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公开(公告)号：US20130035371A1
公开(公告)日：2013-02-07
申请号：US13568898
申请日：2012-08-07
申请人： Kevin Fitzgerald , Gregory Hinkle , Akin Akinc , Stuart Milstein
发明人： Kevin Fitzgerald , Gregory Hinkle , Akin Akinc , Stuart Milstein
IPC分类号： A61K31/713 , A61P3/06 , A61K48/00 , C12N5/071
CPC分类号： A61K31/713 , A61K9/0019 , A61K9/1272 , A61K9/1273 , A61K38/1709 , A61K47/545 , A61K47/55 , A61K47/6911 , C12N15/1137 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3515
摘要： This invention relates to composition and methods using lipid formulated siRNA targeted to a PCSK9 gene.
摘要翻译： 本发明涉及使用针对PCSK9基因的脂质配制的siRNA的组合物和方法。
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公开(公告)号：US08273869B2
公开(公告)日：2012-09-25
申请号：US12816207
申请日：2010-06-15
申请人： Kevin Fitzgerald , Gregory Hinkle , Akin Akinc , Stuart Milstein
发明人： Kevin Fitzgerald , Gregory Hinkle , Akin Akinc , Stuart Milstein
CPC分类号： A61K31/713 , A61K9/0019 , A61K9/1272 , A61K9/1273 , A61K38/1709 , A61K47/545 , A61K47/55 , A61K47/6911 , C12N15/1137 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3515
摘要： This invention relates to composition and methods using lipid formulated siRNA targeted to a PCSK9 gene.
摘要翻译： 本发明涉及使用针对PCSK9基因的脂质配制的siRNA的组合物和方法。
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公开(公告)号：US20110015252A1
公开(公告)日：2011-01-20
申请号：US12816207
申请日：2010-06-15
申请人： Kevin Fitzgerald , Gregory Hinkle , Akin Akinc , Stuart Milstein
发明人： Kevin Fitzgerald , Gregory Hinkle , Akin Akinc , Stuart Milstein
IPC分类号： A61K31/713 , A61P9/10
CPC分类号： A61K31/713 , A61K9/0019 , A61K9/1272 , A61K9/1273 , A61K38/1709 , A61K47/545 , A61K47/55 , A61K47/6911 , C12N15/1137 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3515
摘要： This invention relates to composition and methods using lipid formulated siRNA targeted to a PCSK9 gene.
摘要翻译： 本发明涉及使用针对PCSK9基因的脂质配制的siRNA的组合物和方法。
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公开(公告)号：US08598139B2
公开(公告)日：2013-12-03
申请号：US13568898
申请日：2012-08-07
申请人： Kevin Fitzgerald , Gregory Hinkle , Akin Akinc , Stuart Milstein
发明人： Kevin Fitzgerald , Gregory Hinkle , Akin Akinc , Stuart Milstein
CPC分类号： A61K31/713 , A61K9/0019 , A61K9/1272 , A61K9/1273 , A61K38/1709 , A61K47/545 , A61K47/55 , A61K47/6911 , C12N15/1137 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3515
摘要： This invention relates to composition and methods using lipid formulated siRNA targeted to a PCSK9 gene.
摘要翻译： 本发明涉及使用针对PCSK9基因的脂质配制的siRNA的组合物和方法。
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5.发明授权Compositions and method for inhibiting hepcidin antimicrobial peptide (HAMP) or HAMP-related gene expression 有权抑制铁调素抗菌肽（HAMP）或HAMP相关基因表达的组合物和方法公开(公告)号：US09228188B2
公开(公告)日：2016-01-05
申请号：US14118489
申请日：2012-06-21
申请人： Brian Bettencourt , Akin Akinc , Alfica Sehgal , Don Foster , Stuart Milstein , Satyanarayana Kuchimanchi , Martin A. Maier , Klaus Charisse , Kallanthottathil Rajeev
发明人： Brian Bettencourt , Akin Akinc , Alfica Sehgal , Don Foster , Stuart Milstein , Satyanarayana Kuchimanchi , Martin A. Maier , Klaus Charisse , Kallanthottathil Rajeev
IPC分类号： C12N15/11 , C12N15/113 , A61K31/7105 , A61K33/26 , A61K47/48
CPC分类号： C12N15/113 , A61K31/7105 , A61K33/26 , A61K47/48092 , A61K47/549 , C12N15/1136 , C12N15/1138 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3233 , C12N2310/351 , C12N2310/3515 , C12N2310/3521 , C12N2310/3533 , C12N2320/30
摘要： The invention relates to lipid formulated double-stranded ribonucleic acid (dsRNA) targeting a hepcidin antimicrobial peptide (HAMP) and/or HAMP-related gene, and methods of using the dsRNA to inhibit expression of HAMP and/or HAMP-related genes.
摘要翻译： 本发明涉及靶向铁调素抗体肽（HAMP）和/或HAMP相关基因的脂质配制双链核糖核酸（dsRNA），以及使用dsRNA抑制HAMP和/或HAMP相关基因表达的方法。
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6.发明申请Compositions and Method for Inhibiting Hepcidin Antimicrobial Peptide (HAMP) or HAMP-Related Gene Expression 有权抑制Hepcidin抗菌肽（HAMP）或HAMP相关基因表达的组合物和方法公开(公告)号：US20140127325A1
公开(公告)日：2014-05-08
申请号：US14118489
申请日：2012-06-21
申请人： Brian Bettencourt , Akin Akinc , Alfica Sehgal , Don Foster , Stuart Milstein , Satyanarayana Kuchimanchi , Martin A. Maier , Klaus Charisse , Kallanthottathil Rajeev
发明人： Brian Bettencourt , Akin Akinc , Alfica Sehgal , Don Foster , Stuart Milstein , Satyanarayana Kuchimanchi , Martin A. Maier , Klaus Charisse , Kallanthottathil Rajeev
IPC分类号： C12N15/113 , A61K47/48 , A61K33/26 , A61K31/7105
CPC分类号： C12N15/113 , A61K31/7105 , A61K33/26 , A61K47/48092 , A61K47/549 , C12N15/1136 , C12N15/1138 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3233 , C12N2310/351 , C12N2310/3515 , C12N2310/3521 , C12N2310/3533 , C12N2320/30
摘要： The invention relates to lipid formulated double-stranded ribonucleic acid (dsRNA) targeting a hepcidin antimicrobial peptide (HAMP) and/or HAMP-related gene, and methods of using the dsRNA to inhibit expression of HAMP and/or HAMP-related genes.
摘要翻译： 本发明涉及靶向铁调素抗体肽（HAMP）和/或HAMP相关基因的脂质配制双链核糖核酸（dsRNA），以及使用dsRNA抑制HAMP和/或HAMP相关基因表达的方法。
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公开(公告)号：US08598335B2
公开(公告)日：2013-12-03
申请号：US13614836
申请日：2012-09-13
申请人： Antonin De Fougerolles , John Diener , Emma Hickman , Gregory Hinkle , Stuart Milstein , Anne-Marie Pulichino , Andrew Griffin Sprague
发明人： Antonin De Fougerolles , John Diener , Emma Hickman , Gregory Hinkle , Stuart Milstein , Anne-Marie Pulichino , Andrew Griffin Sprague
CPC分类号： C12N15/1138 , A61K31/713 , C12N2310/111 , C12N2310/14 , C12N2310/31 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/351 , C12N2310/3513 , C12N2310/3515 , C12N2310/3517 , C12N2310/3521
摘要： The present disclosure relates to RNAi agents useful in methods of treating Beta-ENaC-related diseases such as cystic fibrosis, pseudohypoaldosteronism type 1 (PHA1), Liddle's syndrome, hypertension, alkalosis, hypokalemia, and obesity-associated hypertension, using a therapeutically effective amount of a RNAi agent to Beta-ENaC.
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公开(公告)号：US08344129B2
公开(公告)日：2013-01-01
申请号：US13355879
申请日：2012-01-23
申请人： Antonin De Fougerolles , John L. Diener , Emma Hickman , Gregory Hinkle , Stuart Milstein , Anne-Marie Pulichino , Andrew Griffin Sprague
发明人： Antonin De Fougerolles , John L. Diener , Emma Hickman , Gregory Hinkle , Stuart Milstein , Anne-Marie Pulichino , Andrew Griffin Sprague
CPC分类号： C12N15/1138 , A61K31/713 , C12N2310/111 , C12N2310/14 , C12N2310/31 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/351 , C12N2310/3513 , C12N2310/3515 , C12N2310/3517 , C12N2310/3521
摘要： The present disclosure relates to RNAi agents useful in methods of treating Beta-ENaC-related diseases such as cystic fibrosis, pseudohypoaldosteronism type 1 (PHA1), Liddle's syndrome, hypertension, alkalosis, hypokalemia, and obesity-associated hypertension, using a therapeutically effective amount of a RNAi agent to Beta-ENaC.
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公开(公告)号：US08293718B2
公开(公告)日：2012-10-23
申请号：US12970268
申请日：2010-12-16
申请人： Gregory Hinkle , Satyanarayana Kuchimanchi , Stuart Milstein , Markus Warmuth , Wenlai Zhou , Ping Zhu , Tracy S. Zimmermann
发明人： Gregory Hinkle , Satyanarayana Kuchimanchi , Stuart Milstein , Markus Warmuth , Wenlai Zhou , Ping Zhu , Tracy S. Zimmermann
IPC分类号： C12N15/11
CPC分类号： C12N15/113 , A61K31/713 , A61K45/06 , C07H21/02 , C12N2310/14 , C12N2310/321 , C12N2310/322 , C12N2320/31 , C12N2320/51 , C12N2320/53 , Y02A50/467 , C12N2310/3521
摘要： The present disclosure relates to methods of treating heat shock factor 1 (HSF1)-related diseases such as cancer and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF.
摘要翻译： 本公开涉及使用治疗有效量的RNAi剂对HSF治疗热休克因子1（HSF1）相关疾病如癌症和病毒性疾病的方法。
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10.发明申请公开(公告)号：US20120225927A1
公开(公告)日：2012-09-06
申请号：US13410262
申请日：2012-03-01
IPC分类号： A61K31/713 , A61P25/28 , C12N5/071 , C12N15/113
CPC分类号： C12N15/113 , A61K9/0019 , A61K31/713 , C12N15/111 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/335 , C12N2310/3515 , C12N2320/30 , C12N2320/32 , C12N2310/3521
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression of TTR.
摘要翻译： 本发明涉及靶向转甲状腺素蛋白（TTR）基因的双链核糖核酸（dsRNA）以及使用dsRNA抑制TTR表达的方法。
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