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公开(公告)号：US20230167065A1
公开(公告)日：2023-06-01
申请号：US17998018
申请日：2021-05-10
申请人： Oregon Health & Science University , The United States Government as Represented by the Department of Veterans Affairs
IPC分类号： C07D215/233
CPC分类号： C07D215/233
摘要： The present invention provides synthetic methods and novel intermediates in the preparation of 3-aryl Endochin-like quinolone (ELQ) compounds.
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公开(公告)号：US20230149469A1
公开(公告)日：2023-05-18
申请号：US17947360
申请日：2022-09-19
申请人： The United States Government as represented by The Department of Veterans Affairs , The Brigham and Women's Hospital, Inc. , Children's Medical Center Corporation
CPC分类号： A61K35/28 , C12N5/0668 , A61L27/26 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L27/3886 , C12N5/063 , A61K38/00
摘要： The present invention is directed to wound healing scaffolds cografted with a population of stem cells, wherein the population of stem cells are ABCB5+ stem cells. The scaffolds are, for instance, collagen glycosaminoglycan scaffolds.
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公开(公告)号：US20230145832A1
公开(公告)日：2023-05-11
申请号：US17980164
申请日：2022-11-03
申请人： The Cleveland Clinic Foundation , The United States Government as Represented by the Department of Veterans Affairs
发明人： Paul D. Marasco , Jonathon S. Schofield , Courtney E. Shell , Zachary C. Thumser , Dylan Beckler , Jonathan Sakai
CPC分类号： A61M21/02 , A61M5/52 , A61M2021/0022
摘要： A cognitive illusion of ownership over a proxy extremity (e.g. a hand) is provided by discordant touch and visual information to a user. While the user feels the touch on their real extremity, they see a corresponding touch on the proxy extremity. The user's internally modeled reality is then updated to move the felt location of the real extremity to the seen location of the proxy extremity. As a result, the user embodies the proxy extremity, thereby disembodying the real extremity. Pain associated with medical procedures performed on the real extremity is then mitigated. And because an epileptic brain is less stringent when resolving conflict between what is seen and what is felt, correlations in time or space can shift attribution of the sensation of the felt touch on the user's real extremity to the location of the proxy extremity. This can be helpful in treating and/or diagnosing epilepsy.
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公开(公告)号：US20230002480A1
公开(公告)日：2023-01-05
申请号：US17677757
申请日：2022-02-22
申请人： Dongkyoon Kim , Guy Cavet , University of Maryland, Baltimore , The United States Government as Represented by the Department of Veterans Affairs
发明人： Mohammad Sajadi , George K. Lewis , Anthony DeVico , Dongkyoon Kim , Guy Cavet
摘要： The present invention provides broadly neutralizing antibodies against HIV, compositions comprising the same and methods of use thereof.
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25.发明申请公开(公告)号：US20220387650A1
公开(公告)日：2022-12-08
申请号：US17892018
申请日：2022-08-19
发明人： Chetan Jinadatha
摘要： The invention provides method for organizing the disinfection of one or more items contaminated with biological agent(s) comprising (a) attaching a radio-frequency ID (RFID) tag to an item(s) to be disinfected; exposing the item(s) of (a) to a disinfecting means for a period sufficient to disinfect the item; and (c) obtaining a signal from the tagged item when disinfection is complete thereby organizing the disinfection of one or more items.
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公开(公告)号：US11512052B2
公开(公告)日：2022-11-29
申请号：US16763962
申请日：2018-11-20
申请人： Icahn School of Medicine at Mount Sinai , The United States Government as represented by the Department of Veterans Affairs
发明人： Michael Ohlmeyer , Dongming Cai
IPC分类号： C07D211/90 , A61P25/28
摘要： A genus of dihydropyridine chemical modulators of synaptojanin is disclosed. These modulators are selective inhibitors of synaptojanin 1 and may be used to treat cognitive impairment or traumatic brain injury, including promoting regeneration in cases of traumatic brain injury, or for treating neurodegenerative disorders.
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公开(公告)号：US11510887B2
公开(公告)日：2022-11-29
申请号：US16922852
申请日：2020-07-07
申请人： Oregon Health & Science University , The United States Government as represented by the Department of Veterans Affairs
发明人： Thomas S. Scanlan , Meredith Hartley , Andrew Placzek , Marco Righi , Dennis Bourdette , Gail Marracci , Priya Chaudhary
IPC分类号： A61K31/192 , A61K9/00
摘要： Methods of treating a subject having or at risk of developing a neurodegenerative disease or condition associated with demyelination, insufficient myelination, or underdevelopment of myelin sheath are described. The methods include administration of a therapeutically effective amount of sobetirome, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20220333159A1
公开(公告)日：2022-10-20
申请号：US17715187
申请日：2022-04-07
申请人： The United States Government As Represented By The Department of Veterans Affairs , THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
发明人： Douglas Feinstein , Anne Boullerne
IPC分类号： C12Q1/686
摘要： Disclosed herein, are methods of detecting multiple sclerosis in a subject by measuring relative abundances of multiple oral microbiota in sample. Also, disclosed herein are methods of treatment and prophylaxis of MS.
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公开(公告)号：US20220324998A1
公开(公告)日：2022-10-13
申请号：US17620395
申请日：2020-06-18
申请人： MUSC Foundation for Research Development , New York University , The United States Government as Represented by the Department of Veterans Affairs
发明人： John O'Bryan , Shohei Koide , Akiko Koide
IPC分类号： C07K16/32 , A61K39/395 , A61P35/00 , G01N33/574
摘要： The invention provides compositions and methods for binding Ras in a nucleotide free state (apo RAS) and inhibiting Ras signaling. In one embodiment, the invention provides monobodies that specifically bind apo RAS and methods of use. Thus, in diseases and conditions where a reduction of Ras signaling is beneficial, such inhibitory compositions act as therapeutics.
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公开(公告)号：US20220280472A1
公开(公告)日：2022-09-08
申请号：US17625059
申请日：2020-07-08
申请人： University of Maryland, Baltimore , The Governors of the University of Alberta , The United States Government as represented by the Department of Veterans Affairs
IPC分类号： A61K31/351 , A61K31/713 , A61P11/00
摘要： The present invention provides a method for treating a fibrotic lung disease or fibrotic lung condition in a subject that involves an increase in NEU1 expression and/or activity, comprising administering to the subject an effective amount of an agent that inhibits the activity of NEU 1 sialidase, thereby treating the fibrotic lung disease or fibrotic lung condition in the subject.
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