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公开(公告)号：US20050029448A1
公开(公告)日：2005-02-10
申请号：US10726071
申请日：2003-12-01
申请人： Huan-Cheng Chang , Wen-Ping Peng , Yong Cai
发明人： Huan-Cheng Chang , Wen-Ping Peng , Yong Cai
CPC分类号： H01J49/424 , G01N21/6402 , G01N21/6428 , G01N2021/6419 , G01N2021/6441
摘要： A nanoparticle ion detector includes an ion trap that receives charged particles ejected from a mass selection device. A laser beam illuminates the particles to induce fluorescence, which is detected by the photon detector. Particles are periodically dumped from the ion trap. A mass spectrum of the charged particles can be obtained by comparing signals from the photon detector with the particle ejection characteristics of the mass selection device.
摘要翻译： 纳米颗粒离子检测器包括接收从质量选择装置喷射的带电粒子的离子阱。 激光束照射颗粒以诱导荧光，其由光子检测器检测。 颗粒定期从离子阱中倾倒出来。 通过将来自光子检测器的信号与质量选择装置的粒子喷射特性进行比较，可以获得带电粒子的质谱。
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公开(公告)号：US06777673B2
公开(公告)日：2004-08-17
申请号：US10034459
申请日：2001-12-28
申请人： Huan-Cheng Chang , Wen-Ping Peng , Yong Cai , Shan-Jen Kuo
发明人： Huan-Cheng Chang , Wen-Ping Peng , Yong Cai , Shan-Jen Kuo
IPC分类号： B01D5444
CPC分类号： H01J49/424 , G01N15/1459 , G01N15/1463 , H01J49/0404 , H01J49/165
摘要： A mass spectrometer that includes an ion source, an ion trap, and a light detection module. The ion trap has two end-cap electrodes and a ring electrode. The ring electrode is positioned relative to the end-cap electrodes to confine a charged particle from the ion source within a confinement region when an audio frequency voltage having a first amplitude is applied between the ring electrode and the two end-cap electrodes. The charged particle is ejected from the ion trap when the audio frequency voltage increases to a second amplitude. The light detection module includes a light source that illuminates the ejected particle and a light detector that detects light scattered from the ejected particle.
摘要翻译： 一种包括离子源，离子阱和光检测模块的质谱仪。 离子阱具有两个端盖电极和环形电极。 当在环形电极和两个端盖电极之间施加具有第一幅度的音频电压时，环形电极相对于端帽电极定位，以将来自离子源的带电粒子限制在约束区域内。 当音频电压增加到第二幅度时，带电粒子从离子阱中排出。 光检测模块包括照射喷射的颗粒的光源和检测从喷出的颗粒散射的光的光检测器。
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3.发明授权公开(公告)号：US09459247B2
公开(公告)日：2016-10-04
申请号：US13075160
申请日：2011-03-29
申请人： Huan-Chang Lin , Hsin-Hung Lin , Cai-Yu Kao , Alice L Yu , Wen-Ping Peng , Chung-Hsuan Chen
发明人： Huan-Chang Lin , Hsin-Hung Lin , Cai-Yu Kao , Alice L Yu , Wen-Ping Peng , Chung-Hsuan Chen
IPC分类号： A61K45/06 , C12Q1/70 , G01N33/50 , G01N33/569 , G01N33/68
CPC分类号： G01N33/5091 , G01N33/5008 , G01N33/569 , G01N33/6848
摘要： Methods for detecting the presence of nanoparticles or microparticles by cell mass spectrometry (CMS) are provided. CMS methods are provided for determining the number of nanoparticles or microparticles in each cell. Nanoparticles whose intracellular concentration can be determines by the CMS methods of the invention include polymeric nanoparticles (NPs), liposomes, viral-based NPs, carbon nanotubes, diamond NPs, polymeric micelles, nanocarriers, liposomes, and viral nanoparticles. Determination of the efficiency of drug delivery and intracellular titer of pathogens according to the invention is disclosed. Methods for determining intracellular uptake of virus particles are provided.
摘要翻译： 提供了通过细胞质谱法（CMS）检测纳米颗粒或微粒的存在的方法。 提供CMS方法用于确定每个细胞中纳米颗粒或微粒的数量。 通过本发明的CMS方法可以确定其细胞内浓度的纳米颗粒包括聚合物纳米颗粒（NP），脂质体，基于病毒的NP，碳纳米管，金刚石NP，聚合胶束，纳米载体，脂质体和病毒纳米颗粒。 公开了根据本发明的药物递送效率和病原体细胞内滴度的测定。 提供了确定病毒颗粒的细胞内吸收的方法。
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4.发明授权公开(公告)号：US08963075B2
公开(公告)日：2015-02-24
申请号：US12314520
申请日：2008-12-11
CPC分类号： H01J49/4265 , H01J49/0077 , H01J49/025
摘要： A novel system and method for charge-monitoring mass spectrometry is provided. The mass spectrometer can be used to measure the mass of one or more analytes having masses in the range of about a few Daltons to more than about 1015 Daltons. The invention can be used for rapid mass distribution measurements. For example, the system and method can be used to distinguish cancer cells from normal cells when their mass distributions are different.
摘要翻译： 提供了一种电荷监测质谱的新型系统和方法。 质谱仪可用于测量质量在约几道尔顿至大于约1015道尔顿范围内的一种或多种分析物的质量。 本发明可用于快速质量分布测量。 例如，当它们的质量分布不同时，系统和方法可以用于区分癌细胞与正常细胞。
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5.发明申请QUANTITATIVE MEASUREMENT OF NANO/MICRO PARTICLE ENDOCYTOSIS WITH CELL MASS SPECTROMETRY 审中-公开纳米/微粒子内毒素与细胞质谱的定量测量公开(公告)号：US20110236882A1
公开(公告)日：2011-09-29
申请号：US13075160
申请日：2011-03-29
申请人： Huan-Chang LIN , Hsin-Hung LIN , Cai-Yu KAO , Alice L. Yu , Wen-Ping PENG , Chung-Hsuan Chen
发明人： Huan-Chang LIN , Hsin-Hung LIN , Cai-Yu KAO , Alice L. Yu , Wen-Ping PENG , Chung-Hsuan Chen
CPC分类号： G01N33/5091 , G01N33/5008 , G01N33/569 , G01N33/6848
摘要： Methods for detecting the presence of nanoparticles or microparticles by cell mass spectrometry (CMS) are provided. CMS methods are provided for determining the number of nanoparticles or microparticles in each cell. Nanoparticles whose intracellular concentration can be determines by the CMS methods of the invention include polymeric nanoparticles (NPs), liposomes, viral-based NPs, carbon nanotubes, diamond NPs, polymeric micelles, nanocarriers, liposomes, and viral nanoparticles. Determination of the efficiency of drug delivery and intracellular titer of pathogens according to the invention is disclosed. Methods for determining intracellular uptake of virus particles are provided.
摘要翻译： 提供了通过细胞质谱法（CMS）检测纳米颗粒或微粒的存在的方法。 提供CMS方法用于确定每个细胞中纳米颗粒或微粒的数量。 通过本发明的CMS方法可以确定其细胞内浓度的纳米颗粒包括聚合物纳米颗粒（NP），脂质体，基于病毒的NP，碳纳米管，金刚石NP，聚合胶束，纳米载体，脂质体和病毒纳米颗粒。 公开了根据本发明的药物递送效率和病原体细胞内滴度的测定。 提供了确定病毒颗粒的细胞内吸收的方法。
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6.发明授权公开(公告)号：US07910377B2
公开(公告)日：2011-03-22
申请号：US12156635
申请日：2008-06-03
CPC分类号： C40B50/18 , B01J19/0046 , B01J37/34 , B01J2219/00436 , B01J2219/00443 , B01J2219/00527 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/0063 , B01J2219/00659 , B01J2219/0072 , B01J2219/00738 , B01J2219/00747 , B82Y30/00 , C40B40/00 , H01J49/42 , Y10T436/24 , Y10T436/25 , Y10T436/25375
摘要： The invention provides methods and apparatuses that utilize mass spectrometry for preparation of a surface to have catalytic activity through molecular soft-landing of mass selected ions. Mass spectrometry is used to generate combinations of atoms in a particular geometrical arrangement, and ion soft-landing selects this molecular entity or combination of entities and gently deposits the entity or combination intact onto a surface.
摘要翻译： 本发明提供了利用质谱法制备表面以通过质量选择离子的分子软着陆具有催化活性的方法和装置。 质谱用于产生特定几何排列的原子的组合，离子软着陆选择该分子实体或实体的组合，并将实体或组合轻轻沉积到表面上。
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7.发明申请公开(公告)号：US20090011953A1
公开(公告)日：2009-01-08
申请号：US12156635
申请日：2008-06-03
CPC分类号： C40B50/18 , B01J19/0046 , B01J37/34 , B01J2219/00436 , B01J2219/00443 , B01J2219/00527 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/0063 , B01J2219/00659 , B01J2219/0072 , B01J2219/00738 , B01J2219/00747 , B82Y30/00 , C40B40/00 , H01J49/42 , Y10T436/24 , Y10T436/25 , Y10T436/25375
摘要： The invention provides methods and apparatuses that utilize mass spectrometry for preparation of a surface to have catalytic activity through molecular soft-landing of mass selected ions. Mass spectrometry is used to generate combinations of atoms in a particular geometrical arrangement, and ion soft-landing selects this molecular entity or combination of entities and gently deposits the entity or combination intact onto a surface.
摘要翻译： 本发明提供了利用质谱法制备表面以通过质量选择离子的分子软着陆具有催化活性的方法和装置。 质谱用于产生特定几何排列的原子的组合，离子软着陆选择该分子实体或实体的组合，并将实体或组合轻轻沉积到表面上。
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公开(公告)号：US07119331B2
公开(公告)日：2006-10-10
申请号：US10726071
申请日：2003-12-01
申请人： Huan-Cheng Chang , Wen-Ping Peng , Yong Cai
发明人： Huan-Cheng Chang , Wen-Ping Peng , Yong Cai
IPC分类号： B01D59/44
CPC分类号： H01J49/424 , G01N21/6402 , G01N21/6428 , G01N2021/6419 , G01N2021/6441
摘要： A nanoparticle ion detector includes an ion trap that receives charged particles ejected from a mass selection device. A laser beam illuminates the particles to induce fluorescence, which is detected by the photon detector. Particles are periodically dumped from the ion trap. A mass spectrum of the charged particles can be obtained by comparing signals from the photon detector with the particle ejection characteristics of the mass selection device.
摘要翻译： 纳米颗粒离子检测器包括接收从质量选择装置喷射的带电粒子的离子阱。 激光束照射颗粒以诱导荧光，其由光子检测器检测。 颗粒定期从离子阱中倾倒出来。 通过将来自光子检测器的信号与质量选择装置的粒子喷射特性进行比较，可以获得带电粒子的质谱。
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公开(公告)号：US20090189069A1
公开(公告)日：2009-07-30
申请号：US12314520
申请日：2008-12-11
CPC分类号： H01J49/4265 , H01J49/0077 , H01J49/025
摘要： A novel system and method for charge-monitoring mass spectrometry is provided. The mass spectrometer can be used to measure the mass of one or more analytes having masses in the range of about a few Daltons to more than about 1015 Daltons. The invention can be used for rapid mass distribution measurements. For example, the system and method can be used to distinguish cancer cells from normal cells when their mass distributions are different.
摘要翻译： 提供了一种电荷监测质谱的新型系统和方法。 质谱仪可用于测量质量在约几道尔顿至大于约1015道尔顿范围内的一种或多种分析物的质量。 本发明可用于快速质量分布测量。 例如，当它们的质量分布不同时，系统和方法可以用于区分癌细胞与正常细胞。
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