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21.发明授权公开(公告)号：US12077772B2
公开(公告)日：2024-09-03
申请号：US17092240
申请日：2020-11-07
Inventor： Steven J. Gray , Frances C. Shaffo
CPC classification number: C12N15/86 , A61K9/0085 , A61K38/1787 , A61K48/005 , A61K48/0083 , C07K14/70571 , C12N7/00 , C12N2750/14143 , C12N2800/22 , C12N2830/50
Abstract: The present disclosure provides methods and compositions for the treatment of diseases and genetic disorders linked to SLC6A1 loss and/or misfunction. The methods and compositions of the present disclosure comprise rAAV vectors and rAAV viral vectors comprising transgene nucleic acid molecules comprising nucleic acid sequences encoding for a GAT1 polypeptide.
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公开(公告)号：US12073541B2
公开(公告)日：2024-08-27
申请号：US17633133
申请日：2020-08-10
Inventor： Zbyszek Otwinowski , Raquel Bromberg , Dominika Borek
CPC classification number: G06T5/80 , H01J37/222 , G06T2207/10061 , H01J2237/223 , H01J2237/2826
Abstract: Methods for correcting one or more image aberrations in an electron microscopy image, including cryo-EM images, are provided. The method includes obtaining a plurality of electron microscope (EM) images of an internal reference grid sample having one or more known properties, the plurality of electron microscope images obtained for a plurality of optical conditions and for a plurality of coordinated beam-image shifts. The method may also include, among other features, determining an aberration correction function that predicts aberrations for every point in the imaged area using kernel canonical correlation analysis (KCCA).
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公开(公告)号：US20240263385A1
公开(公告)日：2024-08-08
申请号：US18639315
申请日：2024-04-18
Inventor： Mohammed Jasim Uddin , Jared Jaksik , H. Justin Moore
IPC: D06M11/83 , A41D13/11 , A41D31/30 , D06M16/00 , D06M101/06
CPC classification number: D06M11/83 , A41D13/1161 , A41D13/1192 , A41D31/30 , D06M16/00 , D06M2101/06 , D06M2200/00 , D06M2200/01 , D06M2400/02
Abstract: A method for forming a metallic nanoparticle and semiconductor coated surface, such as the surface of a fiber or other material is provided. The method can include the steps of coating at least one surface of a material, for example a textile material, with a semiconducting layer, and providing metallic nanoparticles on the semiconducting layer. The steps for coating a surface of a material with a semiconducting layer can include forming a titanium dioxide film on the surface of the textile or other material. The steps for depositing and/or providing metallic nanoparticles on the semiconducting layer can include immersing a surface having a semiconductor layer into a metallic nanoparticle precursor solution, drying the semiconductor layer, and exposing the semiconductor layer on the surface to UV radiation. The metallic nanoparticles can include gold and/or silver nanoparticles. Also disclosed are surface treated materials having a semiconductor layer thereon, wherein the semiconductor layer is treated to include metallic nanoparticles. The surface treated materials may comprise surfaces of a textile material, such as fibers. The surface treated materials are anti-microbial and resistant to peeling, as well as non-toxic to biological surfaces, such as skin. Treated fiber materials may be used in garments, masks, and other products that contact the skin, that are free of toxic/rash side effects.
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公开(公告)号：US20240245620A1
公开(公告)日：2024-07-25
申请号：US18590737
申请日：2024-02-28
Inventor： Qiang CHENG , Tuo WEI , Daniel J. SIEGWART
IPC: A61K9/51 , A61K48/00 , C12N9/22 , C12N15/11 , C12N15/113
CPC classification number: A61K9/5123 , A61K48/0033 , C12N9/22 , C12N15/11 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/20 , C12N2320/32
Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.
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公开(公告)号：US20240239903A1
公开(公告)日：2024-07-18
申请号：US18409571
申请日：2024-01-10
Inventor： Linda DONNELLY , Xiaofeng QI , Xiaochun LI
CPC classification number: C07K16/2863 , A61K45/06 , G01N33/6893 , C07K2317/21 , C07K2317/24 , C07K2317/76 , G01N2333/705 , G01N2800/7057
Abstract: Disclosures herein are directed to antibodies and epitope binding agents that specifically bind to the extracellular domain of Patched-1 and compositions thereof for use in clinical and non-clinical applications. Also provided are methods to treat and/or prevent Hedgehog pathway related disorders.
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Patent Agency Ranking
公开(公告)号：US20240229029A9
公开(公告)日：2024-07-11
申请号：US18471280
申请日：2023-09-20
Inventor： David COREY , Liande LI
IPC: C12N15/113 , A61K45/06 , A61P25/00
CPC classification number: C12N15/113 , A61K45/06 , A61P25/00 , C12N2310/14 , C12N2310/315 , C12N2310/3231
Abstract: Described are compounds and methods useful for the treatment and investigation of Friedreich's Ataxia.
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27.发明公开公开(公告)号：US20240200139A1
公开(公告)日：2024-06-20
申请号：US18547830
申请日：2022-02-25
Inventor： Nikolaos Mellios , Madhukar H. Trivedi
IPC: C12Q1/6883
CPC classification number: C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178
Abstract: A plurality of circular RNAs (circRNAs) the expression of which is correlated with diagnosis for Major Depressive Disorder (MDD) and Bipolar Disorder (BD) and response to treatment with various antidepressants is provided. The circRNAs are useful for compositions, kits, assays, and methods for the identification, diagnosis, screening, treatment, and/or monitoring of brain disorders such as MDD and BD.
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公开(公告)号：US20240191254A1
公开(公告)日：2024-06-13
申请号：US18411647
申请日：2024-01-12
Inventor： Steven J. GRAY , Sarah SINNETT
IPC: C12N15/86 , C12N15/113
CPC classification number: C12N15/86 , C12N15/113 , C12N2310/141 , C12N2310/315 , C12N2310/321
Abstract: The present disclosure provides methods and compositions for the treatment of diseases and genetic disorders linked to MeCP2 loss and/or misfunction, including RETT syndrome. The methods and compositions of the present disclosure comprise rAAV vectors and rAAV viral vectors comprising transgene nucleic acid molecules comprising nucleic acid sequences encoding for a MeCP2 polypeptide.
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公开(公告)号：US20240150396A1
公开(公告)日：2024-05-09
申请号：US18280400
申请日：2022-03-03
Inventor： Thomas D. Meek , Linfeng Li , Chien-Te Kent Tseng , Aleksandra Drelich
CPC classification number: C07K5/06139 , A61P31/14 , A61P33/02 , A61K38/00
Abstract: Provided herein are pharmaceutical compositions including compounds having Formula (I) in an effective amount to inhibit cysteine protease as well as methods of using thereof.
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公开(公告)号：US11969522B2
公开(公告)日：2024-04-30
申请号：US16922355
申请日：2020-07-07
Inventor： Jonathan Cheng , Edward Keefer , Srikanth Vasudevan
IPC: A61L27/18 , A61K38/18 , A61K45/06 , A61K31/395 , A61K31/5377 , C07D257/02
CPC classification number: A61L27/18 , A61K38/18 , A61K38/185 , A61K38/1866 , A61K45/06 , A61K31/395 , A61K31/5377 , A61L2430/32 , C07D257/02
Abstract: The present disclosure describes the use of immune modulators to promote nerve growth and regeneration, particularly in the context of nerve deficit stemming from trauma and disease. In particular, the disclosure provides for the use of CXCR4 antagonsists, STAT3 activators, and an agent that increase nitric oxide, alone or in combination, to treat nerve deficit conditions.
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