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    NOVEL COMPOUNDS AND METHODS OF TREATING CELL PROLIFERATIVE DISEASES, RETINOPATHIES AND ARTHRITIS
    21.
    发明申请
    NOVEL COMPOUNDS AND METHODS OF TREATING CELL PROLIFERATIVE DISEASES, RETINOPATHIES AND ARTHRITIS 审中-公开
    新型化合物和治疗细胞增殖性疾病，再狭窄和ARTHRITIS的方法

    公开(公告)号：US20090216014A1

    公开(公告)日：2009-08-27

    申请号：US12388828

    申请日：2009-02-19

    申请人： Bertrand LEBLOND ,  Silvere Petit ,  Virginie Picard ,  Thierry Taverne ,  Fabien Schweighoffer

    发明人： Bertrand LEBLOND ,  Silvere Petit ,  Virginie Picard ,  Thierry Taverne ,  Fabien Schweighoffer

    IPC分类号： C07D413/14 ,  C07D405/12 ,  A61P35/00 ,  C07D407/12 ,  C07D409/12

    CPC分类号： C07D405/12 ,  C07D411/12

    摘要： The present invention relates to compounds and their uses, particularly in the pharmaceutical industry. The invention discloses compounds having anti-proliferative and antiangiogenic activities, as well as methods for treating various diseases associated with abnormal cell proliferation, including cancer, or associated with unregulated angiogenesis including growth and metastasis of solid tumors, ocular diseases and especially retinopathies, or arthritis, by administering said compounds. It further deals with pharmaceutical compositions comprising said compounds, more particularly useful to treat cancers (such as leukemia), ocular diseases and arthritis.

    摘要翻译： 本发明涉及化合物及其用途，特别是在制药工业中。 本发明公开了具有抗增殖和抗血管生成活性的化合物，以及用于治疗与异常细胞增殖相关的各种疾病（包括癌症）或与不稳定的血管生成相关的方法，包括实体瘤，眼部疾病，特别是视网膜病变或关节炎的生长和转移 ，通过施用所述化合物。 它还涉及包含所述化合物的药物组合物，更特别可用于治疗癌症（如白血病），眼部疾病和关节炎。

    Use of pyrazolopyridines for the treatment of cognitive deficits
    22.
    发明申请
    Use of pyrazolopyridines for the treatment of cognitive deficits 审中-公开
    使用吡唑并吡啶治疗认知缺陷

    公开(公告)号：US20060142326A1

    公开(公告)日：2006-06-29

    申请号：US10560774

    申请日：2004-06-25

    申请人： Fabien Schweighoffer ,  Laurent Desire ,  Annelies Resink ,  Magali Rouquette

    发明人： Fabien Schweighoffer ,  Laurent Desire ,  Annelies Resink ,  Magali Rouquette

    IPC分类号： A61K31/4745

    CPC分类号： A61K31/437

    摘要： The invention relates to methods which are used to improve, increase or facilitate the cognition of individuals with neurodegenerative pathologies. More specifically, the invention relates to the use of compounds from the family of pyrazolopyridines in order to improve the cognitive faculties of individuals with neurodegenerative diseases. The invention can be used to improve the condition of individuals with different neurodegenerative diseases and, in particular, Alzheimer's disease and vascular dementia.

    摘要翻译： 本发明涉及用于改善，增加或促进具有神经变性病理学的个体认知的方法。 更具体地，本发明涉及使用吡唑并吡啶酮类化合物，以改善具有神经变性疾病的个体的认知能力。 本发明可用于改善具有不同神经变性疾病，特别是阿尔茨海默病和血管性痴呆的个体的状况。

    Qualitative differential screening
    23.
    发明授权
    Qualitative differential screening 失效
    定性差异筛选

    公开(公告)号：US06881571B1

    公开(公告)日：2005-04-19

    申请号：US09623828

    申请日：1999-03-11

    申请人： Fabien Schweighoffer ,  Laurent Bracco ,  Bruno Tocque

    发明人： Fabien Schweighoffer ,  Laurent Bracco ,  Bruno Tocque

    IPC分类号： C12Q1/68 ,  C12M1/34 ,  C07H21/02 ,  C07H21/04 ,  C12P19/34

    CPC分类号： C12Q1/6809 ,  C12Q2537/113 ,  C12Q2539/105 ,  C12Q2565/501 ,  C12Q2521/301

    摘要： The invention concerns a method for identifying and/or cloning nucleic acid regions representing qualitative differences associated with alternative splicing events and/or with insertions, deletions located in RNA transcribed genome regions, between two physiological situations, comprising either hybridization of RNA derived from the test situation with cDNA's derived from the reference situation and/or reciprocally, or double-strand hybridization of cDNA derived from the test situation with cDNA's derived from the reference situation; and identifying and/or cloning nucleic acids representing qualitative differences. The invention also concerns compositions or banks of nucleic acids representing qualitative differences between two physiological situations, obtainable by the above method, and their use as probe, for identifying genes or molecules of interest, or still for example in methods of pharmacogenomics, and profiling of molecules relative to their therapeutic and/or toxic effects. The invention further concerns the use of dysregulation of splicing RNA as markers for predicting molecule toxicity and/or efficacy, and as markers in pharmacogenomics.

    摘要翻译： 本发明涉及用于鉴定和/或克隆代表与选择性剪接事件相关的定性差异的核酸区域的方法和/或在两个生理情境之间的位于RNA转录基因组区域中的插入，缺失的方法，其包括衍生自测试的RNA的杂交 来自参考情况的cDNA的情况和/或来自测试情况的​​cDNA的双链杂交和/或来自参考情况的cDNA的双链杂交; 以及鉴定和/或克隆代表定性差异的核酸。 本发明还涉及表示通过上述方法获得的两种生理情况之间的定性差异的核酸组合物或组，以及它们作为探针的用途，用于鉴定感兴趣的基因或分子，或者仍然例如在药物基因组学的方法中，以及 分子相对于其治疗和/或毒性作用。 本发明还涉及使用拼接RNA的调节作为用于预测分子毒性和/或功效的标记物，以及作为药物基因组学中的标记物。

    Methods and composition for the detection of pathologic events
    24.
    发明授权
    Methods and composition for the detection of pathologic events 有权
    用于检测病理事件的方法和组成

    公开(公告)号：US06372432B1

    公开(公告)日：2002-04-16

    申请号：US09456461

    申请日：1999-12-08

    申请人： Bruno Tocque ,  Laurent Bracco ,  Fabien Schweighoffer

    发明人： Bruno Tocque ,  Laurent Bracco ,  Fabien Schweighoffer

    IPC分类号： C12Q168

    CPC分类号： G01N33/56972 ,  C12Q1/6809

    摘要： The present invention concerns new compositions and methods for the detection of pathological events. It more specifically concerns methods for the detection in vitro of the presence of a pathology or a pathological event in a subject, comprising taking a sample of blood cells from the subject and determining, in this sample, the presence of blood cells presenting a physiological state characteristic of the pathology. The invention also concerns the tools, kits and compositions for the implementation of such methods, as well as their uses in the field of human and animal health, or in experimental research for example.

    摘要翻译： 本发明涉及用于检测病理事件的新组合物和方法。 更具体地涉及在体外检测受试者中病理学或病理学事件的存在的方法，其包括从受试者中取出血细胞样品，并在该样品中确定呈现生理状态的血细胞的存在 病理特征。 本发明还涉及用于实施这些方法的工具，试剂盒和组合物，以及它们在人类和动物健康领域或在实验研究领域中的用途。

    Methods and Tools for The Therapy of Neurodegenerative Pathologies
    26.
    发明申请
    Methods and Tools for The Therapy of Neurodegenerative Pathologies 审中-公开
    神经退行性病变治疗方法与工具

    公开(公告)号：US20090317842A1

    公开(公告)日：2009-12-24

    申请号：US12309492

    申请日：2007-07-20

    申请人： Fabien Schweighoffer ,  Laurent Desire ,  Jérôme Bourdin

    发明人： Fabien Schweighoffer ,  Laurent Desire ,  Jérôme Bourdin

    IPC分类号： G01N33/53 ,  C07D471/04 ,  C07D243/14

    CPC分类号： G01N33/6896 ,  G01N33/5306 ,  G01N33/9426 ,  G01N2800/2821 ,  G01N2800/52

    摘要： The present invention concerns compositions and methods for the treatment of neurodegenerative diseases in which the cognitive functions are altered, such as observed in Alzheimer's disease. More particularly, the invention presents a strategy for human clinical monitoring of the activity and/or effectiveness of neuroprotective treatments, based on biochemical assay of certain platelet parameters, and thus can be done by blood sampling. The invention also concerns methods, tools, constructions and compositions suitable for implementing these strategies.

    摘要翻译： 本发明涉及用于治疗其中认知功能改变的神经变性疾病的组合物和方法，例如在阿尔茨海默病中观察到的。 更具体地说，本发明基于某些血小板参数的生物化学测定，提出了人类临床监测神经保护治疗的活性和/或有效性的策略，因此可以通过血液取样进行。 本发明还涉及适于实施这些策略的方法，工具，构造和组合。

    METHODS UTILIZING DIFFERENTIAL SPLICING EVENTS IN BLOOD CELLS FOR THE DETECTION OF PATHOLOGICAL EVENTS
    27.
    发明申请
    METHODS UTILIZING DIFFERENTIAL SPLICING EVENTS IN BLOOD CELLS FOR THE DETECTION OF PATHOLOGICAL EVENTS 审中-公开
    方法利用血液细胞中的差异性分离事件检测病理活动

    公开(公告)号：US20090264301A1

    公开(公告)日：2009-10-22

    申请号：US12494039

    申请日：2009-06-29

    申请人： Bruno Tocque ,  Laurent Bracco ,  Fabien Schweighoffer

    发明人： Bruno Tocque ,  Laurent Bracco ,  Fabien Schweighoffer

    IPC分类号： C40B30/00

    CPC分类号： G01N33/56972 ,  C12Q1/6809

    摘要： The present invention concerns new compositions and methods for the detection of pathological events. It more specifically concerns methods for the detection in vitro of the presence of a pathology or a pathological event in a subject, comprising taking a sample of blood cells from the subject and determining, in this sample, the presence of blood cells presenting a physiological state characteristic of the pathology. The invention also concerns the tools, kits and compositions for the implementation of such methods, as well as their uses in the field of human and animal health, or in experimental research for example.

    摘要翻译： 本发明涉及用于检测病理事件的新组合物和方法。 更具体地涉及在体外检测受试者中病理学或病理学事件的存在的方法，其包括从受试者中取出血细胞样品，并在该样品中确定呈现生理状态的血细胞的存在 病理特征。 本发明还涉及用于实施这些方法的工具，试剂盒和组合物，以及它们在人类和动物健康领域或在实验研究领域中的用途。

    Compounds and methods of treating cell proliferative diseases, retinopathies and arthritis
    28.
    发明授权
    Compounds and methods of treating cell proliferative diseases, retinopathies and arthritis 失效
    治疗细胞增殖性疾病，视网膜病变和关节炎的化合物和方法

    公开(公告)号：US07514432B2

    公开(公告)日：2009-04-07

    申请号：US10541328

    申请日：2004-02-27

    申请人： Bertrand Leblond ,  Silvère Petit ,  Virginie Picard ,  Thierry Taverne ,  Fabien Schweighoffer

    发明人： Bertrand Leblond ,  Silvère Petit ,  Virginie Picard ,  Thierry Taverne ,  Fabien Schweighoffer

    IPC分类号： A61K31/5377 ,  C07D413/14

    CPC分类号： C07D405/12 ,  C07D411/12

    摘要： The present invention relates to compounds and their uses, particularly in the pharmaceutical industry. The invention discloses compounds having anti-proliferative and antiangiogenic activities, as well as methods for treating various diseases associated with abnormal cell proliferation, including cancer, or associated with unregulated angiogenesis including growth and metastasis of solid tumors, ocular diseases and especially retinopathies, or arthritis, by administering said compounds. It further deals with pharmaceutical compositions comprising said compounds, more particularly useful to treat cancers (such as leukemia), ocular diseases and arthritis.

    摘要翻译： 本发明涉及化合物及其用途，特别是在制药工业中。 本发明公开了具有抗增殖和抗血管生成活性的化合物，以及用于治疗与异常细胞增殖相关的各种疾病（包括癌症）或与不稳定的血管生成相关的方法，包括实体瘤，眼部疾病，特别是视网膜病变或关节炎的生长和转移 ，通过施用所述化合物。 它还涉及包含所述化合物的药物组合物，更特别可用于治疗癌症（如白血病），眼部疾病和关节炎。