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公开(公告)号：US20090011159A1
公开(公告)日：2009-01-08
申请号：US12167085
申请日：2008-07-02
IPC分类号： B32B1/02
CPC分类号： A61F15/001 , A61F13/551 , A61F2013/00165 , A61F2013/00365 , Y10T428/13
摘要： The present invention relates to a patch package structure which includes: a package including a first sheet material and a second sheet material, the first and second sheet materials being sealed together in peripheral parts thereof; and a patch disposed in the package, the patch contains a backing, a pressure-sensitive adhesive layer laminated on at least one side of the backing, and a release liner which protects a pressure-sensitive adhesive surface of the pressure-sensitive adhesive layer, the release liner having on a surface thereof a cut line supporting a peel-off of the release liner at the time of using the patch, the patch being disposed in the package so that the release liner faces the inner surface of the first sheet material, the first sheet material having a first region in which the inner surface of the first sheet material faces the cut line of the release liner, the first sheet material having in the first region a minimum first distance between the inner surface of the first sheet material and the surface of the release liner, and the inner surface of the first sheet material being spaced from the surface of the release liner at the minimum first distance in the first region.
摘要翻译： 贴片包装结构技术领域本发明涉及一种贴片包装结构，其包括：包括第一片材和第二片材的封装，所述第一片材和第二片材在其周边部分被密封在一起; 以及布置在所述包装中的贴片，所述贴片包含背衬，层压在所述背衬的至少一侧上的压敏粘合剂层以及保护所述压敏粘合剂层的压敏粘合剂表面的剥离衬垫， 所述剥离衬垫在其表面上具有在使用所述贴片时支撑所述剥离衬垫剥离的切割线，所述贴片设置在所述包装中，使得所述剥离衬垫面向所述第一片材的内表面， 所述第一片材具有第一区域，其中所述第一片材的内表面面向所述剥离衬垫的切割线，所述第一片材在所述第一区域中具有所述第一片材的内表面与所述第一片材的内表面之间的最小第一距离， 释放衬垫的表面，并且第一片材的内表面在第一区域中以最小第一距离与释放衬垫的表面间隔开。
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公开(公告)号：US20080172015A1
公开(公告)日：2008-07-17
申请号：US11972910
申请日：2008-01-11
CPC分类号： A61F13/0203 , A61F13/551 , A61F15/001
摘要： The present invention provides a patch package structure, which includes: a package including a first sheet material which is planar and a second sheet material which has been molded, the first and second sheet materials being sealed together in peripheral parts thereof, and a patch disposed in the package, in which the patch contains a backing, a pressure-sensitive adhesive layer laminated on at least one side of the backing, and a release liner which protects a pressure-sensitive adhesive surface of the pressure-sensitive adhesive layer; the second sheet material has been molded so as to have a protrudent part in at least a substantially central area thereof, the protrudent part having a planar outer shape larger than a planar outer shape of the release liner and having at least one recessed part; d is not smaller than T, in which d is the minimum gap distance between the inner surface of the first sheet material and the inner surface of the second sheet material at the recessed part and T is a thickness of the patch; and, at the boundary between the sealed part where the first and second sheet materials are sealed together and an unsealed part, the outer surface of the second sheet material rises at an obtuse angle.
摘要翻译： 本发明提供了一种贴片包装结构，其包括：包括平面的第一片材和已经模制的第二片材的封装，第一和第二片材在其周边部分被密封在一起，并且贴片布置 在其中贴片包含背衬的包装中，层压在背衬的至少一侧上的压敏粘合剂层和保护压敏粘合剂层的压敏粘合剂表面的剥离衬垫; 第二片材已经被模制成在其至少大致中心区域具有突出部分，突出部分具有比剥离衬垫的平面外形大的平面外形，并且具有至少一个凹部; d不小于T，其中d是第一片材的内表面和凹陷部分的第二片材的内表面之间的最小间隙距离，T是贴片的厚度; 并且在第一和第二片材密封在一起的密封部分与未密封部分之间的边界处，第二片材的外表面以钝角上升。
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公开(公告)号：US07029693B2
公开(公告)日：2006-04-18
申请号：US09946889
申请日：2001-09-05
CPC分类号： A61K9/7061
摘要： A percutaneously absorptive preparation is provided, which preparation having a support and an adhesive layer having a release-controlling layer, which is formed at least on one side of the support, wherein the adhesive layer contains an adhesive and 0.5–60 wt % of a drug except 1,2-ethanediol derivatives.
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公开(公告)号：US20060034900A1
公开(公告)日：2006-02-16
申请号：US11196935
申请日：2005-08-04
申请人： Yuji Saeki , Masato Nishimura , Kensuke Matsuoka , Takateru Muraoka , Yoshifumi Hosaka , Mitsuhiko Hori , Kazuhisa Ninomiya , Hitoshi Akemi , Hidetoshi Kuroda
发明人： Yuji Saeki , Masato Nishimura , Kensuke Matsuoka , Takateru Muraoka , Yoshifumi Hosaka , Mitsuhiko Hori , Kazuhisa Ninomiya , Hitoshi Akemi , Hidetoshi Kuroda
IPC分类号： A61K31/445 , A61F13/02
CPC分类号： A61K9/7053 , A61K31/4468
摘要： The present invention provides a Fentanyl-containing percutaneously absorbable adhesive preparation, which is obtained from economic starting materials, has a constitution simpler than that of conventional ones, has sufficient skin permeability, and which permits control of skin permeability by changing the mixing ratio of two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid. Specifically, the present invention provides a percutaneously absorbable adhesive preparation comprising a support and an adhesive layer laminated on one surface thereof, wherein the adhesive layer comprises Fentanyl, two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid compatible with the aforementioned two kinds of polyisobutylene and the aforementioned tackifier.
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公开(公告)号：US20140158571A1
公开(公告)日：2014-06-12
申请号：US14232358
申请日：2012-07-13
申请人： Kensuke Matsuoka , Yoshihiro Iwao , Jun Harima , Masakatsu Konno , Kazuhiro Aoyagi , Tomoya Tanaka , Mikio Toyota , Yasuhiko Akita , Tadashi Matsui
发明人： Kensuke Matsuoka , Yoshihiro Iwao , Jun Harima , Masakatsu Konno , Kazuhiro Aoyagi , Tomoya Tanaka , Mikio Toyota , Yasuhiko Akita , Tadashi Matsui
IPC分类号： A61J1/00
CPC分类号： A61J1/00 , A61F13/00076 , A61F2013/00646 , A61F2013/00906
摘要： A packaging structure (100) for a patch includes a first and second base materials (120, 130) which have a peripheral edge part laminated with each other, and the patch is included therein. The first and second base materials (120, 130) have a first to forth sides (121 to 124, 131-134). At least one of the first and second base materials (120, 130) has a first to third opening parts (125 to 127, 135 to 137). The first to third opening parts (125 to 127, 135 to 137) guides so as to open toward the inner peripheral edge (120c1, 120c2, 120c4, 130c1, 130c2, 130c4) of the sealing part (120c, 130c).
摘要翻译： 用于贴片的包装结构（100）包括具有彼此层压的周缘部分的第一和第二基底材料（120,130），并且其中包括贴片。 第一和第二基材（120,130）具有第一至第四侧（121至124,131-134）。 第一和第二基底材料（120,130）中的至少一个具有第一至第三开口部分（125至127,135至137）。 第一至第三开口部（125〜127,135〜137）引导朝向密封部（120c，130c）的内周缘（120c1,120c2,120c4,130c1,130c2,130c4）开口。
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公开(公告)号：US08703178B2
公开(公告)日：2014-04-22
申请号：US12528194
申请日：2008-03-06
IPC分类号： A61K9/70 , A61K31/138 , A61P9/00
CPC分类号： A61K31/138 , A61K9/7053 , A61K9/7061
摘要： The present invention relates to a percutaneous administration device of bisoprolol, which includes a backing; and a pressure-sensitive adhesive layer containing bisoprolol, which is laminated on one surface of the backing, wherein the maximum value of a release rate of bisoprolol during a period of from immediately after the application on skin until a lapse of 24 hours is 30 μg/cm2/hr or less; and wherein the release rate of bisoprolol at the time of a lapse of 24 hours after the application on skin is 10 μg/cm2/hr or less. The percutaneous administration device of the present invention is reduced in the skin irritation during the application, especially at the time of peeling, and is capable of persistently administrating a therapeutically or preventively effective amount of bisoprolol into a living body.
摘要翻译： 本发明涉及比索洛尔的经皮给药装置，其包括背衬; 以及层压在背衬的一个表面上的含有比索洛尔的压敏粘合剂层，其中在施用于皮肤上直到24小时之后的期间，比索洛尔的释放速率的最大值为30μg / cm 2 / hr以下; 并且其中在皮肤上施用后24小时时比索洛尔的释放速率为10μg/ cm 2 / hr以下。 本发明的经皮给药装置，特别是剥离时，皮肤刺激性降低，能够将治疗或预防有效量的比索洛尔施用于生物体。
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公开(公告)号：US08309119B2
公开(公告)日：2012-11-13
申请号：US12071867
申请日：2008-02-27
IPC分类号： A61K9/70 , A61K31/4468 , A61F13/02
CPC分类号： A61L24/0015 , A61L15/58 , A61L24/04 , A61L2300/402
摘要： The present invention aims at providing an adhesive preparation wherein a drug is sufficiently dissolved in an adhesive layer and is not easily separated from the adhesive layer even during preservation of the adhesive preparation.The present invention provides an adhesive preparation having an adhesive layer on at least one surface of a support, wherein the adhesive layer comprises a first synthetic rubber having a viscosity average molecular weight of 1,600,000-6,500,000, a drug, an organic liquid component and a tackifier. The present invention further provides the aforementioned adhesive preparation, wherein the organic liquid component is contained in the adhesive layer in a proportion of 20 wt % or above relative to the total weight of the adhesive layer.
摘要翻译： 本发明的目的在于提供一种粘合剂制剂，其中药物在粘合剂层中充分溶解，并且即使在粘合剂制备过程中也不容易与粘合层分离。 本发明提供一种在支撑体的至少一个表面上具有粘合剂层的粘合剂制剂，其中粘合剂层包括粘均分子量为1,600,000-6,500,000的第一合成橡胶，药物，有机液体组分和增粘剂 。 本发明还提供了上述粘合剂制剂，其中粘合剂层中的有机液体组分相对于粘合剂层的总重量为20重量％以上。
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公开(公告)号：US20120189796A1
公开(公告)日：2012-07-26
申请号：US13357718
申请日：2012-01-25
IPC分类号： B32B33/00
CPC分类号： A61K9/703 , A61F2013/00646 , A61K9/7053 , A61M35/00 , Y10T428/1476
摘要： The present invention relates to a sheet-shaped patch including a pressure-sensitive adhesive layer on one surface of a backing to provide a pressure-sensitive adhesive surface showing adhesiveness at ordinary temperature and further including a release liner covering the pressure-sensitive adhesive surface. More specifically, the present invention relates to a sheet-shaped patch where the release liner is formed in a state of being splittable by a parting line. The patch ensures that the pressure-sensitive adhesive surface can be kept from being largely exposed due to slight stress before use and at the same time, the release liner can be easily split when using the patch.
摘要翻译： 本发明涉及一种片状贴片，其包括在背衬的一个表面上的压敏粘合剂层，以提供在常温下显示粘合性的压敏粘合剂表面，并且还包括覆盖该压敏粘合剂表面的剥离衬垫。 更具体地，本发明涉及一种片状贴片，其中剥离衬垫形成为可由分型线分割的状态。 该贴剂确保了压敏粘合剂表面在使用之前由于轻微的应力而能够被大大暴露，并且同时使用贴片时可以容易地分离剥离衬垫。
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公开(公告)号：US20110243998A1
公开(公告)日：2011-10-06
申请号：US13074911
申请日：2011-03-29
申请人： Sachiko SAKAMOTO , Akinori Hanatani , Arimichi Okazaki , Hitoshi Akemi , Yoshihiro Iwao , Kensuke Matsuoka
发明人： Sachiko SAKAMOTO , Akinori Hanatani , Arimichi Okazaki , Hitoshi Akemi , Yoshihiro Iwao , Kensuke Matsuoka
IPC分类号： A61K9/00 , A61K31/445 , A61K31/4174 , A61K31/34 , A61K31/192 , A61K31/195 , A61K31/4152 , A61K31/46
CPC分类号： A61K9/7061 , A61K9/7053
摘要： The invention provides a patch preparation containing (a) a support and (b) an adhesive layer containing a drug on the surface of the support, wherein a crystal of the drug is formed in the adhesive layer immediately after application of a physical stimulation to the adhesive layer, while a crystal of the drug is formed during preservation after the physical stimulation. The patch preparation which does not require an increase in the area and thickness of an adhesive layer, achieves a sufficiently high skin permeation amount of the drug, shows good adhesiveness to skin, and permits a long-term adhesion to skin. The invention also provides a method of producing the patch preparation.
摘要翻译： 本发明提供了一种补片制剂，其包含（a）支持物和（b）在载体表面上含有药物的粘合剂层，其中在施加物理刺激之后立即在粘合剂层中形成药物的晶体 而在物理刺激后的保存期间形成药物的晶体。 不需要增加粘合剂层的面积和厚度的贴片制剂能够获得足够高的皮肤渗透量的药物，对皮肤具有良好的粘附性，并且可以长期粘附到皮肤上。 本发明还提供一种制备贴剂的方法。
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公开(公告)号：US20100122927A1
公开(公告)日：2010-05-20
申请号：US12618931
申请日：2009-11-16
IPC分类号： B65D83/00
CPC分类号： B65D75/366 , B65D2215/00
摘要： Provision of a blister package that cannot be opened easily by infants, but can be opened easily, certainly and safely by a user when in use. A blister package 100 containing a blister 1 and a cover sheet 2, wherein the blister has a groove 3 formed in an outer edge section 1A thereof where the cover sheet is adhered and the groove 3 is free of adhesion of the sheet. The cover sheet is adhered to the outermost circumference 1a of the outer edge section 1A, the groove 3 is formed on the inward side of the outermost circumference 1a, and the cover sheet is not adhered to the area on the inward side of the groove 3.
摘要翻译： 提供婴儿不能轻松打开的泡罩包装，但使用时可以方便，安全地打开。 包含泡罩1和覆盖片2的泡罩包装100，其中泡罩具有形成在其外缘部分1A中的覆盖片粘附的槽3，并且槽3没有片材的粘附。 覆盖片附着在外缘部1A的最外周1a上，槽3形成在最外周1a的内侧，覆盖片不粘附在槽3的内侧的区域 。
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