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公开(公告)号：US11458267B2
公开(公告)日：2022-10-04
申请号：US16754885
申请日：2018-10-17
发明人： John H. Hebrank , Christopher W. Maurer , Charles Eric Hunter , Chengjie Li , Louis Thomas Germinario
摘要： A nasal droplet delivery device and related methods for delivering precise and repeatable dosages to a subject via the nasal passageways and sinus cavities is disclosed. The droplet delivery device includes a housing, a nosepiece, a reservoir, an ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically actuated by the user when the differential pressure sensor senses a predetermined pressure change within the nosepiece. The droplet delivery device is then actuated to generate a plume of droplets having an average ejected particle diameter of greater than about 6 microns, preferably greater than about 10 micron, so as to target the nasal passageways and sinus cavities of the user.
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22.发明申请公开(公告)号：US20220296823A1
公开(公告)日：2022-09-22
申请号：US17619960
申请日：2020-06-29
摘要： An ejector mechanism, droplet delivery device and related methods or delivering small droplets to the respiratory system of a users disclosed. The ejector mechanism comprises a piezoelectric actuator and an aperture plate, the aperture plate having and a plurality of openings formed through its thickness, wherein at least the fluid entrance side of one or more of said openings is configured to provide a surface contact angle of less than 90 degrees and the piezoelectric actuator is operable to oscillate the aperture plate at a frequency to thereby generate an ejected stream of droplets during use. The droplet delivery device is automatically breath actuated by a user when the differential pressure sensor senses a predetermined pressure change. The ejector mechanism is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range having a diameter of less than about 4 um so as to target the respiratory system of the user.
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公开(公告)号：US11285285B2
公开(公告)日：2022-03-29
申请号：US16098805
申请日：2017-05-03
发明人： Louis Thomas Germinario , John H. Hebrank , Charles Eric Hunter , Thomas P. Stern , Jack C. Hunter
摘要： A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 μm, so as to target the pulmonary system of the user.
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24.发明申请公开(公告)号：US20190125987A1
公开(公告)日：2019-05-02
申请号：US16098805
申请日：2017-05-03
发明人： Louis Thomas Germinario , John H. Hebrank , Charles Eric Hunter , Thomas P. Stern , Jack C. Hunter
摘要： A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 μm, so as to target the pulmonary system of the user.
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25.发明申请公开(公告)号：US20180369515A1
公开(公告)日：2018-12-27
申请号：US16058857
申请日：2018-08-08
发明人： Louis Thomas Germinario , John H. Hebrank , Charles Eric Hunter , Jack C. Hunter , Chengjie Li , Christopher W. Maurer
摘要： A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 μm, so as to target the pulmonary system of the user.
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26.发明申请公开(公告)号：US20170319797A1
公开(公告)日：2017-11-09
申请号：US15596935
申请日：2017-05-16
发明人： Louis Thomas Germinario , John H. Hebrank , Charles Eric Hunter , Jack C. Hunter , Chengjie Li , Christopher W. Maurer
CPC分类号： A61M15/0021 , A61M11/003 , A61M15/00 , A61M15/0085 , A61M15/025 , A61M16/0051 , A61M16/0066 , A61M16/021 , A61M16/10 , A61M16/107 , A61M16/108 , A61M16/142 , A61M2016/0021 , A61M2016/0027 , A61M2016/0039 , A61M2205/33 , A61M2205/3306 , A61M2205/3569 , A61M2205/3592 , A61M2205/7536
摘要： A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 μm, so as to target the pulmonary system of the user.
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公开(公告)号：US20240269397A1
公开(公告)日：2024-08-15
申请号：US18382637
申请日：2023-10-23
发明人： Charles Eric Hunter , Michael Scoggin , Jeffrey Miller , Jose Salazar , Brian Beach , Caley Modlin , Matthew Culpepper , Jianqiang Li , Chengjie Li , Shi Bo Wang , Chao-Ping Lee , Gregory Rapp , Judson Sidney Clements
CPC分类号： A61M11/003 , A61M11/005 , A61M15/0001 , A61M15/002 , A61M15/0085 , A61M2206/11
摘要： A droplet delivery device includes a housing with a mouthpiece port or outlet from a nasal device for releasing fluid droplets, a fluid reservoir, and an ejector bracket having a membrane positioned between a mesh with a plurality of openings and a vibrating member that is coupled to an electronic transducer, such as an ultrasonic transducer. The transducer vibrates the vibrating member which causes the membrane to push fluid supplied by the reservoir through the mesh to generate droplets in an ejected stream released through the outlet.
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28.发明公开公开(公告)号：US20240226469A1
公开(公告)日：2024-07-11
申请号：US18454645
申请日：2023-08-23
发明人： John H. Hebrank , Christopher W. Maurer , Charles Eric Hunter , Chengjie Li , Louis Thomas Germinario
IPC分类号： A61M15/00
CPC分类号： A61M15/009 , A61M15/002 , A61M15/0021 , A61M15/003 , A61M15/008 , A61M2205/02 , A61M2205/076 , A61M2205/3331 , A61M2205/3553 , A61M2205/50 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/587
摘要： A droplet delivery device with a small volume drug ampoule and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device is configured to facilitate the ejection of small, e.g., single use, volumes of a therapeutic agent. The droplet delivery device includes a housing, a mouthpiece, a small volume drug ampoule, an ejector mechanism, and at least one differential pressure sensor. The delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range, e.g, less than about 5-6 μm, so as to target the pulmonary system of the user. The small volume drug ampoule may include a reservoir which comprises an internal flexible membrane separating two internal volumes, a first background pressure fluid volume and a second drug volume.
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公开(公告)号：US20240226462A1
公开(公告)日：2024-07-11
申请号：US18408349
申请日：2024-01-09
发明人： Charles Eric Hunter , Gregory Rapp
IPC分类号： A61M11/00
CPC分类号： A61M11/005 , A61M2205/18 , A61M2205/33
摘要： A droplet delivery device includes a high dose confidence mode that monitors a user's inhalation of a composition and activates and deactivates aerosol generation via monitoring the user's inhalation to assist the user to complete a full dosage when a user does not inhale a full dosage of the composition when using the device.
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公开(公告)号：US11738158B2
公开(公告)日：2023-08-29
申请号：US16651715
申请日：2018-10-04
发明人： John H. Hebrank , Charles Eric Hunter , Christopher W. Maurer , Chengjie Li , Louis Thomas Germinario
CPC分类号： A61M11/005 , A61M15/008 , A61M15/0026 , A61M2205/3331 , A61M2205/3592 , A61M2205/502 , A61M2205/581 , A61M2205/583 , A61M2205/587 , A61M2205/8206
摘要： An in-line droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The in-line droplet delivery device includes a housing, a mouthpiece, a reservoir, an ejector mechanism, and at least one differential pressure sensor. The in-line droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The in-line droplet delivery device is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range, e.g, less than about 5-6 μm, so as to target the pulmonary system of the user. the droplet delivery device is configured in an in-line orientation in that the housing, its internal components, and various device components (e.g., the mouthpiece, air inlet flow element, etc.) are orientated in a substantially in-line or parallel configuration (e.g., along the airflow path) so as to form a small, hand-held device.
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