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公开(公告)号：US08481509B2
公开(公告)日：2013-07-09
申请号：US13363493
申请日：2012-02-01
Applicant: Gregory Hinkle , Satyanarayana Kuchimanchi , Stuart Milstein , Markus Warmuth , Wenlai Zhou , Ping Zhu , Tracy S. Zimmermann
Inventor： Gregory Hinkle , Satyanarayana Kuchimanchi , Stuart Milstein , Markus Warmuth , Wenlai Zhou , Ping Zhu , Tracy S. Zimmermann
IPC: C12N15/11
CPC classification number: C12N15/113 , A61K31/713 , A61K45/06 , C07H21/02 , C12N2310/14 , C12N2310/321 , C12N2310/322 , C12N2320/31 , C12N2320/51 , C12N2320/53 , Y02A50/467 , C12N2310/3521
Abstract: The present disclosure relates to methods of treating heat shock factor 1 (HSF1)-related diseases such as cancer and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF.
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公开(公告)号：US20130035371A1
公开(公告)日：2013-02-07
申请号：US13568898
申请日：2012-08-07
Applicant: Kevin Fitzgerald , Gregory Hinkle , Akin Akinc , Stuart Milstein
Inventor： Kevin Fitzgerald , Gregory Hinkle , Akin Akinc , Stuart Milstein
IPC: A61K31/713 , A61P3/06 , A61K48/00 , C12N5/071
CPC classification number: A61K31/713 , A61K9/0019 , A61K9/1272 , A61K9/1273 , A61K38/1709 , A61K47/545 , A61K47/55 , A61K47/6911 , C12N15/1137 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3515
Abstract: This invention relates to composition and methods using lipid formulated siRNA targeted to a PCSK9 gene.
Abstract translation: 本发明涉及使用针对PCSK9基因的脂质配制的siRNA的组合物和方法。
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公开(公告)号：US08344131B2
公开(公告)日：2013-01-01
申请号：US13355930
申请日：2012-01-23
Applicant: Antonin De Fougerolles , John L. Diener , Emma Hickman , Gregory Hinkle , Stuart Milstein , Anne-Marie Pulichino , Andrew Griffin Sprague
Inventor： Antonin De Fougerolles , John L. Diener , Emma Hickman , Gregory Hinkle , Stuart Milstein , Anne-Marie Pulichino , Andrew Griffin Sprague
CPC classification number: C12N15/1138 , A61K31/713 , C12N2310/111 , C12N2310/14 , C12N2310/31 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/351 , C12N2310/3513 , C12N2310/3515 , C12N2310/3517 , C12N2310/3521
Abstract: The present disclosure relates to RNAi agents useful in methods of treating Beta-ENaC-related diseases such as cystic fibrosis, pseudohypoaldosteronism type 1 (PHA1), Liddle's syndrome, hypertension, alkalosis, hypokalemia, and obesity-associated hypertension, using a therapeutically effective amount of a RNAi agent to Beta-ENaC.
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公开(公告)号：US08273869B2
公开(公告)日：2012-09-25
申请号：US12816207
申请日：2010-06-15
Applicant: Kevin Fitzgerald , Gregory Hinkle , Akin Akinc , Stuart Milstein
Inventor： Kevin Fitzgerald , Gregory Hinkle , Akin Akinc , Stuart Milstein
CPC classification number: A61K31/713 , A61K9/0019 , A61K9/1272 , A61K9/1273 , A61K38/1709 , A61K47/545 , A61K47/55 , A61K47/6911 , C12N15/1137 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3515
Abstract: This invention relates to composition and methods using lipid formulated siRNA targeted to a PCSK9 gene.
Abstract translation: 本发明涉及使用针对PCSK9基因的脂质配制的siRNA的组合物和方法。
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公开(公告)号：US20120129915A1
公开(公告)日：2012-05-24
申请号：US13363504
申请日：2012-02-01
Applicant: Gregory HINKLE , Satyanarayana KUCHIMANCHI , Stuart MILSTEIN , Markus WARMUTH , Wenlai ZHOU , Ping ZHU , Tracy S. ZIMMERMANN
Inventor： Gregory HINKLE , Satyanarayana KUCHIMANCHI , Stuart MILSTEIN , Markus WARMUTH , Wenlai ZHOU , Ping ZHU , Tracy S. ZIMMERMANN
IPC: A61K31/713 , C07K9/00 , C08B37/08 , C07K14/00 , A61P37/08 , A61P35/00 , A61P31/12 , A61P35/02 , A61P31/18 , C07H21/02 , C07K14/79
CPC classification number: C12N15/113 , A61K31/713 , A61K45/06 , C07H21/02 , C12N2310/14 , C12N2310/321 , C12N2310/322 , C12N2320/31 , C12N2320/51 , C12N2320/53 , Y02A50/467 , C12N2310/3521
Abstract: The present disclosure relates to methods of treating heat shock factor 1 (HSF1)-related diseases such as cancer and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF.
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Patent Agency Ranking
公开(公告)号：US20120129914A1
公开(公告)日：2012-05-24
申请号：US13363493
申请日：2012-02-01
Applicant: Gregory HINKLE , Satyanarayana KUCHIMANCHI , Stuart MILSTEIN , Markus WARMUTH , Wenlai ZHOU , Ping ZHU , Tracy S. ZIMMERMANN
Inventor： Gregory HINKLE , Satyanarayana KUCHIMANCHI , Stuart MILSTEIN , Markus WARMUTH , Wenlai ZHOU , Ping ZHU , Tracy S. ZIMMERMANN
IPC: A61K31/713 , C07K2/00 , A61P35/00 , A61P19/02 , A61P35/02 , A61P31/22 , A61P31/18 , A61P31/20 , C07H21/02 , A61P31/12
CPC classification number: C12N15/113 , A61K31/713 , A61K45/06 , C07H21/02 , C12N2310/14 , C12N2310/321 , C12N2310/322 , C12N2320/31 , C12N2320/51 , C12N2320/53 , Y02A50/467 , C12N2310/3521
Abstract: The present disclosure relates to methods of treating heat shock factor 1 (HSF1)-related diseases such as cancer and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF.
Abstract translation: 本公开涉及使用治疗有效量的RNAi剂对HSF治疗热休克因子1（HSF1）相关疾病如癌症和病毒性疾病的方法。
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公开(公告)号：US20110263681A1
公开(公告)日：2011-10-27
申请号：US13090580
申请日：2011-04-20
Applicant: Antonin DE FOUGEROLLES , John L. DIENER , Emma HICKMAN , Gregory HINKLE , Stuart MILSTEIN , Anne-Marie PULICHINO , Andrew SPRAGUE
Inventor： Antonin DE FOUGEROLLES , John L. DIENER , Emma HICKMAN , Gregory HINKLE , Stuart MILSTEIN , Anne-Marie PULICHINO , Andrew SPRAGUE
CPC classification number: C12N15/1138 , A61K31/713 , C12N2310/111 , C12N2310/14 , C12N2310/31 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/351 , C12N2310/3513 , C12N2310/3515 , C12N2310/3517 , C12N2310/3521
Abstract: The present disclosure relates to RNAi agents useful in methods of treating Beta-ENaC-related diseases such as cystic fibrosis, pseudohypoaldosteronism type 1 (PHA1), Liddle's syndrome, hypertension, alkalosis, hypokalemia, and obesity-associated hypertension, using a therapeutically effective amount of a RNAi agent to Beta-ENaC.
Abstract translation: 本公开涉及可用于使用治疗有效量治疗β-ENAC相关疾病如囊性纤维化，1型假性醛固酮增多症（1例（PHA1），跛行综合征，高血压，碱中毒，低钾血症和肥胖相关性高血压）的方法中的RNAi剂 的RNAi试剂到β-ENaC。
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28.发明授权Compositions and method for inhibiting hepcidin antimicrobial peptide (HAMP) or HAMP-related gene expression 有权抑制铁调素抗菌肽（HAMP）或HAMP相关基因表达的组合物和方法公开(公告)号：US09228188B2
公开(公告)日：2016-01-05
申请号：US14118489
申请日：2012-06-21
Applicant: Brian Bettencourt , Akin Akinc , Alfica Sehgal , Don Foster , Stuart Milstein , Satyanarayana Kuchimanchi , Martin A. Maier , Klaus Charisse , Kallanthottathil Rajeev
Inventor： Brian Bettencourt , Akin Akinc , Alfica Sehgal , Don Foster , Stuart Milstein , Satyanarayana Kuchimanchi , Martin A. Maier , Klaus Charisse , Kallanthottathil Rajeev
IPC: C12N15/11 , C12N15/113 , A61K31/7105 , A61K33/26 , A61K47/48
CPC classification number: C12N15/113 , A61K31/7105 , A61K33/26 , A61K47/48092 , A61K47/549 , C12N15/1136 , C12N15/1138 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3233 , C12N2310/351 , C12N2310/3515 , C12N2310/3521 , C12N2310/3533 , C12N2320/30
Abstract: The invention relates to lipid formulated double-stranded ribonucleic acid (dsRNA) targeting a hepcidin antimicrobial peptide (HAMP) and/or HAMP-related gene, and methods of using the dsRNA to inhibit expression of HAMP and/or HAMP-related genes.
Abstract translation: 本发明涉及靶向铁调素抗体肽（HAMP）和/或HAMP相关基因的脂质配制双链核糖核酸（dsRNA），以及使用dsRNA抑制HAMP和/或HAMP相关基因表达的方法。
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29.发明申请Compositions and Method for Inhibiting Hepcidin Antimicrobial Peptide (HAMP) or HAMP-Related Gene Expression 有权抑制Hepcidin抗菌肽（HAMP）或HAMP相关基因表达的组合物和方法公开(公告)号：US20140127325A1
公开(公告)日：2014-05-08
申请号：US14118489
申请日：2012-06-21
Applicant: Brian Bettencourt , Akin Akinc , Alfica Sehgal , Don Foster , Stuart Milstein , Satyanarayana Kuchimanchi , Martin A. Maier , Klaus Charisse , Kallanthottathil Rajeev
Inventor： Brian Bettencourt , Akin Akinc , Alfica Sehgal , Don Foster , Stuart Milstein , Satyanarayana Kuchimanchi , Martin A. Maier , Klaus Charisse , Kallanthottathil Rajeev
IPC: C12N15/113 , A61K47/48 , A61K33/26 , A61K31/7105
CPC classification number: C12N15/113 , A61K31/7105 , A61K33/26 , A61K47/48092 , A61K47/549 , C12N15/1136 , C12N15/1138 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3233 , C12N2310/351 , C12N2310/3515 , C12N2310/3521 , C12N2310/3533 , C12N2320/30
Abstract: The invention relates to lipid formulated double-stranded ribonucleic acid (dsRNA) targeting a hepcidin antimicrobial peptide (HAMP) and/or HAMP-related gene, and methods of using the dsRNA to inhibit expression of HAMP and/or HAMP-related genes.
Abstract translation: 本发明涉及靶向铁调素抗体肽（HAMP）和/或HAMP相关基因的脂质配制双链核糖核酸（dsRNA），以及使用dsRNA抑制HAMP和/或HAMP相关基因表达的方法。
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30.发明申请COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF KLF-1 AND BCL11A GENES 有权用于抑制KLF-1和BCL11A基因表达的组合物和方法公开(公告)号：US20140018410A1
公开(公告)日：2014-01-16
申请号：US13992669
申请日：2011-12-09
Applicant: Tatiana Novobrantseva , Brian Bettencourt , Stuart Milstein , Anna Borodovsky
Inventor： Tatiana Novobrantseva , Brian Bettencourt , Stuart Milstein , Anna Borodovsky
IPC: C12N15/113
CPC classification number: C12N15/113 , C12N2310/14 , C12N2310/344 , C12N2310/321 , C12N2310/3521
Abstract: The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the KLF1 gene and the BCL11A gene, and methods of using such dsRNA compositions to inhibit expression of KLF1 and BCL11 A, respectively.
Abstract translation: 本发明涉及靶向KLF1基因和BCL11A基因的双链核糖核酸（dsRNA）组合物，以及分别使用这些dsRNA组合物抑制KLF1和BCL11A表达的方法。
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