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公开(公告)号：US09889093B2
公开(公告)日：2018-02-13
申请号：US14910173
申请日：2014-08-06
发明人： Henry Sun , Xiaohui Ma , Zhixin Guo , Sen Lin , Genbei Wang , Lulu Yan , Lihua Zhang , Shuiping Zhou , Shunnan Zhang
IPC分类号： A61K9/16 , A61K31/365 , A61K9/50 , B01J2/00
CPC分类号： A61K9/1682 , A61K9/1635 , A61K9/1676 , A61K9/5026 , A61K9/5078 , A61K31/365 , B01J2/006
摘要： The present invention relates to an andrographolide enteric targeting micropellet and a method for preparation thereof; furthermore, the present invention also relates to uses of andrographolide and andrographolide enteric targeting micropellets in preparation of a pharmaceutical for treatment of inflammatory bowel disease.
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22.发明申请NEW SALVIANOLIC ACID COMPOUND T, PREPARATION METHOD THEREFOR, AND USE THEREOF 审中-公开新的维生素A化合物T，其制备方法及其用途公开(公告)号：US20160200661A1
公开(公告)日：2016-07-14
申请号：US14914166
申请日：2014-08-26
发明人： Shuiping Zhou , Wei Li , Yuanpeng Jin , Xinxin Li , Xiaohui Ma , Wei Zhou , Min Han , Shuming Li
IPC分类号： C07C69/732 , C07C67/56
CPC分类号： C07C69/732 , A61K36/537 , A61K2236/00 , C07B2200/09 , C07C67/56
摘要： The present invention relates to the medical field, specifically a salvianolic acid T as described in structural formula (I), a chiral isomer thereof, a preparation method therefor, pharmaceutical compositions, antioxidants, and free radical scavengers thereof, and a use of the compound.
摘要翻译： 本发明涉及医学领域，特别是结构式（I）所述的丹酚酸T，其手性异构体，其制备方法，药物组合物，抗氧化剂及其自由基清除剂，以及该化合物 。
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公开(公告)号：US20230201293A1
公开(公告)日：2023-06-29
申请号：US17920888
申请日：2021-04-28
发明人： He SUN , Xuefeng SU , Zhiyong ZHONG , Anni LI , Xijun YAN , Naifeng WU , Kaijing YAN
IPC分类号： A61K36/537 , A61K36/258 , A61K31/05 , A61K9/51 , A61P11/00
CPC分类号： A61K36/537 , A61K36/258 , A61K31/05 , A61K9/5123 , A61K9/5161 , A61K9/5146 , A61P11/00
摘要： The present invention relates to an application of a traditional Chinese medicine composition and formulation thereof in the preparation of medicaments for preventing and/or treating novel coronavirus pneumonia.
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公开(公告)号：US11491173B2
公开(公告)日：2022-11-08
申请号：US16976832
申请日：2019-04-04
发明人： Shuiping Zhou , He Sun , Yiqian Zhang , Xiaohui Ma , Jiawen Shi , Yi He , Xinxin Li , Jing Wang , Xiaoqing Li , Lijun Fan , Jingjing Zhang
IPC分类号： A61K31/7048 , A61P9/04 , A61K31/216 , A61K31/343 , A61K31/405 , A61K31/704
摘要： Disclosed are a pharmaceutical composition and an application thereof. The pharmaceutical composition of the present invention comprises the following components in parts by weight: 2-20 parts of phenolic acids, 0.5-5 parts of flavonoids, 0.005-0.5 part of tanshinones, 5-20 parts of saponins, and 10-18 parts of volatile oils. The pharmaceutical composition has the functions of protecting against myocardial damage and treating heart failure.
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公开(公告)号：USRE49050E1
公开(公告)日：2022-04-26
申请号：US16713533
申请日：2019-12-13
发明人： Xijun Yan , Naifeng Wu , Kaijing Yan , Zhengliang Ye , Shunnan Zhang , Lihong Zhou , Wensheng Zhang , Hai'ou Dong , Yongfeng Zheng , Lijun Fan
IPC分类号： A61K36/00 , A61K36/537 , A61K31/045 , A61K31/343 , A61K36/258 , A61K9/50 , A61K31/11 , A61K31/192 , A61K31/704 , A61K31/222 , A61K31/216
摘要： A traditional Chinese medicine composition for treating cardiovascular disease, and a preparation thereof, particularly a micro drop pill preparation thereof, and a method for preparing the preparation; the method for preparing the micro drop pill preparation can be used to prepare drop pills, coated drop pills, and drop pill capsules with a high drug loading capacity.
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26.发明申请公开(公告)号：US20210038668A1
公开(公告)日：2021-02-11
申请号：US17041795
申请日：2019-03-25
发明人： Jingyan HAN , Qingfang CHEN , Dandan HUANG , Xiaohui MA , Yi HE , Shuiping ZHOU
IPC分类号： A61K36/258 , A61K36/481 , A61P9/10 , A61K31/343 , A61K31/704
摘要： The present invention discloses a traditional Chinese medicinal composition for preventing and/or treating ischemia reperfusion injury; the traditional Chinese medicinal composition consists of salvianolic acids, Panax notoginseng saponins and total saponins of Astragalus.
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公开(公告)号：US20190274962A1
公开(公告)日：2019-09-12
申请号：US16422857
申请日：2019-05-24
发明人： Xijun Yan , Naifeng Wu , Kaijing Yan , Xiaobing Sun , Shunnan Zhang , Zhengliang Ye , Hai'ou Dong , Hongbo Zhang , Wensheng Zhang , Lihong Zhou , Chenming Li , Cong Chen , Xiaofeng Liu , Shiqing Wang , Changsheng Rong , Yongfeng Zheng , Lijun Fan
IPC分类号： A61K9/20 , A61K36/481 , A61K36/48 , A61J3/06 , A61K45/06 , A61K9/50 , A61K36/258 , A61K36/537
摘要： The present invention relates to a preparation method for a traditional Chinese medicine drop pill and a traditional Chinese medicine micro drop pill prepared by using the method, and in particular, the present invention relates to a micro drop pill preparation method with high drug-loading capacity, simple preparation process and high production rate and a micro drop pill prepared by using the method. Specially, The drop pill preparation method used comprises the following steps: (1) material melting step: heat melting a medicine and a drop pill matrix to obtain a molten medicine liquid; (2) dropping step: delivering the molten medicine liquid to a dripper, and acquiring medicine drops of the molten medicine liquid by means of vibration dropping; and, (3) condensation step: cooling the medicine drops with a cooling gas to obtain micro drop pills.
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公开(公告)号：US10314923B2
公开(公告)日：2019-06-11
申请号：US15541556
申请日：2015-12-24
发明人： Jianming Chen , Baoan Gao , Qinqin Zhou , Shuiping Zhou , Nan Cai , Yuansheng Zhang , Chan Wu , Nong Yu , Lina Chen , Wenli Liu
IPC分类号： A61K9/00 , A61K9/08 , A61K9/16 , A61K9/19 , A61K41/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/24 , A61K47/26 , A61K47/69 , A61K31/357
摘要： A silybin injection contains silybin, sulfobutyl ether-β-cyclodextrin, an organic solvent for injection, a pH regulator, and may further contain a co-solvent, a lyophilization bulking agent, and water for injection.
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公开(公告)号：US20180263851A1
公开(公告)日：2018-09-20
申请号：US15760441
申请日：2016-09-14
发明人： Kaijing YAN , Xiaobing SUN , Changsheng RONG , Xuefei CAI , Liang WANG
IPC分类号： A61J3/06
CPC分类号： A61J3/06
摘要： An intelligent dripping pill machine for continuous liquid solidification comprises: a feeding device (1), a material combining device (2), a homogenizing device (3), a dripping device (4) and a de-oiling device (5) sequentially connected via a transmission channel. The intelligent dripping pill machine removes, via high-speed centrifugation, a cooling liquid attached to dripping pills, and each component device is connected compactly, thereby achieving a continuous manufacturing operation, and reducing an occupied space of the devices as a whole while ensuring the yield of the dripping pills.
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公开(公告)号：US09987320B2
公开(公告)日：2018-06-05
申请号：US14903684
申请日：2014-07-11
发明人： Xijun Yan , Naifeng Wu , Kaijing Yan , Zhengliang Ye , Shunnan Zhang , Lihong Zhou , Wensheng Zhang , Hai'ou Dong , Yongfeng Zheng , Lijun Fan
IPC分类号： A61K36/00 , A61K36/537 , A61K31/045 , A61K31/343 , A61K36/258 , A61K9/50 , A61K31/11 , A61K31/192 , A61K31/216 , A61K31/222 , A61K31/704
CPC分类号： A61K36/537 , A61K9/5015 , A61K9/5026 , A61K9/5042 , A61K9/5089 , A61K31/045 , A61K31/11 , A61K31/192 , A61K31/216 , A61K31/222 , A61K31/343 , A61K31/704 , A61K36/258 , A61K2300/00
摘要： A traditional Chinese medicine composition for treating cardiovascular disease, and a preparation thereof, particularly a micro drop pill preparation thereof, and a method for preparing the preparation; the method for preparing the micro drop pill preparation can be used to prepare drop pills, coated drop pills, and drop pill capsules with a high drug loading capacity.
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