公开(公告)号：US11007147B2

公开(公告)日：2021-05-18

申请号：US16811515

申请日：2020-03-06

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu ,  Weiwei Gao ,  Jonathan Copp

IPC: A61K9/06 ,  A61K9/16 ,  A61K9/51 ,  A61K38/17 ,  A61K35/17 ,  A61K35/18 ,  A61K35/19 ,  A61K35/58 ,  A61K35/63 ,  A61K45/06 ,  A61K31/49 ,  A61L26/00 ,  A61K9/00 ,  A61L27/52 ,  A61L27/54 ,  A61K9/50

Abstract: The present invention provides for compositions comprising a polymeric hydrogel impregnated with a toxin-absorbing or binding nanoparticle. The present invention also provides for the use of the above compositions for decreasing or neutralizing the effect of a toxin, or for treating or preventing an infection by a microbe that produces a toxin, in a subject. The exemplary toxin is a biological toxin such as a viral, bacterial, fungal, plant or animal toxin.

公开(公告)号：US20190358171A1

公开(公告)日：2019-11-28

申请号：US16515906

申请日：2019-07-18

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Weiwei Gao ,  Ronnie H. Fang ,  Che-Ming Jack Hu

IPC: A61K9/51 ,  A61K31/545 ,  A61K31/49 ,  A61K31/43 ,  A61K31/427 ,  A61K39/02 ,  A61K9/50 ,  A61K45/06

Abstract: Nanoparticles are provided comprising an inner core comprising a non-cellular material, and an outer surface comprising a bacterial membrane, e.g., a bacterial membrane derived from a bacteria outer membrane vesicle. Also provided are compositions, e.g., medicament delivery systems and pharmaceutical compositions, comprising the present nanoparticles. Also provided are uses of the present nanoparticles, pharmaceutical compositions and medicament delivery systems for treating and/or preventing a disease or condition, e.g., bacterial infection, in a subject.

公开(公告)号：US10383830B2

公开(公告)日：2019-08-20

申请号：US15558636

申请日：2016-03-18

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Weiwei Gao ,  Ronnie H. Fang ,  Che-Ming Jack Hu

IPC: A61K39/00 ,  A61K9/51 ,  A61K45/06 ,  A61K31/427 ,  A61K31/43 ,  A61K31/49 ,  A61K31/545 ,  A61K9/50 ,  A61K39/02 ,  B82Y5/00

Abstract: Nanoparticles are provided comprising an inner core comprising a non-cellular material, and an outer surface comprising a bacterial membrane, e.g., a bacterial membrane derived from a bacteria outer membrane vesicle. Also provided are compositions, e.g., medicament delivery systems and pharmaceutical compositions, comprising the present nanoparticles. Also provided are uses of the present nanoparticles, pharmaceutical compositions and medicament delivery systems for treating and/or preventing a disease or condition, e.g., bacterial infection, in a subject.

公开(公告)号：US11357736B2

公开(公告)日：2022-06-14

申请号：US16779070

申请日：2020-01-31

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Zhiqing Pang ,  Ronnie H. Fang ,  Che-Ming Jack Hu

IPC: A61K9/51 ,  A61K9/50 ,  A61P39/02 ,  A61K45/06

Abstract: The present invention relates treatments of a toxin in a subject. The toxin at least partially effects its toxicity in the subject via binding to a target cell of the subject. The present invention provides for methods, combinations and pharmaceutical compositions for decreasing or neutralizing the effect of a toxin in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, and an outer surface comprising a cellular membrane derived from a source cell. Exemplary toxins include acetylcholinesterase (AChE) inhibitors such as organophosphate poisoning.

公开(公告)号：US20200222334A1

公开(公告)日：2020-07-16

申请号：US16779070

申请日：2020-01-31

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Zhiqing Pang ,  Ronnie H. Fang ,  Che-Ming Jack Hu

IPC: A61K9/51 ,  A61K9/50 ,  A61K45/06

Abstract: The present invention relates treatments of a toxin in a subject. The toxin at least partially effects its toxicity in the subject via binding to a target cell of the subject. The present invention provides for methods, combinations and pharmaceutical compositions for decreasing or neutralizing the effect of a toxin in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, and an outer surface comprising a cellular membrane derived from a source cell. Exemplary toxins include acetylcholinesterase (AChE) inhibitors such as organophosphate poisoning.

公开(公告)号：US10285952B2

公开(公告)日：2019-05-14

申请号：US15000110

申请日：2016-01-19

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu

IPC: A61K9/00 ,  A61K9/51 ,  A61K9/50 ,  A61K35/17 ,  A61K35/18 ,  A61K35/19 ,  A61K31/4709 ,  A61K49/00 ,  G01N33/569 ,  G01N33/58

Abstract: Provided are methods, combinations and pharmaceutical compositions for treating or preventing an infection in a subject using a nanoparticle comprising a) an inner core comprising a non-cellular material, and b) an outer surface comprising a cellular membrane configured for adhesion of a pathogen that causes said infection. Exemplary infection includes infection caused by a virus, bacterium, fungus, or protozoan.

公开(公告)号：US10098839B2

公开(公告)日：2018-10-16

申请号：US15126342

申请日：2015-03-20

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu ,  Weiwei Gao ,  Jonathan Copp

IPC: A61K9/16 ,  A61K9/06 ,  A61K9/51 ,  A61K38/17 ,  A61K35/17 ,  A61K35/18 ,  A61K35/19 ,  A61K35/58 ,  A61K35/63 ,  A61K45/06 ,  A61K31/49 ,  A61L26/00 ,  A61K9/00 ,  A61L27/52 ,  A61L27/54 ,  A61K9/50

Abstract: The present invention provides for compositions comprising a polymeric hydrogel impregnated with a toxin-absorbing or binding nanoparticle. The present invention also provides for the use of the above compositions for decreasing or neutralizing the effect of a toxin, or for treating or preventing an infection by a microbe that produces a toxin, in a subject. The exemplary toxin is a biological toxin such as a viral, bacterial, fungal, plant or animal toxin.

公开(公告)号：US12285472B2

公开(公告)日：2025-04-29

申请号：US15505148

申请日：2015-08-20

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu ,  Jonathan Copp ,  Ronnie H. Fang ,  Brian T. Luk

IPC: A61K39/00 ,  A61K9/00 ,  A61K9/51 ,  A61K35/12 ,  A61K39/385 ,  A61K45/06 ,  A61K47/34

Abstract: The invention provides a composition, and method of use thereof, comprising self-antigen displaying nanoparticles to target auto-reactive immune components for treating and/or preventing the autoimmune diseases associated therewith. The nanoparticles can also be loaded with cytotoxic drugs for targeted cell killing or with immune-tolerizing compounds to normalize the immune regulation.

公开(公告)号：US20220151948A1

公开(公告)日：2022-05-19

申请号：US17590684

申请日：2022-02-01

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu ,  Ronnie H. Fang ,  Brian T. Luk ,  Kuei-Chun Wang ,  Shu Chien

IPC: A61K9/51 ,  A61K47/69 ,  A61P7/04 ,  A61P9/00 ,  A61P35/00 ,  A61K31/337

Abstract: The present invention relates to prevention and/or treatment of diseases or disorders associated with a damaged or leaky vasculature in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating a disease or disorder associated with a damaged or leaky vasculature in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, an outer surface comprising a cellular membrane derived from a platelet; and optionally an agent for preventing, treating, diagnosing, or prognosing the disease or disorder and/or monitoring prevention or treatment of the disease or disorder. Exemplary diseases or disorders include hemorrhage (bleeding), cardiovascular diseases or disorders, diseases or disorders associated with narrowing of a blood vessel, tumors or cancers.

公开(公告)号：US11241394B2

公开(公告)日：2022-02-08

申请号：US15737566

申请日：2016-06-07

Applicant: The Regents of the University of California

Inventor： Liangfang Zhang ,  Che-Ming Jack Hu ,  Ronnie H. Fang ,  Brian T. Luk ,  Kuei-Chun Wang ,  Shu Chien

IPC: A61K9/51 ,  A61K47/69 ,  A61P7/04 ,  A61P9/00 ,  A61P35/00 ,  A61K31/337 ,  B82Y5/00 ,  B82Y30/00

Abstract: The present invention relates to prevention and/or treatment of diseases or disorders associated with a damaged or leaky vasculature in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating a disease or disorder associated with a damaged or leaky vasculature in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, an outer surface comprising a cellular membrane derived from a platelet; and optionally an agent for preventing, treating, diagnosing, or prognosing the disease or disorder and/or monitoring prevention or treatment of the disease or disorder. Exemplary diseases or disorders include hemorrhage (bleeding), cardiovascular diseases or disorders, diseases or disorders associated with narrowing of a blood vessel, tumors or cancers.