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    Benzoimidazole derivatives and pharmaceutical composition comprising the same
    21.
    发明授权
    Benzoimidazole derivatives and pharmaceutical composition comprising the same 有权
    苯并咪唑衍生物和包含其的药物组合物

    公开(公告)号：US09199965B2

    公开(公告)日：2015-12-01

    申请号：US11815009

    申请日：2006-01-27

    申请人： Ji Duck Kim ,  Hong Chul Yoon ,  In Woo Kim ,  Hyae Jung Hyun

    发明人： Ji Duck Kim ,  Hong Chul Yoon ,  In Woo Kim ,  Hyae Jung Hyun

    IPC分类号： C07D401/10 ,  C07D417/14 ,  C07D471/04 ,  C07D403/04 ,  C07D403/14

    CPC分类号： C07D401/10 ,  C07D417/14 ,  C07D471/04

    摘要： Disclosed herein are novel benzoimidazole derivatives functioning as antagonists to vanilloid receptor-1, and a pharmaceutical composition comprising the same. They are useful in preventing or treating pain, acute pain, chronic pain, neuropathic pain, postoperative pain, migraines, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neurological illness, neurodermatitis, strokes, bladder hypersensitivity, irritable bowel syndrome, respiratory disorders such as asthma, chronic obstructive pulmonary disease, etc., burns, psoriasis, itching, vomiting, irritation of the skin, eyes, and mucous membranes, gastric-duodenal ulcers, inflammatory intestinal diseases, and inflammatory diseases.

    摘要翻译： 本文公开了用作香草素受体-1的拮抗剂的新型苯并咪唑衍生物和包含其的药物组合物。 它们可用于预防或治疗疼痛，急性疼痛，慢性疼痛，神经性疼痛，术后疼痛，偏头痛，关节痛，神经病，神经损伤，糖尿病性神经病，神经病，神经性皮炎，中风，膀胱过敏，肠易激综合征，呼吸系统疾病 作为哮喘，慢性阻塞性肺病等，烧伤，牛皮癣，瘙痒，呕吐，对皮肤，眼睛和粘膜的刺激​​，胃十二指肠溃疡，炎症性肠病和炎性疾病。

    Method for treating atrophic skin scars using a mixture of botulinum toxin and air
    23.
    发明授权
    Method for treating atrophic skin scars using a mixture of botulinum toxin and air 有权
    使用肉毒毒素和空气的混合物治疗萎缩性皮肤瘢痕的方法

    公开(公告)号：US09050337B2

    公开(公告)日：2015-06-09

    申请号：US14114443

    申请日：2012-06-26

    申请人： Sang Duck Kim

    发明人： Sang Duck Kim

    IPC分类号： A61K38/48 ,  A61K9/00 ,  A61K9/12

    CPC分类号： A61K8/66 ,  A61K8/64 ,  A61K9/0014 ,  A61K9/12 ,  A61K38/4893 ,  A61K47/02 ,  A61K47/26 ,  A61Q19/00

    摘要： The present invention relates to a pharmaceutical composition for treating scars on the skin, comprising a mixture of botulinum toxin and air. The mixture of botulinum toxin and air according to the present invention, when injected in the dermis, may temporarily removed the elasticity of the dermis and flatten out the depressed part of the scar, and thus enables elaborate intradermic resection and increases the therapeutic effects of lasers for treating pulsed dye laser or of fractional lasers. Thus, scars on the skin can be effectively improved through a one-time operation without negatively affecting the daily lives of patients.

    摘要翻译： 本发明涉及用于治疗皮肤瘢痕的药物组合物，其包含肉毒杆菌毒素和空气的混合物。 根据本发明的肉毒杆菌毒素和空气的混合物当注射到真皮中时，可以暂时除去真皮的弹性并使瘢痕的凹陷部分变平，从而能够进行精细的皮内切除并增加激光的治疗效果 用于处理脉冲染料激光或分数激光。 因此，可以通过一次性手术有效地改善皮肤上的疤痕，而不会对患者的日常生活造成负面影响。

    N1-Cyclic Amine-N5-Substituted Phenyl Biguanide Derivatives, Methods of Preparing the Same and Pharmaceutical Composition Comprising the Same
    24.
    发明申请
    N1-Cyclic Amine-N5-Substituted Phenyl Biguanide Derivatives, Methods of Preparing the Same and Pharmaceutical Composition Comprising the Same 有权
    N1环状胺-N5取代苯基双胍衍生物，其制备方法和药物组合物

    公开(公告)号：US20140179660A1

    公开(公告)日：2014-06-26

    申请号：US14237514

    申请日：2012-08-08

    申请人： Sung Wuk Kim ,  Chang Hee Min ,  Se Hwan Park ,  Duck Kim ,  Ji Sun Lee ,  Yong Eun Kim ,  Ju Hoon Oh

    发明人： Sung Wuk Kim ,  Chang Hee Min ,  Se Hwan Park ,  Duck Kim ,  Ji Sun Lee ,  Yong Eun Kim ,  Ju Hoon Oh

    IPC分类号： C07D211/14 ,  C07D257/04 ,  C07D295/14 ,  C07D205/04 ,  C07D207/06 ,  C07D223/04

    CPC分类号： C07D211/14 ,  C07D205/04 ,  C07D207/04 ,  C07D207/06 ,  C07D211/06 ,  C07D223/04 ,  C07D257/04 ,  C07D295/14 ,  C07D295/215

    摘要： An N1-cyclic amine-N5-substituted phenyl biguanide derivative of Formula 1 or a pharmaceutically acceptable salt thereof, a method of manufacturing the same, and a pharmaceutical composition including the biguanide derivative or the pharmaceutically acceptable salt thereof as an active ingredient are provided. The biguanide derivatives have an effect of inhibiting cancer cell proliferation and also exhibit anticancer activity including inhibition of cancer metastasis and cancer recurrence, because they are effective in activating AMPK, which is associated with the control of energy metabolism, even when administered in a small dose compared with conventional drugs. Also, the biguanide derivatives are highly effective at lowering blood glucose and lipid concentration by AMPK activation, thus they may be effectively used to treat diabetes mellitus, obesity, hyperlipemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndrome and metabolic syndrome.

    摘要翻译： 提供式1的N 1 - 环胺-N 5 - 取代的苯基双胍衍生物或其药学上可接受的盐，其制备方法和包含双胍衍生物或其药学上可接受的盐作为活性成分的药物组合物。 双胍衍生物具有抑制癌细胞增殖的作用，并且还表现出抗肿瘤活性，包括抑制癌症转移和癌症复发，因为即使以小剂量施用也能有效地激活与能量代谢控制有关的AMPK 与常规药物相比。 此外，双胍衍生物通过AMPK活化降低血糖和脂质浓度高度有效，因此可有效用于治疗糖尿病，肥胖症，高脂血症，高胆固醇血症，脂肪肝，冠状动脉疾病，骨质疏松症，多囊卵巢综合征和代谢 综合征

    PHARMACEUTICAL COMPOSITION FOR TREATING SCARS ON THE SKIN, AND METHOD FOR TREATING SCARS ON THE SKIN USING SAME
    25.
    发明申请
    PHARMACEUTICAL COMPOSITION FOR TREATING SCARS ON THE SKIN, AND METHOD FOR TREATING SCARS ON THE SKIN USING SAME 审中-公开
    用于治疗皮肤上的斑点的药物组合物，以及使用其处理皮肤上的斑块的方法

    公开(公告)号：US20140127186A1

    公开(公告)日：2014-05-08

    申请号：US14114443

    申请日：2012-06-26

    申请人： Sang Duck Kim

    发明人： Sang Duck Kim

    IPC分类号： A61K38/48

    CPC分类号： A61K8/66 ,  A61K8/64 ,  A61K9/0014 ,  A61K9/12 ,  A61K38/4893 ,  A61K47/02 ,  A61K47/26 ,  A61Q19/00

    摘要： The present invention relates to a pharmaceutical composition for treating scars on the skin, comprising a mixture of botulinum toxin and air. The mixture of botulinum toxin and air according to the present invention, when injected in the dermis, may temporarily removed the elasticity of the dermis and flatten out the depressed part of the scar, and thus enables elaborate intradermic resection and increases the therapeutic effects of lasers for treating pulsed dye laser or of fractional lasers. Thus, scars on the skin can be effectively improved through a one-time operation without negatively affecting the daily lives of patients.

    摘要翻译： 本发明涉及用于治疗皮肤瘢痕的药物组合物，其包含肉毒杆菌毒素和空气的混合物。 根据本发明的肉毒杆菌毒素和空气的混合物当注射到真皮中时，可以暂时除去真皮的弹性并使瘢痕的凹陷部分变平，从而能够进行精细的皮内切除并增加激光的治疗效果 用于处理脉冲染料激光或分数激光。 因此，可以通过一次性手术有效地改善皮肤上的疤痕，而不会对患者的日常生活造成负面影响。

    Printing control apparatus, image forming apparatus, and printing control method of analyzing printing option for pre-processing in an XPS file
    26.
    发明授权
    Printing control apparatus, image forming apparatus, and printing control method of analyzing printing option for pre-processing in an XPS file 有权
    打印控制装置，图像形成装置以及用于分析XPS文件中预处理的打印选项的打印控制方法

    公开(公告)号：US08599409B2

    公开(公告)日：2013-12-03

    申请号：US12706895

    申请日：2010-02-17

    申请人： Sung-won Chae ,  Yong-in Eom ,  Joo-duck Kim

    发明人： Sung-won Chae ,  Yong-in Eom ,  Joo-duck Kim

    IPC分类号： G06F3/12

    CPC分类号： G06F3/1285 ,  G06F3/1213 ,  G06F3/1248

    摘要： A printing control apparatus is provided. The printing control apparatus includes a user interface to set a printing option for a document to be printed, an extraction unit to determine whether the set printing option is a printing option for pre-processing, a generation unit to generate a setting file corresponding to the pre-processing printing option if the printing option is the pre-processing printing option, a conversion unit to convert an XPS file into an enhanced XPS file that includes the generated setting file, and a controller to transmit the enhanced XPS file to the image forming apparatus.

    摘要翻译： 提供一种打印控制装置。 打印控制装置包括用于设置要打印的文档的打印选项的用户界面，提取单元，用于确定所设置的打印选项是否是用于预处理的打印选项;生成单元，用于生成对应于 如果打印选项是预处理打印选项，则将预处理打印选项，将XPS文件转换成包括所生成的设置文件的增强XPS文件的转换单元，以及将增强XPS文件传输到图像形成的控制器 仪器。

    Method of manufacturing hydrophilic membrane having improved antifouling property and hydrophilic membrane manufactured by the method
    27.
    发明授权
    Method of manufacturing hydrophilic membrane having improved antifouling property and hydrophilic membrane manufactured by the method 有权
    通过该方法制造具有改进防污性能的亲水膜和亲水膜的方法

    公开(公告)号：US08528746B2

    公开(公告)日：2013-09-10

    申请号：US12845223

    申请日：2010-07-28

    申请人： Jaehoon Kim ,  Young Haeng Lee ,  Jae-Duck Kim ,  Jong Min Park ,  Jongsoo Jurng

    发明人： Jaehoon Kim ,  Young Haeng Lee ,  Jae-Duck Kim ,  Jong Min Park ,  Jongsoo Jurng

    IPC分类号： B01D39/00 ,  B01D29/00 ,  B01D39/14 ,  B01D71/26 ,  B01D3/12 ,  B01D67/00

    CPC分类号： B01D65/08 ,  B01D67/0006 ,  B01D71/26 ,  B01D71/34 ,  B01D71/36 ,  B01D71/50 ,  B01D71/64 ,  B01D71/68 ,  B01D2321/16 ,  B01D2323/225 ,  B01D2323/30 ,  B01D2325/36

    摘要： A method of manufacturing a hydrophilic membrane and hydrophilic membranes having improved antifouling property using a supercritical fluid or a subcritical fluid. The method involves combining a coating solution from a hydrophilic group-containing monomer, an initiator, a cross-linking agent and a supercritical fluid or subcritical fluid in a high pressure solution vessel and transferring the coating solution to a membrane in a high pressure coating vessel, coating the surfaces and micropores of the membranes through cross-linking polymerization reactions. Non-reacted coating material is returned to the high pressure solution vessel. The membranes are removed from the coating vessel, cleaned and dried. The hydrophilic membrane manufactured by the present invention is excellent in properties of hydrophobic membranes such as thermal stability, chemical stability and mechanical strength, and surfaces and micropores of the membranes are uniformly coated.

    摘要翻译： 使用超临界流体或亚临界流体制备具有改进的防污性能的亲水膜和亲水膜的方法。 该方法包括在高压溶液容器中将来自含亲水基团的单体，引发剂，交联剂和超临界流体或亚临界流体的涂布溶液合并，并将涂布溶液转移到高压涂布容器中的膜 ，通过交联聚合反应涂覆膜的表面和微孔。 未反应的涂料返回到高压溶液容器中。 将膜从涂布容器中取出，清洗干燥。 本发明制造的亲水膜的热稳定性，化学稳定性和机械强度等疏水膜的特性优异，膜的表面和微孔均匀地被涂布。

    Biaryl benzolmidazole derivatives and pharmaceutical composition comprising the same
    28.
    发明授权
    Biaryl benzolmidazole derivatives and pharmaceutical composition comprising the same 有权
    双芳基苯并咪唑衍生物及其组合物

    公开(公告)号：US08436022B2

    公开(公告)日：2013-05-07

    申请号：US12373193

    申请日：2007-07-11

    申请人： Ji Duck Kim ,  Hong-Chul Yoon ,  In Woo Kim ,  Hyae Jung Hyun

    发明人： Ji Duck Kim ,  Hong-Chul Yoon ,  In Woo Kim ,  Hyae Jung Hyun

    IPC分类号： A61K31/4439 ,  C07D401/04

    CPC分类号： C07D401/10 ,  C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  C07D471/04

    摘要： Disclosed are biaryl benzoimidazo derivatives. They have an inhibitory effect on calcium influx in HEK cells, thereby showing a powerful antagonistic effect on a vanilloid receptor, and further have an analgesic effect, thereby being useful for preventing or treating pain, acute pain, chronic pain, neuropathic pain, postoperative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurological illness, neurodermatitis, stroke, bladder hypersensitivity, irritable bowel syndrome, a respiratory disorder such as cough, asthma, and chronic obstructive pulmonary disease, burning, psoriasis, itching, vomiting, irritation of the skin, eyes, and mucous membranes, gastric-duodenal ulcers, inflammatory intestinal diseases, and inflammatory diseases.

    摘要翻译： 公开了联芳基苯并咪唑衍生物。 它们对HEK细胞中的钙流入具有抑制作用，从而对香草素受体具有强大的拮抗作用，并具有镇痛作用，因此可用于预防或治疗疼痛，急性疼痛，慢性疼痛，神经性疼痛，术后疼痛 ，偏头痛，关节痛，神经病，神经损伤，糖尿病性神经病，神经系统疾病，神经性皮炎，中风，膀胱过敏，肠易激综合征，呼吸障碍如咳嗽，哮喘和慢性阻塞性肺病，灼烧，牛皮癣，瘙痒，呕吐， 刺激皮肤，眼睛和粘膜，胃十二指肠溃疡，炎性肠道疾病和炎性疾病。