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    PROGNOSTIC METHODS, COMPOSITIONS AND KITS FOR PREDICTION OF ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) RELAPSE
    25.
    发明申请
    PROGNOSTIC METHODS, COMPOSITIONS AND KITS FOR PREDICTION OF ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) RELAPSE 审中-公开
    预防性淋巴细胞白血病（ALL）相关的预防方法，组合物和试剂盒

    公开(公告)号：US20160222464A1

    公开(公告)日：2016-08-04

    申请号：US15014074

    申请日：2016-02-03

    Applicant: Mor Research Applications Ltd.

    Inventor： Smadar Avigad ,  Isaac Yaniv

    IPC: C12Q1/68

    Abstract: The present invention relates to prognostic methods and kits for the assessment and monitoring of relapse-free or disease-free survival of ALL patients. The detection is based on the use of detecting nucleic acids, specific for determination of the expression of at least one of miR-151-5p and miR-451 in a test sample. The invention thereby also provides methods and kits for monitoring and early diagnosis of cancerous disorders associated with low miR-151-5p and/or miR-451 expression, specifically ALL, and appropriate associated treatments thereof.

    Abstract translation: 本发明涉及用于评估和监测ALL患者无复发或无病生存的预后方法和试剂盒。 该检测基于检测核酸的用途，其特异性用于确定测试样品中miR-151-5p和miR-451中的至少一种的表达。 因此，本发明还提供了用于监测和早期诊断与低miR-151-5p和/或miR-451表达（特别是ALL）相关的癌症的方法和试剂盒及其适当的相关治疗。

    TREATMENTS FOR FIBROTIC DISEASES
    26.
    发明申请
    TREATMENTS FOR FIBROTIC DISEASES 审中-公开
    纤维性疾病治疗

    公开(公告)号：US20160206591A1

    公开(公告)日：2016-07-21

    申请号：US15083370

    申请日：2016-03-29

    Applicant: MOR RESEARCH APPLICATIONS LTD.

    Inventor： Ayala Pollack ,  Zeev Dvashi

    IPC: A61K31/335 ,  C07K16/40

    CPC classification number: A61K31/335 ,  A61K31/365 ,  C07K16/40

    Abstract: Disclosed herein are methods for treatment for fibrosis, ocular pathologies associated with fibrosis, including proliferative vitreoretinopathy (PVR) by inhibiting the activity of activated transforming growth factor β activated kinase 1 (TAK1), or activation thereof. Pharmaceutical compositions for use in the described treatments are also provided.

    Abstract translation: 本文公开了通过抑制活化的转化生长因子和活性的活性来治疗纤维化，与纤维化相关的眼部病理学的方法，包括增殖性玻璃体视网膜病变（PVR） 活化激酶1（TAK1）或其活化。 还提供了用于所述治疗的药物组合物。

    DEVICE FOR PLACEMENT IN THE TRICUSPID ANNULUS
    27.
    发明申请
    DEVICE FOR PLACEMENT IN THE TRICUSPID ANNULUS 有权
    TRICUSPID ANNULUS中的放置装置

    公开(公告)号：US20160184098A1

    公开(公告)日：2016-06-30

    申请号：US15066051

    申请日：2016-03-10

    Applicant: Mor Research Applications Ltd.

    Inventor： Mordehay VATURI

    IPC: A61F2/24

    CPC classification number: A61F2/24 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2454 ,  A61F2/246 ,  A61F2/2463

    Abstract: A device (200) for implantation in or near an annulus of a tricuspid valve comprising at least one blood flow control element (202) adapted to capture a volume of blood therein. Optionally or alternatively, the blood flow control element is adapted to allow at least some volume of blood (406) to regurgitate through the annulus during at least some part of systole. Optionally or alternatively, the device comprises a relatively rigid annulus with an arc length of less than 300 degrees. Optionally or alternatively, the relatively rigid annulus comprises a plurality of tissue fixation elements positioned along no more than 300 degrees of a circumference of the annulus, for example to avoid damaging conduction pathways between an atria and a chamber.

    Abstract translation: 一种用于植入三尖瓣环或其附近的装置（200），包括适于捕获一定体积的血液的至少一个血流控制元件（202）。 任选地或替代地，血流控制元件适于允许至少一定体积的血液（406）在至少一部分收缩期间通过环带回流。 可选地或替代地，该装置包括弧形长度小于300度的相对刚性的环形空间。 可选地或替代地，相对刚性的环形空间包括多个组织固定元件，所述多个组织固定元件沿环形圆周不超过300度定位，例如以避免损坏心房和腔室之间的传导路径。

    ADJUSTABLE ANNULOPLASTY APPARATUS
    28.
    发明申请
    ADJUSTABLE ANNULOPLASTY APPARATUS 审中-公开
    可调节的ANNULOPLASTY装置

    公开(公告)号：US20160008130A1

    公开(公告)日：2016-01-14

    申请号：US14770842

    申请日：2014-02-27

    Applicant: MOR RESEARCH APPLICATIONS LTD. ,  RAMBAM HEALTH CORPORATION

    Inventor： Tal HASIN

    IPC: A61F2/24

    CPC classification number: A61F2/2445 ,  A61F2/2418 ,  A61F2/2454 ,  A61F2/2466 ,  A61F2230/001 ,  A61F2230/0069 ,  A61F2250/001 ,  A61F2250/006

    Abstract: An adjustable implantable annuloplasty apparatus suited for post-implantation adjustments according to changing needs of the patient. The apparatus comprises a ring shaped main body, and a designated adjustment section extending from the main body. The main body and designated adjustment section of a deployed apparatus are fully contained within a 5 cm diameter. Optionally, the apparatus is mechanically adjusted in a minimally invasive procedure, for example by engaging the designated adjustment section using a balloon catheter. Optionally, the apparatus is adjusted at least one month post implantation.

    Abstract translation: 一种可调节植入式瓣膜成形术装置，适合于根据患者不断变化的需要进行植入后调整。 该装置包括环形主体和从主体延伸的指定的调节部。 展开装置的主体和指定的调节部分完全包含在5厘米直径内。 可选地，该装置以微创程序机械地调节，例如通过使用球囊导管接合指定的调整部分。 任选地，在植入后至少一个月调整该装置。

    MIDDLE EAR PROSTHESIS
    29.
    发明申请
    MIDDLE EAR PROSTHESIS 审中-公开
    中年前景

    公开(公告)号：US20150039088A1

    公开(公告)日：2015-02-05

    申请号：US14385956

    申请日：2013-03-14

    Applicant: MOR RESEARCH APPLICATIONS LTD.

    Inventor： Salim Mazzawi

    IPC: A61F2/18

    CPC classification number: A61F2/18 ,  A61F2002/183

    Abstract: A middle ear prosthesis (40) is provided for mounting in the middle ear (4). The middle ear prosthesis comprises a shaft (42) having a distal end configured for the introduction into the inner ear (8) through an aperture (30) formed in a footplate (23) of a stapes bone and in a membrane of an oval window of the inner ear, by moving the shaft in an introduction direction, the shaft being configured for transmitting sound wave vibrations to the inner ear. The prosthesis further comprises a coupling portion (46), for coupling, the shaft to at least one of the ossicles (17) so as to allow transmitting thereby sound wave vibrations from the ossicles to the shaft; and a stop member (48) spaced from the distal end of the shaft and configured for bearing against the remaining portions thereby limiting the movement of the shaft in the introduction direction.

    Abstract translation: 中耳假体（40）用于安装在中耳（4）中。 中耳假体包括轴（42），其具有构造成通过形成在镫骨的脚板（23）中的孔（30）并在椭圆形窗口的膜中引入内耳（8）的远端 通过沿着引导方向移动轴，所述轴构造成用于将声波振动传递到内耳。 所述假体还包括联接部分（46），用于将所述轴联接到所述小骨（17）中的至少一个，以便允许从所述小骨向所述轴传播声波振动; 以及与所述轴的远端间隔开并且被构造用于抵靠所述剩余部分的止动构件（48），从而限制所述轴在所述引入方向上的移动。

    DEVICE FOR PLACEMENT IN THE TRICUSPID ANNULUS
    30.
    发明申请
    DEVICE FOR PLACEMENT IN THE TRICUSPID ANNULUS 有权
    TRICUSPID ANNULUS中的放置装置

    公开(公告)号：US20140350662A1

    公开(公告)日：2014-11-27

    申请号：US14359646

    申请日：2012-11-21

    Applicant: Mor Research Applications Ltd.

    Inventor： Mordehay Vaturi

    IPC: A61F2/24

    CPC classification number: A61F2/24 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2454 ,  A61F2/246 ,  A61F2/2463

    Abstract: A device (200) for implantation in or near an annulus of a tricuspid valve comprising at least one blood flow control element (202) adapted to capture a volume of blood therein. Optionally or alternatively, the blood flow control element is adapted to allow at least some volume of blood (406) to regurgitate through the annulus during at least some part of systole. Optionally or alternatively, the device comprises a relatively rigid annulus with an arc length of less than 300 degrees. Optionally or alternatively, the relatively rigid annulus comprises a plurality of tissue fixation elements positioned along no more than 300 degrees of a circumference of the annulus, for example to avoid damaging conduction pathways between an atria and a chamber.

    Abstract translation: 一种用于植入三尖瓣环或其附近的装置（200），包括适于捕获一定体积的血液的至少一个血流控制元件（202）。 任选地或替代地，血流控制元件适于允许至少一定体积的血液（406）在至少一部分收缩期间通过环带回流。 可选地或替代地，该装置包括弧形长度小于300度的相对刚性的环形空间。 可选地或替代地，相对刚性的环形空间包括多个组织固定元件，所述多个组织固定元件沿环形圆周不超过300度定位，例如以避免损坏心房和腔室之间的传导路径。

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