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公开(公告)号：US20080167380A1
公开(公告)日：2008-07-10
申请号：US11910673
申请日：2006-03-10
申请人： Rolf Gericke , Dieter Dorsch , Werner Mederski , Markus Klein , Norbert Beier , Florian Lang
发明人： Rolf Gericke , Dieter Dorsch , Werner Mederski , Markus Klein , Norbert Beier , Florian Lang
IPC分类号： A61K31/275
CPC分类号： C07C323/62 , C07C243/38 , C07C255/57
摘要： Novel acyl hydrazides of the formula (I), in which R1-R9 have the meanings indicated in claim 1, are SGK inhibitors and can be used for the treatment of SGK-induced diseases and complaints, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and renal diseases, generally in fibroses and inflammatory processes of any type.
摘要翻译： 式（I）的新型酰基酰肼，其中R 1〜R 9具有权利要求1所示的含义，为SGK抑制剂，可用于治疗 SGK引起的疾病和投诉，例如糖尿病，肥胖症，代谢综合征（血脂异常），全身性和肺性高血压症，心血管疾病和肾脏疾病，通常在任何类型的纤维和炎症过程中。
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公开(公告)号：US20080003214A1
公开(公告)日：2008-01-03
申请号：US11575711
申请日：2005-08-24
IPC分类号： A61K38/48 , A61K31/407 , A61K31/497 , C07D285/12 , C07D403/00 , C07D413/00 , C07D401/00 , A61P7/02 , A61K31/529
CPC分类号： A61K31/4545 , A61K31/4025 , A61K31/427 , A61K31/4412 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/5355 , A61K31/5377 , A61K31/553 , A61K45/06 , A61K2300/00
摘要： Use of compounds of the formula (I) in which D, E, G, W, X, Y, T, R1 and R2 have the meaning indicated in Patent Claim 1, for the prophylaxis and/or therapy of thromboembolic diseases
摘要翻译： 其中D，E，G，W，X，Y，T，R 1和R 2的式（I）化合物具有专利中所示的含义 权利要求1，用于预防和/或治疗血栓栓塞性疾病
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公开(公告)号：US20070299065A1
公开(公告)日：2007-12-27
申请号：US11792133
申请日：2005-11-07
IPC分类号： A61K31/5355 , A61K31/351 , A61K31/4433 , A61K31/453 , A61P3/10 , C07D315/00 , C07D413/12 , C07D405/12 , C07D239/36 , A61K31/497 , A61K31/501 , A61K31/506
CPC分类号： C07H15/203
摘要： Novel compounds of the formula (I), in which T, E, R, R′, R″, R1, R2 and R2′ have the meanings indicated in patent Claim 1, are suitable as antidiabetics.
摘要翻译： 式（I）的新型化合物，其中T，E，R，R'，R“，R”，R“2和R”2“ 具有专利权利要求1中所示的含义，适合作为抗糖尿病药。
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公开(公告)号：US20060241111A1
公开(公告)日：2006-10-26
申请号：US10559385
申请日：2004-05-12
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/454 , A61K31/4439 , C07D413/02 , C07D417/02 , C07D409/02 , C07D403/02 , C07D405/02
CPC分类号： C07D409/12 , C07D413/12
摘要： Novel compounds of the formula (I) in which Het, R1, R2 and R3 have the meaning indicated in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 其中Het，R 1，R 2和R 3的新型式（I）化合物具有专利权利要求1中所示的含义， 是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病和治疗肿瘤。
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25.发明申请Pyrazolidine-1,2-dicarboxyldiphenylamide derivatives as coagulation factor xa inhibitors for the treatment of thromboses 失效吡唑烷-1,2-二羧基二苯胺衍生物作为治疗血栓形成的凝血因子xa抑制剂公开(公告)号：US20060183742A1
公开(公告)日：2006-08-17
申请号：US10551559
申请日：2004-03-09
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/454 , A61K31/4439 , A61K31/4178 , A61K31/416 , C07D413/02 , C07D403/02
CPC分类号： C07D401/12 , C07D403/12 , C07D413/12 , C07D453/06
摘要： Novel compounds of the formula (I), in which R, R1, R2 and R3 have the meanings indicated in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 式（I）的新型化合物，其中R 1，R 1，R 2和R 3具有专利权利要求1中所示的含义 是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病和治疗肿瘤。
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26.发明申请Heterocyclic amides and their use treating thromboembolic diseases and tumors 审中-公开杂环酰胺及其用途治疗血栓栓塞性疾病和肿瘤公开(公告)号：US20060135515A1
公开(公告)日：2006-06-22
申请号：US10530876
申请日：2003-09-18
申请人： Dieter Dorsch , Bertram Cezanne , Werner Mederski , Christos Tsaklakidis , Johannes Gleitz , Christopher Barnes
发明人： Dieter Dorsch , Bertram Cezanne , Werner Mederski , Christos Tsaklakidis , Johannes Gleitz , Christopher Barnes
IPC分类号： A61K31/5377 , C07D413/02
CPC分类号： C07D409/12 , C07D333/36 , C07D409/14 , C07D413/12
摘要： Novel compounds of the formula (I), in which D, W, X, Y, T and R1 have the meaning indicated in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours
摘要翻译： 式（I）的新型化合物，其中D，W，X，Y，T和R 1具有专利权利要求1中所示的含义，是凝血因子Xa的抑制剂，可用于 预防和/或治疗血栓栓塞性疾病和治疗肿瘤
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公开(公告)号：US20060084648A1
公开(公告)日：2006-04-20
申请号：US10547130
申请日：2004-01-30
申请人： Werner Mederski , Christos Tsaklakidis , Dieter Dorsch , Bertram Cezanne , Johannes Gleitz , Christoph van Amsterdam
发明人： Werner Mederski , Christos Tsaklakidis , Dieter Dorsch , Bertram Cezanne , Johannes Gleitz , Christoph van Amsterdam
IPC分类号： A61K31/537 , A61K31/4172 , C07D265/30 , C07D413/02
CPC分类号： C07D213/64 , C07D233/46 , C07D265/32 , C07D401/12 , C07D403/12 , C07F9/6533
摘要： Novel compounds of the formula (I), in which R1, R2, R3, X and Y have the meaning indicated in Patent claim 1, are inhibitors ocoagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
摘要翻译： 式（I）的新化合物，其中R 1，R 2，R 3，X和Y具有专利中所示的含义 权利要求1是抑制凝血因子Xa，可用于预防和/或治疗血栓栓塞性疾病和治疗肿瘤。
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28.发明申请2-(Phenyl)-2h-pyrazole-3-carboxylic acid-n-4-(thioxo-heterocyclyl)-phenyl-amide derivatives and corresponding imino-heterocyclyl derivatives and relates compounds for use as inhibitors of the coagulation factors xa and/or viia for treating thromboses 审中-公开2-（苯基）-2h-吡唑-3-羧酸 - 正-4-（硫代 - 杂环基） - 苯基 - 酰胺衍生物和相应的亚氨基 - 杂环基衍生物，并涉及用作凝血因子xa和/或 用于治疗血栓的病毒公开(公告)号：US20050203127A1
公开(公告)日：2005-09-15
申请号：US10519356
申请日：2003-06-05
申请人： Bertram Cezanne , Dieter Dorsch , Werner Mederski , Christos Tsaklakidis , Johannes Gleitz , Christopher Barnes
发明人： Bertram Cezanne , Dieter Dorsch , Werner Mederski , Christos Tsaklakidis , Johannes Gleitz , Christopher Barnes
IPC分类号： A61K31/4155 , A61K31/4178 , A61K31/42 , A61K31/433 , A61P7/02 , A61P9/08 , A61P9/10 , A61P25/06 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D403/12 , C07D413/14 , C07D417/12 , C07D413/02 , A61K31/423 , A61K31/4245 , A61K31/4709
CPC分类号： C07D403/12 , A61K31/4155 , A61K31/4178 , A61K31/42 , A61K31/433 , C07D403/14 , C07D413/14 , C07D417/12 , Y02P20/55
摘要： The invention relates to the novel compounds of formula (I), wherein D, M, W, X, Y, T, R1 and R1′ are defined as in patent claim 1. The inventive compounds are inhibitors of coagulation factor Xa and can be used in the prophylaxis and/or therapy of thromboembolic diseases and in the treatment of tumors.
摘要翻译： 本发明涉及新的式（I）化合物，其中D，M，W，X，Y，T，R 1和R 1定义如 本发明化合物是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病和治疗肿瘤。
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29.发明授权Imidazo (4,5-C) pyridine-4-one derivatives with factor XA inhibiting effect 失效咪唑（4,5-C）吡啶-4-酮衍生物，具有因子XA抑制作用公开(公告)号：US06492384B1
公开(公告)日：2002-12-10
申请号：US09806418
申请日：2001-12-13
申请人： Werner Mederski , Horst Juraszyk , Hanns Wurziger , Joachim Gante , Dieter Dorsch , Hans-Peter Buchstaller , Sabine Bernotat-Danielowski , Guido Melzer , Soheila Anzali
发明人： Werner Mederski , Horst Juraszyk , Hanns Wurziger , Joachim Gante , Dieter Dorsch , Hans-Peter Buchstaller , Sabine Bernotat-Danielowski , Guido Melzer , Soheila Anzali
IPC分类号： A61K31437
CPC分类号： C07D471/04
摘要： The invention relates to novel compounds of formula (I), wherein R, R1, R2, R3, n and p have the meaning defined in claim 1. Compounds are inhibitors of clotting factor Xa and can be used for the prophylaxis and/or therapy of thrombo-embolic disorders.
摘要翻译： 本发明涉及式（I）的新化合物，其中R，R 1，R 2，R 3，n和p具有权利要求1中定义的含义。化合物是凝血因子Xa的抑制剂，可用于预防和/或治疗 的血栓栓塞障碍。
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30.发明授权Benzothia(oxa)diazol derivatives and their use as endothelin-receptor antagonists 失效苯并噻唑（oxa）二唑衍生物及其作为内皮素受体拮抗剂的用途公开(公告)号：US06197800B1
公开(公告)日：2001-03-06
申请号：US09463311
申请日：2000-03-27
申请人： Dieter Dorsch , Mathias Osswald , Werner Mederski , Claudia Wilm , Maria Christadler , Claus Jochen Schmitges
发明人： Dieter Dorsch , Mathias Osswald , Werner Mederski , Claudia Wilm , Maria Christadler , Claus Jochen Schmitges
IPC分类号： C07D28514
CPC分类号： C07D285/14 , C07D271/12 , C07D413/04 , C07D417/04
摘要： Novel compounds of the formula I in which R is X is O or S, and R1, R2, R3, R4, R5 and R6 have the meaning indicated in patent claim 1, or a tautomeric ring-closed form, and the (E) isomers and their salts exhibit endothelin receptor-antagonistic properties.
摘要翻译： R为X的式Iin的新型化合物是O或S，R 1，R 2，R 3，R 4，R 5和R 6具有专利权利要求1中所示的含义或互变异构闭环形式，和（E）异构体及其盐类 内皮素受体拮抗性。
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