公开(公告)号：US20230415409A1

公开(公告)日：2023-12-28

申请号：US18249495

申请日：2021-10-20

Applicant: UCL Business Ltd. ,  Imperial College Innovations Limited

Inventor： Chu Lun Alex Leung ,  Iuliia Elizarova ,  Peter D Lee ,  Eduardo Saiz

IPC: B29C64/165 ,  C01B32/194 ,  B29C64/314 ,  B33Y70/10

CPC classification number: B29C64/165 ,  C01B32/194 ,  B29C64/314 ,  B33Y70/10

Abstract: A method for producing an additive manufacturing feedstock, the method comprising adding a photothermal agent to a construction material to cause the photothermal agent to be in thermally conductive contact with the construction material, whereby to produce the additive manufacturing feedstock, wherein the photothermal agent comprises chemically modified graphene, CMG.

公开(公告)号：US20230346755A1

公开(公告)日：2023-11-02

申请号：US18349406

申请日：2023-07-10

Applicant: UCL BUSINESS LTD

Inventor： Edward ZHANG ,  Paul BEARD ,  Nam Trung HUYNH

IPC: A61K31/4365 ,  A61K31/496 ,  A61P35/00 ,  C07K16/22 ,  A61K31/5377

CPC classification number: A61K31/4365 ,  A61K31/496 ,  A61K31/5377 ,  A61P35/00 ,  C07K16/22

Abstract: The present invention is directed to an apparatus and method for performing ultrasound optical imaging with respect to a sample in which an acoustic field is generated in response to a stimulus. The apparatus comprises a sensor head having an acoustically sensitive surface arranged as a reflective surface of a Fabry Perot interferometric cavity, wherein, when the acoustically sensitive surface is placed against the sample, in use, the acoustic field generated in response to said stimulus is incident upon said acoustically sensitive surface to modulate the optical path length in the cavity with a signal indicative of the acoustic field. Interrogation of the sensor head is performed based on regions having common bias phase.

公开(公告)号：US20230277538A1

公开(公告)日：2023-09-07

申请号：US18011583

申请日：2021-06-23

Applicant: UCL BUSINESS LTD

Inventor： Julie DUMONCEAUX ,  Virginie MARIOT ,  Maximilien BENCZE

IPC: A61K31/506 ,  C12N15/86 ,  A61K31/502 ,  A61P21/00

CPC classification number: A61K31/506 ,  C12N15/86 ,  A61K31/502 ,  A61P21/00 ,  C12N2750/14141

Abstract: The present invention relates to methods for treating facioscapulohumeral dystrophy (FSHD). Specifically, the invention relates to the use of an inhibitor of necroptosis for treating FSHD.

公开(公告)号：US20230273221A1

公开(公告)日：2023-08-31

申请号：US18312879

申请日：2023-05-05

Applicant: UCL Business Ltd.

Inventor： Thomas Voit ,  Julie Dumonceaux ,  Virginie Mariot

IPC: G01N33/68 ,  A61K38/17 ,  G01N33/74

CPC classification number: G01N33/6887 ,  A61K38/177 ,  G01N33/74 ,  G01N2800/52

Abstract: The present invention provides a method for determining whether a patient will respond to treatment with a myostatin pathway inhibitor, the method comprising: (a) determining a level of myostatin and/or activin type II receptor (ActRII) and/or follistatin in at least one muscle biopsy obtained from a treatment target muscle in a subject having or suspected of having muscle atrophy or a muscle wasting condition; and (b) determining a level of myostatin and/or follistatin in a systemic sample obtained from the patient, wherein if: (i) the level of myostatin in the systemic sample is higher than a threshold and/or if the level of follistatin in the sample is lower than a threshold; and (ii) the level of myostatin and/or ActRII receptor in the at least one biopsy sample is higher than a threshold level and/or if the level of follistatin in the at least one biopsy sample is lower than a threshold level, the patient will respond to treatment.

公开(公告)号：US20230212166A1

公开(公告)日：2023-07-06

申请号：US18089498

申请日：2022-12-27

Applicant: UCL Business LTD.

Inventor： Stephen Neidle ,  Richard Angell ,  Sally Oxenford

IPC: C07D471/04 ,  A61P35/00

CPC classification number: C07D471/04 ,  A61P35/00

Abstract: The present invention relates to naphthalene diimides, NDIs, and methods of synthesising them. The NDIs have DNA-quadruplex binding and stabilising activity, and potential in treatment of pancreatic, prostate, and other human cancers. The NDIs are a compound of Formula I:

公开(公告)号：US20230190884A1

公开(公告)日：2023-06-22

申请号：US17818623

申请日：2022-08-09

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  UCL BUSINESS LTD

Inventor： Debra A. Thompson ,  Robin R. Ali ,  Alexander J. Smith

IPC: A61K38/44 ,  A61P27/02 ,  C12N7/00

CPC classification number: A61K38/443 ,  A61P27/02 ,  C12Y101/01105 ,  C12N7/00 ,  C12N2710/10043

Abstract: Provided are materials, methods and uses for treating an ophthalmological condition such as Leber Congenital Amaurosis by administering an effective amount of an adeno-associated virus AAV2, serotype 5 (AAV 2/5) or AAV-5 comprising an expressible coding region for human RDH12.

公开(公告)号：US20230159593A1

公开(公告)日：2023-05-25

申请号：US17998595

申请日：2021-05-14

Applicant: UCL BUSINESS LTD

Inventor： Greg Towers ,  David Selwood ,  Lucy Thorne ,  Justin Warne

IPC: C07K7/64 ,  A61P31/18 ,  A61P31/14 ,  C12N5/0789 ,  A61K35/28 ,  A61K47/54 ,  A61K47/55

CPC classification number: C07K7/645 ,  A61P31/18 ,  A61P31/14 ,  C12N5/0647 ,  A61K35/28 ,  A61K47/545 ,  A61K47/55 ,  A61K38/00

Abstract: The present application relates to cyclosporine analogues and their use in medical applications, including as antiviral compounds and in gene therapy.

公开(公告)号：US20230146709A1

公开(公告)日：2023-05-11

申请号：US17903372

申请日：2022-09-06

Applicant: UCL BUSINESS LTD

Inventor： Robin Simon Brooke Williams ,  Matthew Walker

IPC: A61K31/20

CPC classification number: A61K31/20

Abstract: A compound having the formula (I) R1-COOH. R1 is an alkyl or alkenyl group having a C7-11 backbone, optionally branched with a C1-6 alkyl group at any C position in the backbone, or a pharmaceutically acceptable salt, amide or ester thereof. The backbone of the alkyl or alkenyl group, and/or the branched alkyl groups, are optionally interrupted by one or more heteroatoms, provided that when R1 is an alkyl group having a C7 backbone, the branching does not consist only of a hexyl group at the a carbon of R1, or only of a methyl group at the γ carbon of R1, or of only single methyl groups at both the β and ω-1 carbons of R1, and provided that when R1 is an alkyl group having a C8 or C11 backbone, the branching does not consist only of a propyl group at the a carbon of R1.

公开(公告)号：US20230101069A1

公开(公告)日：2023-03-30

申请号：US17904393

申请日：2021-02-18

Applicant: UCL BUSINESS LTD

Inventor： Mark Brian PEPYS ,  Christopher SWAIN ,  Graham Walter TAYLOR ,  Stephen Paul WOOD ,  Melanie Susanne GLOSSOP ,  Charlotte Alice Louise LANE

IPC: A61K31/439 ,  A61K45/06

Abstract: An agent for use in medicine, wherein the agent comprises a compound of Formula (I): wherein Ar is an aryl linker group, for example a 1,4-phenyl group, including individual pharmaceutically acceptable salts, solvates, prodrugs or derivatives thereof. The compounds of Formula (I) are inhibitors of human C-reactive protein (CRP) and may be used for the treatment of medical conditions mediated by CRP. Also provided are methods of making the compounds of Formula (I) and chemical intermediates thereof.

公开(公告)号：US20230068155A1

公开(公告)日：2023-03-02

申请号：US17819757

申请日：2022-08-15

Applicant: UCL Business LTD.

Inventor： Danail STOYANOV ,  Hani Joseph MARCUS ,  Emmanouil DIMITRAKAKIS

IPC: A61B17/00

Abstract: An end-effector for an endoscopic surgical instrument, the end-effector comprising: a tool configured to interact with tissue; a main body comprising a bearing stud, the tool being connected to the bearing stud; a base comprising a surface facing the bearing stud, the bearing stud and the surface forming a ball joint; and a plurality of tendons connected to the main body so as to control movement of the tool in two degrees of freedom.