公开(公告)号：US20110201513A1

公开(公告)日：2011-08-18

申请号：US12944468

申请日：2010-11-11

Applicant: Neal Gordon ,  James R. Graham

Inventor： Neal Gordon ,  James R. Graham

IPC: C40B30/04 ,  G01N33/53

CPC classification number: G01N33/6878 ,  G01N33/6803

Abstract: The invention relates to methods, reagents and apparatus for detecting protein isoforms (e.g., those due to alternative splicing, or different disease protein isoforms or degradation products) in a sample, including using combinations of capture agents, each combination being unique to the splicing variant to be detected/measured.

Abstract translation: 本发明涉及用于检测样品中蛋白质同种型（例如，由于可选剪接或不同疾病蛋白质同种型或降解产物）的方法，试剂和装置，包括使用捕获剂的组合，每种组合对于剪接变体是唯一的 被检测/测量。

公开(公告)号：US20100331200A1

公开(公告)日：2010-12-30

申请号：US12295239

申请日：2007-03-30

Applicant: Neal F. Gordon ,  James R. Graham ,  Timothy Kenneth Nadler

Inventor： Neal F. Gordon ,  James R. Graham ,  Timothy Kenneth Nadler

IPC: C40B30/04 ,  G01N33/53 ,  C40B40/00

CPC classification number: G01N33/6842

Abstract: This invention relates to methods and apparatus for detecting the pattern of post translational modification in a protein or in a plurality of proteins in a sample. One or more target proteins are subjected to predetermined proteolysis to yield plural peptide fragments comprising potential post translational modification sites. The fragments and the state of such sites are analyzed to yield a post translational pattern for the protein or proteins.

Abstract translation: 本发明涉及用于检测样品中蛋白质或多种蛋白质中翻译后修饰的模式的方法和装置。 对一种或多种靶蛋白进行预定的蛋白水解以产生包含潜在翻译后修饰位点的多个肽片段。 分析这些位点的片段和状态以产生蛋白质或蛋白质的翻译后模式。

公开(公告)号：US07563311B2

公开(公告)日：2009-07-21

申请号：US11825843

申请日：2007-07-09

Applicant: James R. Graham

Inventor： James R. Graham

IPC: B01D53/02

CPC classification number: B01J20/3042 ,  A61L9/014 ,  B01D53/02 ,  B01D53/8668 ,  B01D2251/40 ,  B01D2253/10 ,  B01D2253/102 ,  B01D2253/112 ,  B01D2257/304 ,  B01D2257/708 ,  B01D2257/90 ,  B01D2258/00 ,  B01J20/041 ,  B01J20/20 ,  B01J20/28026 ,  B01J20/2803 ,  B01J20/3007 ,  B01J20/3021 ,  B01J20/3078 ,  B01J21/18 ,  B01J23/02 ,  B01J37/0201 ,  B01J37/04 ,  B01J37/14 ,  B01J2220/42 ,  C01B32/30 ,  C01B32/336 ,  Y10T428/30

Abstract: An activated carbon-metal oxide matrix is disclosed. The activated carbon-metal oxide matrix may be obtained by a method including the steps of: preoxidizing a carbon material, grinding the preoxidized carbon material; mixing the ground preoxidized material with a metal oxide to form a carbon mixture; extruding the carbon mixture; carbonizing and activating the extrudate. The activated carbon-metal oxide matrix may be used to remove odorous compounds, acidic gases, and volatile organic compounds from a gas.

Abstract translation: 公开了一种活性炭 - 金属氧化物基质。 活性炭 - 金属氧化物基质可以通过包括以下步骤的方法获得：将碳材料预氧化，研磨预氧化碳材料; 将地面预氧化材料与金属氧化物混合以形成碳混合物; 挤出碳混合物; 碳化和活化挤出物。 活性炭 - 金属氧化物基质可用于从气体中除去有气味的化合物，酸性气体和挥发性有机化合物。

公开(公告)号：US06321163B1

公开(公告)日：2001-11-20

申请号：US09389092

申请日：1999-09-02

Applicant: James R. Graham ,  Kamalakar Gulukota

Inventor： James R. Graham ,  Kamalakar Gulukota

IPC: G01N3348

CPC classification number: G06F19/22 ,  G06F19/18

Abstract: A method and apparatus are disclosed for identifying protein-coding regions in a nucleic acid sequence. In order to predict the coding regions within a sequence, a single metric is used without reference or comparison to a predetermined noise level or signal-to-noise ratio. This single metric, periodicity at ⅓, is analyzed using a discrete cosine transformation (DiCTion) function. For each open reading frame or sequence region, a score is generated using the discrete cosine transformation function. Regions within a sequence that have a score above a predetermined threshold are identified as protein-coding regions. The aspects of the invention may also be applied to gather other information from sequences, such as the location of the borders of a putative coding region, within a genomic sequence.

Abstract translation: 公开了用于鉴定核酸序列中的蛋白质编码区的方法和装置。 为了预测序列内的编码区域，使用单个度量而不参考或与预定的噪声电平或信噪比进行比较。 使用离散余弦变换（DiCTion）函数来分析1/3的周期性。 对于每个开放阅读框或序列区，使用离散余弦变换函数生成得分。 具有高于预定阈值的分数的序列内的区域被鉴定为蛋白质编码区域。 也可以应用本发明的方面从序列收集其他信息，例如基因组序列内的推定编码区的边界的位置。

公开(公告)号：US5813093A

公开(公告)日：1998-09-29

申请号：US792305

申请日：1997-01-31

Applicant: Joseph James Giordano, Jr. ,  James R. Graham ,  William Vincent Jackwicz ,  Pratod V. Kasbekar ,  Harish Shankar Mangrulkar ,  Romano M. Zambon

Inventor： Joseph James Giordano, Jr. ,  James R. Graham ,  William Vincent Jackwicz ,  Pratod V. Kasbekar ,  Harish Shankar Mangrulkar ,  Romano M. Zambon

IPC: E05D11/10 ,  H04M1/02

CPC classification number: H04M1/0216 ,  E05D11/1078 ,  E05Y2900/606 ,  Y10T16/5402 ,  Y10T16/540254 ,  Y10T16/540256

Abstract: A hinge assembly which has a limited number of stable positions and in which the hinge automatically moves to the closest of such stable positions is disclosed. The movement of the hinge is accomplished in one illustrative embodiment by positioning the protrusion on one of a pair of ramps inclined opposite to one another and toward the adjacent recess so that the parts of the hinge rotate relative to one another, moving the protrusion into the adjacent recess. The protrusion is pressed against the ramps and the grooves by a connecting portion that joins the arm portions and is flexed when the hinge parts are assembled so as to bias the arm portions toward one another.

Abstract translation: 公开了一种铰链组件，其具有有限数量的稳定位置，并且铰链自动地移动到最接近这样的稳定​​位置。 铰链的运动在一个说明性实施例中通过将突起定位在彼此相对倾斜并且朝向相邻凹部倾斜的一对斜面中的一个上，使得铰链的部分相对于彼此旋转，将突起移动到 相邻的凹槽。 突起通过连接臂部分的连接部分压靠在斜面和凹槽上，并且当铰链部件组装时使凸起部分彼此偏置。

公开(公告)号：USD383127S

公开(公告)日：1997-09-02

申请号：US32902

申请日：1994-12-30

Applicant: Joseph James Giordano, Jr. ,  James R. Graham ,  Joel Thomas Holl ,  William Vincent Jackwicz ,  Pratod V. Kasbekar ,  Harish Shankar Mangrulkar ,  Michael L. Moroze ,  Michael John Nuttall ,  Joseph J. Rizzo ,  Christopher A. Robinette ,  John Henry Schaffeld ,  Susan L. Tuttle ,  William E. Venth ,  Karl Edward Werner ,  Romano M. Zambon

Designer： Joseph James Giordano, Jr. ,  James R. Graham ,  Joel Thomas Holl ,  William Vincent Jackwicz ,  Pratod V. Kasbekar ,  Harish Shankar Mangrulkar ,  Michael L. Moroze ,  Michael John Nuttall ,  Joseph J. Rizzo ,  Christopher A. Robinette ,  John Henry Schaffeld ,  Susan L. Tuttle ,  William E. Venth ,  Karl Edward Werner ,  Romano M. Zambon

公开(公告)号：US4625056A

公开(公告)日：1986-11-25

申请号：US105355

申请日：1979-12-19

Applicant: James R. Graham ,  John G. Huntington

Inventor： James R. Graham ,  John G. Huntington

IPC: C07C51/21 ,  C07C51/16

CPC classification number: C07C51/21 ,  Y02P20/582

Abstract: This invention relates to a method of producing benzene carboxylic acids from an aromatic material, especially coal, by the oxidation of the aromatic material in an aqueous alkaline mixture containing an aliphatic organic acid promoter agent with a source of gaseous oxygen. Use of the aliphatic organic acid promoter agent results in a surprising and unexpected increase in the benzene carboxylic acid yield which is higher than that obtained without the promoter agent.A finely divided coal, potassium carbonate, water, and aliphatic carboxylic acid promoter agent are charged to a feed tank (10) where they are mixed with an agitator (14). A slurry pump (18) pumps the mixture through a preheater (20) to an autoclave (30). Air is continuously fed to the autoclave (30) by a gas compressor (34). The coal slurry is oxidized in the autoclave (30) while being agitated by a mixer (36). Gaseous products, and in particular carbon dioxide, is continuously removed from the autoclave (30) through a vent conduit (42). Benzene carboxylic acid salts produced in the autoclave (30) are removed and cooled in a cooler (52) and stored in a product tank (54).

Abstract translation: 本发明涉及一种通过在含有气态氧源的脂肪族有机酸促进剂的含水碱性混合物中氧化芳族物质从芳香族物质，特别是煤中生产苯羧酸的方法。 脂肪族有机酸助剂的使用导致苯羧酸产率惊人而出人意料地增加，高于不含启动剂的产物。 将细碎的煤，碳酸钾，水和脂肪族羧酸促进剂加入到进料罐（10）中，在搅拌器（14）中混合。 浆料泵（18）将混合物通过预热器（20）泵送到高压灭菌器（30）。 空气通过气体压缩机（34）连续供给到高压釜（30）。 煤浆在高压釜（30）中被氧化，同时用混合器（36）搅拌。 气体产物，特别是二氧化碳通过排气导管（42）从高压釜（30）中连续地移出。 在高压釜（30）中产生的苯甲酸盐被除去并在冷却器（52）中冷却并储存在产品罐（54）中。