公开(公告)号：US20180153821A1

公开(公告)日：2018-06-07

申请号：US15737566

申请日：2016-06-07

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu ,  Ronnie H. Fang ,  Brian T. Luk ,  Kuei-Chun Wang ,  Shu Chien

IPC: A61K9/51 ,  A61P7/04 ,  A61P9/00 ,  A61P35/00 ,  A61K31/337

CPC classification number: A61K9/5176 ,  A61K9/5153 ,  A61K9/5169 ,  A61K31/337 ,  A61K47/6901 ,  A61P7/04 ,  A61P9/00 ,  A61P35/00 ,  B82Y5/00 ,  B82Y30/00

Abstract: The present invention relates to prevention and/or treatment of diseases or disorders associated with a damaged or leaky vasculature in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating a disease or disorder associated with a damaged or leaky vasculature in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, an outer surface comprising a cellular membrane derived from a platelet; and optionally an agent for preventing, treating, diagnosing, or prognosing the disease or disorder and/or monitoring prevention or treatment of the disease or disorder. Exemplary diseases or disorders include hemorrhage (bleeding), cardiovascular diseases or disorders, diseases or disorders associated with narrowing of a blood vessel, tumors or cancers.

公开(公告)号：US12285472B2

公开(公告)日：2025-04-29

申请号：US15505148

申请日：2015-08-20

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu ,  Jonathan Copp ,  Ronnie H. Fang ,  Brian T. Luk

IPC: A61K39/00 ,  A61K9/00 ,  A61K9/51 ,  A61K35/12 ,  A61K39/385 ,  A61K45/06 ,  A61K47/34

Abstract: The invention provides a composition, and method of use thereof, comprising self-antigen displaying nanoparticles to target auto-reactive immune components for treating and/or preventing the autoimmune diseases associated therewith. The nanoparticles can also be loaded with cytotoxic drugs for targeted cell killing or with immune-tolerizing compounds to normalize the immune regulation.

公开(公告)号：US20220151948A1

公开(公告)日：2022-05-19

申请号：US17590684

申请日：2022-02-01

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu ,  Ronnie H. Fang ,  Brian T. Luk ,  Kuei-Chun Wang ,  Shu Chien

IPC: A61K9/51 ,  A61K47/69 ,  A61P7/04 ,  A61P9/00 ,  A61P35/00 ,  A61K31/337

Abstract: The present invention relates to prevention and/or treatment of diseases or disorders associated with a damaged or leaky vasculature in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating a disease or disorder associated with a damaged or leaky vasculature in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, an outer surface comprising a cellular membrane derived from a platelet; and optionally an agent for preventing, treating, diagnosing, or prognosing the disease or disorder and/or monitoring prevention or treatment of the disease or disorder. Exemplary diseases or disorders include hemorrhage (bleeding), cardiovascular diseases or disorders, diseases or disorders associated with narrowing of a blood vessel, tumors or cancers.

公开(公告)号：US11241394B2

公开(公告)日：2022-02-08

申请号：US15737566

申请日：2016-06-07

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu ,  Ronnie H. Fang ,  Brian T. Luk ,  Kuei-Chun Wang ,  Shu Chien

IPC: A61K9/51 ,  A61K47/69 ,  A61P7/04 ,  A61P9/00 ,  A61P35/00 ,  A61K31/337 ,  B82Y5/00 ,  B82Y30/00

Abstract: The present invention relates to prevention and/or treatment of diseases or disorders associated with a damaged or leaky vasculature in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating a disease or disorder associated with a damaged or leaky vasculature in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, an outer surface comprising a cellular membrane derived from a platelet; and optionally an agent for preventing, treating, diagnosing, or prognosing the disease or disorder and/or monitoring prevention or treatment of the disease or disorder. Exemplary diseases or disorders include hemorrhage (bleeding), cardiovascular diseases or disorders, diseases or disorders associated with narrowing of a blood vessel, tumors or cancers.

公开(公告)号：US11224577B2

公开(公告)日：2022-01-18

申请号：US15737594

申请日：2016-06-07

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu ,  Ronnie H. Fang ,  Brian T. Luk ,  Soracha Kun Thamphiwatana

IPC: A61K9/51 ,  A61K31/337 ,  A61K31/7042 ,  A61K47/69 ,  A61P31/04 ,  A61K9/50 ,  A61K45/06 ,  B82Y5/00

Abstract: The present invention relates to prevention and/or treatment of infection by a platelet-targeting microbe in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating (and/or related uses) infection by a platelet-targeting microbe in a subject, using, inter alia, an effective amount of a nanoparticle comprising a) an inner core comprising a non-cellular material, b) an outer surface comprising a cellular membrane derived from a platelet; and optionally c) an agent for preventing said infection, treating said infection, diagnosing said infection, prognosing said infection and/or monitoring prevention or treatment of said infection. Exemplary platelet-targeting infections include infections by a bacterium, a virus, a fungus and/or a parasite.

公开(公告)号：US20180169027A1

公开(公告)日：2018-06-21

申请号：US15737594

申请日：2016-06-07

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu ,  Ronnie H. Fang ,  Brian T. Luk ,  Soracha Kun Thamphiwatana

IPC: A61K9/51 ,  A61K31/337 ,  A61K47/69 ,  A61K31/7042 ,  A61K9/50 ,  A61K45/06 ,  A61P31/04

CPC classification number: A61K9/51 ,  A61K9/5068 ,  A61K9/5084 ,  A61K9/5094 ,  A61K31/337 ,  A61K31/7042 ,  A61K45/06 ,  A61K47/6901 ,  A61K2300/00 ,  A61P31/04 ,  B82Y5/00

Abstract: The present invention relates to prevention and/or treatment of infection by a platelet-targeting microbe in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating (and/or related uses) infection by a platelet-targeting microbe in a subject, using, inter alia, an effective amount of a nanoparticle comprising a) an inner core comprising a non-cellular material, b) an outer surface comprising a cellular membrane derived from a platelet; and optionally c) an agent for preventing said infection, treating said infection, diagnosing said infection, prognosing said infection and/or monitoring prevention or treatment of said infection. Exemplary platelet-targeting infections include infections by a bacterium, a virus, a fungus and/or a parasite.

公开(公告)号：US20170274059A1

公开(公告)日：2017-09-28

申请号：US15505148

申请日：2015-08-20

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu ,  Jonathan Copp ,  Ronnie H. Fang ,  Brian T. Luk

IPC: A61K39/00 ,  A61K45/06 ,  A61K47/34

CPC classification number: A61K39/0008 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/5146 ,  A61K9/5184 ,  A61K35/12 ,  A61K39/385 ,  A61K45/06 ,  A61K47/34 ,  A61K2039/55555 ,  A61K2039/6006

Abstract: The invention provides a composition, and method of use thereof, comprising self-antigen displaying nanoparticles to target auto-reactive immune components for treating and/or preventing the autoimmune diseases associated therewith. The nanoparticles can also be loaded with cytotoxic drugs for targeted cell killing or with immune-tolerizing compounds to normalize the immune regulation.