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公开(公告)号：US10098839B2
公开(公告)日：2018-10-16
申请号：US15126342
申请日：2015-03-20
Applicant: The Regents of the University of California
Inventor： Liangfang Zhang , Che-Ming Jack Hu , Weiwei Gao , Jonathan Copp
IPC: A61K9/16 , A61K9/06 , A61K9/51 , A61K38/17 , A61K35/17 , A61K35/18 , A61K35/19 , A61K35/58 , A61K35/63 , A61K45/06 , A61K31/49 , A61L26/00 , A61K9/00 , A61L27/52 , A61L27/54 , A61K9/50
Abstract: The present invention provides for compositions comprising a polymeric hydrogel impregnated with a toxin-absorbing or binding nanoparticle. The present invention also provides for the use of the above compositions for decreasing or neutralizing the effect of a toxin, or for treating or preventing an infection by a microbe that produces a toxin, in a subject. The exemplary toxin is a biological toxin such as a viral, bacterial, fungal, plant or animal toxin.
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公开(公告)号：US20200276122A1
公开(公告)日：2020-09-03
申请号：US16811515
申请日：2020-03-06
Applicant: The Regents of the University of California
Inventor： Liangfang Zhang , Che-Ming Jack Hu , Weiwei Gao , Jonathan Copp
IPC: A61K9/06 , A61K9/16 , A61K9/51 , A61K38/17 , A61K35/17 , A61K35/18 , A61K35/19 , A61K35/58 , A61K35/63 , A61K45/06 , A61K31/49 , A61L26/00 , A61K9/00 , A61L27/52 , A61L27/54
Abstract: The present invention provides for compositions comprising a polymeric hydrogel impregnated with a toxin-absorbing or binding nanoparticle. The present invention also provides for the use of the above compositions for decreasing or neutralizing the effect of a toxin, or for treating or preventing an infection by a microbe that produces a toxin, in a subject. The exemplary toxin is a biological toxin such as a viral, bacterial, fungal, plant or animal toxin.
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公开(公告)号：US20130337066A1
公开(公告)日：2013-12-19
申请号：US13827906
申请日：2013-03-14
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Liangfang Zhang , Che-Ming (Jack) Hu , Ronnie Hongbo Fang , Jonathan Copp
CPC classification number: A61K9/148 , A61K39/0011 , A61K39/085 , A61K39/39 , A61K45/06 , A61K2039/55555
Abstract: Provided are nanoparticles and methods of using and making thereof. The inventive nanoparticle comprises a) an inner core comprising a non-cellular material; and b) an outer surface comprising a cellular membrane derived from a cell or a membrane derived from a virus. Medicament delivery systems or pharmaceutical compositions comprising the inventive nanoparticles are also provided. Further provided are immunogenic compositions comprising the inventive nanoparticles, and methods of using the inventive immunogenic compositions for eliciting an immune response, and for treating or preventing diseases or condition, such as neoplasm or cancer, or disease or conditions associated with cell membrane inserting toxin. Vaccines comprising the immunogenic composition comprising the nanoparticles are also provided.
Abstract translation: 提供了纳米颗粒及其使用和制造方法。 本发明的纳米颗粒包括a）包含非多孔材料的内核; 和b）包含衍生自细胞的细胞膜或源自病毒的膜的外表面。 还提供了包含本发明纳米颗粒的药物递送系统或药物组合物。 还提供了包含本发明的纳米颗粒的免疫原性组合物，以及使用本发明的免疫原性组合物引发免疫应答以及用于治疗或预防疾病或病症如肿瘤或癌症或与细胞膜插入毒素相关的疾病或病症的方法。 还提供了包含包含纳米颗粒的免疫原性组合物的疫苗。
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公开(公告)号：US20240252438A1
公开(公告)日：2024-08-01
申请号：US18582123
申请日：2024-02-20
Applicant: The Regents of the University of California
Inventor： Liangfang Zhang , Che-Ming (Jack) Hu , Ronnie Hongbo Fang , Jonathan Copp
IPC: A61K9/14 , A61K39/00 , A61K39/085 , A61K39/39 , A61K45/06
CPC classification number: A61K9/148 , A61K39/001102 , A61K39/085 , A61K39/39 , A61K45/06 , A61K2039/55555 , A61K2039/80
Abstract: Provided are nanoparticles and methods of using and making thereof. The inventive nanoparticle comprises a) an inner core comprising a non-cellular material; and b) an outer surface comprising a cellular membrane derived from a cell or a membrane derived from a virus. Medicament delivery systems or pharmaceutical compositions comprising the inventive nanoparticles are also provided. Further provided are immunogenic compositions comprising the inventive nanoparticles, and methods of using the inventive immunogenic compositions for eliciting an immune response, and for treating or preventing diseases or condition, such as neoplasm or cancer, or disease or conditions associated with cell membrane inserting toxin. Vaccines comprising the immunogenic composition comprising the nanoparticles are also provided.
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公开(公告)号：US11007147B2
公开(公告)日：2021-05-18
申请号：US16811515
申请日：2020-03-06
Applicant: The Regents of the University of California
Inventor： Liangfang Zhang , Che-Ming Jack Hu , Weiwei Gao , Jonathan Copp
IPC: A61K9/06 , A61K9/16 , A61K9/51 , A61K38/17 , A61K35/17 , A61K35/18 , A61K35/19 , A61K35/58 , A61K35/63 , A61K45/06 , A61K31/49 , A61L26/00 , A61K9/00 , A61L27/52 , A61L27/54 , A61K9/50
Abstract: The present invention provides for compositions comprising a polymeric hydrogel impregnated with a toxin-absorbing or binding nanoparticle. The present invention also provides for the use of the above compositions for decreasing or neutralizing the effect of a toxin, or for treating or preventing an infection by a microbe that produces a toxin, in a subject. The exemplary toxin is a biological toxin such as a viral, bacterial, fungal, plant or animal toxin.
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Patent Agency Ranking
6.发明授权公开(公告)号：US12285472B2
公开(公告)日：2025-04-29
申请号：US15505148
申请日：2015-08-20
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Liangfang Zhang , Che-Ming Jack Hu , Jonathan Copp , Ronnie H. Fang , Brian T. Luk
Abstract: The invention provides a composition, and method of use thereof, comprising self-antigen displaying nanoparticles to target auto-reactive immune components for treating and/or preventing the autoimmune diseases associated therewith. The nanoparticles can also be loaded with cytotoxic drugs for targeted cell killing or with immune-tolerizing compounds to normalize the immune regulation.
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公开(公告)号：US20250049716A1
公开(公告)日：2025-02-13
申请号：US18814247
申请日：2024-08-23
Applicant: The Regents of the University of California
Inventor： Liangfang Zhang , Che-Ming (Jack) Hu , Ronnie Hongbo Fang , Jonathan Copp
IPC: A61K9/14 , A61K39/00 , A61K39/085 , A61K39/39 , A61K45/06
Abstract: Provided are nanoparticles and methods of using and making thereof. The inventive nanoparticle comprises a) an inner core comprising a non-cellular material; and b) an outer surface comprising a cellular membrane derived from a cell or a membrane derived from a virus. Medicament delivery systems or pharmaceutical compositions comprising the inventive nanoparticles are also provided. Further provided are immunogenic compositions comprising the inventive nanoparticles, and methods of using the inventive immunogenic compositions for eliciting an immune response, and for treating or preventing diseases or condition, such as neoplasm or cancer, or disease or conditions associated with cell membrane inserting toxin. Vaccines comprising the immunogenic composition comprising the nanoparticles are also provided.
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8.发明申请公开(公告)号：US20170274059A1
公开(公告)日：2017-09-28
申请号：US15505148
申请日：2015-08-20
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Liangfang Zhang , Che-Ming Jack Hu , Jonathan Copp , Ronnie H. Fang , Brian T. Luk
CPC classification number: A61K39/0008 , A61K9/0014 , A61K9/0019 , A61K9/5146 , A61K9/5184 , A61K35/12 , A61K39/385 , A61K45/06 , A61K47/34 , A61K2039/55555 , A61K2039/6006
Abstract: The invention provides a composition, and method of use thereof, comprising self-antigen displaying nanoparticles to target auto-reactive immune components for treating and/or preventing the autoimmune diseases associated therewith. The nanoparticles can also be loaded with cytotoxic drugs for targeted cell killing or with immune-tolerizing compounds to normalize the immune regulation.
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公开(公告)号：US20250049715A1
公开(公告)日：2025-02-13
申请号：US18814200
申请日：2024-08-23
Applicant: The Regents of the University of California
Inventor： Liangfang Zhang , Che-Ming (Jack) Hu , Ronnie Hongbo Fang , Jonathan Copp
IPC: A61K9/14 , A61K39/00 , A61K39/085 , A61K39/39 , A61K45/06
Abstract: Provided are nanoparticles and methods of using and making thereof. The inventive nanoparticle comprises a) an inner core comprising a non-cellular material; and b) an outer surface comprising a cellular membrane derived from a cell or a membrane derived from a virus. Medicament delivery systems or pharmaceutical compositions comprising the inventive nanoparticles are also provided. Further provided are immunogenic compositions comprising the inventive nanoparticles, and methods of using the inventive immunogenic compositions for eliciting an immune response, and for treating or preventing diseases or condition, such as neoplasm or cancer, or disease or conditions associated with cell membrane inserting toxin. Vaccines comprising the immunogenic composition comprising the nanoparticles are also provided.
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公开(公告)号：US20250017860A1
公开(公告)日：2025-01-16
申请号：US18814271
申请日：2024-08-23
Applicant: The Regents of the University of California
Inventor： Liangfang Zhang , Che-Ming (Jack) Hu , Ronnie Hongbo Fang , Jonathan Copp
IPC: A61K9/14 , A61K39/00 , A61K39/085 , A61K39/39 , A61K45/06
Abstract: Provided are nanoparticles and methods of using and making thereof. The inventive nanoparticle comprises a) an inner core comprising a non-cellular material; and b) an outer surface comprising a cellular membrane derived from a cell or a membrane derived from a virus. Medicament delivery systems or pharmaceutical compositions comprising the inventive nanoparticles are also provided. Further provided are immunogenic compositions comprising the inventive nanoparticles, and methods of using the inventive immunogenic compositions for eliciting an immune response, and for treating or preventing diseases or condition, such as neoplasm or cancer, or disease or conditions associated with cell membrane inserting toxin. Vaccines comprising the immunogenic composition comprising the nanoparticles are also provided.
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