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49 条记录 (耗时 0.015 秒)

    1-(Benzodioxanylalkylene)piperidines
    21.
    发明授权
    1-(Benzodioxanylalkylene)piperidines 失效
    1-（苯并二恶烷基亚烷基）哌啶

    公开(公告)号：US3919242A

    公开(公告)日：1975-11-11

    申请号：US52400674

    申请日：1974-11-15

    申请人： WYETH JOHN & BROTHER LTD

    发明人： CAVALLA JOHN FREDERICK ,  ARCHIBALD JOHN LEHEUP

    IPC分类号： C07D211/58 ,  C07D211/72 ,  C07D213/75 ,  C07D333/16 ,  C07D333/56

    CPC分类号： C07D213/75 ,  C07D211/58 ,  C07D211/72 ,  C07D333/16 ,  C07D333/56

    摘要： A group of benzodioxanyl compounds useful in the treatment of disorders and diseases of the cardiovascular system and/or in the treatment of superficial and deep allergic phenomena is described. These are piperidine compounds linked by the nitrogen atom to a substituted or unsubstituted benzo-1,4-dioxanyl radical through the intermediary of a lower-alkylene radical. The piperidine ring is further substituted by an acylamino residue.

    摘要翻译： 描述了一组可用于治疗心血管系统疾病和疾病和/或治疗浅表和深度过敏现象的苯并二恶烷化合物。 这些是通过氮原子连接到取代或未取代的苯并-1,4-二氧杂环己基通过中间的亚烷基自由基的哌啶化合物。 哌啶环进一步被酰氨基残基取代。

    1-Pyrrolyl alkylene-piperidines
    22.
    发明授权
    1-Pyrrolyl alkylene-piperidines 失效
    1-吡咯基亚烷基 - 哌啶

    公开(公告)号：US3917614A

    公开(公告)日：1975-11-04

    申请号：US52416174

    申请日：1974-11-15

    申请人： WYETH JOHN & BROTHER LTD

    发明人： CAVALLA JOHN FREDERICK ,  ARCHIBALD JOHN LEHEUP

    IPC分类号： C07D211/58 ,  C07D211/72 ,  C07D213/75 ,  C07D333/16 ,  C07D333/56

    CPC分类号： C07D213/75 ,  C07D211/58 ,  C07D211/72 ,  C07D333/16 ,  C07D333/56 ,  Y10S514/821 ,  Y10S514/929

    摘要： A group of pyrrole compounds useful in the treatment of disorders and diseases of the cardiovascular system is described. These compounds and intermediates for their preparation are piperidine compounds linked by the nitrogen atom to a substituted or unsubstituted pyrrole radical through the intermediary of a group selected from a lower-alkylene radical, a mono- or di-keto lower-alkylene radical or a hydroxy-lower-alkylene radical. The piperidine rings are further substituted by an amino or acylamino residue.

    摘要翻译： 描述了一组可用于治疗心血管系统疾病和疾病的吡咯化合物。 这些化合物及其制备的中间体是通过氮原子连接到取代或未取代的吡咯基的哌啶化合物，通过选自低级亚烷基，一或二酮低级亚烷基或羟基的基团 - 低级 - 亚烷基。 哌啶环进一步被氨基或酰氨基残基取代。

    10,10-Disubstituted-2,3,4,10-tetrahydro-and 1,2,3,4,10a-hexahydropyrimidol {8 1,2-a{9 indole derivatives
    24.
    发明授权
    10,10-Disubstituted-2,3,4,10-tetrahydro-and 1,2,3,4,10a-hexahydropyrimidol {8 1,2-a{9 indole derivatives 失效
    10,10-二取代-2,3,4,10-四氢和1,2,3,4,10a-六氢嘧啶醇{8,1-a {9吲哚衍生物

    公开(公告)号：US3891644A

    公开(公告)日：1975-06-24

    申请号：US36170173

    申请日：1973-05-18

    申请人： WYETH JOHN & BROTHER LTD

    发明人： WHITE ALAN CHAPMAN

    IPC分类号： C07D209/38 ,  C07D233/04 ,  C07D233/20 ,  C07D233/22 ,  C07D487/04 ,  C07D51/46

    CPC分类号： C07D487/04 ,  C07D209/38 ,  C07D233/04 ,  C07D233/20 ,  C07D233/22

    摘要： A group of heterocyclic compounds useful as anti-depressant agents is described. The compounds may also be used as antiinflammatory agents, anti-histamine agents, diuretics and hypoglycaemics. The compounds are 2,3,4,10-tetrahydropyrimido(1,2-a)indoles and 1,2,3,4,10, 10a-hexahydropyrimido(1,2a)indoles substituted in the 10-position by a hydroxy or lower acyloxy residue together with a phenyl, substituted phenyl, lower alkyl, lower alkynyl, benzyl, naphthyl, thienyl or pyridyl residue. The compounds are optionally substituted in the 2,3,4,6,7,8, or 9 positions and the Hexahydropyrimido(1,2-a) indoles may also be substituted in the 1-position. Exemplary of the compounds of the invention is 10-(m-chlorophenyl)-2,3,4,10tetrahydropyrimido(1,2-a)indol-10-ol.

    摘要翻译： 描述了一组用作抗抑郁剂的杂环化合物。 化合物也可以用作抗炎剂，抗组胺剂，利尿剂和低血糖药。 化合物是在10位上取代的2,3,4,10-四氢 - 嘧啶并[1,2-a]吲哚和1,2,3,4,10,10a-六氢嘧啶并[1,2-a]吲哚 羟基或低级酰氧基残基连同苯基，取代的苯基，低级烷基，低级炔基，苄基，萘基，噻吩基或吡啶基残基。 该化合物任选在2,3,4,6,7,8或9位取代，六氢嘧啶并[1,2-a]吲哚也可以在1-位取代。 本发明化合物的实例是10-（间氯苯基）-2,3,4,10-四氢嘧啶并[1,2-a]吲哚-10-醇。

    (4-Quinolylamino)-(N-piperidyl)benzamides and N-{8 (quinolylamino)-benzoyl{9 piperidines
    25.
    发明授权
    (4-Quinolylamino)-(N-piperidyl)benzamides and N-{8 (quinolylamino)-benzoyl{9 piperidines 失效
    （4-喹啉基氨基） - （N-哌啶基）苯甲酰胺和N- {8（喹啉基氨基） - 苯甲酰基{9-哌啶

    公开(公告)号：US3875165A

    公开(公告)日：1975-04-01

    申请号：US33479973

    申请日：1973-02-22

    申请人： WYETH JOHN & BROTHER LTD

    发明人： ARCHIBALD JOHN LEHEUP ,  BOYLE JOHN TERENCE ARNOTT ,  SAUNDERS JOHN CHRISTOPHER

    IPC分类号： C07D215/44 ,  C07D33/54

    CPC分类号： C07D215/44 ,  Y10S514/822 ,  Y10S514/826 ,  Y10S514/895

    摘要： The disclosure describes new 4-aminoquinoline derivatives of general formula

    AND THEIR ACID ADDITION SALTS, WHERE X is a halogen atom or a trifluoromethyl group, Z is a hydrogen atom or a defined substituent, R is group of the formula -R3N-A-NR1R2 (II),

    where A in formula II is a chain of 1 to 5 methylene groups which may be substituted with alkyl, the ring in formula IIIa and IIIb is a piperidine or pyrrolidine ring that may be substituted with alkyl and R1, R2 and R3 represent hydrogen or certain defined substituents. The new 4-aminoquinoline derivatives show anti-malarial activity and, in some cases, shows one or more of the following activities: antiinflammatory activity, anti-hypertensive activity, antitrichomonal activity, inhibition of blood platelet aggregation, anti-ulcer activity and activity against allergic asthma.

    摘要翻译： 本公开内容描述了新的通式为它们的4-氨基喹啉衍生物及其添加剂的盐，其中X是卤素原子或三氟甲基，Z是氢原子或定义的取代基，R是式-R3N-A-NR1R2的基团 （II），其中式II中的A是可以被烷基取代的1至5个亚甲基的链，式IIIa和IIIb中的环是可被烷基取代的哌啶或吡咯烷环，R 1，R 2和R 3 表示氢或某些定义的取代基。 新的4-氨基喹啉衍生物显示抗疟疾活性，并且在某些情况下显示以下一种或多种活性：抗炎活性，抗高血压活性，抗毛滴虫活性，血小板聚集抑制，抗溃疡 针对过敏性哮喘的活动和活动。

    3-(2-(4-cyclohexanecarboxamido-1-piperidyl)ethyl)indole
    27.
    发明授权
    3-(2-(4-cyclohexanecarboxamido-1-piperidyl)ethyl)indole 失效
    3-（2-（4-环己基硫代氨基甲酰基-1-哌啶基）乙基）吲哚

    公开(公告)号：US3655674A

    公开(公告)日：1972-04-11

    申请号：US3655674D

    申请日：1969-07-23

    申请人： WYETH JOHN & BROTHER LTD

    发明人： ARCHIBALD JOHN LEHEUP

    IPC分类号： C07D401/06 ,  C07D29/30

    CPC分类号： C07D401/06

    摘要： THE INVENTION RELATES TO THE FIELD OF SUBSTITUTED INDOLES, IN PARTICULAR TO INDO-3-YL-LOWER ALKYLPIPERIDINES SUBSTITUTED IN THE PIPERIDINE RING BY A CYCLOALKANOYLAMINO RESIDUE, THEIR ACID ADDITION AND QUATERNARY AMMONIUM SALTS, AND TO INTERMEDIATES AND PROCESS FOR THE PREPARATION THEREOF. THE COMPOUNDS OF THE INVENTION ARE PHARMACOLOGICALLY EFFICATIOUS AS HYPOTENSIVE AND ANTI-HISTAMINE AGENTS.