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1.发明授权Protein splice variant/isoform discrimination and quantitative measurements thereof 失效蛋白质剪接变体/同种型鉴别及其定量测定公开(公告)号：US07855057B2
公开(公告)日：2010-12-21
申请号：US11387389
申请日：2006-03-23
Applicant: Neal Gordon , James R. Graham
Inventor： Neal Gordon , James R. Graham
IPC: G01N33/53
CPC classification number: G01N33/6878 , G01N33/6803
Abstract: The invention relates to methods, reagents and apparatus for detecting protein isoforms (e.g., those due to alternative splicing, or different disease protein isoforms or degradation products) in a sample, including using combinations of capture agents, each combination being unique to the splicing variant to be detected/measured.
Abstract translation: 本发明涉及用于检测样品中蛋白质同种型（例如，由于可选剪接或不同疾病蛋白质同种型或降解产物）的方法，试剂和装置，包括使用捕获剂的组合，每种组合对于剪接变体是唯一的 被检测/测量。
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2.发明申请PROTEIN SPLICE VARIANT / ISOFORM DISCRIMINATION AND QUANTITATIVE MEASUREMENTS THEREOF 审中-公开蛋白质差异变异/定性分析及其定量测量公开(公告)号：US20110201513A1
公开(公告)日：2011-08-18
申请号：US12944468
申请日：2010-11-11
Applicant: Neal Gordon , James R. Graham
Inventor： Neal Gordon , James R. Graham
CPC classification number: G01N33/6878 , G01N33/6803
Abstract: The invention relates to methods, reagents and apparatus for detecting protein isoforms (e.g., those due to alternative splicing, or different disease protein isoforms or degradation products) in a sample, including using combinations of capture agents, each combination being unique to the splicing variant to be detected/measured.
Abstract translation: 本发明涉及用于检测样品中蛋白质同种型（例如，由于可选剪接或不同疾病蛋白质同种型或降解产物）的方法，试剂和装置，包括使用捕获剂的组合，每种组合对于剪接变体是唯一的 被检测/测量。
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公开(公告)号：US20090057228A1
公开(公告)日：2009-03-05
申请号：US11847081
申请日：2007-08-29
Applicant: James R. Graham , Robert Craw
Inventor： James R. Graham , Robert Craw
CPC classification number: C02F1/283 , B01J20/20 , B01J20/28052 , B01J20/3242 , C02F1/288 , C02F1/42 , C02F2101/103 , C02F2101/12 , C02F2101/22 , C02F2103/06
Abstract: A stratified bed of activated carbon having regions of functionalized and non-functionalized activated carbon can be utilized to remove contaminants from fluids such as groundwater. The functionalized region has activated carbon particles comprising a cationic or anionic compound that can remove organic or inorganic anionic or cationic compounds from the fluid to be treated. The non-functionalized region comprises powdered or granular activated carbon or adsorbent media downstream of the functionalized region and captures any leaching species or compounds from the functionalized region.
Abstract translation: 具有官能化和非官能化活性炭区域的活性炭分层床可用于从诸如地下水的流体中除去污染物。 官能化区域具有包含阳离子或阴离子化合物的活性炭颗粒，其可从待处理流体中除去有机或无机阴离子或阳离子化合物。 非官能化区域包括在官能化区域下游的粉末状或粒状活性炭或吸附剂介质，并捕获来自官能化区域的任何浸出物质或化合物。
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公开(公告)号：USD379810S
公开(公告)日：1997-06-10
申请号：US32947
申请日：1994-12-30
Applicant: Joseph J. Giordano, Jr. , James R. Graham , Joel T. Holl , William V. Jackwicz , Pratod V. Kasbekar , Harish S. Mangrulkar , Michael L. Moroze , Michael J. Nuttall , Joseph J. Rizzo , Christopher A. Robinette , John H. Schaffeld , Susan L. Tuttle , William E. Venth , Karl E. Werner , Romano M. Zambon
Designer： Joseph J. Giordano, Jr. , James R. Graham , Joel T. Holl , William V. Jackwicz , Pratod V. Kasbekar , Harish S. Mangrulkar , Michael L. Moroze , Michael J. Nuttall , Joseph J. Rizzo , Christopher A. Robinette , John H. Schaffeld , Susan L. Tuttle , William E. Venth , Karl E. Werner , Romano M. Zambon
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公开(公告)号：US5073454A
公开(公告)日：1991-12-17
申请号：US403234
申请日：1989-09-05
Applicant: James R. Graham
Inventor： James R. Graham
CPC classification number: C04B41/009 , C01B31/084 , C01B31/087 , C04B41/4584 , C04B41/81 , Y10S502/514 , Y10T428/2991 , Y10T428/2993 , Y10T428/30
Abstract: An activated carbon coated with an intumescent material which will expand at an elevated temperature and render the activated carbon resistant to oxidation. The activation carbon can be in granulated form, including pelletized, and impregnated. The intumescent material is preferably attached to about 10% of the exterior surface of the activated carbon and when exposed to a certain elevated temperature the intumescent material will expand and cover all or almost all of the exterior surface of the activated carbon thereby preventing its burning. The amount of intumescent material is not operable for causing a detrimental reduction in the adsorption capacity of the activated carbon when the coated activated carbon is at temperatures below the certain designed elevated temperature.
Abstract translation: 涂有膨胀材料的活性炭，其将在升高的温度下膨胀并使活性炭抗氧化。 活化炭可以是颗粒形式，包括造粒和浸渍。 膨胀材料优选连接到活性炭的外表面的约10％，并且当暴露于一定的升高温度时，膨胀材料将膨胀并覆盖活性炭的所有或几乎所有的外表面，从而防止其燃烧。 当涂覆的活性炭处于低于某一设计的升高温度的温度时，膨胀材料的量不能用于引起活性炭吸附能力的有害降低。
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Patent Agency Ranking
公开(公告)号：US20090136507A1
公开(公告)日：2009-05-28
申请号：US12219294
申请日：2008-07-18
Applicant: Kristina Allen , Anthony Anisowicz , James R. Graham , Arturo Morales , Paul J. Yaworsky , Wei Liu
Inventor： Kristina Allen , Anthony Anisowicz , James R. Graham , Arturo Morales , Paul J. Yaworsky , Wei Liu
IPC: A61K39/395 , C07K16/18
CPC classification number: C12N15/8509 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2227/50 , A01K2267/02 , A01K2267/03 , A01K2267/0362 , A61K38/00 , C07K14/51 , C07K16/18 , C12N2800/30 , C12N2800/60 , C12N2830/00 , C12N2830/008 , C12N2830/30 , C12N2840/105 , C12N2840/203 , G01N2333/51 , G01N2500/00
Abstract: The present invention relates to methods and materials used to express an HBM-like polypeptide derived from HBM, LRP5 or LRP6 in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing the HBM-like polypeptides. The invention provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development and lipid modulation. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.
Abstract translation: 本发明涉及用于表达在动物细胞和转基因动物中衍生自HBM，LRP5或LRP6的HBM样多肽的方法和材料。 本发明还涉及表达HBM样多肽的转基因动物。 本发明提供核酸，包括编码序列，寡核苷酸引物和探针，蛋白质，克隆载体，表达载体，转化的宿主，开发药物组合物的方法，鉴定涉及骨发育的分子的方法，以及诊断和治疗涉及的疾病的方法 骨发育和脂质调节。 在优选的实施方案中，本发明涉及治疗，诊断和预防骨质疏松症的方法。
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公开(公告)号：USD383129S
公开(公告)日：1997-09-02
申请号：US32960
申请日：1994-12-30
Applicant: Joseph James Giordano, Jr. , James R. Graham , Joel Thomas Holl , William Vincent Jackwicz , Pratod V. Kasbekar , Harish Shankar Mangrulkar , Michael L. Moroze , Michael John Nuttall , Joseph J. Rizzo , Christopher A. Robinette , John Henry Schaffeld , Susan L. Tuttle , William E. Venth , Karl Edward Werner , Romano M. Zambon
Designer： Joseph James Giordano, Jr. , James R. Graham , Joel Thomas Holl , William Vincent Jackwicz , Pratod V. Kasbekar , Harish Shankar Mangrulkar , Michael L. Moroze , Michael John Nuttall , Joseph J. Rizzo , Christopher A. Robinette , John Henry Schaffeld , Susan L. Tuttle , William E. Venth , Karl Edward Werner , Romano M. Zambon
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公开(公告)号：USD364621S
公开(公告)日：1995-11-28
申请号：US31718
申请日：1994-12-05
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公开(公告)号：US07645586B2
公开(公告)日：2010-01-12
申请号：US11728185
申请日：2007-03-23
Applicant: Neal F. Gordon , James R. Graham
Inventor： Neal F. Gordon , James R. Graham
IPC: G01N33/53
CPC classification number: G01N33/6878 , G01N33/6803
Abstract: The invention relates to methods, reagents and apparatus for detecting protein isoforms (e.g., those due to alternative splicing, or different disease protein isoforms or degradation products) in a sample, including using combinations of capture agents to identify the isoforms to be detected/measured.
Abstract translation: 本发明涉及用于检测样品中蛋白质异构体（例如，由于可选剪接或不同疾病蛋白质同种型或降解产物引起的那些）的方法，试剂和装置，包括使用捕获剂的组合来鉴定待检测/测量的同种型 。
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公开(公告)号：US07101417B2
公开(公告)日：2006-09-05
申请号：US10729274
申请日：2003-12-05
Applicant: James R. Graham
Inventor： James R. Graham
CPC classification number: B01D39/2068 , B01D39/2055 , Y10S95/901 , Y10T428/30
Abstract: An activated carbon/metal oxide filter element is disclosed. The filter element may be prepared by blending an activated carbon, a metal oxide, and a binder to form a filter media mixture, shaping the filter media mixture into a filter body. The filter body may be calcined to form a filter element. The activated carbon/metal oxide filter element may be used to remove odorous compounds, acidic gases, and volatile organic compounds from a gas.
Abstract translation: 公开了一种活性炭/金属氧化物过滤元件。 过滤元件可以通过混合活性炭，金属氧化物和粘合剂以形成过滤介质混合物来制备，将过滤介质混合物成型为过滤体。 过滤体可以被煅烧以形成过滤元件。 活性炭/金属氧化物过滤元件可用于从气体中除去恶臭化合物，酸性气体和挥发性有机化合物。
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