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公开(公告)号：US20070213374A1
公开(公告)日：2007-09-13
申请号：US10563830
申请日：2004-06-18
申请人： David Bruge , Hans-Peter Buchstaller , Matthias Wiesner , Dirk Finsinger , Manfred Baumgarth , Christian Sirrenberg , Frank Zenke , Christian Amendt , Matthias Grell
发明人： David Bruge , Hans-Peter Buchstaller , Matthias Wiesner , Dirk Finsinger , Manfred Baumgarth , Christian Sirrenberg , Frank Zenke , Christian Amendt , Matthias Grell
IPC分类号： A61K31/395 , A61K31/422 , C07C233/15 , C07D213/38 , C07D213/66 , C07D213/68 , C07D213/75 , C07D213/79 , C07D213/81 , C07D261/14 , C07D413/12
CPC分类号： C07D213/66 , C07C233/15 , C07D213/38 , C07D213/68 , C07D213/75 , C07D213/79 , C07D213/81 , C07D261/14 , C07D413/12
摘要： The present invention relates to malonamide derivatives of formula A-D-B-1, as inhibitors of raf-kinase and the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition.
摘要翻译： 本发明涉及作为raf-激酶抑制剂的式A-D-B-1的丙二酰胺衍生物和式（I）化合物在制备药物组合物中的用途。
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公开(公告)号：US08410143B2
公开(公告)日：2013-04-02
申请号：US12488191
申请日：2009-06-19
申请人： Hans-Peter Buchstaller , Matthias Wiesner , Oliver Schadt , Christiane Amendt , Frank Zenke , Christian Sirrenberg , Matthias Grell , Dirk Finsinger
发明人： Hans-Peter Buchstaller , Matthias Wiesner , Oliver Schadt , Christiane Amendt , Frank Zenke , Christian Sirrenberg , Matthias Grell , Dirk Finsinger
IPC分类号： A61K31/4412 , C07D213/68
CPC分类号： C07D213/68 , A61K31/44 , A61K31/4439 , A61K45/00 , C07D213/75 , C07D213/79 , C07D213/81 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to methylene urea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
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公开(公告)号：US07691886B2
公开(公告)日：2010-04-06
申请号：US10564185
申请日：2004-06-15
申请人： Hans-Peter Buchstaller , Dirk Finsinger , Matthias Wiesner , Lars Thore Burgdorf , Christiane Amendt , Matthias Grell , Christian Sirrenberg , Frank Zenke
发明人： Hans-Peter Buchstaller , Dirk Finsinger , Matthias Wiesner , Lars Thore Burgdorf , Christiane Amendt , Matthias Grell , Christian Sirrenberg , Frank Zenke
IPC分类号： C07D401/00 , A01N43/64
CPC分类号： C07D401/12
摘要： The present invention relates to benzimidazole derivatives of formula I, the use of the compounds of formula I as inhibitors of one or more kinases, the use of the compounds of formula I for the manufacture of a pharmaceutical compositions and methods of treatment, comprising administering said pharmaceutical compositions to patients.
摘要翻译： 本发明涉及式I的苯并咪唑衍生物，式I化合物作为一种或多种激酶抑制剂的用途，式I化合物在制备药物组合物和治疗方法中的应用，包括给予所述 药物组合物给患者。
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公开(公告)号：US20060199844A1
公开(公告)日：2006-09-07
申请号：US10532574
申请日：2003-10-08
申请人： Hans-Peter Buchstaller , Matthias Wiesner , Oliver Schadt , Christiane Amendt , Frank Zenke , Christian Sirrenberg , Matthias Grell , Dirk Finsinger
发明人： Hans-Peter Buchstaller , Matthias Wiesner , Oliver Schadt , Christiane Amendt , Frank Zenke , Christian Sirrenberg , Matthias Grell , Dirk Finsinger
IPC分类号： A61K31/444 , C07D401/02 , A61K31/44 , C07D213/53
CPC分类号： C07D213/68 , A61K31/44 , A61K31/4439 , A61K45/00 , C07D213/75 , C07D213/79 , C07D213/81 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to methylene urea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
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公开(公告)号：US20070149594A1
公开(公告)日：2007-06-28
申请号：US10579825
申请日：2004-10-26
申请人： Dirk Finsinger , Hans-Peter Buchstaller , Lars Burgdorf , Matthias Wiesner , Christiane Amendt , Matthias Grell , Christian Sirrenberg , Frank Zenke
发明人： Dirk Finsinger , Hans-Peter Buchstaller , Lars Burgdorf , Matthias Wiesner , Christiane Amendt , Matthias Grell , Christian Sirrenberg , Frank Zenke
IPC分类号： A61K31/401 , C07D207/30 , A61K31/40
CPC分类号： C07D207/337 , C07D401/12
摘要： Compounds of the formula (I), in which X, Y, Z and Ar have the meanings indicated in claim 1, are inhibitors of Raf kinase and can be employed, inter alia, for the treatment of tumours
摘要翻译： 其中X，Y，Z和Ar具有权利要求1所述含义的式（I）化合物是Raf激酶的抑制剂，并且可以用于治疗肿瘤
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公开(公告)号：US20090298885A1
公开(公告)日：2009-12-03
申请号：US12488191
申请日：2009-06-19
申请人： Hans-Peter Buchstaller , Matthias Wiesner , Oliver Schadt , Christiane Amendt , Frank Zenke , Christian Sirrenberg , Matthias Grell , Dirk Finsinger
发明人： Hans-Peter Buchstaller , Matthias Wiesner , Oliver Schadt , Christiane Amendt , Frank Zenke , Christian Sirrenberg , Matthias Grell , Dirk Finsinger
IPC分类号： A61K31/4439 , A61K31/4412 , C07D213/78 , C07D413/12 , C07D417/00
CPC分类号： C07D213/68 , A61K31/44 , A61K31/4439 , A61K45/00 , C07D213/75 , C07D213/79 , C07D213/81 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to methylene urea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
摘要翻译： 本发明涉及式（I）的亚甲基脲衍生物，式（I）化合物作为raf-激酶抑制剂的用途，式（I）化合物用于制备药物组合物和 包括将所述药物组合物施用于患者。
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公开(公告)号：US20090253688A1
公开(公告)日：2009-10-08
申请号：US10590664
申请日：2005-02-14
申请人： Hans-Peter Buchstaller , Dirk Finsinger , Frank Stieber , Matthias Wiesner , Christiane Amendt , Christian Sirrenberg , Frank Zenke , Matthias Grell
发明人： Hans-Peter Buchstaller , Dirk Finsinger , Frank Stieber , Matthias Wiesner , Christiane Amendt , Christian Sirrenberg , Frank Zenke , Matthias Grell
IPC分类号： A61K31/541 , C07D213/68 , A61K31/4409 , A61K31/5377 , C07D413/12 , C07D417/12 , A61P35/00
CPC分类号： C07D213/68 , C07D213/81 , C07D401/12
摘要： The present invention relates to semicarbazide derivatives of formula I, the use of the compounds of formula I as inhibitors of one or more kinases, the use of the compounds of formula I for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
摘要翻译： 本发明涉及式I的氨基脲衍生物，式I化合物作为一种或多种激酶的抑制剂的用途，式I化合物在制备药物组合物中的用途及其治疗方法，其包括施用 所述药物组合物对患者而言。
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公开(公告)号：US07598274B2
公开(公告)日：2009-10-06
申请号：US10579825
申请日：2004-10-26
申请人： Dirk Finsinger , Hans-Peter Buchstaller , Lars Burgdorf , Matthias Wiesner , Christiane Amendt , Matthias Grell , Christian Sirrenberg , Frank Zenke
发明人： Dirk Finsinger , Hans-Peter Buchstaller , Lars Burgdorf , Matthias Wiesner , Christiane Amendt , Matthias Grell , Christian Sirrenberg , Frank Zenke
IPC分类号： A61K31/4439 , C07D401/02
CPC分类号： C07D207/337 , C07D401/12
摘要： Compounds of the formula (I), in which X, Y, Z and Ar have the meanings indicated in claim 1, are inhibitors of Raf kinase and can be employed, inter alia, for the treatment of tumours
摘要翻译： 其中X，Y，Z和Ar具有权利要求1所述含义的式（I）化合物是Raf激酶的抑制剂，并且可以用于治疗肿瘤
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公开(公告)号：US07589112B2
公开(公告)日：2009-09-15
申请号：US10532574
申请日：2003-10-08
申请人： Hans-Peter Buchstaller , Matthias Wiesner , Oliver Schadt , Christiane Amendt , Frank Zenke , Christian Sirrenberg , Matthias Grell , Dirk Finsinger
发明人： Hans-Peter Buchstaller , Matthias Wiesner , Oliver Schadt , Christiane Amendt , Frank Zenke , Christian Sirrenberg , Matthias Grell , Dirk Finsinger
IPC分类号： A61K31/4412 , C07D213/68
CPC分类号： C07D213/68 , A61K31/44 , A61K31/4439 , A61K45/00 , C07D213/75 , C07D213/79 , C07D213/81 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to methylene urea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
摘要翻译： 本发明涉及式（I）的亚甲基脲衍生物，式（I）化合物作为raf-激酶抑制剂的用途，式（I）化合物用于制备药物组合物和 包括将所述药物组合物施用于患者。
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公开(公告)号：US20070191423A1
公开(公告)日：2007-08-16
申请号：US10590797
申请日：2005-02-01
申请人： Hans-Peter Buchstaller , Lars Burgdorf , Dirk Finsinger , Christiana Amendt , Matthias Grell , Christian Sirrenberg , Frank Zenke
发明人： Hans-Peter Buchstaller , Lars Burgdorf , Dirk Finsinger , Christiana Amendt , Matthias Grell , Christian Sirrenberg , Frank Zenke
CPC分类号： C07D217/26 , C07C211/45 , C07C211/52 , C07C265/12 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to isoquinoline derivatives of formula (I), the use of the compounds of formula (I), as inhibitors of one or more kinases, the use of the compounds of formula (I), for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
摘要翻译： 本发明涉及式（I）的异喹啉衍生物，式（I）化合物的用途，作为一种或多种激酶的抑制剂，使用式（I）化合物，用于制备药物组合物 和一种治疗方法，包括将药物组合物给予患者。
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