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公开(公告)号：US20220080137A1
公开(公告)日：2022-03-17
申请号：US17425029
申请日：2020-01-23
摘要： Methods, devices and systems are provided wherein compositions are delivered to the pulmonary system of an intended user via inhalation in a controlled manner and at a desired doses and/or amounts, e.g., within a desired dosage window and/or inhalation topography. In certain embodiments, dosage windows and/or inhalation topography may be used, e.g., to provide for controlled cessation of use or to provide a desired therapeutic window.
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公开(公告)号：US20210106772A1
公开(公告)日：2021-04-15
申请号：US17044636
申请日：2019-04-02
摘要： A handheld digital nebulizer device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The handheld digital nebulizer device includes a housing having an exhalation valve, a reservoir, an ejector mechanism, and at least one differential pressure sensor. The handheld digital nebulizer device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The handheld digital nebulizer device is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range, e.g, less than about 5-6 μm, so as to target the pulmonary system of the user.
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3.发明申请公开(公告)号：US20190125985A1
公开(公告)日：2019-05-02
申请号：US16098800
申请日：2017-05-03
摘要： A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 μm, so as to target the pulmonary system of the user.
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4.发明申请公开(公告)号：US20190117907A1
公开(公告)日：2019-04-25
申请号：US16098721
申请日：2017-05-03
发明人： Louis Thomas Germinario , John H. Hebrank , Charles Eric Hunter , Jack C. Hunter , Chemgjie Li , Christopher W. Maurer
摘要： A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 μm, so as to target the pulmonary system of the user.
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5.发明申请公开(公告)号：US20180344955A1
公开(公告)日：2018-12-06
申请号：US15910826
申请日：2018-03-02
发明人： Louis Thomas Germinario , John H. Hebrank , Charles Eric Hunter , Jack C. Hunter , Chengjie Li , Christopher W. Maurer
CPC分类号： A61M15/0021 , A61M11/003 , A61M15/00 , A61M15/0085 , A61M15/025 , A61M16/0051 , A61M16/0066 , A61M16/021 , A61M16/10 , A61M16/107 , A61M16/108 , A61M16/142 , A61M2016/0021 , A61M2016/0027 , A61M2016/0039 , A61M2205/33 , A61M2205/3306 , A61M2205/3569 , A61M2205/3592 , A61M2205/7536
摘要： A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 μm, so as to target the pulmonary system of the user.
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公开(公告)号：US20240316291A1
公开(公告)日：2024-09-26
申请号：US18383354
申请日：2023-10-24
CPC分类号： A61M15/0025 , A24F7/00 , A24F40/05 , A24F40/10 , A24F40/485 , A61M11/003 , A61M15/06 , A61M2205/3331
摘要： A droplet delivery device including a face seal within a cover of the droplet delivery device to seal over an ejector mechanism when the cover couples to a mouthpiece.
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公开(公告)号：US20240181175A1
公开(公告)日：2024-06-06
申请号：US18219329
申请日：2023-07-07
发明人： John H. Hebrank , Charles Eric Hunter , Christopher W. Maurer , Chengjie Li , Louis Thomas Germinario
CPC分类号： A61M11/005 , A61M15/0026 , A61M15/008 , A61M2205/3331 , A61M2205/3592 , A61M2205/502 , A61M2205/581 , A61M2205/583 , A61M2205/587 , A61M2205/8206
摘要： An in-line droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The in-line droplet delivery device includes a housing, a mouthpiece, a reservoir, an ejector mechanism, and at least one differential pressure sensor. The in-line droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The in-line droplet delivery device is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range, e.g, less than about 5-6 μm, so as to target the pulmonary system of the user, the droplet delivery device is configured in an in-line orientation in that the housing, its internal components, and various device components (e.g., the mouthpiece, air inlet flow element, etc.) are orientated in a substantially in-line or parallel configuration (e.g., along the airflow path) so as to form a small, hand-held device.
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公开(公告)号：US20230330362A1
公开(公告)日：2023-10-19
申请号：US18080520
申请日：2022-12-13
IPC分类号： A61M15/00
CPC分类号： A61M15/0091 , A61M15/0048 , A61M2202/064 , A61M2205/3306 , A61M2205/3331 , A61M2205/3576 , A61M2205/8225 , A61M2206/11
摘要： A dry powder aerosol delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The dry powder aerosol delivery device includes a housing, a cartridge, and a dry powder dispersion mechanism, and at least one differential pressure sensor. The dry powder delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The dry powder aerosol delivery device is then actuated to generate a plume of particles having an average ejected particle diameter within the respirable size range, e.g., less than about 5-6 μm, so as to target the pulmonary system of the user.
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公开(公告)号：US20230000150A1
公开(公告)日：2023-01-05
申请号：US17852742
申请日：2022-06-29
摘要： A droplet delivery device with an ejector mechanism and fluid reservoir includes an accelerometer to determine and communicate optimized mixing of fluid in the reservoir for inhalation of droplets, such as into the lungs, from the droplet delivery device.
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10.发明申请公开(公告)号：US20210236745A1
公开(公告)日：2021-08-05
申请号：US16098698
申请日：2017-05-03
发明人： Louis Thomas Germinario , John H. Hebrank , Charles Eric Hunter , Jack C. Hunter , Chengjie Li , Christopher W. Maurer
摘要： A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 μm, so as to target the pulmonary system of the user.
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