产生的超压，以有效地将泵组件密封以防意外的流体流动。 防止机构本身产生所有必要的力以防止不需要的流体流向气缸。 这通过在泵本身内并入适当的机构来实现。

公开(公告)号：US06537222B1

公开(公告)日：2003-03-25

申请号：US08920057

申请日：1997-08-26

申请人： David W. Clark ,  Patrick G. Rafter

发明人： David W. Clark ,  Patrick G. Rafter

IPC分类号： A61B800

CPC分类号： A61B8/481 ,  G01S7/52028 ,  G01S7/52038

摘要： Quadrature demodulation apparatus and method for detecting a contrast agent in an ultrasonic echographic system, including an in phase/quadrature demodulator for determining the resolved complex real and imaginary in phase and quadrature components of return signals and a contrast agent detector determining the complex difference between first and second return signals. The detector is implemented as a magnitude of difference detector determining the magnitude of the complex difference of pairs of first and second return signals wherein the real and imaginary components of the return signals, including magnitude and phase information, are used to determine the magnitude of the complex difference between first and second return signals. The detector is also implemented as an asymmetrical weighting detector resolving the complex difference between first and second return signals into components in phase with and orthogonal to the second signal and weighting the magnitudes of in phase and orthogonal components of the complex difference and indicating a contrast agent present when the combination of differently weighted component exceeds the corresponding threshold value. The detector is also implemented as an extrapolation detector for receiving three successive return signals along each line wherein the second return signal and a third return signal are used to extrapolate what the first return signal would have been without the contrast agent component and to generate a decision threshold that is compared to the complex difference between the actual first return signal and the extrapolated first return signal.

摘要翻译： 用于检测超声波回波成像系统中的造影剂的正交解调装置和方法，包括用于确定分离的复数实数和虚数的相位和正交分量的回波信号的同相/正交解调器和确定第一 和第二个返回信号。 检测器被实现为差分检测器的大小，其确定第一和第二返回信号对的复差的幅度，其中包括幅度和相位信息的返回信号的实部和虚部被用于确定 第一和第二返回信号之间的复杂差异。 检测器还被实现为不对称加权检测器，将第一和第二返回信号之间的复差分解成与第二信号同相并与其正交的分量，并对复差的相位和正交分量的大小加权并指示造影剂 当不同加权分量的组合超过相应的阈值时出现。 检测器还被实现为外推检测器，用于沿着每条线接收三个连续的返回信号，其中第二返回信号和第三返回信号用于外推第一返回信号将没有造影剂分量并且产生决定 阈值与实际的第一返回信号和外插的第一返回信号之间的复差进行比较。

公开(公告)号：US06190322B1

公开(公告)日：2001-02-20

申请号：US09342820

申请日：1999-06-29

申请人： David W Clark

发明人： David W Clark

IPC分类号： A61B800

CPC分类号： G01S7/52017 ,  G01S7/52038 ,  G01S15/102

摘要： Disclosed is a system and method for generating an ultrasound echo signal with reduced linear components. In one embodiment, the system comprises an excitation signal source configured to generate a first excitation signal and a second excitation signal, and a transducer coupled to the excitation signal source, the transducer being configured to emit a first asymmetric ultrasonic pulse in response to the first excitation signal and a second asymmetric ultrasonic pulse in response to the second excitation signal, the first and second asymmetric ultrasonic pulses being emitted into a medium. The system also entails a beamformer coupled to the transducer, the beamformer configured to generate a first echo signal and a second echo signal received by the transducer from the medium in response to the first and second asymmetric ultrasonic pulses, and an envelope detector coupled to the beamformer, the envelope detector configured to generate a first echo envelope from the first echo signal and a second echo envelope from the second echo signal. The present system also includes an acoustic line memory coupled to the envelope detector configured to store the first echo envelope, and an arithmetic junction coupled to the envelope detector, the arithmetic junction configured to subtract the first echo envelope from the second echo envelope, thereby canceling nonlinearities.

摘要翻译： 公开了一种用于产生具有减小的线性分量的超声回波信号的系统和方法。 在一个实施例中，系统包括被配置为产生第一激励信号和第二激励信号的激励信号源以及耦合到激励信号源的换能器，所述换能器被配置为响应于第一激励信号发射第一非对称超声波脉冲 激励信号和响应于第二激励信号的第二不对称超声波脉冲，第一和第二不对称超声波脉冲被发射到介质中。 该系统还需要耦合到换能器的波束形成器，波束形成器被配置为响应于第一和第二不对称超声波脉冲从介质产生第一回波信号和由换能器接收的第二回波信号，以及耦合到 波束形成器，所述包络检测器被配置为从所述第一回波信号产生第一回波包络和从所述第二回波信号产生第二回波包络。 本系统还包括耦合到包络检测器的声线存储器，其被配置为存储第一回波包络，以及耦合到包络检测器的算术结，运算结被配置为从第二回波包络中减去第一回波包络，从而取消 非线性

公开(公告)号：US06174285B1

公开(公告)日：2001-01-16

申请号：US09243312

申请日：1999-02-02

申请人： David W. Clark

发明人： David W. Clark

IPC分类号： A61B800

CPC分类号： A61B8/14 ,  A61B8/0883 ,  A61B8/466 ,  A61B8/467 ,  Y10S128/916

摘要： An ultrasound imaging system incorporating the invention enables a user to select a pre-set anatomical view that is not available from standard ultrasound transducer imaging positions. The system includes a transducer which produces an ultrasound beam that acquires a 3-D set of echo signals. A processor enables the system user to be presented with a listing of pre-set anatomical views and is responsive to user selection of one of the pre-set views to control a converter within the system to derive from the 3-D set of echo signals, an image data set which, when displayed, presents the pre-set anatomical view selected by the user. In the preferred embodiment, at least some of the pre-set anatomical views are those that are not otherwise available from the standard transducer imaging positions.

摘要翻译： 结合本发明的超声成像系统使得用户能够选择不能从标准超声换能器成像位置获得的预设解剖视图。 该系统包括产生获得3-D组回波信号的超声波束的换能器。 处理器使得能够向系统用户呈现预设解剖视图的列表，并且响应于用户选择预设视图之一来控制系统内的转换器以从3-D组回波信号中导出 ，当显示时显示由用户选择的预设解剖视图的图像数据集。 在优选实施例中，预设解剖视图中的至少一些是从标准换能器成像位置不能获得的解剖视图。

公开(公告)号：US5995101A

公开(公告)日：1999-11-30

申请号：US960299

申请日：1997-10-29

申请人： David W. Clark ,  Lance Lewis ,  Thomas W. McRae ,  Randolph A. Strauss

发明人： David W. Clark ,  Lance Lewis ,  Thomas W. McRae ,  Randolph A. Strauss

IPC分类号： G06F3/023 ,  G06F3/033 ,  G06F3/048 ,  G06F3/00 ,  G06F3/14

CPC分类号： G06F3/04895 ,  G06F3/0481

摘要： A graphical user interface (GUI) for use in a graphical display on a computer monitor includes a cursor that allows a user to point to an area of interest in the graphical display. The GUI also includes an information element that provides a first level of information in the graphical display when the user first points to the area of interest and then provides a subsequent level of information in the graphical display if the user continues to point to the area of interest or presses a selected keystroke.

摘要翻译： 用于计算机监视器上的图形显示的图形用户界面（GUI）包括允许用户指向图形显示中的感兴趣区域的光标。 GUI还包括信息元素，当用户首先指向感兴趣区域时，在图形显示中提供第一级别的信息，然后如果用户继续指向图像显示区域的区域，则提供图形显示中的后续级别的信息 兴趣或按选择的击键。