公开(公告)号：US06713467B2

公开(公告)日：2004-03-30

申请号：US10035714

申请日：2001-11-07

Applicant: Gregory S. Bisacchi ,  James C. Sutton ,  Shung C. Wu

Inventor： Gregory S. Bisacchi ,  James C. Sutton ,  Shung C. Wu

IPC: A61K3133

CPC classification number: C07D401/12 ,  A61K45/06 ,  C07B2200/07 ,  C07C257/18 ,  C07D207/16 ,  C07D211/60 ,  C07D223/06

Abstract: Compounds of formula I and II, or pharmaceutically-acceptable salts thereof, are useful as inhibitors of Factor VIIa, Factor IXa, Factor Xa, Factor FXIa, tryptase, and urokinase, wherein ring B is phenyl or pyridyl, L is a linker, and R1-R27, W, Z1, and Z2 are as defined in the specification.

Abstract translation: 式I和II的化合物或其药学上可接受的盐可用作因子VIIa，因子IXa，因子Xa，因子FXIa，类胰蛋白酶和尿激酶的抑制剂，其中环B是苯基或吡啶基，L是连接体，和 R1-R27，W，Z1和Z2如说明书中所定义。

公开(公告)号：US08273772B2

公开(公告)日：2012-09-25

申请号：US12619702

申请日：2009-11-17

Applicant: James C. Sutton ,  Zulan Pi ,  Rejean Ruel ,  Alexandre L'Heureux ,  Carl Thibeault ,  Patrick Y. S. Lam

Inventor： James C. Sutton ,  Zulan Pi ,  Rejean Ruel ,  Alexandre L'Heureux ,  Carl Thibeault ,  Patrick Y. S. Lam

IPC: A61K31/4436 ,  C07D417/12

CPC classification number: C07D213/74 ,  C07D213/75 ,  C07D213/80 ,  C07D277/42 ,  C07D277/56 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D487/04 ,  C07D513/04

Abstract: The present invention provides novel heteroaryl compounds and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.

Abstract translation: 本发明提供了新的杂芳基化合物及其类似物，它们是人P2Y1受体的选择性抑制剂。 本发明还提供了相同的各种药物组合物以及治疗对P2Y1受体活性调节作用的疾病的方法。

公开(公告)号：US20120225861A1

公开(公告)日：2012-09-06

申请号：US13453202

申请日：2012-04-23

Applicant: James C. Sutton ,  Marion Wiesmann ,  Weibo Wang ,  Mika Lindvall ,  Jiong Lan ,  Savithri Ramurthy ,  Anu Sharma ,  Elizabeth J. Mieuli ,  Liana M Klivansky ,  William Lenahan ,  Susan Kaufman ,  Hong Yang ,  Simon C. Ng ,  Keith Pfister ,  Allan S. Wagman ,  Victoria Sung ,  Martin Sendzik

Inventor： James C. Sutton ,  Marion Wiesmann ,  Weibo Wang ,  Mika Lindvall ,  Jiong Lan ,  Savithri Ramurthy ,  Anu Sharma ,  Elizabeth J. Mieuli ,  Liana M Klivansky ,  William Lenahan ,  Susan Kaufman ,  Hong Yang ,  Simon C. Ng ,  Keith Pfister ,  Allan S. Wagman ,  Victoria Sung ,  Martin Sendzik

IPC: A61K31/4439 ,  C07D413/14 ,  A61K31/4545 ,  A61K31/5377 ,  C07D417/14 ,  A61P35/02 ,  A61P35/00 ,  A61P19/10 ,  A61P19/02 ,  A61P9/10 ,  A61P13/12 ,  C07D413/12 ,  A61K31/55

CPC classification number: C07D413/12 ,  C07D417/12

Abstract: Benzoxazole and benzothiazole compounds and the stereoisomers, tautomers, solvates, oxides, esters, and prodrugs thereof and pharmaceutically acceptable salts thereof are disclosed. Compositions of the compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier, and uses of the compounds, either alone or in combination with at least one additional therapeutic agent are also disclosed. The embodiments are useful for inhibiting cellular proliferation, inhibiting the growth and/or metathesis of tumors, treating or preventing cancer, treating or preventing degenerating bone diseases such as rheumatoid arthritis, and/or inhibiting molecules such as CSF-1R.

Abstract translation: 公开了苯并恶唑和苯并噻唑化合物及其立体异构体，互变异构体，溶剂合物，氧化物，酯和前药及其药学上可接受的盐。 还公开了单独或与至少一种另外的治疗剂组合的化合物与药学上可接受的载体的组合，以及化合物单独或与至少一种另外的治疗剂组合的用途。 这些实施方案可用于抑制细胞增殖，抑制肿瘤的生长和/或复分解，治疗或预防癌症，治疗或预防退行性骨疾病如类风湿性关节炎和/或抑制分子如CSF-1R。

公开(公告)号：US20100197716A1

公开(公告)日：2010-08-05

申请号：US12761447

申请日：2010-04-16

Applicant: Jennifer Qiao ,  Tammy C. Wang ,  James C. Sutton ,  Timur Gungor

Inventor： Jennifer Qiao ,  Tammy C. Wang ,  James C. Sutton ,  Timur Gungor

IPC: A61K31/438 ,  C07D417/12 ,  A61K31/4709 ,  A61P7/02 ,  A61P9/10 ,  C07D401/04 ,  A61K31/4439 ,  C07D471/10 ,  A61K31/428

CPC classification number: C07D471/10 ,  C07D401/04 ,  C07D401/12 ,  C07D417/12 ,  C07D417/14

Abstract: The present invention provides novel ureas containing N-aryl or N-heteroaryl substituted heterocycles of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, D and W are as defined herein. These compounds are selective inhibitors of the human P2Y1 receptor which can be used as medicaments.

Abstract translation: 本发明提供了包含式（I）的N-芳基或N-杂芳基取代的杂环的新型脲：或其立体异构体，互变异构体，药学上可接受的盐或溶剂化物形式，其中变量A，B，D和W如本文所定义 。 这些化合物是可用作药物的人P2Y1受体的选择性抑制剂。

公开(公告)号：US06344450B1

公开(公告)日：2002-02-05

申请号：US09633751

申请日：2000-08-07

Applicant: Gregory S. Bisacchi ,  Steven M. Seiler ,  R. Michael Lawrence ,  James C. Sutton, Jr. ,  William A. Slusarchyk ,  Guohua Zhao

Inventor： Gregory S. Bisacchi ,  Steven M. Seiler ,  R. Michael Lawrence ,  James C. Sutton, Jr. ,  William A. Slusarchyk ,  Guohua Zhao

IPC: A61K3155

CPC classification number: C07D223/10 ,  A61K31/55 ,  A61K38/00 ,  A61K45/06 ,  C07K5/06139 ,  C07K5/06191 ,  A61K2300/00

Abstract: Lactam inhibitors are provided which have the structure X is wherein Y is O or S and R4 is  R7O— or R8 and R1, R2, R3, R5, R6, R7, and R8, are as defined herein. These compounds are inhibitors of Factor Xa and thus are useful as anticoagulants, and are inhibitors of tryptase and thus are useful in treating asthma. Methods for treating cardiovascular diseases associated with thromboses and for treating asthma and related diseases are also provided.

Abstract translation: 提供具有其中Y是O或S的结构X和R 4是R 7 O-或R 8并且R 1，R 2，R 3，R 5，R 6，R 7和R 8的结构X的内酰胺抑制剂如本文所定义。 这些化合物是因子Xa的抑制剂，因此可用作抗凝剂，并且是类胰蛋白酶的抑制剂，因此可用于治疗哮喘。 还提供了治疗与血栓相关的心血管疾病和治疗哮喘及相关疾病的方法。

公开(公告)号：US06335324B1

公开(公告)日：2002-01-01

申请号：US09458847

申请日：1999-12-13

Applicant: Gregory S. Bisacchi ,  William A. Slusarchyk ,  Uwe Treuner ,  James C. Sutton ,  Robert Zahler ,  Steven Seiler ,  David R. Kronenthal ,  Michael E. Randazzo ,  Mark D. Schwinden ,  Zhongmin Xu ,  Zhongping Shi

Inventor： Gregory S. Bisacchi ,  William A. Slusarchyk ,  Uwe Treuner ,  James C. Sutton ,  Robert Zahler ,  Steven Seiler ,  David R. Kronenthal ,  Michael E. Randazzo ,  Mark D. Schwinden ,  Zhongmin Xu ,  Zhongping Shi

IPC: C07D4014

CPC classification number: C07D403/12 ,  C07D205/08

Abstract: Compounds of the formulas: are disclosed. These compounds inhibit tryptase as well as other enzyme systems or are selective tryptase inhibitors and are useful as antiinflammatory agents particularly in the treatment of chronic asthma.

Abstract translation: 公开了下列化合物： 这些化合物抑制类胰蛋白酶以及其他酶系统或选择性类胰蛋白酶抑制剂，并且可用作抗炎剂，特别是用于治疗慢性哮喘。

公开(公告)号：US5447091A

公开(公告)日：1995-09-05

申请号：US314120

申请日：1994-09-29

Applicant: James C. Sutton

Inventor： James C. Sutton

IPC: F41H5/18

CPC classification number: F41H5/18 ,  F41H5/26

Abstract: A dynamic rotating ballistic shield for protecting an enclosed viewing dee. A rotating inner armor sleeve around the device includes a sleeve opening. When the sleeve aligned with a cap opening of an outer armor cap which concentrically surrounds the rotatable inner armor sleeve, a substantially unobstructed field-of-view for the objective window is obtained, with substantial ballistic shield protection.

Abstract translation: 一种用于保护封闭式观察装置的动态旋转防弹罩。 围绕装置的旋转内装套筒包括套筒开口。 当套筒与同心地围绕可旋转的内装甲套筒的外装甲帽的盖开口对齐时，获得了用于客观窗的基本无阻碍的视场，具有实质的防弹保护。