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    4-benzoyl-4-hydroxy-3-phenyl-1-substituted piperidines
    1.
    发明授权
    4-benzoyl-4-hydroxy-3-phenyl-1-substituted piperidines 失效
    4-苯基-4-羟基-3-苯基-1-取代的哌啶

    公开(公告)号：US3793334A

    公开(公告)日：1974-02-19

    申请号：US3793334D

    申请日：1972-09-01

    申请人： SANDOZ AG

    发明人： EBNOETHER A ,  RISSI E

    IPC分类号： C07D211/32 ,  C07D211/38 ,  C07D211/50 ,  C07D29/36

    CPC分类号： C07D211/38 ,  C07D211/32 ,  C07D211/50

    摘要： THE INVENTION CONCERNS NOVEL COMPOUNDS OF THE FORMULA:

    1-(R-(CH2)N-),3-PHENYL,4-(HO-),4-(PHENYL-CO-)PIPERIDINE

    WHEREIN N IS AN INTEGER FROM 1 TO 4, AND R IS A GROUP --CO--R1, WHEREIN R1 IS HYDROXY, ALKYL OF 1 TO 4 CARBON ATOMS, ALKOXY OF 1 TO 4 CARBON ATOMS, AMINO, ALKYLAMINO, DIALKYYLAMINO, PHENYL, CHLORO-PHENYL, BROMOPHENYL, FLUORO-PHENYL, ALKYL-PHENYL IN WHICH THE ALKYL RADICAL IS OF 1 TO 4 CARBON ATOMS, METHOXYPHENYL OR METHYLTHIO-PHENYL, OR A

    R2-C(-R3)(-OH)-

    WHEREIN EACH OF R2 AND R3 IS HYDROGEN OR ALKYL OF 1 TO 4 CARBON ATOMS, AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF. THE COMPOUNDS ARE HYPOLIPEMICS, PARTICULARLY HYPOCHLESTEREMICS, USEFUL IN THE PROPHYLAXIS OR TREATMENT OF ARTERIOSCLEROSIS.

    Bis-basic ethers and thioethers of dibenzothiophene
    3.
    发明授权
    Bis-basic ethers and thioethers of dibenzothiophene 失效
    二苯并噻吩的双酚A基和二苯醚

    公开(公告)号：US3673191A

    公开(公告)日：1972-06-27

    申请号：US3673191D

    申请日：1970-02-18

    申请人： RICHARDSON MERRELL INC

    发明人： ALBRECHT WILLIAM L ,  FLEMING ROBERT W ,  HORGAN STEPHEN W

    IPC分类号： C07D333/76 ,  C07D29/36

    CPC分类号： C07D333/76

    摘要： The novel bis-basic ethers and thioethers of dibenzothiophene of the present invention have useful antiviral properties. These new compounds are represented by the formula WHEREIN EACH Y is oxygen or divalent sulfur; and each X is WHEREIN EACH A is a straight or branched alkylene chain having from two to eight carbon atoms and which separates the amino nitrogen and Y by at least two carbon atoms; R and R1 are individually hydrogen, (lower)alkyl having from one to six carbon atoms, cycloalkyl having from three to six carbon atoms, alkenyl having from three to six carbon atoms and having the vinyl unsaturation in other that the 1-position of the alkenyl group; or each set of R and R1 taken together with the nitrogen atom to which they are attached is a saturated monocyclic heterocyclic group such as pyrrolidino, piperidino, morpholino, or N(lower)alkylpiperazino; or WHEREIN N IS A WHOLE INTEGER OF FROM 0 TO 2, M IS 1 OR 2, AND R2 is hydrogen, (lower)alkyl having from one to six carbon atoms, or alkenyl of from three to six carbon atoms and having the vinyl unsaturation in other than the 1-position of the alkenyl group. This invention also includes pharmaceutically acceptable acid addition salts of the bases represented by Formula I. These new compounds may be prepared by several different methods which are described.

    摘要翻译： 本发明的二苯并噻吩的新型双碱性醚和硫醚具有有用的抗病毒性质。 这些新化合物以下式表示：其中Y是Y或Y是二价硫; 并且每个X是每个A是具有2至8个碳原子并且将氨基氮和Y分开至少两个碳原子的直链或支链亚烷基链; R和R 1分别是氢，具有1至6个碳原子的（低级）烷基，具有3至6个碳原子的环烷基，具有3至6个碳原子的烯基，并且具有乙烯基不饱和键， 烯基; 或者R和R 1与它们所连接的氮原子一起是饱和的单环杂环基如吡咯烷子基，哌啶子基，吗啉代或N-（低级）烷基哌嗪基; 或其中N为0至2的全部整数，M为1或2，并且R 2为氢，具有1至6个碳原子的（低级）烷基或3至6个碳原子的烯基并且具有乙烯基不饱和度 除了烯基的1位以外。

    ANTIPHLOGISTIC p-AMINOARYLALKANOL DERIVATIES
    4.
    发明授权
    ANTIPHLOGISTIC p-AMINOARYLALKANOL DERIVATIES 失效
    抗微生物对氨基胆碱衍生物

    公开(公告)号：US3669973A

    公开(公告)日：1972-06-13

    申请号：US3669973D

    申请日：1969-07-25

    申请人： MERCK PATENT GMBH

    发明人： BORCK JOACHIM ,  DAHM JOHANN ,  KOPPE VOLKER ,  KRAMER JOSEF ,  SCHOREE GUSTAV ,  HOVY JAN WILLEM HERMAN ,  SCHORSCHER ERNST

    IPC分类号： C07C205/12 ,  C07C205/26 ,  C07C245/14 ,  C07D295/096 ,  C07D295/155 ,  C07D29/36

    CPC分类号： C07D295/096 ,  C07C205/12 ,  C07C205/26 ,  C07C245/14 ,  C07D295/155 ,  Y10S514/866 ,  Y10S514/869 ,  Y10S514/917

    摘要： As antiphlogistic agents having activities as 1-perhydroazepinyl; as indomethacin and much lower acute toxicities, there are provided compounds of the formula WHEREIN R1 represents a free, esterified or etherified OH-group; R2 represents H, CH3 or C2H5; R3 represents H, F, Hal, NO2, NH2, CH3, C2H5, CH3S or C2H5S; R4 and R5 represent H or, together, -CH=CH-CH=CH; Q is pyrrolidino, piperidino or homopiperidino, 1-perhydroazepinyl; and Hal represents Cl, Br or I; With the provision that when R4 and R5 represent H, R3 does not represent H, as well as the acid addition salts and quaternary ammonium salts thereof.

    摘要翻译： 作为具有1-perhydro-azepinyl活性的消炎剂; 作为消炎痛和低得多的急性毒性，提供下式的化合物，其中R1表示游离的，酯化的或醚化的OH-基团; R2代表H，CH3或C2H5; R3表示H，F，Hal，NO2，NH2，CH3，C2H5，CH3S或C2H5S; R4和R5代表H或-CH = CH-CH = CH; Q是吡咯烷子基，哌啶子基或高哌啶子基，1-全氢 - 氮杂子基; Hal表示Cl，Br或I; 当R4和R5代表H时，R3不表示H，以及其酸加成盐和季铵盐。

    2-Sulphenylimino-5-amino-1,3-dithianes
    8.
    发明授权
    2-Sulphenylimino-5-amino-1,3-dithianes 失效
    2-磺基亚氨基-5-氨基-1,3-二噻烷

    公开(公告)号：US3878216A

    公开(公告)日：1975-04-15

    申请号：US38382373

    申请日：1973-07-30

    申请人： SANDOZ AG

    发明人： SCHNEIDER RUPERT

    IPC分类号： A01N43/32 ,  A01N43/40 ,  C07D339/08 ,  C07D29/36

    CPC分类号： C07D339/08

    摘要： The present invention concerns novel 5-amino-1,3-dithiane derivatives of the formula:

    WHEREIN R1, R2, R3 and R4 are substituents such as alkyl. The compounds are useful insecticides.

    摘要翻译： 本发明涉及下式的新型5-氨基-1,3-二噻烷衍生物：