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公开(公告)号：US20230356253A1
公开(公告)日：2023-11-09
申请号：US18311710
申请日：2023-05-03
发明人： Michael Scoggin , Jeffrey Miller , Caley Modlin , Chao-Ping Lee , Jianqiang Li
CPC分类号： B05B17/0646 , B05B1/083
摘要： A droplet delivery device includes an ejector plate having an overall area that includes an outer area that is solid without holes and inner, active area with holes.
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公开(公告)号：US20220080137A1
公开(公告)日：2022-03-17
申请号：US17425029
申请日：2020-01-23
摘要： Methods, devices and systems are provided wherein compositions are delivered to the pulmonary system of an intended user via inhalation in a controlled manner and at a desired doses and/or amounts, e.g., within a desired dosage window and/or inhalation topography. In certain embodiments, dosage windows and/or inhalation topography may be used, e.g., to provide for controlled cessation of use or to provide a desired therapeutic window.
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公开(公告)号：US20210106772A1
公开(公告)日：2021-04-15
申请号：US17044636
申请日：2019-04-02
摘要： A handheld digital nebulizer device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The handheld digital nebulizer device includes a housing having an exhalation valve, a reservoir, an ejector mechanism, and at least one differential pressure sensor. The handheld digital nebulizer device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The handheld digital nebulizer device is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range, e.g, less than about 5-6 μm, so as to target the pulmonary system of the user.
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4.发明申请公开(公告)号：US20190125985A1
公开(公告)日：2019-05-02
申请号：US16098800
申请日：2017-05-03
摘要： A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 μm, so as to target the pulmonary system of the user.
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5.发明申请公开(公告)号：US20190117907A1
公开(公告)日：2019-04-25
申请号：US16098721
申请日：2017-05-03
发明人： Louis Thomas Germinario , John H. Hebrank , Charles Eric Hunter , Jack C. Hunter , Chemgjie Li , Christopher W. Maurer
摘要： A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 μm, so as to target the pulmonary system of the user.
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6.发明申请公开(公告)号：US20180344955A1
公开(公告)日：2018-12-06
申请号：US15910826
申请日：2018-03-02
发明人： Louis Thomas Germinario , John H. Hebrank , Charles Eric Hunter , Jack C. Hunter , Chengjie Li , Christopher W. Maurer
CPC分类号： A61M15/0021 , A61M11/003 , A61M15/00 , A61M15/0085 , A61M15/025 , A61M16/0051 , A61M16/0066 , A61M16/021 , A61M16/10 , A61M16/107 , A61M16/108 , A61M16/142 , A61M2016/0021 , A61M2016/0027 , A61M2016/0039 , A61M2205/33 , A61M2205/3306 , A61M2205/3569 , A61M2205/3592 , A61M2205/7536
摘要： A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 μm, so as to target the pulmonary system of the user.
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公开(公告)号：US20240316291A1
公开(公告)日：2024-09-26
申请号：US18383354
申请日：2023-10-24
CPC分类号： A61M15/0025 , A24F7/00 , A24F40/05 , A24F40/10 , A24F40/485 , A61M11/003 , A61M15/06 , A61M2205/3331
摘要： A droplet delivery device including a face seal within a cover of the droplet delivery device to seal over an ejector mechanism when the cover couples to a mouthpiece.
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公开(公告)号：US20240181175A1
公开(公告)日：2024-06-06
申请号：US18219329
申请日：2023-07-07
发明人： John H. Hebrank , Charles Eric Hunter , Christopher W. Maurer , Chengjie Li , Louis Thomas Germinario
CPC分类号： A61M11/005 , A61M15/0026 , A61M15/008 , A61M2205/3331 , A61M2205/3592 , A61M2205/502 , A61M2205/581 , A61M2205/583 , A61M2205/587 , A61M2205/8206
摘要： An in-line droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The in-line droplet delivery device includes a housing, a mouthpiece, a reservoir, an ejector mechanism, and at least one differential pressure sensor. The in-line droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The in-line droplet delivery device is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range, e.g, less than about 5-6 μm, so as to target the pulmonary system of the user, the droplet delivery device is configured in an in-line orientation in that the housing, its internal components, and various device components (e.g., the mouthpiece, air inlet flow element, etc.) are orientated in a substantially in-line or parallel configuration (e.g., along the airflow path) so as to form a small, hand-held device.
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公开(公告)号：US20240017023A1
公开(公告)日：2024-01-18
申请号：US18354373
申请日：2023-07-18
IPC分类号： A61M11/00
CPC分类号： A61M11/005
摘要： An aerosol generation device includes a circuit or microcontroller for detecting and adjusting vibration frequency of an electronic transducer to a determined resonance frequency that changes during operation of the device.
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公开(公告)号：US20230330362A1
公开(公告)日：2023-10-19
申请号：US18080520
申请日：2022-12-13
IPC分类号： A61M15/00
CPC分类号： A61M15/0091 , A61M15/0048 , A61M2202/064 , A61M2205/3306 , A61M2205/3331 , A61M2205/3576 , A61M2205/8225 , A61M2206/11
摘要： A dry powder aerosol delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The dry powder aerosol delivery device includes a housing, a cartridge, and a dry powder dispersion mechanism, and at least one differential pressure sensor. The dry powder delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The dry powder aerosol delivery device is then actuated to generate a plume of particles having an average ejected particle diameter within the respirable size range, e.g., less than about 5-6 μm, so as to target the pulmonary system of the user.
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