公开(公告)号：US20050239782A1

公开(公告)日：2005-10-27

申请号：US11148114

申请日：2005-06-08

Applicant: Geoffrey Heintzelman ,  Kristin Averill ,  John Dodd ,  Keith Demarest ,  Yuting Tang ,  Paul Jackson

Inventor： Geoffrey Heintzelman ,  Kristin Averill ,  John Dodd ,  Keith Demarest ,  Yuting Tang ,  Paul Jackson

IPC: A61K31/496 ,  A61K31/5377 ,  C07D221/16 ,  C07D401/04 ,  C07D401/12 ,  C07D405/04 ,  C07D409/04 ,  C07D413/02 ,  C07D491/04 ,  C07D43/02

CPC classification number: A61K31/473 ,  C07D221/16 ,  C07D401/04 ,  C07D401/12 ,  C07D405/04 ,  C07D409/04 ,  C07D491/04

Abstract: This invention provides novel arylindenopyridines of the formula: and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing Adensine A2a receptors or reducing PDE activity in appropriate cells. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.

公开(公告)号：US07875744B2

公开(公告)日：2011-01-25

申请号：US12549426

申请日：2009-08-28

Applicant: Gee-Hong Kuo ,  Rui Zhang ,  Aihua Wang ,  Alan DeAngelis ,  Keith Demarest ,  Patricia Pelton

Inventor： Gee-Hong Kuo ,  Rui Zhang ,  Aihua Wang ,  Alan DeAngelis ,  Keith Demarest ,  Patricia Pelton

IPC: C07C59/00 ,  C07C53/135 ,  C07C255/00 ,  A61K31/275 ,  A61K31/20 ,  A61K31/195

CPC classification number: C07C59/68 ,  C07C323/20

Abstract: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.

Abstract translation: 本发明具有4 - （（苯氧基烷基）硫基） - 苯氧基乙酸及其类似物，含有它们的组合物，以及使用它们作为PPAR调节剂来治疗或抑制例如血脂异常进展的方法。

公开(公告)号：US07425649B2

公开(公告)日：2008-09-16

申请号：US11226645

申请日：2005-09-14

Applicant: Gee-Hong Kuo ,  Rui Zhang ,  Aihua Wang ,  Alan DeAngelis ,  Keith Demarest ,  Patricia Pelton

Inventor： Gee-Hong Kuo ,  Rui Zhang ,  Aihua Wang ,  Alan DeAngelis ,  Keith Demarest ,  Patricia Pelton

IPC: C07C59/00 ,  C07C53/134 ,  C07C255/00 ,  A61K31/275 ,  A61K31/20 ,  A61K31/195

CPC classification number: C07C59/68 ,  C07C323/20

Abstract: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.

Abstract translation: 本发明具有4 - （（苯氧基烷基）硫基） - 苯氧基乙酸及其类似物，含有它们的组合物，以及使用它们作为PPAR调节剂来治疗或抑制例如血脂异常进展的方法。

公开(公告)号：US20080076753A1

公开(公告)日：2008-03-27

申请号：US11857891

申请日：2007-09-19

Applicant: Min Xiang ,  Mona Patel ,  Philip Rybczynski ,  Joseph Gunnet ,  Keith Demarest ,  Richard Look ,  Bruce Maryanoff ,  Michael Costanzo ,  Stephen Yabut

Inventor： Min Xiang ,  Mona Patel ,  Philip Rybczynski ,  Joseph Gunnet ,  Keith Demarest ,  Richard Look ,  Bruce Maryanoff ,  Michael Costanzo ,  Stephen Yabut

IPC: A61K31/55 ,  A61P25/00 ,  A61P9/00 ,  C07D471/10 ,  C07D487/10

CPC classification number: C07D487/10

Abstract: The invention is directed to nonpeptide substituted spiroheterobenzazepine of Formula I, which are useful as vasopressin receptor antagonists for treating conditions associated with vasopressin receptor activity such as those involving increased vascular resistance and cardiac insufficiency, including congestive heart failure, hyponatremia, and hypertension. Pharmaceutical compositions comprising a compound of Formula I and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, hyponatremia, renal vasospasm, renal insufficiency, renal failure, diabetic nephropathy, cerebral edema, cerebral ischemia, stroke, thrombosis, or water retention are also disclosed.

Abstract translation: 本发明涉及式I的非肽取代的螺杂肼苯并氮平，其可用作加压素受体拮抗剂，用于治疗与加压素受体活性相关的病症，例如涉及增加的血管阻力和心脏功能不全（包括充血性心力衰竭，低钠血症和高血压）的那些。 包含式I化合物的药物组合物和治疗诸如高血压，充血性心力衰竭，心脏功能不全，冠状动脉血管痉挛，心脏缺血，肝硬化，低钠血症，肾血管痉挛，肾功能不全，肾衰竭，糖尿病性肾病，脑水肿， 还公开了脑缺血，中风，血栓形成或保水。

公开(公告)号：US20070213386A1

公开(公告)日：2007-09-13

申请号：US11800878

申请日：2007-05-08

Applicant: Han-Cheng Zhang ,  Bruce Maryanoff ,  David McComsey ,  Kimberly White ,  Hong Ye ,  Leonard Hecker ,  Bruce Conway ,  Keith Demarest

Inventor： Han-Cheng Zhang ,  Bruce Maryanoff ,  David McComsey ,  Kimberly White ,  Hong Ye ,  Leonard Hecker ,  Bruce Conway ,  Keith Demarest

IPC: A61K31/40 ,  A61K31/415 ,  C07D209/02 ,  C07D221/00 ,  C07D231/56 ,  C07D239/02 ,  C07D401/02

CPC classification number: C07D409/14 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D417/14

Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.

公开(公告)号：US07232906B2

公开(公告)日：2007-06-19

申请号：US10454561

申请日：2003-06-04

Applicant: Han Cheng Zhang ,  Bruce E. Maryanoff ,  David F. McComsey ,  Kimberly White ,  Hong Ye ,  Leonard R. Hecker ,  Bruce Conway ,  Keith Demarest

Inventor： Han Cheng Zhang ,  Bruce E. Maryanoff ,  David F. McComsey ,  Kimberly White ,  Hong Ye ,  Leonard R. Hecker ,  Bruce Conway ,  Keith Demarest

IPC: C07D239/24 ,  C07D209/02

CPC classification number: C07D409/14 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D417/14

Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.

公开(公告)号：US20060205762A1

公开(公告)日：2006-09-14

申请号：US11435999

申请日：2006-05-17

Applicant: Han-Cheng Zhang ,  Gee-Hong Kuo ,  Bruce Maryanoff ,  Hong Ye ,  David O'Neill ,  Lan Shen ,  Keith Demarest ,  Bruce Conway ,  David McComsey

Inventor： Han-Cheng Zhang ,  Gee-Hong Kuo ,  Bruce Maryanoff ,  Hong Ye ,  David O'Neill ,  Lan Shen ,  Keith Demarest ,  Bruce Conway ,  David McComsey

IPC: C07D471/02 ,  A61K31/4745

CPC classification number: C07D471/04

Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.

公开(公告)号：US20060154949A1

公开(公告)日：2006-07-13

申请号：US11042281

申请日：2005-01-24

Applicant: Geoffrey Heintzelman ,  Kristin Averill ,  John Dodd ,  Keith Demarest ,  Yuting Tang ,  Paul Jackson

Inventor： Geoffrey Heintzelman ,  Kristin Averill ,  John Dodd ,  Keith Demarest ,  Yuting Tang ,  Paul Jackson

IPC: A61K31/473

CPC classification number: C07D221/16 ,  A61K31/473 ,  C07D401/04 ,  C07D401/12 ,  C07D405/04 ,  C07D409/04 ,  C07D491/04

Abstract: This invention provides novel arylindenopyridines of the formula: and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing Adensine A2a receptors or reducing PDE activity in appropriate cells. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.

Abstract translation: 本发明提供了新颖的具有下列结构式的Ar 3吲哚并吡啶：和包含该化合物的药物组合物，其可用于治疗通过拮抗Adensine A2a受体或降低适当细胞中PDE活性而改善的病症。 本发明还提供了使用本发明的药物组合物的治疗和预防方法。

公开(公告)号：US20080269336A1

公开(公告)日：2008-10-30

申请号：US12144061

申请日：2008-06-23

Applicant: Gee-Hong Kuo ,  Rui Zhang ,  Aihua Wang ,  Alan DeAngelis ,  Keith Demarest ,  Patricia Pelton

Inventor： Gee-Hong Kuo ,  Rui Zhang ,  Aihua Wang ,  Alan DeAngelis ,  Keith Demarest ,  Patricia Pelton

IPC: A61K31/192 ,  C07C59/13 ,  A61P9/10 ,  A61P3/06 ,  A61P3/10

CPC classification number: C07C59/68 ,  C07C323/20

Abstract: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.

Abstract translation: 本发明具有4 - （（苯氧基烷基）硫基） - 苯氧基乙酸及其类似物，含有它们的组合物，以及使用它们作为PPAR调节剂来治疗或抑制例如血脂异常进展的方法。

公开(公告)号：US20080096802A1

公开(公告)日：2008-04-24

申请号：US11923120

申请日：2007-10-24

Applicant: JACQUELINE Bussolari ,  Xiaoli Chen ,  Bruce Conway ,  Keith Demarest ,  Hamish Ross ,  Rafael Severino

Inventor： JACQUELINE Bussolari ,  Xiaoli Chen ,  Bruce Conway ,  Keith Demarest ,  Hamish Ross ,  Rafael Severino

IPC: A61K38/28 ,  A61K31/19 ,  A61K31/21 ,  A61K31/421 ,  A61P3/10 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/7048

CPC classification number: A61K31/427 ,  A61K31/31 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/7034 ,  A61K2300/00

Abstract: Combination therapy comprising PPAR modulators and glucose reabsorption inhibitors useful for the treatment of diabetes and Syndrome X are disclosed.

Abstract translation: 公开了包含可用于治疗糖尿病和综合征X的PPAR调节剂和葡萄糖再吸收抑制剂的组合疗法。