公开(公告)号：US20250136971A1

公开(公告)日：2025-05-01

申请号：US18657366

申请日：2024-05-07

Applicant: The Regents of the University of California

Inventor： Hugh E. Olsen ,  Miten Jain ,  Mark A. Akeson

IPC: C12N15/10 ,  C12N15/11 ,  C12Q1/6806 ,  C40B30/04 ,  C40B40/06 ,  C40B70/00

Abstract: Provided are methods of producing size-selected nucleic acid libraries. The methods include contacting a nucleic acid sample and a nucleic acid binding reagent including an affinity tag, under conditions in which nucleic acids of less than a desired length are substantially bound to the nucleic acid binding reagent and nucleic acids of the desired length are substantially not bound to the nucleic acid binding reagent. The conditions include the duration of the contacting, the concentration of the nucleic acid binding reagent, or both. The methods further include separating, using the affinity tag, the nucleic acids of less than the desired length bound to the nucleic acid binding reagent from the nucleic acids of the desired length not bound to the nucleic acid binding reagent, to produce a size-selected nucleic acid library. Compositions and kits that find use, e.g., in practicing the methods of the present disclosure, are also provided.

公开(公告)号：US20250136758A1

公开(公告)日：2025-05-01

申请号：US18756764

申请日：2024-06-27

Applicant: The Regents of the University of California

Inventor： Karen Christman ,  Masaki Fujita ,  Michael Madani

IPC: C08G65/48 ,  A61L31/06 ,  A61L31/14 ,  A61L31/16

Abstract: Methods and hydrogels for preventing or reducing cellular adhesion and protein adsorption to a tissue (e.g. cardiac tissue) are disclosed. The hydrogels generally include at least three component polymers, a first polymer including an aminooxy group, a second polymer including a reactive oxo group, that are cross-linked by oxime bonds and a third polymer including a catechol group, that causes better retention on the cardiac tissue. The hydrogels are suitable for binding to and coating a tissue or cell. The hydrogels operate to reduce cellular adhesions and protein adsorption to the tissue or cell.

公开(公告)号：US12287287B2

公开(公告)日：2025-04-29

申请号：US17775530

申请日：2020-11-12

Applicant: The Regents of the University of California

Inventor： Niall O'Dowd ,  Michael Todd

IPC: G01N21/45 ,  G01B11/06 ,  G01N21/88

Abstract: In one aspect, there is provided a system including at least one processor, and at least one memory including program code which when executed by the at least one processor causes operations including capturing an image of at least a portion of a surface of an object; generating, from the captured image, pixel intensity data; in response to generating the pixel intensity data, determining, based on a height error model, height error data, wherein the height error data indicates an uncertainty of at least one height measurement of the object; and determining, based on the height error data, whether the object satisfies a threshold criteria for acceptance of the object. Related system, methods, and articles of manufacture are also disclosed.

公开(公告)号：US12285472B2

公开(公告)日：2025-04-29

申请号：US15505148

申请日：2015-08-20

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu ,  Jonathan Copp ,  Ronnie H. Fang ,  Brian T. Luk

IPC: A61K39/00 ,  A61K9/00 ,  A61K9/51 ,  A61K35/12 ,  A61K39/385 ,  A61K45/06 ,  A61K47/34

Abstract: The invention provides a composition, and method of use thereof, comprising self-antigen displaying nanoparticles to target auto-reactive immune components for treating and/or preventing the autoimmune diseases associated therewith. The nanoparticles can also be loaded with cytotoxic drugs for targeted cell killing or with immune-tolerizing compounds to normalize the immune regulation.

公开(公告)号：US20250133866A1

公开(公告)日：2025-04-24

申请号：US18730604

申请日：2023-02-01

Applicant: The Regents of the University of California

Inventor： Philip Chan ,  Hsun-Ming Chang ,  Vincent Rienzi ,  Shuji Nakamura

IPC: H10H20/01 ,  H01S5/20 ,  H01S5/34 ,  H01S5/343 ,  H10H20/815 ,  H10H20/825

Abstract: A method of growing III-nitride-based devices, such as light emitting diodes (LEDs) and laser diodes (LDs) on or above a strain relaxed template (SRT). The SRT uses a thin, thermally decomposed, InGaN underlayer, which is referred to as a decomposition layer (DL). Above the DL is a n-type GaN or low composition InGaN decomposition stop layer (DSL). A buffer layer comprising an n-type InGaN/GaN superlattice (SL) is then grown. For an LD structure. an n-type waveguide layer comprising a second n-type InGaN/GaN SL is then grown. followed by an active region, a p-type electron blocking layer (EBL), a p-type waveguide layer comprising a p-type InGaN/GaN SL, and p-type GaN or p-type InGaN layers. For an LED structure, the waveguide layers may be omitted. In this disclosure, AlGaN means AlxGa(1-x)N with 1≥x≥0 and InGaN means InxGa(1-x)N with 1≥x≥0.

公开(公告)号：US20250129527A1

公开(公告)日：2025-04-24

申请号：US18836459

申请日：2023-02-07

Applicant: CZ BIOHUB SF, LLC ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Michel M. Maharbiz ,  Wentian Mi ,  Harmanvir Singh Ghuman ,  Karunesh Ganguly

IPC: D03D15/67 ,  A61L31/00 ,  A61L31/16 ,  A61M31/00 ,  A61N1/05 ,  A61N5/06

Abstract: The following relates generally to an implantable device (e.g., a device that is implantable to a human or animal subject). In some embodiments. the implantable device comprises a woven portion comprising two or more pluralities of threads woven together. Each of the pluralities of threads may be of a different thread type. Examples of types of threads include electrical wire. permeable tubing. optical fiber. polymer fiber, surface functionalized fiber. absorbable suture, and/or fiber comprising material configured for sensing. In some embodiments, the implantable device may be used to repair a lesion (e.g., a tumor).

公开(公告)号：US20250128208A1

公开(公告)日：2025-04-24

申请号：US18933872

申请日：2024-10-31

Applicant: The Regents of the University of California

Inventor： Gaurav Sant ,  Erika Callagon La Plante ,  Jingbo Wang ,  David Jassby ,  Dante Simonetti ,  Abdulaziz Alturki ,  Xin Chen

IPC: B01D53/96 ,  B01D53/62 ,  B01D53/78 ,  C01B13/36 ,  C01B32/60 ,  C02F1/461 ,  C02F103/08 ,  C02F103/18

Abstract: Provided herein are methods of removing carbon dioxide from an aqueous stream or gaseous stream by: contacting the gaseous stream comprising carbon dioxide, when present, with an aqueous solution comprising ions capable of forming an insoluble carbonate salt; contacting the aqueous solution comprising carbon dioxide with an electroactive mesh that induces its alkalinization thereby forcing the precipitation of a carbonate solid from the solution and thereby the removal of dissolved inorganic carbon by electrolysis; and removing the precipitated carbonate solids from the solution, or the surface of the mesh where they may deposit. Also provided herein are flow-through electrolytic reactors comprising an intake device in fluid connection with a rotating cylinder comprising an electroactive mesh, and a scraping device and/or liquid-spray based device for separating a solid from the mesh surface.

公开(公告)号：US12282080B1

公开(公告)日：2025-04-22

申请号：US18835654

申请日：2023-01-26

Applicant: The Regents of the University of California

Inventor： Jia Guo

IPC: G01V3/00 ,  G01R33/56 ,  G01R33/563

Abstract: Techniques, systems and apparatus are described for magnetic resonance imaging. A method includes generating an MRI image by processing a first image obtained by applying a first order of modules including at least a first control module at a first time point and a first labeling module at a second time point to a target object, wherein the first control module inverts a magnetization of the target object and a second image obtained by applying a second order of modules including at least a second labeling module at a third time and a second control module at a fourth time to the target object, wherein the second labeling module inverts the magnetization of the target object.

公开(公告)号：US12281941B2

公开(公告)日：2025-04-22

申请号：US17723817

申请日：2022-04-19

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Enrico Gratton ,  Alexander Dvornikov

IPC: G01J3/28 ,  G01J3/44 ,  G01N21/64 ,  H04N23/72 ,  H04N25/13

Abstract: An imaging system comprises an excitation light source, a directing element positioned to direct light from the excitation light source toward a sample, a detector configured to measure incoming light from the sample, a filter cavity positioned between the sample and the detector, a first filter configured to be inserted into the filter cavity, a sine filter configured to be inserted into the filter cavity, and a processing unit communicatively connected to the detector, configured to receive image data from the detector to form an image. Methods of constructing a hyperspectral image of a sample are also described.

公开(公告)号：US12281323B2

公开(公告)日：2025-04-22

申请号：US17601557

申请日：2020-04-15

Applicant: The Regents of the University of California

Inventor： Gerald Lipshutz ,  Matthew Nitzahn

IPC: C12N15/86 ,  C12N9/00

Abstract: Carbamoyl phosphate synthetase 1 (CPS1) deficiency is a metabolic disorder of the liver that results m abnormal nitrogen metabolism. To illustrate the ability of gene therapy to treat CPS1 deficiency, two adeno-associated viruses encoding portions of a codon optimized CPS1 were generated and tested in a conditional CPS1 knock out mouse model. When administered to mice having knocked out endogenous CPS1 expression, mice from this model demonstrate homologous recombination and reconstitution of the codon optimized CPS1 gene, expression of the CPS1 protein and the associated control of plasma ammonia following the administered AAVs comprising the CPS1 gene sequences. While all control mice perish, the mice in this model live and have normal behavior. As there is no effective therapy for human patients with the CPS1 disorder, this invention can address this unmet need for these patients.