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    System and method using multiple timing channels for electrode adjustment during set up of an implanted stimulator device
    21.
    发明授权
    System and method using multiple timing channels for electrode adjustment during set up of an implanted stimulator device 有权
    在植入的刺激器装置的设置期间，使用多个定时通道进行电极调节的系统和方法

    公开(公告)号：US07805197B2

    公开(公告)日：2010-09-28

    申请号：US11399876

    申请日：2006-04-07

    申请人： Kerry Bradley

    发明人： Kerry Bradley

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36125 ,  A61N1/0526 ,  A61N1/0551 ,  A61N1/36185

    摘要： Methods using multiple timing channels for electrode adjustment during set up of an implanted stimulator device are disclosed. In one embodiment, at least two conditions of electrodes (i.e., electrode combinations, pulse widths, pulse frequencies, pulse amplitudes) can be “simultaneously” tested by providing each condition in its own timing channel. In a preferred embodiment, the pulses in each of the timing channels are interleaved and non-overlapping to preserve the ability of the patient to assess the therapeutic feel of both and to allow some time between pulses for recovery. As well as allowing two sets of electrode conditions to be gauged at the same time, the technique allows the electrode to be manipulated during set up with ease and with a reduced possibility of providing the patient with erroneous results. For example, the two conditions in the two timing channels can comprise initial and target final conditions, and transitioning between from one to the other during device set up is facilitated as compared to the prior art because concerns with electrodes having inconsistent properties in both conditions are alleviated.

    摘要翻译： 公开了在植入的刺激器装置的设置期间使用多个定时通道用于电极调节的方法。 在一个实施例中，通过在其自己的定时通道中提供每个条件，可以“同时”测试电极的至少两个条件（即，电极组合，脉冲宽度，脉冲频率，脉冲幅度）。 在优选实施例中，每个定时通道中的脉冲是交错的和不重叠的，以保持患者评估两者的治疗感觉并且允许用于恢复的脉冲之间的一些时间的能力。 同时允许同时测量两组电极条件，该技术允许在设置期间容易地操作电极，并且降低为患者提供错误结果的可能性。 例如，两个定时通道中的两个条件可以包括初始和目标最终条件，并且与现有技术相比，便于在设备设置期间从一个到另一个之间的转换，因为在两个条件下具有不一致特性的电极的关注是 缓解

    SYSTEM AND METHOD FOR CONVERTING TISSUE STIMULATION PROGRAMS IN A FORMAT USABLE BY AN ELECTRICAL CURRENT STEERING NAVIGATOR
    24.
    发明申请
    SYSTEM AND METHOD FOR CONVERTING TISSUE STIMULATION PROGRAMS IN A FORMAT USABLE BY AN ELECTRICAL CURRENT STEERING NAVIGATOR 有权
    用于电流转向导管可用的格式转换组织刺激方案的系统和方法

    公开(公告)号：US20100010566A1

    公开(公告)日：2010-01-14

    申请号：US12501282

    申请日：2009-07-10

    申请人： James R. Thacker ,  Michael Moffitt ,  Kerry Bradley ,  David K.L. Peterson

    发明人： James R. Thacker ,  Michael Moffitt ,  Kerry Bradley ,  David K.L. Peterson

    IPC分类号： A61N1/08 ,  A61N1/34

    CPC分类号： A61N1/37264 ,  A61N1/36071 ,  A61N1/36146 ,  A61N1/3615 ,  A61N1/36167 ,  A61N1/36185 ,  A61N1/37247 ,  G06F19/00 ,  G16H40/63

    摘要： A method, computer medium, and system for programming a controller is provided. The controller controls electrical stimulation energy output to electrodes, and stores a set of programmed stimulation parameters associated with the electrodes. The programmed stimulation parameter set is compared with sets of reference stimulation parameters, each of the reference sets of stimulation parameters being associated with the electrodes. If an identical match is determined between the programmed stimulation parameter set and any one of the reference stimulation parameter sets exists based on the comparison, the identically matched stimulation parameter set is selected as an initial stimulation parameter set. If an identical match does not exist, a best between the programmed stimulation parameter set and the reference stimulation parameter sets is determined and selected as the initial stimulation parameter set. The controller is then programmed with a new set of programmable stimulation parameters based on the initial stimulation parameter set.

    摘要翻译： 提供了一种用于编程控制器的方法，计算机介质和系统。 控制器控制对电极的电刺激能量输出，并且存储与电极相关联的一组编程的刺激参数。 将编程的刺激参数集与参考刺激参数的集合进行比较，每个参考组的刺激参数与电极相关联。 如果在编程的刺激参数集之间确定相同的匹配，并且基于比较存在参考刺激参数集中的任一个，则选择相同匹配的刺激参数集作为初始刺激参数集。 如果不存在相同的匹配，则确定编程的刺激参数集和参考刺激参数集之间的最佳值，并将其选为初始刺激参数集。 然后基于初始刺激参数集，控制器用一组新的可编程刺激参数进行编程。

    Method and apparatus for monitoring drug effects on cardiac electrical signals using an implantable cardiac stimulation device
    27.
    发明授权
    Method and apparatus for monitoring drug effects on cardiac electrical signals using an implantable cardiac stimulation device 有权
    使用可植入心脏刺激装置监测对心脏电信号的药物作用的方法和装置

    公开(公告)号：US07142911B2

    公开(公告)日：2006-11-28

    申请号：US10608409

    申请日：2003-06-26

    申请人： Peter Boileau ,  Janice Barstad ,  Gene A. Bornzin ,  Kerry Bradley ,  Eric Falkenberg ,  Joseph J. Florio

    发明人： Peter Boileau ,  Janice Barstad ,  Gene A. Bornzin ,  Kerry Bradley ,  Eric Falkenberg ,  Joseph J. Florio

    IPC分类号： A61N1/365 ,  A61N1/362

    CPC分类号： A61N1/3622 ,  A61B5/0031 ,  A61B5/04525 ,  A61B5/4839 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2205/3523 ,  A61M2205/3553 ,  A61M2230/10 ,  G06F19/00 ,  G06F19/3456 ,  G06F19/3481 ,  G16H50/20 ,  Y10S514/821

    摘要： An implantable cardiac stimulation device, such as a pacemaker or Implantable Cardioverter Defibrillator, is configured to automatically monitor the effects of antiarrhythmic drugs on cardiac electrical signals within a patient to verify the efficacy of the drugs taken. In one example, an analysis of patient cardiac electrical signals is performed by comparing the cardiac electrical signals with values representative of the effects of different classes of antiarrhythmic drugs. If the implantable device determines that the prescribed antiarrhythmic drugs have not been effective, a warning signal is generated. The warning signal is conveyed directly to the patient via a bedside monitor and to the patient's physician via remote connection to an external programmer device so that both are notified of the drug efficacy problems. Additionally, the implantable device may be configured to automatically adjust pacing and defibrillation control parameters in an attempt to compensate for any lack of efficacy in the drugs. For example, the aggressiveness of overdrive pacing may be increased. Alternatively, a drug pump is controlled to adjust the dosage of antiarrhythmic drugs if an initial dosage is found to be ineffective.

    摘要翻译： 可植入心脏刺激装置，例如起搏器或植入式心律转复除颤器，被配置为自动监测抗心律失常药物对患者内心脏电信号的影响，以验证所用药物的功效。 在一个示例中，通过将心脏电信号与代表不同类别的抗心律失常药物的作用的值进行比较来进行对患者心电信号的分析。 如果植入装置确定规定的抗心律不齐药物没有效果，则产生警告信号。 警告信号通过床边监护仪直接传送给患者，并通过与外部编程器设备的远程连接向病人的医生传送，以便两者被通知药物功效问题。 另外，可植入装置可被配置为自动调节起搏和除颤控制参数，以试图补偿药物中的任何功效缺乏。 例如，可能会增加超速起搏的积极性。 或者，如果发现初始剂量无效，则控制药物泵以调节抗心律失常药物的剂量。

    System and method for choosing electrodes in an implanted stimulator device
    29.
    发明申请
    System and method for choosing electrodes in an implanted stimulator device 审中-公开
    用于在植入的刺激器装置中选择电极的系统和方法

    公开(公告)号：US20060195159A1

    公开(公告)日：2006-08-31

    申请号：US11295168

    申请日：2005-12-05

    申请人： Kerry Bradley ,  Ljubomir Manola ,  Jan Holsheimer

    发明人： Kerry Bradley ,  Ljubomir Manola ,  Jan Holsheimer

    IPC分类号： A61N1/18

    CPC分类号： A61N1/36135 ,  A61N1/36132 ,  A61N1/36185

    摘要： A method of selecting of subset of electrodes in a stimulator device implanted in a patient for further clinical evaluation is disclosed. In one embodiment, the method comprises measuring at least first and second measurement for each of the plurality of electrodes that are indicative of the ability of the electrode if activated to provide useful therapy to the patient in which the stimulator device is implanted, such as electrode impedance, field potential, and nerve response. The measurements can be objective such as those measurements just mentioned, or can comprise subjective measurements which are quantified in response to qualitative feedback from the patient. A weight is then determined for each of the measurements, which may be a predetermined weight or determined on the basis of the variance of the measurement between the electrodes. The weight is then applied to each electrode measurement, which measurement may be normalized, and the weighted measurements for each electrode are preferably summed to arrive at a value which itself is indicative of a particular electrode's ability to provide useful therapy to the patient. These values can then be used to determine a subset of the electrodes useful for further clinical evaluation in the patient, which improved the accuracy and speeding determining appropriate patient therapy.

    摘要翻译： 公开了一种在植入患者中的刺激器装置中选择电极子集的方法，用于进一步的临床评价。 在一个实施例中，该方法包括测量多个电极中的每个电极的至少第一和第二测量，其指示如果被激活的电极的能力为其中植入刺激器装置的患者提供有用的治疗，例如电极 阻抗，场电位和神经反应。 测量可以是客观的，例如刚刚提到的那些测量，或者可以包括根据来自患者的定性反馈量化的主观测量。 然后为每个测量确定权重，其可以是预定权重，或者基于电极之间的测量方差来确定。 然后将重量施加到每个电极测量，该测量可以被归一化，并且优选地将每个电极的加权测量相加以得到其本身指示特定电极向患者提供有用治疗的能力的值。 然后可以使用这些值来确定用于患者进一步临床评估的电极子集，这提高了准确性并加快了确定适当的患者治疗。

    System and method for automatically verifying capture during multi-chamber stimulation
    30.
    发明授权
    System and method for automatically verifying capture during multi-chamber stimulation 有权

    公开(公告)号：US07085603B1

    公开(公告)日：2006-08-01

    申请号：US10353104

    申请日：2003-01-27

    申请人： Joseph J. Florio ,  Euljoon Park ,  Kerry Bradley ,  Gene A. Bornzin

    发明人： Joseph J. Florio ,  Euljoon Park ,  Kerry Bradley ,  Gene A. Bornzin

    IPC分类号： A61N1/365

    CPC分类号： A61N1/3712 ,  A61N1/3627

    摘要： A system and corresponding method are provided to reliably detect capture during multi-chamber stimulation, and to further monitor the progression of congestive heart failure. The system provides a method by which intracardiac electrogram (IEGM) characteristics representing single-chamber capture and bi-ventricular capture are stored in memory and displayed. The annotation of the displayed waveforms is such that events associated with loss of capture, single-chamber capture, and bi-ventricular capture are clearly marked for ready interpretation by the physician. In a first situation, a stimulation pulse is followed by a time delay window and a subsequent depolarization complex that represents intrinsic responses of the chambers that have not been captured. In a second situation, a stimulation pulse is followed almost immediately by an evoked response that represents capture of one chamber, and a subsequent depolarization complex that represents an intrinsic response of one chamber that has not been captured. In a third situation, a stimulation pulse is almost immediately followed by an evoked response that represents simultaneous capture of two chambers.