公开(公告)号：US07326788B2

公开(公告)日：2008-02-05

申请号：US10894940

申请日：2004-07-20

Applicant: Mark J. Wall ,  Mark R. Player ,  Raymond Joseph Patch ,  Sanath Meegalla ,  Jian Liu ,  Carl R. Illig ,  Wing Cheung ,  Jinsheng Chen ,  Davoud Asgari

Inventor： Mark J. Wall ,  Mark R. Player ,  Raymond Joseph Patch ,  Sanath Meegalla ,  Jian Liu ,  Carl R. Illig ,  Wing Cheung ,  Jinsheng Chen ,  Davoud Asgari

IPC: C07D215/38 ,  C07D215/44

CPC classification number: C07D215/227 ,  C07D401/04 ,  C07D409/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  Y02P20/582

Abstract: The invention is directed to compounds of Formulae I and II: wherein R1, R2, R3, R5, R6, Y1, Y2, Y3, Y4 and X are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.

Abstract translation: 本发明涉及式I和II的化合物：其中R 1，R 2，R 3，R 5， 其中，R 6，R 6，Y 1，Y 2，Y 3，Y 4， SUP＆amp; X和X在本说明书中列出，以及其抑制蛋白酪氨酸激酶，特别是c-fms激酶的溶剂合物，水合物，互变异构体或其药学上可接受的盐。

公开(公告)号：US08232409B2

公开(公告)日：2012-07-31

申请号：US12576283

申请日：2009-10-09

Applicant: Mark R. Player ,  Daniel J. Parks ,  William Parsons ,  Sanath K. Meegalla ,  Carl R. Illig ,  Shelley K. Ballentine

Inventor： Mark R. Player ,  Daniel J. Parks ,  William Parsons ,  Sanath K. Meegalla ,  Carl R. Illig ,  Shelley K. Ballentine

IPC: A61K31/4188 ,  A61K31/4184 ,  A61K31/422 ,  A61K31/437 ,  C07D405/00 ,  C07D413/04 ,  C07D413/14

CPC classification number: C07D261/20 ,  C07D263/52 ,  C07D403/04 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04 ,  C07D498/10

Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein W1, W2, W3, R1, R1a, R2, R2a, R3, V, Q, and X are defined herein.

Abstract translation: 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中W1，W2，W3，R1，R1a，R2，R2a，R3，V，Q和X如本文所定义。

公开(公告)号：US08217060B2

公开(公告)日：2012-07-10

申请号：US12773083

申请日：2010-05-04

Applicant: Raul R. Calvo ,  Sanath K. Meegalla ,  Mark R. Player

Inventor： Raul R. Calvo ,  Sanath K. Meegalla ,  Mark R. Player

IPC: A61K31/41 ,  A61K31/415

CPC classification number: C07D235/08 ,  C07D235/10 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06

Abstract: The present invention is directed to benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8 (transient receptor potential M8 channel). More particularly, the compounds of the present invention are useful in the treatment of inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold, anxiety and depression.

Abstract translation: 本发明涉及苯并咪唑衍生物，含有它们的药物组合物及其在治疗由TRP M8（瞬时受体电位M8通道）调节的病症和状况中的用途。 更具体地说，本发明的化合物可用于治疗炎症性疼痛，炎性痛觉过敏，炎性过敏症状，神经性疼痛，神经性寒冷异常性疼痛，炎症性体征痛觉过敏，炎性内脏痛觉过敏，由冷，焦虑和抑郁加重的心血管疾病。

公开(公告)号：US07829584B2

公开(公告)日：2010-11-09

申请号：US11685544

申请日：2007-03-13

Applicant: Mark R. Player ,  Tianbao Lu ,  Huaping Hu ,  Xizhen Zhu ,  Christopher Teleha ,  Kevin Kreutter

Inventor： Mark R. Player ,  Tianbao Lu ,  Huaping Hu ,  Xizhen Zhu ,  Christopher Teleha ,  Kevin Kreutter

IPC: C07D213/00 ,  A61K31/44

CPC classification number: C07D213/89 ,  C07D213/74 ,  C07D213/84 ,  C07D401/14 ,  C07D413/14

Abstract: The present invention describes compounds of Formula I: wherein W, X, Y, Z, and Q are defined herein, or a pharmaceutically acceptable salt thereof, for the prophylaxis, or treatment of diseases and conditions related to thrombin activity in a mammal.

Abstract translation: 本发明描述了式I的化合物：其中W，X，Y，Z和Q在本文中定义，或其药学上可接受的盐，用于预防或治疗与哺乳动物中凝血酶活性相关的疾病和病症。

公开(公告)号：US07829566B2

公开(公告)日：2010-11-09

申请号：US11300626

申请日：2005-12-14

Applicant: Werner Mederski ,  Ralf Devant ,  Gerhard Barnickel ,  Sabine Bernotat-Danielowski ,  James Vickers ,  Bertram Cezanne ,  Daljit Dhanoa ,  Bao-Ping Zhao ,  James Rinker ,  Mark R. Player ,  Edward Jaeger ,  Richard Soll

Inventor： Werner Mederski ,  Ralf Devant ,  Gerhard Barnickel ,  Sabine Bernotat-Danielowski ,  James Vickers ,  Bertram Cezanne ,  Daljit Dhanoa ,  Bao-Ping Zhao ,  James Rinker ,  Mark R. Player ,  Edward Jaeger ,  Richard Soll

IPC: A61K31/497 ,  A61K31/517 ,  A61K31/535 ,  C07D239/84 ,  C07D413/10

CPC classification number: C07D239/94 ,  C07D403/12 ,  C07D405/12 ,  C07D409/10 ,  C07D409/14 ,  C07D413/12

Abstract: Quinazolines of the formula I in which R, R1, R2, R3, R4 and Y have the meaning indicated in Patent Claim 1, and their salts or solvates as glycoprotein IbIX antagonists.

Abstract translation: 其中R，R1，R2，R3，R4和Y具有专利权利要求1中所示含义的式I的喹唑啉及其作为糖蛋白IbIX拮抗剂的盐或溶剂合物。

公开(公告)号：US07642270B2

公开(公告)日：2010-01-05

申请号：US11519611

申请日：2006-09-12

Applicant: Mark R. Player ,  Hui Huang ,  Daniel A. Hutta ,  Renee L. DesJarlais

Inventor： Mark R. Player ,  Hui Huang ,  Daniel A. Hutta ,  Renee L. DesJarlais

IPC: A61K31/44 ,  C07D471/06

CPC classification number: C07D471/04

Abstract: The invention addresses the current need for selective and potent protein tyrosine kinase inhibitors by providing potent inhibitors of c-fms kinase. The invention is directed to the novel compounds of Formula I: or a solvate, hydrate, tautomer or pharmaceutically acceptable salt thereof, wherein: W, A, Y, Z, R101 and R200 are described in the specification.

Abstract translation: 本发明通过提供c-fms激酶的有效抑制剂来解决当前对选择性和有效的蛋白酪氨酸激酶抑制剂的需要。 本发明涉及新的式I化合物：或其溶剂化物，水合物，互变异构体或其药学上可接受的盐，其中：W，A，Y，Z，R 101和R 002在本说明书中描述。