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    Method and apparatus for analyzing nucleic acid sequences
    1.
    发明授权
    Method and apparatus for analyzing nucleic acid sequences 失效
    用于分析核酸序列的方法和装置

    公开(公告)号：US06321163B1

    公开(公告)日：2001-11-20

    申请号：US09389092

    申请日：1999-09-02

    Applicant: James R. Graham ,  Kamalakar Gulukota

    Inventor： James R. Graham ,  Kamalakar Gulukota

    IPC: G01N3348

    CPC classification number: G06F19/22 ,  G06F19/18

    Abstract: A method and apparatus are disclosed for identifying protein-coding regions in a nucleic acid sequence. In order to predict the coding regions within a sequence, a single metric is used without reference or comparison to a predetermined noise level or signal-to-noise ratio. This single metric, periodicity at ⅓, is analyzed using a discrete cosine transformation (DiCTion) function. For each open reading frame or sequence region, a score is generated using the discrete cosine transformation function. Regions within a sequence that have a score above a predetermined threshold are identified as protein-coding regions. The aspects of the invention may also be applied to gather other information from sequences, such as the location of the borders of a putative coding region, within a genomic sequence.

    Abstract translation: 公开了用于鉴定核酸序列中的蛋白质编码区的方法和装置。 为了预测序列内的编码区域，使用单个度量而不参考或与预定的噪声电平或信噪比进行比较。 使用离散余弦变换（DiCTion）函数来分析1/3的周期性。 对于每个开放阅读框或序列区，使用离散余弦变换函数生成得分。 具有高于预定阈值的分数的序列内的区域被鉴定为蛋白质编码区域。 也可以应用本发明的方面从序列收集其他信息，例如基因组序列内的推定编码区的边界的位置。

    SYSTEM AND METHOD OF FILTERING USING STRATIFIED ACTIVATED CARBON
    2.
    发明申请
    SYSTEM AND METHOD OF FILTERING USING STRATIFIED ACTIVATED CARBON 审中-公开
    使用分层活性炭过滤的系统和方法

    公开(公告)号：US20090057228A1

    公开(公告)日：2009-03-05

    申请号：US11847081

    申请日：2007-08-29

    Applicant: James R. Graham ,  Robert Craw

    Inventor： James R. Graham ,  Robert Craw

    IPC: B01D15/04 ,  B01D24/00 ,  C02F1/42

    CPC classification number: C02F1/283 ,  B01J20/20 ,  B01J20/28052 ,  B01J20/3242 ,  C02F1/288 ,  C02F1/42 ,  C02F2101/103 ,  C02F2101/12 ,  C02F2101/22 ,  C02F2103/06

    Abstract: A stratified bed of activated carbon having regions of functionalized and non-functionalized activated carbon can be utilized to remove contaminants from fluids such as groundwater. The functionalized region has activated carbon particles comprising a cationic or anionic compound that can remove organic or inorganic anionic or cationic compounds from the fluid to be treated. The non-functionalized region comprises powdered or granular activated carbon or adsorbent media downstream of the functionalized region and captures any leaching species or compounds from the functionalized region.

    Abstract translation: 具有官能化和非官能化活性炭区域的活性炭分层床可用于从诸如地下水的流体中除去污染物。 官能化区域具有包含阳离子或阴离子化合物的活性炭颗粒，其可从待处理流体中除去有机或无机阴离子或阳离子化合物。 非官能化区域包括在官能化区域下游的粉末状或粒状活性炭或吸附剂介质，并捕获来自官能化区域的任何浸出物质或化合物。

    Oxidation resistant activated carbon and method of preparation
    4.
    发明授权
    Oxidation resistant activated carbon and method of preparation 失效
    抗氧化活性炭及其制备方法

    公开(公告)号：US5073454A

    公开(公告)日：1991-12-17

    申请号：US403234

    申请日：1989-09-05

    Applicant: James R. Graham

    Inventor： James R. Graham

    IPC: C01B31/08 ,  C04B41/45 ,  C04B41/81

    CPC classification number: C04B41/009 ,  C01B31/084 ,  C01B31/087 ,  C04B41/4584 ,  C04B41/81 ,  Y10S502/514 ,  Y10T428/2991 ,  Y10T428/2993 ,  Y10T428/30

    Abstract: An activated carbon coated with an intumescent material which will expand at an elevated temperature and render the activated carbon resistant to oxidation. The activation carbon can be in granulated form, including pelletized, and impregnated. The intumescent material is preferably attached to about 10% of the exterior surface of the activated carbon and when exposed to a certain elevated temperature the intumescent material will expand and cover all or almost all of the exterior surface of the activated carbon thereby preventing its burning. The amount of intumescent material is not operable for causing a detrimental reduction in the adsorption capacity of the activated carbon when the coated activated carbon is at temperatures below the certain designed elevated temperature.

    Abstract translation: 涂有膨胀材料的活性炭，其将在升高的温度下膨胀并使活性炭抗氧化。 活化炭可以是颗粒形式，包括造粒和浸渍。 膨胀材料优选连接到活性炭的外表面的约10％，并且当暴露于一定的升高温度时，膨胀材料将膨胀并覆盖活性炭的所有或几乎所有的外表面，从而防止其燃烧。 当涂覆的活性炭处于低于某一设计的升高温度的温度时，膨胀材料的量不能用于引起活性炭吸附能力的有害降低。

    Protein splice variant/isoform discrimination and quantitative measurements thereof
    5.
    发明授权
    Protein splice variant/isoform discrimination and quantitative measurements thereof 失效
    蛋白质剪接变体/同种型鉴别及其定量测定

    公开(公告)号：US07855057B2

    公开(公告)日：2010-12-21

    申请号：US11387389

    申请日：2006-03-23

    Applicant: Neal Gordon ,  James R. Graham

    Inventor： Neal Gordon ,  James R. Graham

    IPC: G01N33/53

    CPC classification number: G01N33/6878 ,  G01N33/6803

    Abstract: The invention relates to methods, reagents and apparatus for detecting protein isoforms (e.g., those due to alternative splicing, or different disease protein isoforms or degradation products) in a sample, including using combinations of capture agents, each combination being unique to the splicing variant to be detected/measured.

    Abstract translation: 本发明涉及用于检测样品中蛋白质同种型（例如，由于可选剪接或不同疾病蛋白质同种型或降解产物）的方法，试剂和装置，包括使用捕获剂的组合，每种组合对于剪接变体是唯一的 被检测/测量。

    Protein isoform discrimination and quantitative measurements thereof
    9.
    发明授权
    Protein isoform discrimination and quantitative measurements thereof 失效
    蛋白质异构体鉴别及其定量测定

    公开(公告)号：US07645586B2

    公开(公告)日：2010-01-12

    申请号：US11728185

    申请日：2007-03-23

    Applicant: Neal F. Gordon ,  James R. Graham

    Inventor： Neal F. Gordon ,  James R. Graham

    IPC: G01N33/53

    CPC classification number: G01N33/6878 ,  G01N33/6803

    Abstract: The invention relates to methods, reagents and apparatus for detecting protein isoforms (e.g., those due to alternative splicing, or different disease protein isoforms or degradation products) in a sample, including using combinations of capture agents to identify the isoforms to be detected/measured.

    Abstract translation: 本发明涉及用于检测样品中蛋白质异构体（例如，由于可选剪接或不同疾病蛋白质同种型或降解产物引起的那些）的方法，试剂和装置，包括使用捕获剂的组合来鉴定待检测/测量的同种型 。

    Activated carbon for odor control and method for making same
    10.
    发明授权
    Activated carbon for odor control and method for making same 有权
    用于气味控制的活性炭及其制备方法

    公开(公告)号：US07101417B2

    公开(公告)日：2006-09-05

    申请号：US10729274

    申请日：2003-12-05

    Applicant: James R. Graham

    Inventor： James R. Graham

    IPC: B01D53/04 ,  B01D53/48

    CPC classification number: B01D39/2068 ,  B01D39/2055 ,  Y10S95/901 ,  Y10T428/30

    Abstract: An activated carbon/metal oxide filter element is disclosed. The filter element may be prepared by blending an activated carbon, a metal oxide, and a binder to form a filter media mixture, shaping the filter media mixture into a filter body. The filter body may be calcined to form a filter element. The activated carbon/metal oxide filter element may be used to remove odorous compounds, acidic gases, and volatile organic compounds from a gas.

    Abstract translation: 公开了一种活性炭/金属氧化物过滤元件。 过滤元件可以通过混合活性炭，金属氧化物和粘合剂以形成过滤介质混合物来制备，将过滤介质混合物成型为过滤体。 过滤体可以被煅烧以形成过滤元件。 活性炭/金属氧化物过滤元件可用于从气体中除去恶臭化合物，酸性气体和挥发性有机化合物。

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