公开(公告)号：US11098371B2

公开(公告)日：2021-08-24

申请号：US16460546

申请日：2019-07-02

Applicant: National Central University ,  Huan-Cheng Chang ,  DELTA ELECTRONICS, INC.

Inventor： Nian-Han Ma ,  Chien-Lung Chen ,  Chen-Huan Lin ,  An-Lun Li ,  Chiu-Chin Huang ,  Chao-Hsiang Chang

IPC: C12Q1/6886 ,  C12Q1/6837 ,  C12Q1/6853

Abstract: A kit for detecting urothelial carcinoma is provided. The kit includes at least one primer or probe for detecting one or more miRNAs, and the one or more miRNAs are selected from the group consisting of miR-19b-1, miR-636, miR-150, miR-155, miR-183, miR-378, miR-210, miR-487, and combinations thereof. A method for detecting urothelial carcinoma is also provided. The method includes detecting the expression level(s) of one or more miRNAs in a sample of a subject, and the one or more miRNAs are selected from the group consisting of miR-19b-1, miR-636, miR-150, miR-155, miR-183, miR-378, miR-210, miR-487, and combinations thereof.

公开(公告)号：US20210156738A1

公开(公告)日：2021-05-27

申请号：US16698919

申请日：2019-11-27

Applicant: HUAN-CHENG CHANG ,  National Central University

Inventor： Min-Chun PAN ,  Ya-Fen HSU ,  Yan-Yang HSU

IPC: G01J1/44 ,  G06T11/00

Abstract: An optical tomography imaging system includes a signal generator, at least one light emitter, at least one light receiver, a signal processor, and an image processor. The signal generator is configured to generate a periodic signal and a reference signal. The light emitter is configured to be activated by the periodic signal to generate an optical signal passing through an object under test. The light receiver is configured to receive and convert the optical signal passing through the object under test into an electrical signal. The signal processor is configured to generate a comparison signal according to the electrical signal and the reference signal. The image processor is configured to acquire a plurality of disassembled sine waves from the comparison signal and generate a reconstructed image according to the disassembled sine waves.

公开(公告)号：US20180018951A1

公开(公告)日：2018-01-18

申请号：US15495960

申请日：2017-04-24

Applicant: HUAN-CHENG CHANG

Inventor： Chang-Wei HSUEH ,  Yiin-Kuen FUH

IPC: G10K11/16 ,  G10K11/168

CPC classification number: G10K11/161 ,  G10K11/162 ,  G10K11/168

Abstract: A sound-absorbing mask is configured for covering a mouth. The sound-absorbing mask includes a covering body, a ventilation structure and a sound-absorbing portion. The covering body has a first chamber, a first and a second openings. The first chamber communicates with the first and the second openings. The first opening corresponds to the mouth. The ventilation structure is disposed at the second opening and has a second chamber, a third and a fourth openings. The second chamber communicates with the third and the fourth openings. The fourth opening is away from the first opening. The ventilation structure includes a plate disposed in the second chamber. The plate has a functioning surface facing the third opening. An edge of the plate and an inner wall of the ventilation structure have a gap in between. The sound-absorbing portion is disposed between the ventilation structure and the first opening.

公开(公告)号：US20160196644A1

公开(公告)日：2016-07-07

申请号：US14715565

申请日：2015-05-18

Applicant: HUAN-CHENG CHANG ,  National Central University

Inventor： Syu-Jyun PENG ,  Yu-Wei CHEN ,  Jang-Zern TSAI ,  Kuo-Wei WANG

IPC: G06T7/00 ,  A61B5/00 ,  A61B5/055 ,  G01R33/563 ,  G01R33/56

CPC classification number: G06T7/0012 ,  A61B5/0042 ,  A61B5/055 ,  G01R33/5602 ,  G01R33/5608 ,  G01R33/56341 ,  G06T7/11 ,  G06T7/174 ,  G06T2207/10088 ,  G06T2207/30016

Abstract: A magnetic resonance imaging white matter hyperintensities region recognizing method and system are disclosed herein. The white matter hyperintensities region recognizing method includes receiving and storing a FLAIR MRI image, a spin-lattice relaxation time weighted MRI image, and a diffusion weighted MRI image. Registration and fusion are preformed, and a white matter mask is determined. An intersection image of the FLAIR MRI image and the white matter mask is taken, a first region is determined after normalizing the intersection image, a cerebral infarct region is removed from the first image through the diffusion weighted MRI image, and then a determination is made as to whether to remove a remaining region in order to form a white matter hyperintensities region in the FLAIR MRI image.

Abstract translation: 本文公开了磁共振成像白质高信号区域识别方法和系统。 白质高信号区识别方法包括接收和存储FLAIR MRI图像，自旋晶格弛豫时间加权MRI图像和扩散加权MRI图像。 进行注册和融合，并确定白质掩模。 拍摄FLAIR MRI图像和白质掩模的交叉图像，在对交叉图像进行标准化之后确定第一区域，通过扩散加权MRI图像从第一图像中去除脑梗死区域，然后进行确定 关于是否去除剩余区域以形成FLAIR MRI图像中的白质高信号区域。

公开(公告)号：US20080118966A1

公开(公告)日：2008-05-22

申请号：US11939311

申请日：2007-11-13

Applicant: Huan-Cheng Chang ,  Wunshain Fann ,  Chau-Chung Han

Inventor： Huan-Cheng Chang ,  Wunshain Fann ,  Chau-Chung Han

IPC: B32B1/00 ,  C09K11/65

CPC classification number: C09K11/65 ,  C01B32/28 ,  Y10T428/2982

Abstract: A method for preparing luminescent diamond particles (e.g., fluorescent nanodiamonds). The method includes irradiating diamond particles with an ion beam and heating the irradiated diamond particles in a non-oxidizing atmosphere at a temperature between 600 and 1000° C. The diamond particles have a diameter of 1 nm to 1 mm and the ion beam has a kinetic energy of 1 KeV to 900 MeV. Also disclosed are luminescent diamond particles prepared by this method and methods of using them.

Abstract translation: 制备发光金刚石颗粒（例如荧光纳米金刚石）的方法。 该方法包括用离子束照射金刚石颗粒并在600-1000℃的温度下在非氧化性气氛中加热照射的金刚石颗粒。金刚石颗粒的直径为1nm至1mm，离子束具有 1 KeV至900 MeV的动能。 还公开了通过该方法制备的发光金刚石颗粒和使用它们的方法。

公开(公告)号：US07326837B2

公开(公告)日：2008-02-05

申请号：US11361269

申请日：2006-02-23

Applicant: Chau-Chung Han ,  Huan-Cheng Chang ,  Sheng-Chung Lee ,  Wei-Hao Chen

Inventor： Chau-Chung Han ,  Huan-Cheng Chang ,  Sheng-Chung Lee ,  Wei-Hao Chen

IPC: G01N33/00

CPC classification number: G01N33/551 ,  Y10S977/705 ,  Y10S977/904

Abstract: A method for profiling proteins in a biological sample by mixing the sample and a diamond-based composition. The diamond-based composition includes a diamond crystallite having a surface that contains chemically derivatized surface groups and a polymer having a plurality of functional groups non-covalently bound to the surface groups. Proteins in the sample are mixed with and allowed to bind to the diamond-based composition. The bound proteins are then profiled.

Abstract translation: 通过混合样品和基于金刚石的组合物来分析生物样品中的蛋白质的方法。 基于金刚石的组合物包括具有包含化学衍生化表面基团的表面的金刚石微晶和具有多个与表面基团非共价结合的官能团的聚合物。 将样品中的蛋白与基于金刚石的组合物混合并与其结合。 然后将结合的蛋白质分析。

公开(公告)号：US20060154259A1

公开(公告)日：2006-07-13

申请号：US11031601

申请日：2005-01-07

Applicant: Huan-Cheng Chang ,  Chau-Chung Han

Inventor： Huan-Cheng Chang ,  Chau-Chung Han

IPC: C12Q1/68 ,  G01N33/53

CPC classification number: G01N33/551

Abstract: A diamond-based composition that contains (1) a diamond crystallite having chemically derivatized surface groups, and (2) a polymer having functional groups, in which a portion of the functional groups bind to the chemically derivatized surface groups non-covalently. Also disclosed are methods of using such composition for analyzing a biological sample by determining the identity of biomolecules bound to the composition.

Abstract translation: 一种基于金刚石的组合物，其包含（1）具有化学衍生的表面基团的金刚石微晶，和（2）具有官能团的聚合物，其中一部分官能团非共价结合化学衍生的表面基团。 还公开了通过确定与组合物结合的生物分子的身份来使用这种组合物来分析生物样品的方法。

公开(公告)号：US20050029448A1

公开(公告)日：2005-02-10

申请号：US10726071

申请日：2003-12-01

Applicant: Huan-Cheng Chang ,  Wen-Ping Peng ,  Yong Cai

Inventor： Huan-Cheng Chang ,  Wen-Ping Peng ,  Yong Cai

IPC: H01J49/16 ,  H01J49/42

CPC classification number: H01J49/424 ,  G01N21/6402 ,  G01N21/6428 ,  G01N2021/6419 ,  G01N2021/6441

Abstract: A nanoparticle ion detector includes an ion trap that receives charged particles ejected from a mass selection device. A laser beam illuminates the particles to induce fluorescence, which is detected by the photon detector. Particles are periodically dumped from the ion trap. A mass spectrum of the charged particles can be obtained by comparing signals from the photon detector with the particle ejection characteristics of the mass selection device.

Abstract translation: 纳米颗粒离子检测器包括接收从质量选择装置喷射的带电粒子的离子阱。 激光束照射颗粒以诱导荧光，其由光子检测器检测。 颗粒定期从离子阱中倾倒出来。 通过将来自光子检测器的信号与质量选择装置的粒子喷射特性进行比较，可以获得带电粒子的质谱。

公开(公告)号：US06777673B2

公开(公告)日：2004-08-17

申请号：US10034459

申请日：2001-12-28

Applicant: Huan-Cheng Chang ,  Wen-Ping Peng ,  Yong Cai ,  Shan-Jen Kuo

Inventor： Huan-Cheng Chang ,  Wen-Ping Peng ,  Yong Cai ,  Shan-Jen Kuo

IPC: B01D5444

CPC classification number: H01J49/424 ,  G01N15/1459 ,  G01N15/1463 ,  H01J49/0404 ,  H01J49/165

Abstract: A mass spectrometer that includes an ion source, an ion trap, and a light detection module. The ion trap has two end-cap electrodes and a ring electrode. The ring electrode is positioned relative to the end-cap electrodes to confine a charged particle from the ion source within a confinement region when an audio frequency voltage having a first amplitude is applied between the ring electrode and the two end-cap electrodes. The charged particle is ejected from the ion trap when the audio frequency voltage increases to a second amplitude. The light detection module includes a light source that illuminates the ejected particle and a light detector that detects light scattered from the ejected particle.

Abstract translation: 一种包括离子源，离子阱和光检测模块的质谱仪。 离子阱具有两个端盖电极和环形电极。 当在环形电极和两个端盖电极之间施加具有第一幅度的音频电压时，环形电极相对于端帽电极定位，以将来自离子源的带电粒子限制在约束区域内。 当音频电压增加到第二幅度时，带电粒子从离子阱中排出。 光检测模块包括照射喷射的颗粒的光源和检测从喷出的颗粒散射的光的光检测器。

公开(公告)号：US10738363B2

公开(公告)日：2020-08-11

申请号：US15691730

申请日：2017-08-30

Applicant: National Central University ,  Huan-Cheng Chang

Inventor： Nian-Han Ma ,  Tao-Sheng Chung ,  An-Lun Li ,  Yao-Ning Chan ,  Chien-Lung Chen

IPC: C12Q1/6886

Abstract: The present invention provides an analyzer for predicting a prognosis of cancer radiotherapy, including a detection device and an arithmetic device. In a specimen, expression levels of a plurality of microRNAs (miRNAs) can be detected by the detection device. The miRNAs includes hsa-miR-130a-3p, hsa-miR-215-5p, hsa-miR-29a-3p, hsa-let-7b-5p, hsa-miR-19b-3p, hsa-miR-374a-5p and hsa-miR-148a-3p. The expression levels of miRNAs can be analyzed by the arithmetic device using logistic regression, and the analyzed values can be used to determine that the prognosis of cancer radiotherapy is poor or good.