公开(公告)号：US06610826B1

公开(公告)日：2003-08-26

申请号：US09581575

申请日：2000-06-15

Applicant: Jörg Meyer ,  Alfred Jonczyk ,  Berthold Nies ,  Horst Kessler ,  Dirk Finsinger ,  Martin Kantlehner

Inventor： Jörg Meyer ,  Alfred Jonczyk ,  Berthold Nies ,  Horst Kessler ,  Dirk Finsinger ,  Martin Kantlehner

IPC: C07K510

CPC classification number: C07K7/64 ,  A61K38/00 ,  Y02P20/125

Abstract: Compounds of the formula I R—Q—X  I, in which R, Q, and X are as defined herein, can be used as integrin inhibitors. In particular, compounds of formula I are suitable for the treatment of disorders caused by implants, defects, inflammations and of osteolytic disorders such as osteoporosis, thrombosis, cardiac infarct and arteriosclerosis. These compounds are also suitable for the acceleration and reinforcement of the integration process of implants and biocompatible surfaces into tissue.

Abstract translation: R，Q和X如本文所定义的式Iin化合物可用作整联蛋白抑制剂。 特别地，式I化合物适用于治疗由植入物，缺陷，炎症和溶骨性疾病如骨质疏松症，血栓形成，心肌梗死和动脉硬化引起的疾病。 这些化合物也适用于加速和加强植入物和生物相容性表面进入组织的整合过程。

公开(公告)号：US08268845B2

公开(公告)日：2012-09-18

申请号：US11908220

申请日：2006-02-14

Applicant: Dirk Finsinger ,  Armin De Meijere

Inventor： Dirk Finsinger ,  Armin De Meijere

IPC: A61K31/517

CPC classification number: C07D239/90 ,  C07D239/70 ,  C07D239/91

Abstract: The present invention relates to the use of tetrahydro- and dihydroquinazolinones of formula I as protein kinase activators or inhibitors, a method for their manufacture, their use for the preparation of a medicament for the treatment of diseases, their use for the manufacture of a pharmaceutical composition and new tetrahydro- and dihydroquinazolinones.

Abstract translation: 本发明涉及式I的四氢和二氢喹唑啉酮作为蛋白激酶激活剂或抑制剂的用途，其制备方法，其用于制备用于治疗疾病的药物，其用于制备药物的用途 组合物和新的四氢和二氢喹唑啉酮。

公开(公告)号：US07943608B2

公开(公告)日：2011-05-17

申请号：US12158333

申请日：2006-11-28

Applicant: Melanie Schultz ,  Lars Thore Burgdorf ,  Dirk Finsinger ,  Andree Blaukat ,  Hartmut Greiner ,  Christina Esdar

Inventor： Melanie Schultz ,  Lars Thore Burgdorf ,  Dirk Finsinger ,  Andree Blaukat ,  Hartmut Greiner ,  Christina Esdar

IPC: C07D487/04 ,  A61K31/5517

CPC classification number: C07D487/04

Abstract: The invention relates to compounds of the formula (I), to the preparation and use thereof for the preparation of a medicament for the treatment of diseases, in particular tumours and/or diseases in the development or course of which kinases are involved.

Abstract translation: 本发明涉及式（I）化合物的制备和用途，其用于制备用于治疗疾病，特别是涉及激酶发展过程中的肿瘤和/或疾病的药物。

公开(公告)号：US07893082B2

公开(公告)日：2011-02-22

申请号：US11916952

申请日：2006-05-17

Applicant: Kai Schiemann ,  Ulrich Emde ,  Dirk Finsinger ,  Christiane Amendt ,  Nina Heiss ,  Frank Zenke

Inventor： Kai Schiemann ,  Ulrich Emde ,  Dirk Finsinger ,  Christiane Amendt ,  Nina Heiss ,  Frank Zenke

IPC: A61K31/4375 ,  A61K31/436 ,  C07D491/052 ,  C07D471/04

CPC classification number: C07D215/42 ,  C07D401/04 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D491/052

Abstract: Disclosed are compounds of formula (I), wherein W, R, R1, R2, R3, R4, R5, R6, and R7 have the meanings indicated in claim 1. Said compounds can be used for the treatment of tumors, among other things.

Abstract translation: 公开了式（I）的化合物，其中W，R，R 1，R 2，R 3，R 4，R 5，R 6和R 7具有权利要求1中所示的含义。所述化合物可用于治疗肿瘤， 。

公开(公告)号：US20100076012A1

公开(公告)日：2010-03-25

申请号：US12531602

申请日：2008-02-22

Applicant: Kai Schiemann ,  Dirk Finsinger ,  Christiane Amendt ,  Frank Zenke

Inventor： Kai Schiemann ,  Dirk Finsinger ,  Christiane Amendt ,  Frank Zenke

IPC: A61K31/436 ,  C07D491/147 ,  C07D507/00 ,  C07D491/153 ,  A61K31/4375 ,  A61K31/437 ,  A61P35/00

CPC classification number: C07D491/147 ,  C07D495/14

Abstract: Compounds of the formula (I), in which E, R3, R4, R5, X, Y, W, Q1, Q2, Z, s and m have the meanings indicated in claim 1, can be employed, inter alia, for the treatment of tumours.

Abstract translation: 其中E，R3，R4，R5，X，Y，W，Q1，Q2，Z，s和m具有权利要求1所述的含义的式（I）化合物，除其他外，可用于 治疗肿瘤。

公开(公告)号：US20090318444A1

公开(公告)日：2009-12-24

申请号：US11908220

申请日：2006-02-14

Applicant: Dirk Finsinger ,  Armin De Meijere

Inventor： Dirk Finsinger ,  Armin De Meijere

IPC: A61K31/517 ,  C07D239/91 ,  C07D413/04 ,  A61K31/5377 ,  A61P35/00 ,  A61P37/00 ,  A61P19/00 ,  A61P31/00 ,  A61P9/00 ,  A61P25/28

CPC classification number: C07D239/90 ,  C07D239/70 ,  C07D239/91

Abstract: The present invention relates to the use of tetrahydro- and dihydroquinazolinones of formula I as protein kinase activators or inhibitors, a method for their manufacture, their use for the preparation of a medicament for the treatment of diseases, their use for the manufacture of a pharmaceutical composition and new tetrahydro- and dihydroquinazolinones.

Abstract translation: 本发明涉及式I的四氢和二氢喹唑啉酮作为蛋白激酶激活剂或抑制剂的用途，其制备方法，其用于制备用于治疗疾病的药物，其用于制备药物的用途 组合物和新的四氢和二氢喹唑啉酮。

公开(公告)号：US20080221118A1

公开(公告)日：2008-09-11

申请号：US11917283

申请日：2006-05-31

Applicant: Wolfgang Staehle ,  David Bruge ,  Kai Schiemann ,  Dirk Finsinger ,  Hans-Peter Buchstaller ,  Frank Zenke ,  Christiane Amendt

Inventor： Wolfgang Staehle ,  David Bruge ,  Kai Schiemann ,  Dirk Finsinger ,  Hans-Peter Buchstaller ,  Frank Zenke ,  Christiane Amendt

IPC: A61K31/496 ,  C07D221/06 ,  C07D471/04 ,  C07D401/10 ,  A61K31/473 ,  A61K31/4741 ,  A61P35/00 ,  A61P35/02

CPC classification number: C07D491/04 ,  C07D221/16

Abstract: Compounds of the formula I, in which s, k, I, W, R1, R2, R3, and U have the meanings indicated in claim 1, can be employed, inter alia, for the treatment of tumours.

Abstract translation: 其中s，k，I，W，R 1，R 2，R 3和U的式I化合物具有 权利要求1所述的含义可以用于治疗肿瘤。

公开(公告)号：US20070213374A1

公开(公告)日：2007-09-13

申请号：US10563830

申请日：2004-06-18

Applicant: David Bruge ,  Hans-Peter Buchstaller ,  Matthias Wiesner ,  Dirk Finsinger ,  Manfred Baumgarth ,  Christian Sirrenberg ,  Frank Zenke ,  Christian Amendt ,  Matthias Grell

Inventor： David Bruge ,  Hans-Peter Buchstaller ,  Matthias Wiesner ,  Dirk Finsinger ,  Manfred Baumgarth ,  Christian Sirrenberg ,  Frank Zenke ,  Christian Amendt ,  Matthias Grell

IPC: A61K31/395 ,  A61K31/422 ,  C07C233/15 ,  C07D213/38 ,  C07D213/66 ,  C07D213/68 ,  C07D213/75 ,  C07D213/79 ,  C07D213/81 ,  C07D261/14 ,  C07D413/12

CPC classification number: C07D213/66 ,  C07C233/15 ,  C07D213/38 ,  C07D213/68 ,  C07D213/75 ,  C07D213/79 ,  C07D213/81 ,  C07D261/14 ,  C07D413/12

Abstract: The present invention relates to malonamide derivatives of formula A-D-B-1, as inhibitors of raf-kinase and the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition.

Abstract translation: 本发明涉及作为raf-激酶抑制剂的式A-D-B-1的丙二酰胺衍生物和式（I）化合物在制备药物组合物中的用途。

公开(公告)号：US20070191423A1

公开(公告)日：2007-08-16

申请号：US10590797

申请日：2005-02-01

Applicant: Hans-Peter Buchstaller ,  Lars Burgdorf ,  Dirk Finsinger ,  Christiana Amendt ,  Matthias Grell ,  Christian Sirrenberg ,  Frank Zenke

Inventor： Hans-Peter Buchstaller ,  Lars Burgdorf ,  Dirk Finsinger ,  Christiana Amendt ,  Matthias Grell ,  Christian Sirrenberg ,  Frank Zenke

IPC: A61K31/47 ,  C12N9/99

CPC classification number: C07D217/26 ,  C07C211/45 ,  C07C211/52 ,  C07C265/12 ,  C07D401/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: The present invention relates to isoquinoline derivatives of formula (I), the use of the compounds of formula (I), as inhibitors of one or more kinases, the use of the compounds of formula (I), for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.

Abstract translation: 本发明涉及式（I）的异喹啉衍生物，式（I）化合物的用途，作为一种或多种激酶的抑制剂，使用式（I）化合物，用于制备药物组合物 和一种治疗方法，包括将药物组合物给予患者。

公开(公告)号：US20070093529A1

公开(公告)日：2007-04-26

申请号：US10582496

申请日：2004-11-11

Applicant: Dirk Finsinger ,  Hans-Peter Buchstaller ,  Lars Burgdorf ,  Christiane Amendt ,  Matthias Grell ,  Christian Sirrenberg ,  Frank Zenke

Inventor： Dirk Finsinger ,  Hans-Peter Buchstaller ,  Lars Burgdorf ,  Christiane Amendt ,  Matthias Grell ,  Christian Sirrenberg ,  Frank Zenke

IPC: C07D403/02 ,  A61K31/4439 ,  A61K31/4412

CPC classification number: C07D213/81 ,  C04B35/632 ,  C07C243/38 ,  C07D207/327 ,  C07D213/54 ,  C07D213/66 ,  C07D213/68 ,  C07D243/38 ,  C07D249/18 ,  C07D317/68 ,  C07D401/12 ,  C07D413/12

Abstract: The present invention relates to diacylhydrazine derivatives of formula I, the use of the compounds of formula I as inhibitors of raf-kinase, the use of the compounds of formula I for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.

Abstract translation: 本发明涉及式I的二酰肼衍生物，式I化合物作为raf-激酶抑制剂的用途，式I化合物在制备药物组合物中的用途及其治疗方法，包括给予所述 药物组合物给患者。